Natural Products and Bioprospecting最新文献

{"title":"Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies","authors":"Md. Rezaul Islam,&nbsp;Puja Sutro Dhar,&nbsp;Shopnil Akash,&nbsp;Sabeena Hussain Syed,&nbsp;Jeetendra Kumar Gupta,&nbsp;Kumaraswamy Gandla,&nbsp;Muniya Akter,&nbsp;Abdur Rauf,&nbsp;Hassan A. Hemeg,&nbsp;Yasir Anwar,&nbsp;Bassam Oudh Aljohny,&nbsp;Polrat Wilairatana","doi":"10.1007/s13659-023-00411-1","DOIUrl":"10.1007/s13659-023-00411-1","url":null,"abstract":"<div><p>Hypertension (HTN), a complex cardiovascular disease (CVD), significantly impacts global health, prompting a growing interest in complementary and alternative therapeutic approaches. This review article seeks to provide an up-to-date and thorough summary of modern therapeutic techniques for treating HTN, with an emphasis on the molecular mechanisms of action found in substances found in plants, herbs, and seafood. Bioactive molecules have been a significant source of novel therapeutics and are crucial in developing and testing new HTN remedies. Recent advances in science have made it possible to understand the complex molecular mechanisms underlying blood pressure (BP)-regulating effects of these natural substances better. Polyphenols, flavonoids, alkaloids, and peptides are examples of bioactive compounds that have demonstrated promise in influencing several pathways involved in regulating vascular tone, reducing oxidative stress (OS), reducing inflammation, and improving endothelial function. The article explains the vasodilatory, diuretic, and renin–angiotensin–aldosterone system (RAAS) modifying properties of vital plants such as garlic and olive leaf. Phytochemicals from plants are the primary in traditional drug development as models for novel antihypertensive drugs, providing diverse strategies to combat HTN due to their biological actions. The review also discusses the functions of calcium channel blockers originating from natural sources, angiotensin-converting enzyme (ACE) inhibitors, and nitric oxide (NO) donors. Including seafood components in this study demonstrates the increased interest in using bioactive chemicals originating from marine sources to treat HTN. Omega-3 fatty acids, peptides, and minerals obtained from seafood sources have anti-inflammatory, vasodilatory, and antioxidant properties that improve vascular health and control BP. Overall, we discussed the multiple functions of bioactive molecules and seafood components in the treatment of HTN.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted metabolomics analysis of four date palm (Phoenix dactylifera L.) cultivars using MS and NMR","authors":"Shuruq Alsuhaymi,&nbsp;Upendra Singh,&nbsp;Inas Al-Younis,&nbsp;Najeh M. Kharbatia,&nbsp;Ali Haneef,&nbsp;Kousik Chandra,&nbsp;Manel Dhahri,&nbsp;Mohammed A. Assiri,&nbsp;Abdul-Hamid Emwas,&nbsp;Mariusz Jaremko","doi":"10.1007/s13659-023-00406-y","DOIUrl":"10.1007/s13659-023-00406-y","url":null,"abstract":"<div><p>Since ancient times, the inhabitants of dry areas have depended on the date palm (<i>Phoenix</i> <i>dactylifera</i> L.) as a staple food and means of economic security. For example, dates have been a staple diet for the inhabitants of the Arabian Peninsula and Sahara Desert in North Africa for millennia and the local culture is rich in knowledge and experience with the benefits of dates, suggesting that dates contain many substances essential for the human body. Madinah dates are considered one of the most important types of dates in the Arabian Peninsula, with Ajwa being one of the most famous types and grown only in Madinah, Saudi Arabia. Date seeds are traditionally used for animal feed, seed oil production, cosmetics, and as a coffee substitute. Phytochemical compounds that have been detected in date fruits and date seeds include phenolic acids, carotenoids, and flavonoids. Phenolic acids are the most prevalent bioactive constituents that contribute to the antioxidant activity of date fruits. The bioactive properties of these phytochemicals are believed to promote human health by reducing the risk of diseases such as chronic inflammation. Ajwa dates especially are thought to have superior bioactivity properties. To investigate these claims, in this study, we compare the metabolic profiles of Ajwa with different types of dates collected from Saudi Arabia and Tunisia. We show by UHPLC-MS that date seeds contain several classes of flavonoids, phenolic acids, and amino acid derivatives, including citric acid, malic acid, lactic acid, and hydroxyadipic acid. Additionally, GC–MS profiling showed that date seeds are richer in metabolite classes, such as hydrocinnamic acids (caffeic, ferulic and sinapic acids), than flesh samples. Deglet N fruit extract (minimum inhibitory concentration: 27 MIC/μM) and Sukkari fruit extract (IC₅₀: 479 ± 0.58μg /mL) have higher levels of antibacterial and antioxidative activity than Ajwa fruits. However, the seed analysis showed that seed extracts have better bioactivity effects than fruit extracts. Specifically, Ajwa extract showed the best MIC and strongest ABTS radical-scavenging activity among examined seed extracts (minimum inhibitory concentration: 20 μM; IC₅₀: 54 ± 3.61μg /mL). Our assays are a starting point for more advanced in vitro antibacterial models and investigation into the specific molecules that are responsible for the antioxidative and anti-bacterial activities of dates.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological activities of gastropods secretions: snail and slug slime","authors":"Muhammad Rashad,&nbsp;Simone Sampò,&nbsp;Amelia Cataldi,&nbsp;Susi Zara","doi":"10.1007/s13659-023-00404-0","DOIUrl":"10.1007/s13659-023-00404-0","url":null,"abstract":"<div><p>Gastropods, a mollusk class including slugs and snails, represent an extraordinarily diverse and ecologically significant group of organisms featuring the largest class of invertebrates. They can be classified as aquatic and terrestrial animals having coiled shells, although some species have reduced or absent shells. Their unique body structure includes a muscular foot for locomotion, a visceral mass containing essential organs, and a distinct head region with sensory organs such as tentacles and eyes. They are used to secrete a complex mixture of glycoproteins, enzymes, peptides, mucus and other bioactive compounds, namely slime, which represents a tool to allow locomotion, protection, and interaction within different habitats. The biological activities of the slime have attracted considerable interest due to their diverse and potentially valuable properties ranging from defense mechanisms to potential therapeutic applications in wound healing, antimicrobial therapy, management of inflammation, and neurological disorders. This review aims at exploring the beneficial effects of snail and slug slime focusing, in particular, on the improvement of the biological processes underlying them. Continued exploration of the intricate components of these slimy secretions promises to discover new bioactive molecules with diverse applications in various scientific and industrial fields.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The antifungal properties of terpenoids from the endophytic fungus Bipolaris eleusines","authors":"Yin-Zhong Fan,&nbsp;Chun Tian,&nbsp;Shun-Yao Tong,&nbsp;Qing Liu,&nbsp;Fan Xu,&nbsp;Bao-Bao Shi,&nbsp;Hong-Lian Ai,&nbsp;Ji-Kai Liu","doi":"10.1007/s13659-023-00407-x","DOIUrl":"10.1007/s13659-023-00407-x","url":null,"abstract":"<div><p>A series of terpenoids (<b>1–17</b>), comprising six new compounds designated bipolariterpenes A-F (<b>1–6</b>) and eleven recognized compounds (<b>7–17</b>), were isolated from the wheat culture of the potato endophytic fungus <i>Bipolaris</i> <i>eleusines</i>. Their structures and stereochemistry were clarified by HRESIMS, NMR, DP4 + probability analyses, and computations for electronic circular dichroism (ECD). All compounds are made up of six meroterpenoids, four sesterterpenes and seven sesquiterpenes. Among them, four sesterterpenes (<b>4</b>, <b>5</b>, <b>10</b>, <b>11</b>) were investigated for their antifungal, antibacterial and cytotoxic properties, and six meroterpenoids (<b>1–3</b>, <b>7–9</b>) were evaluated for their antifungal properties. The compounds <b>7</b>, <b>9</b>, and <b>10</b> had substantial antifungal activity against <i>Epidermophyton</i> <i>floccosum</i> at a concentration of 100 µM. No antibacterial and cytotoxic activities were observed.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic phenazine and antiallergic phenoxazine alkaloids from an arctic Nocardiopsis dassonvillei SCSIO 502F","authors":"Yue Song,&nbsp;Qi-Yang Li,&nbsp;Meng-Jing Cong,&nbsp;Xiao-Yan Pang,&nbsp;Bo Chen,&nbsp;Yong-Hong Liu,&nbsp;Li Liao,&nbsp;Jun-Feng Wang","doi":"10.1007/s13659-023-00408-w","DOIUrl":"10.1007/s13659-023-00408-w","url":null,"abstract":"<div><p>Microbes well-adapted to the Arctic Ocean are promising for producing novel compounds, due to their fancy strategies for adaptation and being under-investigated. Two new phenazine alkaloids (<b>1</b> and <b>2</b>) and one new phenoxazine (<b>3</b>) were isolated from <i>Nocardiopsis dassonvillei</i> 502F, a strain originally isolated from Arctic deep-sea sediments. AntiSMASH analysis of the genome of <i>Nocardiopsis dassonvillei</i> 502F revealed the presence of 16 putative biosynthetic gene clusters (BGCs), including a phenazine BGC. Most of the isolated compounds were evaluated for their antibacterial, antiallergic, and cytotoxic activities. Among them, compounds <b>4</b> and <b>5</b> exhibited potent in vitro cytotoxic activities against osteosarcoma cell line 143B with IC₅₀ values 0.16 and 20.0 μM, respectively. Besides, the results of antiallergic activities of compounds <b>6</b>–<b>8</b> exhibited inhibitory activities with IC₅₀ values of 10.88 ± 3.05, 38.88 ± 3.29, and 2.44 ± 0.17 μg/mL, respectively (IC₅₀ 91.6 μM for the positive control loratadine).</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of sound stimulation in production of plant secondary metabolites","authors":"Li Wu,&nbsp;Ning Yang,&nbsp;Meng Guo,&nbsp;Didi Zhang,&nbsp;Reza A. Ghiladi,&nbsp;Hasan Bayram,&nbsp;Jun Wang","doi":"10.1007/s13659-023-00409-9","DOIUrl":"10.1007/s13659-023-00409-9","url":null,"abstract":"<div><p>Sound vibration is one of natural stimuli trigging physiological changes in plants. Recent studies showed that sound waves stimulated production of a variety of plant secondary metabolites, including flavonoids, in order to enhance seed germination, flowering, growth or defense. In this review, we examine the potential role of sound stimulation on the biosynthesis of secondary metabolites and the followed cascade of physiological changes in plants, from the perspective of transcriptional regulation and epigenetic regulation for the first time. A systematic summary showed that a wide range of factors may regulate the production of secondary metabolites, including plant species, growth stage, sound types, sound frequency, sound intensity level and exposure time, etc. Biochemical and physiological changes due to sound stimulation were thoroughly summarized as well, for secondary metabolites can also act as a free radical scavenger, or a hormone signaling molecule. We also discussed the limits of previous studies, and the future application of sound waves in biosynthesis of plant secondary metabolites.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of natural bioactive molecules in genitourinary cancers: how far has research progressed?","authors":"Fahadul Islam,&nbsp;Nikhil Nath,&nbsp;Mehrukh Zehravi,&nbsp;Jishan Khan,&nbsp;Sumiya Ben-Ta Jashim,&nbsp;Manoj Shrawan Charde,&nbsp;Rita Dadarao Chakole,&nbsp;K. Praveen Kumar,&nbsp;A. Kishore Babu,&nbsp;Firzan Nainu,&nbsp;Sharuk L. Khan,&nbsp;Safia Obaidur Rab,&nbsp;Talha Bin Emran,&nbsp;Polrat Wilairatana","doi":"10.1007/s13659-023-00400-4","DOIUrl":"10.1007/s13659-023-00400-4","url":null,"abstract":"<div><p>The primary approaches to treat cancerous diseases include drug treatment, surgical procedures, biotherapy, and radiation therapy. Chemotherapy has been the primary treatment for cancer for a long time, but its main drawback is that it kills cancerous cells along with healthy ones, leading to deadly adverse health effects. However, genitourinary cancer has become a concern in recent years as it is more common in middle-aged people. So, researchers are trying to find possible therapeutic options from natural small molecules due to the many drawbacks associated with chemotherapy and other radiation-based therapies. Plenty of research was conducted regarding genitourinary cancer to determine the promising role of natural small molecules. So, this review focused on natural small molecules along with their potential therapeutic targets in the case of genitourinary cancers such as prostate cancer, renal cancer, bladder cancer, testicular cancer, and so on. Also, this review states some ongoing or completed clinical evidence in this regard.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indonesian marine and its medicinal contribution","authors":"Ari Satia Nugraha,&nbsp;Lilla Nur Firli,&nbsp;Dinar Mutia Rani,&nbsp;Ayunda Hidayatiningsih,&nbsp;Nadya Dini Lestari,&nbsp;Hendris Wongso,&nbsp;Kustiariyah Tarman,&nbsp;Ayu Christien Rahaweman,&nbsp;Jeprianto Manurung,&nbsp;Ni Putu Ariantari,&nbsp;Adelfia Papu,&nbsp;Masteria Yunovilsa Putra,&nbsp;Antonius Nugraha Widhi Pratama,&nbsp;Ludger A. Wessjohann,&nbsp;Paul A. Keller","doi":"10.1007/s13659-023-00403-1","DOIUrl":"10.1007/s13659-023-00403-1","url":null,"abstract":"<div><p>The archipelagic country of Indonesia is populated by the densest marine biodiversity in the world which has created strong global interest and is valued by both Indigenous and European settlements for different purposes. Nearly 1000 chemicals have been extracted and identified. In this review, a systematic data curation was employed to collate bioprospecting related manuscripts providing a comprehensive directory based on publications from 1988 to 2022. Findings with significant pharmacological activities are further discussed through a scoping data collection. This review discusses macroorganisms (Sponges, Ascidian, Gorgonians, Algae, Mangrove) and microorganism (Bacteria and Fungi) and highlights significant discoveries, including a potent microtubule stabilizer laulimalide from <i>Hyattella </i>sp.<i>,</i> a prospective doxorubicin complement papuamine alkaloid from <i>Neopetrosia cf exigua</i>, potent antiplasmodial manzamine A from <i>Acanthostrongylophora ingens</i>, the highly potent anti trypanosomal manadoperoxide B from <i>Plakortis cfr.</i> Simplex, mRNA translation disrupter hippuristanol from <i>Briareum </i>sp, and the anti-HIV-1 (+)-8-hydroxymanzamine A isolated from <i>Acanthostrongylophora </i>sp. Further, some potent antibacterial extracts were also found from a limited biomass of bacteria cultures. Although there are currently no examples of commercial drugs from the Indonesian marine environment, this review shows the molecular diversity present and with the known understudied biodiversity, reveals great promise for future studies and outcomes.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritised identification of structural classes of natural products from higher plants in the expedition of antimalarial drug discovery","authors":"Phanankosi Moyo,&nbsp;Luke Invernizzi,&nbsp;Sephora M. Mianda,&nbsp;Wiehan Rudolph,&nbsp;Andrew W. Andayi,&nbsp;Mingxun Wang,&nbsp;Neil R. Crouch,&nbsp;Vinesh J. Maharaj","doi":"10.1007/s13659-023-00402-2","DOIUrl":"10.1007/s13659-023-00402-2","url":null,"abstract":"<div><p>The emergence and spread of drug-recalcitrant <i>Plasmodium falciparum</i> parasites threaten to reverse the gains made in the fight against malaria. Urgent measures need to be taken to curb this impending challenge. The higher plant-derived sesquiterpene, quinoline alkaloids, and naphthoquinone natural product classes of compounds have previously served as phenomenal chemical scaffolds from which integral antimalarial drugs were developed. Historical successes serve as an inspiration for the continued investigation of plant-derived natural products compounds in search of novel molecular templates from which new antimalarial drugs could be developed. The aim of this study was to identify potential chemical scaffolds for malaria drug discovery following analysis of historical data on phytochemicals screened in vitro against <i>P. falciparum</i>. To identify these novel scaffolds, we queried an in-house manually curated database of plant-derived natural product compounds and their in vitro biological data. Natural products were assigned to different structural classes using NPClassifier. To identify the most promising chemical scaffolds, we then correlated natural compound class with bioactivity and other data, namely (i) potency, (ii) resistance index, (iii) selectivity index and (iv) physicochemical properties. We used an unbiased scoring system to rank the different natural product classes based on the assessment of their bioactivity data. From this analysis we identified the top-ranked natural product pathway as the alkaloids. The top three ranked super classes identified were (i) pseudoalkaloids, (ii) naphthalenes and (iii) tyrosine alkaloids and the top five ranked classes (i) quassinoids (of super class triterpenoids), (ii) steroidal alkaloids (of super class pseudoalkaloids) (iii) cycloeudesmane sesquiterpenoids (of super class triterpenoids) (iv) isoquinoline alkaloids (of super class tyrosine alkaloids) and (v) naphthoquinones (of super class naphthalenes). Launched chemical space of these identified classes of compounds was, by and large, distinct from that of ‘legacy’ antimalarial drugs. Our study was able to identify chemical scaffolds with acceptable biological properties that are structurally different from current and previously used antimalarial drugs. These molecules have the potential to be developed into new antimalarial drugs.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41187779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory response","authors":"Tian Lan,&nbsp;Wen Wang,&nbsp;De-Lian Huang,&nbsp;Xi-Xi Zeng,&nbsp;Xiao-Xiao Wang,&nbsp;Jian Wang,&nbsp;Yu-Hua Tong,&nbsp;Zhu-Jun Mao,&nbsp;Si-Wei Wang","doi":"10.1007/s13659-023-00398-9","DOIUrl":"10.1007/s13659-023-00398-9","url":null,"abstract":"<div><p>Quzhou Aurantii Fructus (QAF) has a long history as a folk medicine and food for the treatment of liver diseases. While our earlier study provided evidence of hepatoprotective properties contained within the flavonoids and limonins constituents in QAF, the potential preventative effects afforded by essential oil components present within QAF remains enigmatic. In this study, we prepared Quzhou Aurantii Fructus essential oil (QAFEO) and confirmed its anti-inflammatory effects on liver inflammation through experimentation on lipopolysaccharide and D-galactosamine (LPS/D-GalN) induced acute liver failure (ALF) mouse models. Using RNA-sequence (RNA-seq) analysis, we found that QAFEO prevented ALF by systematically blunting the pathways involved in response to LPS and toll-like receptor signaling pathways. QAFEO effectively suppressed the phosphorylation of tank-binding kinase 1 (TBK1), TGF-beta activated kinase 1 (TAK1), interferon regulatory factor 3 (IRF3), and the activation of mitogen activated kinase-like protein (MAPK) and nuclear factor-kappa B (NF-κB) pathways in vivo and in vitro. Importantly, QAFEO substantially reduced myeloid differentiation primary response gene 88 (MyD88)- toll-like receptor 4 (TLR4) interaction levels. Moreover, 8 compounds from QAFEO could directly bind to REAL, TAK1, MyD88, TBK1, and IRF3. Taken together, the results of our study support the notion that QAFEO exerts a hepatoprotective effect through inhibiting LPS-mediated inflammatory response.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41100598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}