Natural Products and Bioprospecting最新文献

Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-02-05 DOI: 10.1007/s13659-025-00497-9

Yuan Liu, Fa-Qi Wang, Xin-Hao Hua, Shu-Han Yang, Li-Ning Wang, Yun-Sheng Xu, Chen-Yue Shao, Xiang-Bo Gou, Yu-Ming Liu

{"title":"Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents","authors":"Yuan Liu, Fa-Qi Wang, Xin-Hao Hua, Shu-Han Yang, Li-Ning Wang, Yun-Sheng Xu, Chen-Yue Shao, Xiang-Bo Gou, Yu-Ming Liu","doi":"10.1007/s13659-025-00497-9","DOIUrl":"10.1007/s13659-025-00497-9","url":null,"abstract":"<div><p>Natural products are the important sources in cardiovascular drug development. In this study, twenty-nine buthutin derivatives were designed, synthesized, and evaluated for their NHE-1 inhibition and protective effects on cardiomyocyte injury. The structure of the newly synthesized compounds had been confirmed by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and HR-ESI-MS spectra. Among all target compounds at 1 μM, compounds <b>9d</b>, <b>9f</b>, <b>9k</b>, <b>9m</b>, and<b> 9n</b>, with a protection ratio exceeding 30%, exerted stronger protective effects on H9c2 cardiomyocyte than positive control dexrazoxane and buthutin A. Meanwhile, compounds <b>9k</b>, <b>9m</b>, and <b>9o</b> showed the significant NHE-1 inhibitory activities on H9c2 cardiomyocyte, all with a dpHi/min value less than 0.23. What is more, compounds <b>9k</b>, <b>9m</b>, <b>9o</b> and buthutin A all exhibited the specificity on NHE-1 inhibition. Molecular modelling studies suggested the ability of compounds <b>9m</b> and <b>9o</b> to establish interactions with three hydrogen bonds to Asp267 and Glu346 of NHE-1, but also the ability with much lower CDOCKER energies than positive control cariporide and buthutin A. The structure–activity relationship (SAR) studies suggested that the presences of amide group, four-carbon linker, and <i>para</i> hydroxyl benzene ring were advantageous pharmacophores for above two pharmacological actions. This research would open new avenues for developing amide-guanidine-based cardioprotective agents.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00497-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-24 DOI: 10.1007/s13659-024-00493-5

Hesham R. El-Seedi, Mohamed S. Refaey, Nizar Elias, Mohamed F. El-Mallah, Faisal M. K. Albaqami, Ismail Dergaa, Ming Du, Mohamed F. Salem, Haroon Elrasheid Tahir, Maria Dagliaa, Nermeen Yosri, Hongcheng Zhang, Awg H. El-Seedi, Zhiming Guo, Shaden A. M. Khalifa

{"title":"Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)","authors":"Hesham R. El-Seedi, Mohamed S. Refaey, Nizar Elias, Mohamed F. El-Mallah, Faisal M. K. Albaqami, Ismail Dergaa, Ming Du, Mohamed F. Salem, Haroon Elrasheid Tahir, Maria Dagliaa, Nermeen Yosri, Hongcheng Zhang, Awg H. El-Seedi, Zhiming Guo, Shaden A. M. Khalifa","doi":"10.1007/s13659-024-00493-5","DOIUrl":"10.1007/s13659-024-00493-5","url":null,"abstract":"<div><p>Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview of the significant advances made in the discovery and development of marine-derived anticancer drugs between 2019 and 2023. With a focus on recent research findings, the review explores the rich biodiversity of marine organisms, including sponges, corals, algae, and microorganisms, which have yielded numerous compounds exhibiting promising anticancer properties. Emphasizing the multifaceted mechanisms of action, the review discusses the molecular targets and pathways targeted by these compounds, such as cell cycle regulation, apoptosis induction, angiogenesis inhibition, and modulation of signaling pathways. Additionally, the review highlights the innovative strategies employed in the isolation, structural elucidation, and chemical modification of marine natural products to enhance their potency, selectivity, and pharmacological properties. Furthermore, it addresses the challenges and opportunities associated with the development of marine-derived anticancer drugs, including issues related to supply, sustainability, synthesis, and clinical translation. Finally, the review underscores the immense potential of marine natural products as a valuable reservoir of novel anticancer agents and advocates for continued exploration and exploitation of the marine environment to address the unmet medical needs in cancer therapy</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management 没药油胶树脂精油及呋喃半萜：蚊媒管理的新突破

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-20 DOI: 10.1007/s13659-024-00492-6

Eleonora Spinozzi, Marta Ferrati, Cecilia Baldassarri, Paolo Rossi, Guido Favia, Giorgio Cameli, Giovanni Benelli, Angelo Canale, Livia De Fazi, Roman Pavela, Luana Quassinti, Cristiano Giordani, Fabrizio Araniti, Loredana Cappellacci, Riccardo Petrelli, Filippo Maggi

{"title":"Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management","authors":"Eleonora Spinozzi, Marta Ferrati, Cecilia Baldassarri, Paolo Rossi, Guido Favia, Giorgio Cameli, Giovanni Benelli, Angelo Canale, Livia De Fazi, Roman Pavela, Luana Quassinti, Cristiano Giordani, Fabrizio Araniti, Loredana Cappellacci, Riccardo Petrelli, Filippo Maggi","doi":"10.1007/s13659-024-00492-6","DOIUrl":"10.1007/s13659-024-00492-6","url":null,"abstract":"<p>Mosquitoes (Diptera: Culicidae) are vectors of various pathogens of public health concern and replacing conventional insecticides remains a challenge. In this regard, natural products represent valuable sources of potential insecticidal compounds, thus increasingly attracting research interest. <i>Commiphora myrrha</i> (T.Nees) Engl. (Burseraceae) is a medicinal plant whose oleo-gum resin is used in food, cosmetics, fragrances, and pharmaceuticals. Herein, the larvicidal potential of its essential oil (EO) was assessed on four mosquito species (<i>Aedes albopictus</i> Skuse, <i>Aedes aegypti</i> L., <i>Anopheles gambiae</i> Giles and <i>Anopheles stephensi</i> Liston), with LC<sub>50</sub> values ranging from 4.42 to 16.80 μg/mL. The bio-guided EO fractionation identified furanosesquiterpenes as the main larvicidal compounds. A GC–MS-driven untargeted metabolomic analysis revealed 32 affected metabolic pathways in treated larvae. The EO non-target toxicity on <i>Daphnia magna</i> Straus (LC<sub>50</sub> = 4.51 μL/L) and its cytotoxicity on a human kidney cell line (HEK293) (IC<sub>50</sub> of 14.38 μg/mL) were also assessed. This study shows the potential of plant products as innovative insecticidal agents and lays the groundwork for the possible exploitation of <i>C. myrrha</i> EO in sustainable approaches for mosquito management.</p>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00492-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142995335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The need for smart microalgal bioprospecting 对智能微藻生物勘探的需求

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-16 DOI: 10.1007/s13659-024-00487-3

Joan Labara Tirado, Andrei Herdean, Peter J. Ralph

{"title":"The need for smart microalgal bioprospecting","authors":"Joan Labara Tirado, Andrei Herdean, Peter J. Ralph","doi":"10.1007/s13659-024-00487-3","DOIUrl":"10.1007/s13659-024-00487-3","url":null,"abstract":"<div><p>Microalgae’s adaptability and resilience to Earth’s diverse environments have evolved these photosynthetic microorganisms into a biotechnological source of industrially relevant physiological functions and biometabolites. Despite this, microalgae-based industries only exploit a handful of species. This lack of biodiversity hinders the expansion of the microalgal industry. Microalgal bioprospecting, searching for novel biological algal resources with new properties, remains a low throughput and time-consuming endeavour due to inefficient workflows that rely on non-selective sampling, monoalgal culture status and outdated, non-standardized characterization techniques. This review will highlight the importance of microalgal bioprospecting and critically explore commonly employed methodologies. We will also explore current advances driving the next generation of smart algal bioprospecting focusing on novel workflows and transdisciplinary methodologies with the potential to enable high-throughput microalgal biodiscoveries. Images adapted from (Addicted04 in Wikipedia File: Australia on the globe (Australia centered).svg. 2014.; Jin et al. in ACS Appl Bio Mater 4:5080–5089, 2021; Kim et al. in Microchim Acta 189:88, 2022; Tony et al. in Lab on a Chip 15, 19:3810–3810; Thermo Fisher Scientific INC. in CTS Rotea Brochure).</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00487-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation 代谢组学和转录组学分析揭示了意大利Anchusa Retz的潜在机制。通过Wnt/β-catenin通路调节减轻脑缺血再灌注损伤

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-08 DOI: 10.1007/s13659-024-00495-3

Wenta Tan, Shuo Fu, Yufei Wang, Bojun Hu, Guiquan Ding, Li Zhang, Wen Zhang, Guanhua Du, Junke Song

{"title":"Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation","authors":"Wenta Tan, Shuo Fu, Yufei Wang, Bojun Hu, Guiquan Ding, Li Zhang, Wen Zhang, Guanhua Du, Junke Song","doi":"10.1007/s13659-024-00495-3","DOIUrl":"10.1007/s13659-024-00495-3","url":null,"abstract":"<div><p><i>Anchusa italica</i> Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. However, its specific function and mechanism in acute cerebral ischemia–reperfusion injury (CIRI) are not fully understood. This research focused on the interventional effects and potential mechanisms of AIR extract (AIRE) in a rat model of CIRI. The model was established using the filament occlusion method, which involved blocking the middle cerebral artery for 1.5 h and then removing the filament to restore blood flow. Transcriptomic and metabolomic analyses were conducted to explore the molecular pathways and metabolites affected by AIRE. ATP level was measured using an ATP assay kit. Additionally, RT-qPCR and western blot tests were conducted to evaluate the influence of AIRE on the Wnt signaling pathway and mitochondrial function. Transcriptomic and metabolomic analyses indicated that AIRE regulated the Wnt signaling pathway in CIRI and modulated metabolites associated with mitochondrial energy metabolism, such as citrate and succinate. ATP assay result demonstrated that AIRE enhanced ATP production in CIRI. Further, RT-qPCR and western blot analyses revealed that AIRE activated the Wnt/β-catenin signaling pathway and corrected mitochondrial dysfunction. These results proposed that AIRE mitigated mitochondrial energy metabolism deficits in CIRI via the Wnt/β-catenin pathway. By restoring the balance of mitochondrial function and energy metabolism, AIRE might offer a potentially therapeutic strategy for addressing CIRI.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00495-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb. 来自药用和食用植物鱼腥草的内生放线菌链霉菌sp. GZWMJZ-662中的二波西米亚胺I-O。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-06 DOI: 10.1007/s13659-024-00494-4

Dong-Yang Wang, Ming-Xing Li, Yan-Chao Xu, Peng Fu, Wei-Ming Zhu, Li-Ping Wang

引用次数: 0

Novel neo-clerodane diterpenoids from Teucrium quadrifarium and their anti-ferroptosis effect 新克罗丹二萜类化合物及其抗铁下垂作用

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-06 DOI: 10.1007/s13659-024-00489-1

Huan Wang, Han-Fei Liu, Xiao-Qiao Yang, Yu-Qiong Liao, Fen-Cong Pan, Jin-Yu Li, Hua-Yong Lou, Wei-Dong Pan

{"title":"Novel neo-clerodane diterpenoids from Teucrium quadrifarium and their anti-ferroptosis effect","authors":"Huan Wang, Han-Fei Liu, Xiao-Qiao Yang, Yu-Qiong Liao, Fen-Cong Pan, Jin-Yu Li, Hua-Yong Lou, Wei-Dong Pan","doi":"10.1007/s13659-024-00489-1","DOIUrl":"10.1007/s13659-024-00489-1","url":null,"abstract":"<div><p>Teucrifarides A–D (<b>1</b>–<b>4</b>), four previously unreported <i>neo</i>-clerodane-type diterpenoids, combined with sixteen known analogs (5–20), were purified from <i>Teucrium quadrifarium.</i> The absolute forma of compounds <b>1</b>–<b>4</b> were determined via spectroscopic and ECD calculation methods, together with X-ray crystallography experiments. Among them, compound <b>1</b> possessed a 5,20-epoxy ring featuring a unique cage-like 12-oxatricyclo [5.3.2.0<sup>1,6</sup>]undecane skeleton. Meanwhile, 2 incorporated a 6,20-epoxy ring with a novel 12-oxatricyclo [6.2.2.0<sup>2,7</sup>]undecane skeleton. Compounds <b>1</b> and <b>12</b> exhibited significant inhibitory effects against HT-22 cells ferroptosis induced by RSL3, with EC<sub>50</sub> values of 11.8 ± 1.0 μM, and 4.52 ± 1.24 μM, respectively. Moreover, ROS accumulation in HT22 cells treated with compound <b>1</b> was also observed.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00489-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of a parallel family of euglenatide analogs in Euglena gracilis 在绿枝草中发现一平行的绿枝草内酯类似物。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-06 DOI: 10.1007/s13659-024-00490-8

Ahmed H. Elbanna, Xinhui Kou, Dilip V. Prajapati, Surasree Rakshit, Rebecca A. Butcher

引用次数: 0

New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract 新型半合成α-葡萄糖苷酶抑制剂

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-05 DOI: 10.1007/s13659-024-00488-2

María I. Osella, Mario O. Salazar, Carlos M. Solís, Ricardo L. E. Furlan

{"title":"New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract","authors":"María I. Osella, Mario O. Salazar, Carlos M. Solís, Ricardo L. E. Furlan","doi":"10.1007/s13659-024-00488-2","DOIUrl":"10.1007/s13659-024-00488-2","url":null,"abstract":"<div><p>Chemically engineered extracts represent a promising source of new bioactive semi-synthetic molecules. Prepared through direct derivatization of natural extracts, they can include constituents enriched with elements and sub-structures that are less common in natural products compared to drugs. Fourteen such extracts were prepared through sequential reactions with hydrazine and a fluorinating reagent, and their α-glucosidase inhibition properties were compared. For the most bioactive mixture, a chemically modified propolis extract, enzyme inhibition increased 22 times due to the reaction sequence. Bio-guided fractionation led to the isolation of a new fluorinated pyrazole produced within the extract by chemical transformation of the flavonoid chrysin. The inhibitor results from the action of the two reagents used on four common functional groups present in natural products (carbonyl, phenol, aromatic carbon, and a double bond). The reactions led to the opening of a 6-member oxygenated heterocycle to produce a 5-member nitrogenated one, as well as the dehydroxylation and fluorination in two different positions of one of the aromatic rings of the natural starting material, all within a complex mixture of natural products. Overall, these transformations led to an approximately 20-fold increase in the α-glucosidase inhibition by the isolated inhibitor compared to its natural precursor.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00488-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations 利用分子动力学模拟揭示新型天然双抑制剂Mpro和PLpro的作用机制

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-04 DOI: 10.1007/s13659-024-00486-4

Xiaoxia Gu, Xiaotian Zhang, Xueke Zhang, Xinyu Wang, Weiguang Sun, Yonghui Zhang, Zhengxi Hu

{"title":"Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations","authors":"Xiaoxia Gu, Xiaotian Zhang, Xueke Zhang, Xinyu Wang, Weiguang Sun, Yonghui Zhang, Zhengxi Hu","doi":"10.1007/s13659-024-00486-4","DOIUrl":"10.1007/s13659-024-00486-4","url":null,"abstract":"<div><p>In the twenty-first century, we have witnessed multiple coronavirus pandemics. Despite declining SARS-CoV-2 cases, continued research remains vital. We report the discovery of sydowiol B, a natural product, as a dual inhibitor of SARS-CoV-2 main protease (Mpro) and papain-like protease (PLpro). Sydowiol B interacts with the nano-channel at the Mpro dimer interface and the PLpro active site. Molecular dynamics simulations suggest that sydowiol B inhibits Mpro by limiting active site expansion rather than inducing collapse. Furthermore, sydowiol B binding may amplify the fluctuation of two loops coordinating with the structural Zn<sup>2+</sup> in PLpro, displacing Zn<sup>2+</sup> from the zinc finger domain to the S2 helix. Sydowiol B and its analogue, violaceol I, exhibit broad-spectrum antiviral activity against homologous coronaviruses. Given the conservation of Mpro and PLpro, sydowiol B and violaceol I are promising leads for designing and developing anti-coronavirus therapies.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00486-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0