PYGO在癌症通路中的作用

Advances in clinical and medical research (Chandigarh, India) Pub Date : 2023-02-06 DOI:10.52793/acmr.2023.4(1)-48

Shihori Tanabe

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引用次数: 0

摘要

几个分子参与了癌症分子网络。Pygopus家族植物同源结构域（PHD）finger（Pygo）是Wnt/ -连环蛋白转录复合体。Pygo在哺乳动物细胞中有两种同源物，Pygo1和Pygo2。Pygo2作为 -连环蛋白-B细胞CLL/淋巴瘤9（Bcl9）-TCF/LEF复合物。在这篇社论中，Pygo在Wnt/ -综述了与癌症通路相关的连环蛋白信号传导。

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PYGO In Cancer Pathway

Several molecules are involved in cancer molecular network. Pygopus family plant homeodomain (PHD) finger (Pygo) is a component of Wnt/  -catenin transcription complex. Pygo has two homologs, Pygo1 and Pygo2, in mammalian cells. Pygo2 has an important role as a component of  -catenin-B-cell CLL/lymphoma 9 (Bcl9)-TCF/LEF complex. In this Editorial, a role of Pygo in Wnt/  -catenin signaling related to cancer pathway is summarized.

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Advances in clinical and medical research (Chandigarh, India)

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