Future Plans Of Treating A Case Of Acquired Pure Red Cell Aplasia Secondary To Autoimmune Causes Resistant To Combination Of Cyclosporine And Corticosteroid

Abstract

Pure red cell aplasia (PRCA) is an orphan disease, and as such there are no rationally developed standard treatments. Most of the cases are idiopathic with a subset being antibody mediated. An overlap exists among idiopathic cases with those of T cell large granular lymphocytic leukemia, hypogamma globulinemia as well a slow grade lymphoma. Here we report a case of acquired Pure red cell aplasia (aPRCA), out of viral causes, congenital disease as well as drug reactionidiopathic PRCA would be the commonest cause, with the majority of cases believed to be by auto reactive T cells. This is mainly through selective T or NK cell mediated killing of erythroid colony (CFU-E) and burst (BFU-E) forming units, thus inhibiting red cell precursor progression to mature erythrocytes (Figure1) [7,17]. endometriomas and has now displayed partial remission (PR) with a combination of prednisolone 50mg with anabolic steroid danazol 200mg bd for 4 months along with metoclopramide 10mg od and is being continued on same therapy for minimum of 18 months for getting a CR as did another case of SLE as well as a case of anky losing spondylitis. a mass in ovaries trans vaginal sonography (TVS) revealed a solid mass in left ovarymeasuring 50x35.8 mm and right ovary vague mass multiseptate 33x30.5 mm with fluid in pouch of douglas. Only latest LFT increased SGOT/PT was observed.