The MSH3 Gene From A Neuropsychiatrist’s Perspective

Abstract

Introduction We read with great interest the article by Ambati BK, et al. “MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site” published on February 21st, 2022 in Frontiers in Virology. This perspective paper highlights a 19-nucleotide genetic sequence, a reverse complement of the human MSH3 gene, that contains the SARS-CoV-2 furin cleavage site (FCS). As this sequence (SEQ ID11652) was patented by Moderna in 2016 (US patent 9,587,003), some have suggested that the FCS may have been known prior to the COVID-19 pandemic [1].