Natural Products and Bioprospecting最新文献

{"title":"Structurally diverse triterpenoid alkaloids from Buxus myrica with cytotoxic and apoptosis-inducing activities","authors":"Yuwei Wang,&nbsp;Miao Wang,&nbsp;Yang Zhang,&nbsp;Huiyuan Gao","doi":"10.1007/s13659-026-00656-6","DOIUrl":"10.1007/s13659-026-00656-6","url":null,"abstract":"<div><p>Sixteen triterpenoid alkaloids, including twelve previously undescribed ones named myribuxines A–L (<b>1</b>–<b>12</b>), were isolated from the twigs and leaves of <i>Buxus myrica</i> H. Lév. To our knowledge, this species has not yet undergone any phytochemical or pharmacological investigation. Their structures and relative configurations were elucidated by comprehensive spectroscopic analysis and DP4⁺ probability calculations, with their absolute configurations tentatively assigned on the basis of the biosynthetic origin of <i>Buxus</i> alkaloids. Structurally, <b>5</b>, <b>6</b>, <b>7</b>, and <b>12</b> feature a rare C-16 aromatic ester substituent, while <b>9</b>, <b>10</b>, and <b>11</b> possess a rare tetrahydrofuran ring formed by a C-10–O–C-23 ether linkage. All isolated alkaloids were evaluated for cytotoxicity against HepG2, A549, U251, and HCT-116 cell lines. The active alkaloids showed modest cytotoxicity, with half maximal inhibitory concentration (IC₅₀) values ranging from 17.5 to 47.3 μM across the four cell lines. Among them, <b>2</b> exhibited modest inhibitory activity toward HepG2 cells. Flow cytometry analysis revealed that <b>2</b> promoted apoptosis in a dose- and time-dependent manner. Furthermore, network pharmacology screening predicted HSP90α as its potential molecular target. Follow-up molecular docking further revealed the binding model between compound<b> 2</b> and HSP90.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13728022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From structure prediction to ligand–target recognition: expanding the reach of AlphaFold in natural product research","authors":"Guangrui Xu,&nbsp;Haifeng Hu,&nbsp;Weihui Zhao,&nbsp;Zhengxi Liu,&nbsp;Ting Wang,&nbsp;Rui Liu,&nbsp;Song Liu","doi":"10.1007/s13659-026-00654-8","DOIUrl":"10.1007/s13659-026-00654-8","url":null,"abstract":"<div><p>Natural products constitute a structurally diverse reservoir of bioactive molecules and remain an important source of lead compounds for drug discovery. However, the limited availability of structural information on pharmacological targets and biomolecular interactions continues to hinder mechanism elucidation and structure-guided optimization, particularly for complex natural products such as bioactive peptides, proteinaceous natural products, and natural molecular glues. Recent advances in AlphaFold have transformed structural biology by enabling high-confidence prediction of protein structures and biomolecular complexes, providing unprecedented opportunities for structure-guided natural product research. Beyond conventional structure-based virtual screening, emerging co-folding strategies have demonstrated considerable potential for improving early enrichment in natural product screening and for elucidating the binding mechanisms of complex natural products with their targets. This review summarizes recent advances in AlphaFold-assisted natural product research, including target structure prediction, hit and lead discovery, co-folding-enabled interaction analysis, mechanistic investigation of peptide- and protein-derived natural products, and the emerging potential of AlphaFold for natural molecular glue discovery. We further discuss current limitations and future directions in structure prediction and interaction modeling. Overall, AlphaFold is reshaping natural product research from lead discovery to mechanistic characterization, with particular promise for advancing macromolecular natural products and molecular glue-mediated therapeutics.\u0000</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13728038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A drug–drug cocrystal of breviscapine and borneol: harnessing natural product synergy for synchronized release and improved pharmacokinetics","authors":"Jiao Wang,&nbsp;Caixian Wang,&nbsp;Yan Ma,&nbsp;Tong Zhang,&nbsp;Anguo Hou,&nbsp;Wenbin Jin,&nbsp;Yanni Ma,&nbsp;Wenping Wang","doi":"10.1007/s13659-026-00648-6","DOIUrl":"10.1007/s13659-026-00648-6","url":null,"abstract":"<div><p>A drug–drug cocrystal strategy harnessing natural product synergy was developed to address the oral delivery barriers of breviscapine (BRE), a natural flavonoid with poor solubility and extensive first-pass metabolism. BRE was integrated with the monoterpenoid permeation enhancer borneol (BO) via solvent evaporation to form a stable supramolecular assembly. Comprehensive solid-state characterization and density functional theory calculations confirmed that the cocrystal lattice is stabilized by specific hydrogen bonding between the flavonoid and terpenoid scaffolds. The optimized BRE-BO cocrystal exhibited highly synchronized release of both natural products (<i>R</i>² = 0.86), in contrast to the discordant dissolution of the physical mixture, with kinetics following the Korsmeyer–Peppas model (n = 0.45) indicative of Fickian diffusion. In vivo pharmacokinetic evaluation in rats demonstrated that the synergy conferred by co-delivered BO resulted in a 1.6-fold enhancement in oral bioavailability (<i>AUC</i>_0-24), a prolonged <i>T</i>_max (from 2.3 to 3.3 h), and an elevated <i>C</i>_max (1.2 vs. 0.8 mg/L) compared to bulk BRE. These findings demonstrate that drug–drug cocrystallization can simultaneously achieve dissolution synchronization and pharmacokinetic optimization, providing a viable strategy for the formulation of poorly bioavailable natural flavonoids without the use of polymeric excipients.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13728050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, structural characterization, immunomodulatory and indirect tumoricidal activities of an inulin-type fructan from Platycodon grandiflorus via macrophage M1 polarization through the TLR4/NF-κB pathway","authors":"Chen-Xi Wang,&nbsp;Ping-Yan Liao,&nbsp;Cui-Lian Yin,&nbsp;Yue Wang,&nbsp;Jie Hu,&nbsp;Kui Li,&nbsp;Zhao-Kun Li,&nbsp;Yu-Jie Sun,&nbsp;Xian-Yang Li,&nbsp;Jiang-Miao Hu,&nbsp;Ning Li,&nbsp;Meng-Ting Kuang","doi":"10.1007/s13659-026-00657-5","DOIUrl":"10.1007/s13659-026-00657-5","url":null,"abstract":"<div><p>In this study, a homogeneous polysaccharide, designated PGP-1, was successfully isolated and purified from the roots of <i>Platycodon grandiflorus</i>. Comprehensive structural characterization via methylation analysis, GC–MS, and NMR spectroscopy identified PGP-1 as an inulin-type fructan predominantly composed of →1)-β-D-Fru<i>f</i>-(2→ as the main chain with terminal β-D-Fru<i>f</i>-(2→ and α-D-Glc<i>p</i>-(1→ residues, consistent with the structural features of previously reported <i>Platycodon grandiflorus</i> fructans. Unlike conventional chemotherapeutic agents that rely on broad-spectrum and non-specific cytotoxicity, biological evaluations revealed that PGP-1 acts as a safe and targeted immunomodulator. Specifically, PGP-1 effectively induced M1 macrophage polarization in RAW264.7 cells through the TLR4/NF-κB signaling pathway, significantly enhancing their phagocytic capacity and promoting the robust release of tumoricidal factors, including nitric oxide (NO), TNF-α, and IL-6. Crucially, utilizing a macrophage-tumor transwell co-culture model to simulate the tumor microenvironment, it was demonstrated that PGP-1 exhibited negligible direct cytotoxicity to cancer cells but exerted potent indirect tumoricidal activity against hepatocellular (H22) and lung (LLC) carcinoma cells by augmenting macrophage-mediated immune responses. These findings provide preliminary evidence linking the polysaccharide's safety profile with its tumor-suppressive efficacy, suggesting the potential of PGP-1 as a low-toxicity natural immune enhancer for cancer immunotherapy.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13728019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant metabolites from the endophytic fungus Aspergillus spelaeus","authors":"Jia-Tong Zhou,&nbsp;Min Wang,&nbsp;Qian Wu,&nbsp;Min Liang,&nbsp;Wei-Feng Xu,&nbsp;Jun Li,&nbsp;Li-Jun Zhang,&nbsp;Rui-Yun Yang","doi":"10.1007/s13659-026-00637-9","DOIUrl":"10.1007/s13659-026-00637-9","url":null,"abstract":"<div><p>Five undescribed compounds, including two drimane-type sesquiterpenoids, asperdrimanes A and B (<b>1</b> and <b>2</b>), and three amide compounds, asperspamides A–C (<b>3</b>–<b>5</b>), together with four known metabolites <b>6</b>–<b>9</b>, were isolated from the fungus <i>Aspergillus spelaeus</i> GDGJ-286. By extensively analyzing NMR, LC–MS/MS, Marfey's method, and X-ray crystallography, the structures were characterized successfully. Asperdrimanes A and B (<b>1</b> and <b>2</b>) are drimane-type sesquiterpenoids characterized by a spiro-<i>β</i>-lactone moiety. Asperspamide B (<b>4</b>) exhibited exceptional antioxidant capacity in ABTS, FRAP, and DPPH tests, along with significant neuroprotective effects in a hydrogen peroxide-induced PC12 cell oxidative injury model, demonstrating strong anti-apoptotic and anti-necrotic properties. These findings highlight asperspamide B’s potential as a lead compound for developing antioxidant agents.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13728077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Genome mining guided identification of new furo[3,2‑c]pyridones phaeopyridones A–C from the endophytic fungus Phaeobotryon negundinis 12020","authors":"Ke Ye,&nbsp;Jie Shi,&nbsp;Huimin Wu,&nbsp;Shujie Wang,&nbsp;Zexu Lin,&nbsp;Jiale Sun,&nbsp;Yuwei Chen,&nbsp;Bohao Wang,&nbsp;Rongxuan Wang,&nbsp;Chenglin Jiang,&nbsp;Yi Jiang,&nbsp;Tom Hsiang,&nbsp;Bin Zhu,&nbsp;Lixin Zhang,&nbsp;Xueting Liu,&nbsp;Guoliang Zhu","doi":"10.1007/s13659-026-00666-4","DOIUrl":"10.1007/s13659-026-00666-4","url":null,"abstract":"","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149293810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, structural characterization of oligosaccharide AMO-1 from Avicennia marina fruit and its anti-osteoporotic effects via PI3K/AKT/HIF‑1α signaling pathway activation","authors":"Lishuang Zhou,&nbsp;Zhenhui Feng,&nbsp;Yijing Zhang,&nbsp;Lei Tan,&nbsp;Pan Zhou,&nbsp;Xia Wu,&nbsp;Xing Chen,&nbsp;Qinyuan Zhang,&nbsp;Qiwen Cai,&nbsp;Liutong Yu,&nbsp;Kefeng Wu,&nbsp;Luming Deng","doi":"10.1007/s13659-026-00646-8","DOIUrl":"10.1007/s13659-026-00646-8","url":null,"abstract":"<div><p><i>Avicennia marina</i> (Forssk.) Vierh. is an important mangrove plant with high nutritional and medicinal values, featuring saccharides as its primary bioactive compounds. In this study, we successfully isolated a neutral tetrasaccharide (AMO-1) from the fruits of <i>A. marina</i>. Through monosaccharide composition, methylation, UPLC-ESI–MS/MS, and NMR analyses, we revealed that the structure of AMO-1 was α-D-Gal<i>p</i>-(1 → 6)-α-D-Gal<i>p</i>-(1 → 6)-α-D-Glc<i>p</i>-(1 → 2)-β-D-Fru<i>f</i>. Subsequently, we investigated the anti-osteoporosis (anti-OP) efficacy and underlying mechanisms of AMO-1. Our findings demonstrated that AMO-1 promoted the differentiation and mineralization of MC3T3-E1 cells. Furthermore, AMO-1 increased trabecular bone density and restored its reticular structure in dexamethasone-induced OP mice. Additionally, AMO-1 upregulated the expression levels of osteogenic factors and elevated serum levels of osteocalcin and PINP. Mechanistically, AMO-1 promoted osteogenesis through activation of the PI3K/AKT/HIF-1α signaling pathway, thus exerting anti-OP effects. Overall, these findings indicate that AMO-1 is a promising functional food ingredient with therapeutic potential for the prevention and management of OP.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00646-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149234929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive components from Sinomenium acutum exhibit anti-inflammatory activity and sensitize cervical cancer cells to paclitaxel","authors":"Xilei Wang,&nbsp;Chengjing Zhu,&nbsp;Xinyu Du,&nbsp;Qiang Wang,&nbsp;Jianqing Yu","doi":"10.1007/s13659-026-00652-w","DOIUrl":"10.1007/s13659-026-00652-w","url":null,"abstract":"<div><p>Six previously undescribed compounds, together with twelve known compounds, were isolated from <i>Sinomenium acutum</i>. The structures of the unreported compounds were determined by comprehensive spectroscopic data analysis, ¹³C NMR calculations followed by DP4 + analysis, ECD calculations, and single-crystal X-ray diffraction analysis. Nine compounds exhibited more potent anti-inflammatory activities than the positive control indomethacin. The structure–activity relationship of the isolates with anti-inflammatory effects was elucidated, providing some useful clues for designing and developing structurally novel anti-inflammatory drugs. Furthermore, five compounds reversed the paclitaxel resistance in paclitaxel-resistant cervical cancer cells HeLa/PTX. The combination of compound <b>4</b> and paclitaxel promoted cancer cell apoptosis.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in 6-pentyl-alpha-pyrone production by Trichoderma spp. in liquid medium using in situ removal by adsorbent resin","authors":"Alex Maan,&nbsp;Eirian Jones,&nbsp;John Hampton,&nbsp;Travis Glare,&nbsp;Artemio Mendoza-Mendoza","doi":"10.1007/s13659-026-00650-y","DOIUrl":"10.1007/s13659-026-00650-y","url":null,"abstract":"<div><p>The <i>Trichoderma</i>-produced secondary metabolite 6-pentyl-alpha-pyrone (6-PP) has demonstrated promise for agricultural applications, but cost-effective bioproduction remains limited by product inhibition during fermentation. This study aimed to evaluate the effect of media type on 6-PP production in <i>T. atroviride</i> IMI206040, screen production by nine New Zealand <i>Trichoderma</i> strains, and assess Amberlite XAD-4 in situ product removal in five strains to overcome self-inhibition. <i>T. atroviride</i> IMI206040 was cultured for 5 days in potato dextrose broth (PDB) or minimal media supplemented with ammonium or nitrate, and 6-PP production was assessed by thin-layer chromatography (TLC). The ten <i>Trichoderma</i> strains were cultured for 7 days in PDB and 6-PP production quantified by spectrophotometry. Finally, five strains were cultured in PDB for 14 days with and without Amberlite XAD-4, and 6-PP quantified by spectrophotometry and gas chromatography (GC). In <i>T. atroviride</i> IMI206040, PDB supported the highest 6-PP production, while ammonium-based minimal media repressed production, consistent with nitrogen catabolite repression. Screening revealed up to 14.6-fold variation among strains, with T<i>. gamsii</i> LU771 and <i>T. viridescens</i> LU1369 as the highest producers. Spectrophotometric and GC measurements showed strain-dependent disagreement, indicating GC is more reliable for cross-strain comparisons. Amberlite XAD-4 increased total 6-PP production 3- to 5.2-fold across all five strains, with &gt; 99% of secreted 6-PP sequestered. The highest-producing strains, <i>T. gamsii</i> LU771 and <i>T. atroviride</i> LU132, achieved titres approaching 500 mg/L. These findings support Amberlite XAD-4 as an effective in situ product removal method for increasing 6-PP bioproduction and identifying strains with high intrinsic biosynthetic capacity in the absence of product inhibition.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13680593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytochalasins are a fascinating class of natural compounds: advances in the chemistry, biological activities, mode of action, and structure-activity relationships of novel cytochalasins isolated in the last decade are described","authors":"Antonio Evidente","doi":"10.1007/s13659-026-00651-x","DOIUrl":"10.1007/s13659-026-00651-x","url":null,"abstract":"<div><p>Cytochalasins are a very intriguing group of natural compounds. Since the first isolation of the well-known cytochalasins A and B in 1966, over 300 analogues have been described as metabolites, primarily produced by various fungal genera. Their bioactivities, targets, total syntheses, and biosyntheses had been also extensively investigated. After the review of Scherlach et al., 2010 several other cytochalasins, isolated from different fungal sources, their biological activities and potential applications, were extensively described. In particular, during the last decades (2014–2024), as deduced from SciFinder research 259 articles, excluding reviews, were published essentially on new cytochalasins from new fungal sources and their biological activity and their potential application were reported. The reviews published in the same time (2014–2024) treated essentially the biological activities, the mode of action, the biosynthesis of already known cytochalasins and frequently the description was also extended and compared to other classes of natural compounds. The aims of the present review is to cover this gap reporting about the structure and biological activities of new cytochalasins isolated in the last decade (2014–2024) by fungi, endophytic fungi, essentially cohabitants in plants, and marine organisms. Furthermore, a brief section describing the cytochalasins Produced by lichens is also included. For some cytochalasins, the results of structure–activity and on the mode of action studies and potential biotechnological application will be also described.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00651-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}