Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2024-02-22 DOI:10.1007/s13659-024-00439-x

Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L. Pinto, Otília Deusdenia L. Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C. Gomes

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Abstract

According to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 million people worldwide suffer from Alzheimer’s Disease (AD). A crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (AChE) activity. Marine organisms synthesize several classes of compounds, some of which exhibit significant AChE inhibition, such as petrosamine, a coloured pyridoacridine alkaloid. The aim of this work was to characterize the activity of petrosamine isolated for the first time from a Brazilian marine sponge, using two neurotoxicity models with aluminium chloride, as exposure to aluminium is associated with the development of neurodegenerative diseases. The in vitro model was based in a neuroblastoma cell line and the in vivo model exploited the potential of zebrafish (Danio rerio) embryos in mimicking hallmarks of AD. To our knowledge, this is the first report on petrosamine’s activity over these parameters, either in vitro or in vivo, in order to characterize its full potential for tackling neurotoxicity.

Graphical Abstract

Abstract Image

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从海洋海绵 Petrosia sp.中分离出的 Petrosamine 可在体外和体内对神经毒性起到保护作用。

据阿尔茨海默病国际组织（ADI）发布的《2023 年世界阿尔茨海默病报告》估计，全球有 3300 万至 3850 万人患有阿尔茨海默病（AD）。这种疾病的一个重要特征是，由于乙酰胆碱酯酶（AChE）活性受到影响，大脑神经递质乙酰胆碱缺乏。海洋生物能合成几类化合物，其中一些具有明显的乙酰胆碱酯酶抑制作用，如 petrosamine（一种有色的吡啶吖啶生物碱）。由于接触铝与神经退行性疾病的发生有关，这项工作的目的是利用氯化铝的两种神经毒性模型，分析首次从巴西海洋海绵中分离出来的石炭酸胺的活性特征。体外模型以神经母细胞瘤细胞系为基础，体内模型则利用斑马鱼（Danio rerio）胚胎在模拟注意力缺失症特征方面的潜力。据我们所知，这是第一份关于石炭酸胺在体外或体内对这些参数的活性的报告，目的是描述石炭酸胺在应对神经毒性方面的全部潜力。

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.