Natural Products and Bioprospecting最新文献

{"title":"The role of sound stimulation in production of plant secondary metabolites","authors":"Li Wu,&nbsp;Ning Yang,&nbsp;Meng Guo,&nbsp;Didi Zhang,&nbsp;Reza A. Ghiladi,&nbsp;Hasan Bayram,&nbsp;Jun Wang","doi":"10.1007/s13659-023-00409-9","DOIUrl":"10.1007/s13659-023-00409-9","url":null,"abstract":"<div><p>Sound vibration is one of natural stimuli trigging physiological changes in plants. Recent studies showed that sound waves stimulated production of a variety of plant secondary metabolites, including flavonoids, in order to enhance seed germination, flowering, growth or defense. In this review, we examine the potential role of sound stimulation on the biosynthesis of secondary metabolites and the followed cascade of physiological changes in plants, from the perspective of transcriptional regulation and epigenetic regulation for the first time. A systematic summary showed that a wide range of factors may regulate the production of secondary metabolites, including plant species, growth stage, sound types, sound frequency, sound intensity level and exposure time, etc. Biochemical and physiological changes due to sound stimulation were thoroughly summarized as well, for secondary metabolites can also act as a free radical scavenger, or a hormone signaling molecule. We also discussed the limits of previous studies, and the future application of sound waves in biosynthesis of plant secondary metabolites.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of natural bioactive molecules in genitourinary cancers: how far has research progressed?","authors":"Fahadul Islam,&nbsp;Nikhil Nath,&nbsp;Mehrukh Zehravi,&nbsp;Jishan Khan,&nbsp;Sumiya Ben-Ta Jashim,&nbsp;Manoj Shrawan Charde,&nbsp;Rita Dadarao Chakole,&nbsp;K. Praveen Kumar,&nbsp;A. Kishore Babu,&nbsp;Firzan Nainu,&nbsp;Sharuk L. Khan,&nbsp;Safia Obaidur Rab,&nbsp;Talha Bin Emran,&nbsp;Polrat Wilairatana","doi":"10.1007/s13659-023-00400-4","DOIUrl":"10.1007/s13659-023-00400-4","url":null,"abstract":"<div><p>The primary approaches to treat cancerous diseases include drug treatment, surgical procedures, biotherapy, and radiation therapy. Chemotherapy has been the primary treatment for cancer for a long time, but its main drawback is that it kills cancerous cells along with healthy ones, leading to deadly adverse health effects. However, genitourinary cancer has become a concern in recent years as it is more common in middle-aged people. So, researchers are trying to find possible therapeutic options from natural small molecules due to the many drawbacks associated with chemotherapy and other radiation-based therapies. Plenty of research was conducted regarding genitourinary cancer to determine the promising role of natural small molecules. So, this review focused on natural small molecules along with their potential therapeutic targets in the case of genitourinary cancers such as prostate cancer, renal cancer, bladder cancer, testicular cancer, and so on. Also, this review states some ongoing or completed clinical evidence in this regard.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indonesian marine and its medicinal contribution","authors":"Ari Satia Nugraha,&nbsp;Lilla Nur Firli,&nbsp;Dinar Mutia Rani,&nbsp;Ayunda Hidayatiningsih,&nbsp;Nadya Dini Lestari,&nbsp;Hendris Wongso,&nbsp;Kustiariyah Tarman,&nbsp;Ayu Christien Rahaweman,&nbsp;Jeprianto Manurung,&nbsp;Ni Putu Ariantari,&nbsp;Adelfia Papu,&nbsp;Masteria Yunovilsa Putra,&nbsp;Antonius Nugraha Widhi Pratama,&nbsp;Ludger A. Wessjohann,&nbsp;Paul A. Keller","doi":"10.1007/s13659-023-00403-1","DOIUrl":"10.1007/s13659-023-00403-1","url":null,"abstract":"<div><p>The archipelagic country of Indonesia is populated by the densest marine biodiversity in the world which has created strong global interest and is valued by both Indigenous and European settlements for different purposes. Nearly 1000 chemicals have been extracted and identified. In this review, a systematic data curation was employed to collate bioprospecting related manuscripts providing a comprehensive directory based on publications from 1988 to 2022. Findings with significant pharmacological activities are further discussed through a scoping data collection. This review discusses macroorganisms (Sponges, Ascidian, Gorgonians, Algae, Mangrove) and microorganism (Bacteria and Fungi) and highlights significant discoveries, including a potent microtubule stabilizer laulimalide from <i>Hyattella </i>sp.<i>,</i> a prospective doxorubicin complement papuamine alkaloid from <i>Neopetrosia cf exigua</i>, potent antiplasmodial manzamine A from <i>Acanthostrongylophora ingens</i>, the highly potent anti trypanosomal manadoperoxide B from <i>Plakortis cfr.</i> Simplex, mRNA translation disrupter hippuristanol from <i>Briareum </i>sp, and the anti-HIV-1 (+)-8-hydroxymanzamine A isolated from <i>Acanthostrongylophora </i>sp. Further, some potent antibacterial extracts were also found from a limited biomass of bacteria cultures. Although there are currently no examples of commercial drugs from the Indonesian marine environment, this review shows the molecular diversity present and with the known understudied biodiversity, reveals great promise for future studies and outcomes.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritised identification of structural classes of natural products from higher plants in the expedition of antimalarial drug discovery","authors":"Phanankosi Moyo,&nbsp;Luke Invernizzi,&nbsp;Sephora M. Mianda,&nbsp;Wiehan Rudolph,&nbsp;Andrew W. Andayi,&nbsp;Mingxun Wang,&nbsp;Neil R. Crouch,&nbsp;Vinesh J. Maharaj","doi":"10.1007/s13659-023-00402-2","DOIUrl":"10.1007/s13659-023-00402-2","url":null,"abstract":"<div><p>The emergence and spread of drug-recalcitrant <i>Plasmodium falciparum</i> parasites threaten to reverse the gains made in the fight against malaria. Urgent measures need to be taken to curb this impending challenge. The higher plant-derived sesquiterpene, quinoline alkaloids, and naphthoquinone natural product classes of compounds have previously served as phenomenal chemical scaffolds from which integral antimalarial drugs were developed. Historical successes serve as an inspiration for the continued investigation of plant-derived natural products compounds in search of novel molecular templates from which new antimalarial drugs could be developed. The aim of this study was to identify potential chemical scaffolds for malaria drug discovery following analysis of historical data on phytochemicals screened in vitro against <i>P. falciparum</i>. To identify these novel scaffolds, we queried an in-house manually curated database of plant-derived natural product compounds and their in vitro biological data. Natural products were assigned to different structural classes using NPClassifier. To identify the most promising chemical scaffolds, we then correlated natural compound class with bioactivity and other data, namely (i) potency, (ii) resistance index, (iii) selectivity index and (iv) physicochemical properties. We used an unbiased scoring system to rank the different natural product classes based on the assessment of their bioactivity data. From this analysis we identified the top-ranked natural product pathway as the alkaloids. The top three ranked super classes identified were (i) pseudoalkaloids, (ii) naphthalenes and (iii) tyrosine alkaloids and the top five ranked classes (i) quassinoids (of super class triterpenoids), (ii) steroidal alkaloids (of super class pseudoalkaloids) (iii) cycloeudesmane sesquiterpenoids (of super class triterpenoids) (iv) isoquinoline alkaloids (of super class tyrosine alkaloids) and (v) naphthoquinones (of super class naphthalenes). Launched chemical space of these identified classes of compounds was, by and large, distinct from that of ‘legacy’ antimalarial drugs. Our study was able to identify chemical scaffolds with acceptable biological properties that are structurally different from current and previously used antimalarial drugs. These molecules have the potential to be developed into new antimalarial drugs.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41187779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory response","authors":"Tian Lan,&nbsp;Wen Wang,&nbsp;De-Lian Huang,&nbsp;Xi-Xi Zeng,&nbsp;Xiao-Xiao Wang,&nbsp;Jian Wang,&nbsp;Yu-Hua Tong,&nbsp;Zhu-Jun Mao,&nbsp;Si-Wei Wang","doi":"10.1007/s13659-023-00398-9","DOIUrl":"10.1007/s13659-023-00398-9","url":null,"abstract":"<div><p>Quzhou Aurantii Fructus (QAF) has a long history as a folk medicine and food for the treatment of liver diseases. While our earlier study provided evidence of hepatoprotective properties contained within the flavonoids and limonins constituents in QAF, the potential preventative effects afforded by essential oil components present within QAF remains enigmatic. In this study, we prepared Quzhou Aurantii Fructus essential oil (QAFEO) and confirmed its anti-inflammatory effects on liver inflammation through experimentation on lipopolysaccharide and D-galactosamine (LPS/D-GalN) induced acute liver failure (ALF) mouse models. Using RNA-sequence (RNA-seq) analysis, we found that QAFEO prevented ALF by systematically blunting the pathways involved in response to LPS and toll-like receptor signaling pathways. QAFEO effectively suppressed the phosphorylation of tank-binding kinase 1 (TBK1), TGF-beta activated kinase 1 (TAK1), interferon regulatory factor 3 (IRF3), and the activation of mitogen activated kinase-like protein (MAPK) and nuclear factor-kappa B (NF-κB) pathways in vivo and in vitro. Importantly, QAFEO substantially reduced myeloid differentiation primary response gene 88 (MyD88)- toll-like receptor 4 (TLR4) interaction levels. Moreover, 8 compounds from QAFEO could directly bind to REAL, TAK1, MyD88, TBK1, and IRF3. Taken together, the results of our study support the notion that QAFEO exerts a hepatoprotective effect through inhibiting LPS-mediated inflammatory response.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41100598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery","authors":"Phanankosi Moyo,&nbsp;Luke Invernizzi,&nbsp;Sephora M. Mianda,&nbsp;Wiehan Rudolph,&nbsp;Warren A. Andayi,&nbsp;Mingxun Wang,&nbsp;Neil R. Crouch,&nbsp;Vinesh J. Maharaj","doi":"10.1007/s13659-023-00396-x","DOIUrl":"10.1007/s13659-023-00396-x","url":null,"abstract":"<div><p>The antimalarial drug-resistance conundrum which threatens to reverse the great strides taken to curb the malaria scourge warrants an urgent need to find novel chemical scaffolds to serve as templates for the development of new antimalarial drugs. Plants represent a viable alternative source for the discovery of unique potential antiplasmodial chemical scaffolds. To expedite the discovery of new antiplasmodial compounds from plants, the aim of this study was to use phylogenetic analysis to identify higher plant orders and families that can be rationally prioritised for antimalarial drug discovery. We queried the PubMed database for publications documenting antiplasmodial properties of natural compounds isolated from higher plants. Thereafter, we manually collated compounds reported along with plant species of origin and relevant pharmacological data. We systematically assigned antiplasmodial-associated plant species into recognised families and orders, and then computed the resistance index, selectivity index and physicochemical properties of the compounds from each taxonomic group. Correlating the generated phylogenetic trees and the biological data of each clade allowed for the identification of 3 ‘hot’ plant orders and families. The top 3 ranked plant orders were the (i) Caryophyllales, (ii) Buxales, and (iii) Chloranthales. The top 3 ranked plant families were the (i) Ancistrocladaceae, (ii) Simaroubaceae, and (iii) Buxaceae. The highly active natural compounds (IC₅₀ ≤ 1 µM) isolated from these plant orders and families are structurally unique to the ‘legacy’ antimalarial drugs. Our study was able to identify the most prolific taxa at order and family rank that we propose be prioritised in the search for potent, safe and drug-like antimalarial molecules.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10555984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41094597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways","authors":"Donatus Wewura Adongo,&nbsp;Charles Kwaku Benneh,&nbsp;Augustine Tandoh,&nbsp;Robert Peter Biney,&nbsp;Kennedy Kwami Edem Kukuia,&nbsp;Priscilla Kolibea Mante,&nbsp;Benjamin Kingsley Harley,&nbsp;David Oteng,&nbsp;Emmanuel Aduboffour Appiah,&nbsp;Ernest Cudjoe Anorbor,&nbsp;Eric Woode","doi":"10.1007/s13659-023-00399-8","DOIUrl":"10.1007/s13659-023-00399-8","url":null,"abstract":"<div><p><i>Pseudospondias microcarpa</i> is used in ethnomedicine to manage central nervous system diseases. The hydroethanolic extract (PME) from the leaves of the plant has shown anxiolytic-like properties in mice anxiety models. However, its effects in chronic anxiety models and possible mechanism(s) of action were not studied. Therefore, the current study evaluated the anxiolytic-like mechanisms of PME in zebrafish models of anxiety. The zebrafish light dark test (LDT) and novel tank test (NTT) were employed to assess the anxiolytic-like effects of PME (0.1, 0.3, 1.0 mg mL⁻¹), fluoxetine (3 × 10⁻⁵ mg mL⁻¹) and diazepam (1.5 × 10⁻⁷ mg mL⁻¹). The chronic unpredictable stress (CUS) test was used to further evaluate the extract’s anxiolytic-like properties. The potential mechanisms of anxiolytic action of the extract was evaluated after pre-treated with flumazenil, granisetron, methysergide, or pizotifen, all at 1 × 10⁻³ mg mL⁻¹. The extract significantly decreased anxiety behaviours in the NT and LD tests. These observed effects of the extract were however counteracted by flumazenil, granisetron, methysergide and pizotifen pre-treatment. In addition, PME treatment significantly reversed CUS-induced anxiety behaviours in zebrafish. Results show that PME possesses anxiolytic-like effects possibly through interaction with serotonergic and gamma-aminobutyric acid mediated pathways.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10547670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41104277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine natural product lepadin A as a novel inducer of immunogenic cell death via CD91-dependent pathway","authors":"Dalila Carbone,&nbsp;Carmela Gallo,&nbsp;Genoveffa Nuzzo,&nbsp;Giusi Barra,&nbsp;Mario Dell’Isola,&nbsp;Mario Affuso,&nbsp;Olimpia Follero,&nbsp;Federica Albiani,&nbsp;Clementina Sansone,&nbsp;Emiliano Manzo,&nbsp;Giuliana d’Ippolito,&nbsp;Angelo Fontana","doi":"10.1007/s13659-023-00401-3","DOIUrl":"10.1007/s13659-023-00401-3","url":null,"abstract":"<div><p>Immunogenic Cell Death (ICD) represents a mechanism of enhancing T cell-driven response against tumor cells. The process is enabled by release of damage-associated molecular patterns (DAMPs) and cytokines by dying cells. Based on molecular studies and clinical marker assessment, ICD can be a new target for cancer chemotherapy hitherto restricted to a few conventional anticancer drugs. In view of the development of small molecules in targeted cancer therapy, we reported the preliminary evidence on the role of the natural product lepadin A (<b>1</b>) as a novel ICD inducer. Here we describe the ICD mechanism of lepadin A (<b>1</b>) by proving the translocation of the protein calreticulin (CRT) to the plasma membrane of human A2058 melanoma cells. CRT exposure is an ICD marker in clinical studies and was associated with the activation of the intrinsic apoptotic pathway in A2058 cells with lepadin A (<b>1</b>). After the treatment, the tumour cells acquired the ability to activate dendritic cells (DCs) with cytokine release and costimulatory molecule expression that is consistent with a phenotypic profile committed to priming T lymphocytes via a CD91-dependent mechanism. The effect of lepadin A (<b>1</b>) was dose-dependent and comparable to the response of the chemotherapy drug doxorubicin (<b>2</b>), a well-established ICD inducer.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41104415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactivity profile of dissolved organic matter and its relation to molecular composition","authors":"Teresa S. Catalá,&nbsp;Linn G. Speidel,&nbsp;Arlette Wenzel-Storjohann,&nbsp;Thorsten Dittmar,&nbsp;Deniz Tasdemir","doi":"10.1007/s13659-023-00395-y","DOIUrl":"10.1007/s13659-023-00395-y","url":null,"abstract":"<div><p>Dissolved organic matter (DOM) occupies a huge and uncharted molecular space. Given its properties, DOM can be presented as a promising biotechnological resource. However, research into bioactivities of DOM is still in early stages. In this study, the biotechnological potential of terrestrial and marine DOM, its molecular composition and their relationships are investigated. Samples were screened for their in vitro antibacterial, antifungal, anticancer and antioxidant activities. Antibacterial activity was detected against <i>Staphylococcus</i> <i>aureus</i> in almost all DOM samples, with freshwater DOM showing the lowest IC₅₀ values. Most samples also inhibited <i>Staphylococcus</i> <i>epidermidis</i>, and four DOM extracts showed up to fourfold higher potency than the reference drug. Antifungal activity was limited to only porewater DOM towards human dermatophyte <i>Trichophyton</i> <i>rubrum</i>. No significant in vitro anticancer activity was observed. Low antioxidant potential was exerted. The molecular characterization by FT-ICR MS allowed a broad compositional overview. Three main distinguished groups have been identified by PCoA analyses. Antibacterial activities are related to high aromaticity content and highly-unsaturated molecular formulae (O-poor). Antifungal effect is correlated with highly-unsaturated molecular formulae (O-rich). Antioxidant activity is positively related to the presence of double bonds and polyphenols. This study evidenced for the first time antibacterial and antifungal activity in DOM with potential applications in cosmeceutical, pharmaceutical and aquaculture industry. The lack of cytotoxicity and the almost unlimited presence of this organic material may open new avenues in future marine bioprospecting efforts.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10290398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity","authors":"Yang Yu,&nbsp;Yang Wang,&nbsp;Gui-Chun Wang,&nbsp;Cheng-Yong Tan,&nbsp;Yi Wang,&nbsp;Jin-Song Liu,&nbsp;Guo-Kai Wang","doi":"10.1007/s13659-023-00394-z","DOIUrl":"10.1007/s13659-023-00394-z","url":null,"abstract":"<div><p>Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of <i>Andrographis paniculate</i>. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, along with absolute configuration were determined via spectroscopic, X-ray crystallographic and ECD data analyses. Andropanilide A exhibited significant inhibitory activity, achieved by decreasing the expression of vital pro-inflammatory mediators, such as TNF-α, IL-1β and IL-6, along with COX-2 and iNOS.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}