Natural Products and Bioprospecting最新文献

{"title":"Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression","authors":"Xinxin Li,&nbsp;Runlu Shi,&nbsp;Lingchen Yan,&nbsp;Weiwei Chu,&nbsp;Ruishuang Sun,&nbsp;Binkai Zheng,&nbsp;Shuai Wang,&nbsp;Hui Tan,&nbsp;Xusheng Wang,&nbsp;Ying Gao","doi":"10.1007/s13659-023-00421-z","DOIUrl":"10.1007/s13659-023-00421-z","url":null,"abstract":"<div><p>Norepinephrine (NA), a stress hormone, can accelerate hair graying by binding to β2 adrenergic receptors (β₂AR) on melanocyte stem cells (McSCs). From this, NA-β₂AR axis could be a potential target for preventing the stress effect. However, identifying selective blockers for β₂AR has been a key challenge. Therefore, in this study, advanced computer-aided drug design (CADD) techniques were harnessed to screen natural molecules, leading to the discovery of rhynchophylline as a promising compound. Rhynchophylline exhibited strong and stable binding within the active site of β₂AR, as verified by molecular docking and dynamic simulation assays. When administered to cells, rhynchophylline effectively inhibited NA-β₂AR signaling. This intervention resulted in a significant reduction of hair graying in a stress-induced mouse model, from 28.5% to 8.2%. To gain a deeper understanding of the underlying mechanisms, transcriptome sequencing was employed, which revealed that NA might disrupt melanogenesis by affecting intracellular calcium balance and promoting cell apoptosis. Importantly, rhynchophylline acted as a potent inhibitor of these downstream pathways. In conclusion, the study demonstrated that rhynchophylline has the potential to mitigate the negative impact of NA on melanogenesis by targeting β₂AR, thus offering a promising solution for preventing stress-induced hair graying.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis","authors":"Orawan Jongsomjainuk,&nbsp;Jutatip Boonsombat,&nbsp;Sanit Thongnest,&nbsp;Hunsa Prawat,&nbsp;Paratchata Batsomboon,&nbsp;Sitthivut Charoensutthivarakul,&nbsp;Saroj Ruchisansakun,&nbsp;Kittipong Chainok,&nbsp;Jitnapa Sirirak,&nbsp;Chulabhorn Mahidol,&nbsp;Somsak Ruchirawat","doi":"10.1007/s13659-023-00420-0","DOIUrl":"10.1007/s13659-023-00420-0","url":null,"abstract":"<div><p>Four highly oxidized pimarane diterpenoids were isolated from <i>Kaempferia takensis</i> rhizomes. Kaemtakols A–C possess a tetracyclic ring with either a fused tetrahydropyran or tetrahydrofuran motif. Kaemtakol D has an unusual rearranged A/B ring spiro-bridged pimarane framework with a C-10 spirocyclic junction and an adjacent 1-methyltricyclo[3.2.1.0^2,7]octene ring. Structural characterization was achieved using spectroscopic analysis, DP4 + and ECD calculations, as well as X-ray crystallography, and their putative biosynthetic pathways have been proposed. Kaemtakol B showed significant potency in inhibiting nitric oxide production with an IC₅₀ value of 0.69 μM. Molecular docking provided some perspectives on the action of kaemtakol B on iNOS protein.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra","authors":"Jin-Ning Chu,&nbsp;Premanand Krishnan,&nbsp;Kuan-Hon Lim","doi":"10.1007/s13659-023-00418-8","DOIUrl":"10.1007/s13659-023-00418-8","url":null,"abstract":"<div><p><i>Sarcandra glabra</i> (Thunb.) Nakai is a perennial evergreen herb categorised within the <i>Sarcandra Gardner</i> genus under the Chloranthaceae family. Indigenous to tropical and subtropical regions of East Asia and India, this species is extensively distributed across China, particularly in the southern regions (Sichuan, Yunnan, and Jiangxi). In addition to its high ornamental value, <i>S. glabra</i> has a rich history of use in traditional Chinese medicine, evident through its empirical prescriptions for various ailments like pneumonia, dysentery, fractures, bruises, numbness, amenorrhea, rheumatism, and other diseases. Besides, modern pharmacological studies have revealed various biological activities, such as antitumour, anti-bacterial, anti-viral anti-inflammatory and immunomodulatory effects. The diverse chemical constituents of <i>S. glabra</i> have fascinated natural product researchers since the 1900s. To date, over 400 compounds including terpenoids, coumarins, lignans, flavonoids, sterols, anthraquinones, organic acids, and organic esters have been isolated and characterised, some featuring unprecedented structures. This review comprehensively examines the current understanding of <i>S. glabra</i>’s phytochemistry and pharmacology, with emphasis on the chemistry and biosynthesis of its unique chemotaxonomic marker, the lindenane-type sesquiterpenoids.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinones from Cordia species from 1972 to 2023: isolation, structural diversity and pharmacological activities","authors":"Rostanie Dongmo Zeukang,&nbsp;Jarmo-Charles Kalinski,&nbsp;Babalwa Tembeni,&nbsp;Eleonora D. Goosen,&nbsp;Jacqueline Tembu,&nbsp;Turibio Tabopda Kuiate,&nbsp;Dominique Serge Ngono Bikobo,&nbsp;Maurice Tagatsing Fotsing,&nbsp;Alex de Théodore Atchadé,&nbsp;Xavier Siwe-Noundou","doi":"10.1007/s13659-023-00414-y","DOIUrl":"10.1007/s13659-023-00414-y","url":null,"abstract":"<div><p>Plants of the genus <i>Cordia</i> (Boraginaceae family) are widely distributed in the tropical regions of America, Africa, and Asia. They are extensively used in folk medicine due to their rich medicinal properties. This review presents a comprehensive analysis of the isolation, structure, biogenesis, and biological properties of quinones from <i>Cordia</i> species reported from 1972 to 2023. Meroterpenoids were identified as the major quinones in most <i>Cordia</i> species and are reported as a chemotaxonomic markers of the <i>Cordia</i>. In addition to this property, quinones are reported to display a wider and broader spectrum of activities, are efficient scaffold in biological activity, compared to other classes of compounds reported in <i>Cordia</i>, hence our focus on the study of quinones reported from <i>Cordia</i> species. About 70 types of quinones have been isolated, while others have been identified by phytochemical screening or gas chromatography. Although the biosynthesis of quinones from <i>Cordia</i> species is not yet fully understood, previous reports suggest that they may be derived from geranyl pyrophosphate and an aromatic precursor unit, followed by oxidative cyclization of the allylic methyl group. Studies have demonstrated that quinones from this genus exhibit antifungal, larvicidal, antileishmanial, anti-inflammatory, antibiofilm, antimycobacterial, antioxidant, antimalarial, neuroinhibitory, and hemolytic activities. In addition, they have been shown to exhibit remarkable cytotoxic effects against several cancer cell lines which is likely related to their ability to inhibit electron transport as well as oxidative phosphorylation, and generate reactive oxygen species (ROS). Their biological activities indicate potential utility in the development of new drugs, especially as active components in drug-carrier systems, against a broad spectrum of pathogens and ailments.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138298058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A recent update on development, synthesis methods, properties and application of natural products derived carbon dots","authors":"Soumitra Sahana,&nbsp;Anupam Gautam,&nbsp;Rajveer Singh,&nbsp;Shivani Chandel","doi":"10.1007/s13659-023-00415-x","DOIUrl":"10.1007/s13659-023-00415-x","url":null,"abstract":"<div><p>Natural resources are practically infinitely abundant in nature, which stimulates scientists to create new materials with inventive uses and minimal environmental impact. Due to the various benefits of natural carbon dots (NCDs) from them has received a lot of attention recently. Natural products-derived carbon dots have recently emerged as a highly promising class of nanomaterials, showcasing exceptional properties and eco-friendly nature, which make them appealing for diverse applications in various fields such as biomedical, environmental sensing and monitoring, energy storage and conversion, optoelectronics and photonics, agriculture, quantum computing, nanomedicine and cancer therapy. Characterization techniques such as Photoinduced electron transfer, Aggregation-Induced-Emission (AIE), Absorbance, Fluorescence in UV–Vis and NIR Regions play crucial roles in understanding the structural and optical properties of Carbon dots (CDs). The exceptional photoluminescence properties exhibited by CDs derived from natural products have paved the way for applications in tissue engineering, cancer treatment, bioimaging, sensing, drug delivery, photocatalysis, and promising remarkable advancements in these fields. In this review, we summarized the various synthesis methods, physical and optical properties, applications, challenges, future prospects of natural products-derived carbon dots etc. In this expanding sector, the difficulties and prospects for NCD-based materials research will also be explored.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89716581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The alkynyl-containing compounds from mushrooms and their biological activities","authors":"Ji-shuang Qi,&nbsp;Yingce Duan,&nbsp;Zhao-chen Li,&nbsp;Jin-ming Gao,&nbsp;Jianzhao Qi,&nbsp;Chengwei Liu","doi":"10.1007/s13659-023-00416-w","DOIUrl":"10.1007/s13659-023-00416-w","url":null,"abstract":"<div><p>Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties. They are a crucial natural source of bioactive secondary metabolites, and recent advancements have led to the isolation of several alkynyl-containing compounds with potential medicinal uses. Despite their relatively low abundance, naturally occurring alkynyl compounds have attracted considerable attention due to their high reactivity. Bioactivity studies have shown that alkynyl compounds exhibit significant biological and pharmacological activities, including antitumor, antibacterial, antifungal, insecticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. This review systematically compiles 213 alkynyl-containing bioactive compounds isolated from mushrooms since 1947 and summarizes their diverse biological activities, focusing mainly on cytotoxicity and anticancer effects. This review serves as a detailed and comprehensive reference for the chemical structures and bioactivity of alkynyl-containing secondary metabolites from mushrooms. Moreover, it provides theoretical support for the development of chemical constituents containing alkynyl compounds in mushrooms based on academic research and theory.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress","authors":"Lingli Ding,&nbsp;Zhao Gao,&nbsp;Siluo Wu,&nbsp;Chen Chen,&nbsp;Yamei Liu,&nbsp;Min Wang,&nbsp;Yage Zhang,&nbsp;Ling Li,&nbsp;Hong Zou,&nbsp;Guoping Zhao,&nbsp;Shengnan Qin,&nbsp;Liangliang Xu","doi":"10.1007/s13659-023-00405-z","DOIUrl":"10.1007/s13659-023-00405-z","url":null,"abstract":"<div><p>Osteoporosis (OP), a systemic and chronic bone disease, is distinguished by low bone mass and destruction of bone microarchitecture. Ginsenoside Compound-K (CK), one of the metabolites of ginsenoside Rb1, has anti-aging, anti-inflammatory, anti-cancer, and hypolipidemic activities. We have demonstrated CK could promote osteogenesis and fracture healing in our previous study. However, the contribution of CK to osteoporosis has not been examined. In the present study, we investigated the effect of CK on osteoclastogenesis and ovariectomy (OVX)-induced osteoporosis. The results showed that CK inhibited receptor activator for nuclear factor-κB ligand (RANKL)-mediated osteoclast differentiation and reactive oxygen species (ROS) activity by inhibiting the phosphorylation of NF-κB p65 and oxidative stress in RAW264.7 cells. In addition, we also demonstrated that CK could inhibit bone resorption using bone marrow-derived macrophages. Furthermore, we demonstrated that CK attenuated bone loss by suppressing the activity of osteoclast and alleviating oxidative stress in vivo. Taken together, these results showed CK could inhibit osteoclastogenesis and prevent OVX-induced bone loss by inhibiting NF-κB signaling pathway.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"l-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis","authors":"Juan Yang,&nbsp;Lina Cha,&nbsp;Yepeng Wang,&nbsp;Quan Zhang,&nbsp;Xiaopeng Tang,&nbsp;Jianlin Shao,&nbsp;Zilei Duan","doi":"10.1007/s13659-023-00413-z","DOIUrl":"10.1007/s13659-023-00413-z","url":null,"abstract":"<div><p><span>l</span>-Palmitoylcarnitine (L-PC) is an important endogenous fatty acid metabolite. Its classical biological functions are involved in the regulations of membrane molecular dynamics and the β-oxidation of fatty acids. Decreased plasma long-chain acylcarnitines showed the association of venous thrombosis, implying anticoagulant activity of the metabolites and inspiring us to investigate if and how L-PC, a long-chain acylcarnitine, takes part in coagulation. Here we show that L-PC exerted anti-coagulant effects by potentiating the enzymatic activities of plasmin and tissue plasminogen activator (tPA). L-PC directly interacts with plasmin and tPA with an equilibrium dissociation constant (KD) of 6.47 × 10^–9 and 4.46 × 10^–9 M, respectively, showing high affinities. In mouse model, L-PC administration significantly inhibited FeCl₃-induced arterial thrombosis. It also mitigated intracerebral thrombosis and inflammation in a transient middle cerebral artery occlusion (tMCAO) mouse model. L-PC induced little bleeding complications. The results show that L-PC has anti-thrombotic function by potentiating plasmin and tPA.</p><h3>Graphical Abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71476805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of D-amino acids in natural products","authors":"Daniel W. Armstrong,&nbsp;Alain Berthod","doi":"10.1007/s13659-023-00412-0","DOIUrl":"10.1007/s13659-023-00412-0","url":null,"abstract":"<div><p>Since the identified standard genetic code contains 61 triplet codons of three bases for the 20 L-proteinogenic amino acids (AAs), no D-AA should be found in natural products. This is not what is observed in the living world. D-AAs are found in numerous natural compounds produced by bacteria, algae, fungi, or marine animals, and even vertebrates. A review of the literature indicated the existence of at least 132 peptide natural compounds in which D-AAs are an essential part of their structure. All compounds are listed, numbered and described herein. The two biosynthetic routes leading to the presence of D-AA in natural products are: non-ribosomal peptide synthesis (NRPS), and ribosomally synthesized and post-translationally modified peptide (RiPP) synthesis which are described. The methods used to identify the AA chirality within naturally occurring peptides are briefly discussed. The biological activity of an all-L synthetic peptide is most often completely different from that of the D-containing natural compounds. Analyzing the selected natural compounds showed that D-Ala, D-Val, D-Leu and D-Ser are the most commonly encountered D-AAs closely followed by the non-proteinogenic D-<i>allo-</i>Thr. D-Lys and D-Met were the least prevalent D-AAs in naturally occurring compounds.</p><h3>Graphical Abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71476806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus","authors":"Jing Fan,&nbsp;Pai Liu,&nbsp;Kuan Zhao,&nbsp;He-Ping Chen","doi":"10.1007/s13659-023-00410-2","DOIUrl":"10.1007/s13659-023-00410-2","url":null,"abstract":"<div><p>Three previously undescribed compounds, cordycicadione (<b>1</b>), cordycicadin F (<b>2</b>), and 7-hydroxybassiatin (<b>3</b>), were isolated from the cultures of <i>Cordyceps cicadae</i> JXCH1, an entomopathogenic fungus. Their structures and relative configurations were elucidated primarily by NMR spectroscopic analysis. The absolute configurations of <b>1</b> and <b>2</b> were determined by ECD calculations. Single-crystal X-ray diffraction method was adopted to determine the absolute configuration of <b>3</b>. Compound <b>2</b> is a polycyclic polyketide with an unusual enol ether moiety and a spiro ring. The compounds obtained in this study were subjected to screening their inhibition against the proliferation of the human lung cancer cell line A549 and the production of nitric oxide in murine macrophages RAW264.7.</p><h3>Graphical Abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10622384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71419485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}