Advances in clinical and medical research (Chandigarh, India)最新文献

{"title":"Cellular Internalization And RNA Regulation Of RNA Virus","authors":"S. Elfaituri, Fatma Emaetig","doi":"10.52793/acmr.2022.3(2)-29","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(2)-29","url":null,"abstract":"","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46468525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular Internalization And RNA Regulation Of RNA Virus","authors":"Shihori Tanabe","doi":"10.52793/acmr.2020.1(1)-02","DOIUrl":"https://doi.org/10.52793/acmr.2020.1(1)-02","url":null,"abstract":"Biological responses are regulated by various molecular networks. It is significantly important to reveal the mechanisms of diseases and cellular responses for the prevention and drug development. The infection mechanism of RNA virus consists of viral internalization, replication including RNA transcription, and expansion. RNA regulation of the RNA virus is critical for the replication of RNA virus. The therapy for the infectious diseases may target the viral internalization, replication and expansion. In this Editorial, the internalization and replication mechanism of RNA virus, especially novel corona virus SARS-CoV-2 which causes infectious diseases, is focused on and described.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47341750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future Plans Of Treating A Case Of Acquired Pure Red Cell Aplasia Secondary To Autoimmune Causes Resistant To Combination Of Cyclosporine And Corticosteroid","authors":"K. Kaur, M. Singh","doi":"10.52793/acmr.2020.1(1)-01","DOIUrl":"https://doi.org/10.52793/acmr.2020.1(1)-01","url":null,"abstract":"Pure red cell aplasia (PRCA) is an orphan disease, and as such there are no rationally developed standard treatments. Most of the cases are idiopathic with a subset being antibody mediated. An overlap exists among idiopathic cases with those of T cell large granular lymphocytic leukemia, hypogamma globulinemia as well a slow grade lymphoma. Here we report a case of acquired Pure red cell aplasia (aPRCA), out of viral causes, congenital disease as well as drug reactionidiopathic PRCA would be the commonest cause, with the majority of cases believed to be by auto reactive T cells. This is mainly through selective T or NK cell mediated killing of erythroid colony (CFU-E) and burst (BFU-E) forming units, thus inhibiting red cell precursor progression to mature erythrocytes (Figure1) [7,17]. endometriomas and has now displayed partial remission (PR) with a combination of prednisolone 50mg with anabolic steroid danazol 200mg bd for 4 months along with metoclopramide 10mg od and is being continued on same therapy for minimum of 18 months for getting a CR as did another case of SLE as well as a case of anky losing spondylitis. a mass in ovaries trans vaginal sonography (TVS) revealed a solid mass in left ovarymeasuring 50x35.8 mm and right ovary vague mass multiseptate 33x30.5 mm with fluid in pouch of douglas. Only latest LFT increased SGOT/PT was observed.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42737811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Associated And Risk Factor Of HPV Wharts: A Review Article","authors":"Gofur Nrp, Gofur Arp, Soesilaningtyas , , Gofur Rnrp, Kahdina M, Putri Hm","doi":"10.52793/acmr.2022.3(1)-23","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(1)-23","url":null,"abstract":"Introduction: HPV can infect basal epithelial cells of the skin or deep tissue and are categorized as either skin type or mucosal type. This skin type is epidermotropic and infects the surface of the keratinized skin, targeting the skin of the hands and feet. The type of mucosa that is infected is the lining of the mouth, throat, respiratory, or anogenital as 28 types that have been identified so far can use various methods. Identification of viral DNA or RNA by various hybridization techniques. Time to analyze the results is also very important to know the validity of the different HPV techniques, the sensitivity, specificity, and the spectrum of HPV types detected. Southern Blot hybridization is still used as the standard for DNA identification of various types of HPV. However, between 5000 and 50 000 copies of HPV DNA must be present in a clinical sample to be detected [4]. In addition to VLP, HPV DNA is also most common in women under 25 years of age prevalence tends to peak in women over 25 years of age using HPV antibodies. Number of sexual partners was recognized as an independent risk factor for genital HPV infection in patients with immunosuppression will also be a risk factor for HPV infection, for example in patients with autoimmune, HIV infection and organ transplantation in patients with autoimmune, HIV and organ transplantation. Serological tests for certain types of HPV have been used to detect antibodies to viral particles such as (VLP), which is a viral capsid synthesized from the viral L1 protein. The prevalence of HPV infection using VLP as antigen showed that, among women clinically absent of HPV, 2-43% had antibodies to HPV 16, and 9-25% had antibodies to HPV 6 or 11. The seroprevalence of other types, including 18, 31, 33, 39, 58, and 59, ranging from 9% to 23%. In addition to VLP, HPV DNA is also most common in women under 25 years of age, prevalence tends to peak in women over 25 years of age using HPV antibodies The study 21% of = 90) reported having only one male sexual partner positive PCR method compared with 69% Frequently changing partners more Previous studies have not shown an association between HPV detection and sexual activity, due to the possibility of misclassifying HPV and its manifestations and the small sample size of subjects may distort the results. Subclinical HPV infection and HPV-associated disease common (64% male HPV intraepithelial","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43765713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future Plans Of Treating A Case Of Acquired Pure Red Cell Aplasia Secondary To Autoimmune Causes Resistant To Combination Of Cyclosporine And Corticosteroid","authors":"Yukta Ramesh, C. Cronin, J. Trujillo","doi":"10.52793/acmr.2022.3(2)-28","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(2)-28","url":null,"abstract":"","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45158400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}