Natural Products and Bioprospecting最新文献_第6页

Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway 黄芩苷通过 TGF-β1 信号通路改善糖尿病肾病

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-04-24 DOI: 10.1007/s13659-024-00446-y

Bangrui Huang, Rui Han, Hong Tan, Wenzhuo Zhu, Yang Li, Fakun Jiang, Chun Xie, Zundan Ren, Rou Shi

{"title":"Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway","authors":"Bangrui Huang, Rui Han, Hong Tan, Wenzhuo Zhu, Yang Li, Fakun Jiang, Chun Xie, Zundan Ren, Rou Shi","doi":"10.1007/s13659-024-00446-y","DOIUrl":"10.1007/s13659-024-00446-y","url":null,"abstract":"<div><p>Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb <i>Erigeron breviscapus</i> (Vant.) Hand-Mazz, has demonstrated a promising potential in improving diabetic nephropathy (DN). However, the specific active constituent(s) responsible for its therapeutic effects and the underlying pharmacological mechanisms remain unclear. In this study, we aimed to investigate the impact of scutellarin, a constituent of breviscapine, on streptozotocin-induced diabetic nephropathy and elucidate its pharmacological mechanism(s). Our findings demonstrate that scutellarin effectively ameliorates various features of DN in vivo, including proteinuria, glomerular expansion, mesangial matrix accumulation, renal fibrosis, and podocyte injury. Mechanistically, scutellarin appears to exert its beneficial effects through modulation of the transforming growth factor-β1 (TGF-β1) signaling pathway, as well as its interaction with the extracellular signal-regulated kinase (Erk) and Wnt/β-catenin pathways.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00446-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural compounds proposed for the management of non-alcoholic fatty liver disease 建议用于治疗非酒精性脂肪肝的天然化合物。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-04-01 DOI: 10.1007/s13659-024-00445-z

Théodora Merenda, Florian Juszczak, Elisabeth Ferier, Pierre Duez, Stéphanie Patris, Anne-Émilie Declèves, Amandine Nachtergael

{"title":"Natural compounds proposed for the management of non-alcoholic fatty liver disease","authors":"Théodora Merenda, Florian Juszczak, Elisabeth Ferier, Pierre Duez, Stéphanie Patris, Anne-Émilie Declèves, Amandine Nachtergael","doi":"10.1007/s13659-024-00445-z","DOIUrl":"10.1007/s13659-024-00445-z","url":null,"abstract":"<div><p>Although non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalence, the often-recommended lifestyle interventions mostly lack high-level evidence of efficacy and there are currently no effective drugs proposed for this indication. The present review delves into NAFLD pathology, its diverse underlying physiopathological mechanisms and the available in vitro<i>, </i>in vivo, and clinical evidence regarding the use of natural compounds for its management, through three pivotal targets (oxidative stress, cellular inflammation, and insulin resistance). The promising perspectives that natural compounds offer for NAFLD management underscore the need for additional clinical and lifestyle intervention trials. Encouraging further research will contribute to establishing more robust evidence and practical recommendations tailored to patients with varying NAFLD grades.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others Agathis dammara 中的化合物通过增强葡萄糖摄取发挥降血糖作用：木酚素、萜烯等。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-03-22 DOI: 10.1007/s13659-024-00440-4

Zhe-Wei Yu, Bang-Ping Cai, Su-Zhi Xie, Yi Zhang, Wen-Hui Wang, Shun-Zhi Liu, Yan-Lin Bin, Qi Chen, Mei-Juan Fang, Rong Qi, Ming-Yu Li, Ying-Kun Qiu

引用次数: 0

Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata 从天麻花枝中提取的天麻素衍生物和炔化黄酮类化合物

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-03-20 DOI: 10.1007/s13659-024-00430-6

Shi-Hui Qin, Zhi-Lan Li, Liu Yang, Jiang-Miao Hu

{"title":"Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata","authors":"Shi-Hui Qin, Zhi-Lan Li, Liu Yang, Jiang-Miao Hu","doi":"10.1007/s13659-024-00430-6","DOIUrl":"10.1007/s13659-024-00430-6","url":null,"abstract":"<div><p>Based on the research progress and traditional usage with whole herbal of the TCM \"Tianma\", chemical studies herein on the flower branch of <i>Gastrodia</i> <i>elata</i> were carried out in-depth and got 13 compounds including the gastrodinols (<b>1–4</b>), the flavonoid morins (<b>5–8, 11–12</b>), together with the specialist mulberrofurans (<b>9</b>, <b>13</b>) and gastrodiamide (<b>10</b>) for the first time from the species. The antibacterial and cholinesterase inhibitory activities were then evaluated and the results showed that compounds<b> 5</b>, <b>11</b>, <b>12</b>, <b>13</b> have good activity against anti-methicillin-resistant <i>Staphylococcus</i> <i>aureus</i>, and compounds <b>9</b>, <b>13</b> had good acetylcholinesterase inhibitory activity. All these results provide new chemical composition for better understanding the traditional application of \"Tianma\" and for exploring new pharmacological ingredients.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00430-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Which is the optimal choice for neonates’ formula or breast milk? 新生儿配方奶粉和母乳哪个更好？

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-03-15 DOI: 10.1007/s13659-024-00444-0

Yueqi Hu, Xing Wu, Li Zhou, Jikai Liu

{"title":"Which is the optimal choice for neonates’ formula or breast milk?","authors":"Yueqi Hu, Xing Wu, Li Zhou, Jikai Liu","doi":"10.1007/s13659-024-00444-0","DOIUrl":"10.1007/s13659-024-00444-0","url":null,"abstract":"<div><p>The incidence of prematurity has been increasing since the twenty-first century. Premature neonates are extremely vulnerable and require a rich supply of nutrients, including carbohydrates, proteins, docosahexaenoic acid (DHA), arachidonic acid (ARA) and others. Typical breast milk serves as the primary source for infants under six months old to provide these nutrients. However, depending on the individual needs of preterm infants, a more diverse and intricate range of nutrients may be necessary. This paper provides a comprehensive review of the current research progress on the physical and chemical properties, biological activity, function, and structure of breast milk, as well as explores the relationship between the main components of milk globular membrane and infant growth. Additionally, compare the nutritional composition of milk from different mammals and newborn milk powder, providing a comprehensive understanding of the differences in milk composition and detailed reference for meeting daily nutritional needs during lactation.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10942964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation 蟾蜍胆中的 3α-Hydroxybufadienolides: 结构见解和生物转化。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-03-04 DOI: 10.1007/s13659-024-00442-2

Li-Jun Ruan, Zhi-Jun Song, Ren-Wang Jiang

引用次数: 0

Current advances on the therapeutic potential of scutellarin: an updated review 黄芩苷治疗潜力的最新进展：最新综述。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-03-04 DOI: 10.1007/s13659-024-00441-3

Yifei Xie, Guotong Sun, Yue Tao, Wen Zhang, Shiying Yang, Li Zhang, Yang Lu, Guanhua Du

{"title":"Current advances on the therapeutic potential of scutellarin: an updated review","authors":"Yifei Xie, Guotong Sun, Yue Tao, Wen Zhang, Shiying Yang, Li Zhang, Yang Lu, Guanhua Du","doi":"10.1007/s13659-024-00441-3","DOIUrl":"10.1007/s13659-024-00441-3","url":null,"abstract":"<div><p>Scutellarin is widely distributed in <i>Scutellaria baicalensis</i>, family Labiatae, and <i>Calendula officinalis</i>, family Asteraceae, and belongs to flavonoids. Scutellarin has a wide range of pharmacological activities, it is widely used in the treatment of cerebral infarction, angina pectoris, cerebral thrombosis, coronary heart disease, and other diseases. It is a natural product with great research and development prospects. In recent years, with in-depth research, researchers have found that wild scutellarin also has good therapeutic effects in anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, treatment of metabolic diseases, and protection of kidney. The cancer treatment involves glioma, breast cancer, lung cancer, renal cancer, colon cancer, and so on. In this paper, the sources, pharmacological effects, in vivo and in vitro models of scutellarin were summarized in recent years, and the current research status and future direction of scutellarin were analyzed.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10912075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140020605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin 头孢噻肟通过下调β-catenin的表达抑制APC突变的结直肠癌。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-02-29 DOI: 10.1007/s13659-024-00443-1

Guifeng Su, Dan Wang, Qianqing Yang, Lingmei Kong, Xiaoman Ju, Qihong Yang, Yiying Zhu, Shaohua Zhang, Yan Li

{"title":"Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin","authors":"Guifeng Su, Dan Wang, Qianqing Yang, Lingmei Kong, Xiaoman Ju, Qihong Yang, Yiying Zhu, Shaohua Zhang, Yan Li","doi":"10.1007/s13659-024-00443-1","DOIUrl":"10.1007/s13659-024-00443-1","url":null,"abstract":"<div><p>The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various carcinomas, especially colorectal cancers (CRCs), where adenomatous colorectal polyposis (APC) mutations are the most frequently observed, which limits the anti-tumor efficiency of inhibitors targeting the upstream of Wnt/β-catenin pathway. The anti-tumor activity of the naturally occurring alkaloid cepharanthine (CEP) extracted from the plant <i>Stephania cepharantha </i>Hayata has been reported in various types of tumors. We previously observed that its derivatives inhibited the Wnt/β-catenin signaling in liver cancer; however, the specific mechanism remains unknown. In this study, we confirmed CEP can effectively inhibit <i>APC</i>-mutant CRC cell lines (SW480, SW620, LoVo) through disturbing of the Wnt/β-catenin signaling and elucidated the underlying mechanisms. Here, we demonstrate that CEP attenuates the Wnt/β-catenin signaling by decreasing the β-catenin, subsequently impeding the proliferation of <i>APC</i>-mutant CRCs. Moreover, CEP induced β-catenin transcription inhibition rather than the instability of β-catenin protein and mRNA contributes to reduction of β-catenin. Taken together, our findings identify CEP as the first β-catenin transcriptional inhibitor in the modulation of Wnt/β-catenin signaling and indicate CEP as a potential therapeutic option for the treatment of <i>APC</i>-mutated CRCs.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition 利贝尔酮 C 具有抑制 NLRP3 的能力，可减轻氧化应激和神经炎症。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-02-26 DOI: 10.1007/s13659-024-00438-y

Jie Cao, Lanqin Li, Runge Zhang, Zhou Shu, Yaxin Zhang, Weiguang Sun, Yonghui Zhang, Zhengxi Hu

{"title":"Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition","authors":"Jie Cao, Lanqin Li, Runge Zhang, Zhou Shu, Yaxin Zhang, Weiguang Sun, Yonghui Zhang, Zhengxi Hu","doi":"10.1007/s13659-024-00438-y","DOIUrl":"10.1007/s13659-024-00438-y","url":null,"abstract":"<div><p>Neurodegenerative diseases (NDs) are common chronic diseases arising from progressive damage to the nervous system. Here, in-house natural product database screening revealed that libertellenone C (LC) obtained from the fermentation products of <i>Arthrinium arundinis</i> separated from the gut of a centipede collected in our Tongji campus, showed a remarkable neuroprotective effect. Further investigation was conducted to clarify the specific mechanism. LC dose-dependently reversed glutamate-induced decreased viability, accumulated reactive oxygen species, mitochondrial membrane potential loss, and apoptosis in SH-SY5Y cells. Network pharmacology analysis predicted that the targets of LC were most likely directly related to oxidative stress and the regulation of inflammatory factor-associated signaling pathways. Further study demonstrated that LC attenuated nitrite, TNF-α, and IL-1β production and decreased inducible nitric oxide synthase and cyclooxygenase expression in lipopolysaccharide-induced BV-2 cells. LC could directly inhibit NLRP3 inflammasome activation by decreasing the expression levels of NLRP3, ASC, cleaved Caspase-1, and NF-κB p65. Our results provide a new understanding of how LC inhibits the NLRP3 inflammasome in microglia, providing neuroprotection. These findings might guide the development of effective LC-based therapeutic strategies for NDs.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10897105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo 从海洋海绵 Petrosia sp.中分离出的 Petrosamine 可在体外和体内对神经毒性起到保护作用。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-02-22 DOI: 10.1007/s13659-024-00439-x

Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L. Pinto, Otília Deusdenia L. Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C. Gomes

{"title":"Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo","authors":"Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L. Pinto, Otília Deusdenia L. Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C. Gomes","doi":"10.1007/s13659-024-00439-x","DOIUrl":"10.1007/s13659-024-00439-x","url":null,"abstract":"<div><p>According to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 million people worldwide suffer from Alzheimer’s Disease (AD). A crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (AChE) activity. Marine organisms synthesize several classes of compounds, some of which exhibit significant AChE inhibition, such as petrosamine, a coloured pyridoacridine alkaloid. The aim of this work was to characterize the activity of petrosamine isolated for the first time from a Brazilian marine sponge, using two neurotoxicity models with aluminium chloride, as exposure to aluminium is associated with the development of neurodegenerative diseases. The in vitro model was based in a neuroblastoma cell line and the in vivo model exploited the potential of zebrafish (<i>Danio rerio</i>) embryos in mimicking hallmarks of AD. To our knowledge, this is the first report on petrosamine’s activity over these parameters, either in vitro or in vivo, in order to characterize its full potential for tackling neurotoxicity.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10881933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139929399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0