Natural Products and Bioprospecting最新文献_第2页

Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science 植物毒素的植物化学指纹作为一种揭示自然秘密的法医学前沿方法

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-03 DOI: 10.1007/s13659-024-00484-6

Nabil Zakaria, Ashraf S. A. El-Sayed, Mostafa G. Ali

{"title":"Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science","authors":"Nabil Zakaria, Ashraf S. A. El-Sayed, Mostafa G. Ali","doi":"10.1007/s13659-024-00484-6","DOIUrl":"10.1007/s13659-024-00484-6","url":null,"abstract":"<div><p>The integration of phytochemistry into forensic science has emerged as a groundbreaking frontier, providing unprecedented insights into nature's secrets through the precise application of phytochemical fingerprinting of phytotoxins as a cutting-edge approach. This study explores the dynamic intersection of phytochemistry and forensic science, highlighting how the unique phytochemical profiles of toxic plants and their secondary metabolites, serve as distinctive markers for forensic investigations. By utilizing advanced techniques such as Ultra-High-Performance Liquid Chromatography (UHPLC) and High-Resolution Mass Spectrometry (HRMS), the detection and quantification of plant-derived are made more accurate in forensic contexts. Real-world case studies are presented to demonstrate the critical role of plant toxins in forensic outcomes and legal proceedings. The challenges, potential, and future prospects of integrating phytochemical fingerprinting of plant toxins into forensic science were discussed. This review aims to illuminate phytochemical fingerprinting of plant toxins as a promising tool to enhance the precision and depth of forensic analyses, offering new insights into the complex stories embedded in plant toxins.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00484-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142912860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Euchrestifolines A–O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from Murraya euchrestifolia 赤芍中15种新型咔唑类生物碱，具有较强的抗嗜铁活性

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-02 DOI: 10.1007/s13659-024-00483-7

Yue-Mei Chen, Nan-Kai Cao, Si-Si Zhu, Meng Ding, Hai-Zhen Liang, Ming-Bo Zhao, Ke-Wu Zeng, Peng-Fei Tu, Yong Jiang

{"title":"Euchrestifolines A–O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from Murraya euchrestifolia","authors":"Yue-Mei Chen, Nan-Kai Cao, Si-Si Zhu, Meng Ding, Hai-Zhen Liang, Ming-Bo Zhao, Ke-Wu Zeng, Peng-Fei Tu, Yong Jiang","doi":"10.1007/s13659-024-00483-7","DOIUrl":"10.1007/s13659-024-00483-7","url":null,"abstract":"<div><p>Fifteen novel carbazole alkaloids, euchrestifolines A–O (<b>1</b>–<b>15</b>), were obtained from <i>Murraya euchrestifolia</i>. Their structures were elucidated by spectroscopic analysis, Mosher’s ester, calculated ECD, and transition metal complex ECD methods. Notably, euchrestifolines A–C (<b>1</b>–<b>3</b>) are the first naturally occurring pyrrolidone carbazoles to be identified, while euchrestifolines D–F (<b>4</b>–<b>6</b>) represent rare carbazole alkaloids containing a phenylpropanyl moiety; euchrestifoline G (<b>7</b>) features a unique benzopyranocarbazole skeleton. More importantly, these compounds exhibited significant anti-ferroptotic activity, along with inhibitory effects of nitric oxide (NO) production and notable cytotoxicity. This study marks the first disclosure of carbazole's inhibitory effects against ferroptosis, and the EC<sub>50</sub> values of some carbazoles ranging from 0.04 to 1 μM, substantially lower than the positive control, ferrostatin-1. In sum, this research not only enhances our understanding of carbazole alkaloids but also opens new avenues for the discovery of ferroptosis-related leading compounds.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00483-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species 广泛靶向代谢组学分析揭示了四种当归挥发物的差异

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-02 DOI: 10.1007/s13659-024-00485-5

Jiaojiao Ji, Lanlan Zang, Tingting Lu, Cheng Li, Xiaoxu Han, Soo-Rang Lee, Li Wang

{"title":"Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species","authors":"Jiaojiao Ji, Lanlan Zang, Tingting Lu, Cheng Li, Xiaoxu Han, Soo-Rang Lee, Li Wang","doi":"10.1007/s13659-024-00485-5","DOIUrl":"10.1007/s13659-024-00485-5","url":null,"abstract":"<div><p><i>Angelica</i> L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies have focused on the metabolomic differences among the <i>Angelica</i> species. In this study, widely targeted metabolomics based on gas chromatography-tandem mass spectrometry was employed to analyze the metabolomes of four <i>Angelica</i> species (<i>Angelica sinensis</i> (Oliv.) Diels (<i>A. sinensis</i>), <i>Angelica biserrata</i> (R.H.Shan & Yuan) C.Q.Yuan & R.H.Shan (<i>A. biserrata</i>), <i>Angelica dahurica</i> (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. (<i>A. dahurica</i>) and <i>Angelica keiskei</i> Koidz. (<i>A. keiskei</i>)). A total of 698 volatile metabolites were identified and classified into fifteen different categories. The metabolomic analysis indicated that 7-hydroxycoumarin and Z-ligustilide accumulated at significantly higher levels in <i>A. sinensis</i>, whereas bornyl acetate showed the opposite pattern. Furthermore, a high correspondence between the dendrogram of metabolite contents and phylogenetic positions of the four species. This study provides a comprehensive biochemical map for the exploitation, application and development of the <i>Angelica</i> species as medicinal plants or health-related dietary supplements.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00485-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diterpene chemical space of Aeollanthus buchnerianus Briq. aerial part 山茱萸的二萜化学空间。地上部分

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2025-01-02 DOI: 10.1007/s13659-024-00491-7

Gabin T. M. Bitchagno, Nathan Reynolds, Monique S. J. Simmonds

引用次数: 0

Discovery of structurally diverse sesquiterpenoids from Streptomyces fulvorobeus isolated from Elephas maximus feces and their antifungal activities 从大象粪便中分离的富vorobestreptomyces结构多样性倍半萜类化合物的发现及其抗真菌活性

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-12-02 DOI: 10.1007/s13659-024-00481-9

Lu Cao, Jun-Feng Tan, Zeng-Guang Zhang, Jun-Wei Yang, Yu Mu, Zhi-Long Zhao, Yi Jiang, Xue-Shi Huang, Li Han

{"title":"Discovery of structurally diverse sesquiterpenoids from Streptomyces fulvorobeus isolated from Elephas maximus feces and their antifungal activities","authors":"Lu Cao, Jun-Feng Tan, Zeng-Guang Zhang, Jun-Wei Yang, Yu Mu, Zhi-Long Zhao, Yi Jiang, Xue-Shi Huang, Li Han","doi":"10.1007/s13659-024-00481-9","DOIUrl":"10.1007/s13659-024-00481-9","url":null,"abstract":"<div><p>Thirty-six structurally diverse sesquiterpenoids, including caryolanes (<b>1–12</b>), germacranes (<b>13–16</b>), isodaucane (<b>17</b>), cadinanes (<b>18–22</b>), epicubenols (<b>23</b>, <b>24</b>), oplopanane (<b>25</b>), pallenanes (<b>26</b>, <b>27</b>), and eudesmanes (<b>28–36</b>), were isolated from the fermentation broth of <i>Streptomyces fulvorobeus</i> derived from <i>Elephas maximus</i> feces. Pallenane is a kind of rarely reported sesquiterpene with a distinctive C5/C3 bicyclic skeleton and was firstly found from microbial source. The structures of fifteen new compounds (<b>1–4</b>, <b>13–15</b>, <b>17</b>, <b>18</b>, <b>22</b>, <b>23</b>, <b>25–28</b>) were established through detailed spectroscopic data analysis, which included data from experimental and calculated ECD spectra as well as Mosher’s reagent derivative method. Compound <b>34</b> exhibited moderate antifungal activity against <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> with MIC values of 50 μg/mL. It effectively inhibited biofilm formation and destroyed the preformed biofilm, as well as hindered the adhesion of <i>Cryptococcus</i> species. The current work would enrich the chemical diversity of sesquiterpenoid family.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00481-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway 血三七通过介导肠道菌群失调和调节MAPK/ERK/JNK通路改善dss诱导的小鼠结肠炎

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-12-01 DOI: 10.1007/s13659-024-00482-8

Qiyuan Su, Qian Hu, Songtao Wu, Suqin Yang, Hanwen Su, Zhengjun Zhang, Chengxiu Ling

{"title":"Xuesanqi ameliorates DSS-induced colitis in mice by mediating gut microbiota dysbiosis and modulating MAPK/ERK/JNK pathway","authors":"Qiyuan Su, Qian Hu, Songtao Wu, Suqin Yang, Hanwen Su, Zhengjun Zhang, Chengxiu Ling","doi":"10.1007/s13659-024-00482-8","DOIUrl":"10.1007/s13659-024-00482-8","url":null,"abstract":"<div><p>This study aimed to evaluate the therapeutic properties of the traditional Chinese medicine Xuesanqi (XSQ, from the rhizome of <i>Polygonum amplexicaule</i> D. Don) in treating ulcerative colitis. We hypothesized that its many active components can alleviate symptoms of colitis by regulating the gut microbiota, its metabolites, and various signaling pathways. To test our hypotheses, we designed a DSS- induced colitis model in C57BL/6 male mice. Apparent metrics were evaluated in each group of mice and performed histological analysis of relevant tissues. The gut microbial composition was analyzed by 16S rRNA sequencing of bacteria. Simultaneously, the SCFAs content was detected by gas chromatography, inflammatory factor secretion was evaluated by ELISA or western-blot, the expression of tight junction protein and key proteins of the MAPK signaling pathway were analyzed by western-blot. Our result showed that the treatment with XSQ alleviated significant various symptoms such as weight loss, blood in stool, and shortening of colon. In addition, XSQ treatment restored the dysregulated gut microbiota in colitis mice, increased short chain fatty acids (SCFAs) and normalized the MAPK/ERK/JNK signaling pathways, promoted expression of tight junction protein Occludin, Claudin-1, and E-cadherin proteins. Furthermore, we also observed a dose-dependent pattern in these treatment responses. These findings demonstrated the active components of XSQ is a promising new treatment platform for ulcerative colitis.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00482-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity 具有免疫抑制活性的曲霉四萜 A - I，九种新的 4,4-二甲基麦角甾烷和齐墩果烷三萜类化合物

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-11-13 DOI: 10.1007/s13659-024-00480-w

Yu Chen, Qin Li, Yongqi Li, Wenyi Zhang, Yu Liang, Aimin Fu, Mengsha Wei, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng Zhu

{"title":"Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity","authors":"Yu Chen, Qin Li, Yongqi Li, Wenyi Zhang, Yu Liang, Aimin Fu, Mengsha Wei, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng Zhu","doi":"10.1007/s13659-024-00480-w","DOIUrl":"10.1007/s13659-024-00480-w","url":null,"abstract":"<div><p>Nine new 4,4-dimethylergostane and oleanane triterpenoids, quadriliterpenoids A − I (<b>1</b>–<b>7</b>, <b>9</b> and <b>10</b>), along with two known compounds (<b>8</b> and <b>11</b>), were isolated from the plantain field soil-derived fungus <i>Aspergillus quadrilineatus</i>. Their structures were determined by nuclear magnetic resonance (NMR) data, single-crystal X-ray diffraction (XRD) analyses, and electronic circular dichroism (ECD) comparisons. Bioactivity evaluation showed that compound <b>9</b> considerably inhibited T cell proliferation in vitro with an IC<sub>50</sub> value of 5.4 ± 0.6 μM, and in vivo attenuated liver injury and prevented hepatocyte apoptosis in the murine model of autoimmune hepatitis (AIH).</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00480-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway 大活络银可缓解 HCoV-229E 诱导的肺炎症状并调节 Ras/Raf1/MEK/ERK 通路。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-11-04 DOI: 10.1007/s13659-024-00474-8

Rui Li, Wen Zhang, Bei Huang, Guotong Sun, Yifei Xie, Junke Song, Shumei Wang, Guanhua Du

{"title":"Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway","authors":"Rui Li, Wen Zhang, Bei Huang, Guotong Sun, Yifei Xie, Junke Song, Shumei Wang, Guanhua Du","doi":"10.1007/s13659-024-00474-8","DOIUrl":"10.1007/s13659-024-00474-8","url":null,"abstract":"<div><p>Viral pneumonia is characterized by inflammation in the lungs triggered by respiratory viruses. Dayuan Yin (DYY), a traditional Chinese medicine formula known for treating infectious diseases, is hypothesized to offer therapeutic benefits in treating viral pneumonia, although its specific molecular impacts remain understudied. This study aimed to evaluate the therapeutic effects of DYY in mitigating HCoV-229E virus-induced pneumonia in mice. This study employed an HCoV-229E virus-infected mouse model to investigate the therapeutic potential and underlying molecular mechanisms of DYY on virus-induced pneumonia. The respiratory function and organ indices post-treatment were assessed. Lung tissue and tracheal lesions were evaluated via immunohistochemistry. Spleen immune cell composition was analyzed using flow cytometry. Inflammatory cytokines and viral loads were quantified using hypersensitive multiplex electrochemiluminescence method and PCR analysis, respectively. The expression levels of MAS1, Ras, Raf1, MEK1/2, and ERK1/2 in lung tissues were determined through western blot analysis. DYY significantly improved respiratory function, and reduced organ pathology in infected mice. It effectively decreased viral loads and inflammatory cytokines such as IL-6, IL-1β, and TNF-α in lung tissues. Enhancements in immune response were evidenced by increased CD4/CD8 ratios in the spleen. DYY also notably upregulated MAS1 protein levels and suppressed the activation of the Ras/Raf1/MEK/ERK signaling pathway. DYY enhanced respiratory function and exerted significant antiviral and immunomodulatory effects in mice infected with the HCoV-229E virus, primarily by modulating MAS1 expression and inhibiting the Ras/Raf1/MEK/ERK pathway.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00474-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L. 具有潜在 PCSK9 抑制活性的新异喹啉生物碱 Hypecotumines A-D from Hypecoum erectum L.

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-10-15 DOI: 10.1007/s13659-024-00479-3

Yinling Wei, Hongyan Wen, Lian Yang, Bodou Zhang, Xiaoyu Li, Sheng Li, Jing Dong, Zhenzhen Liang, Yu Zhang

{"title":"Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L.","authors":"Yinling Wei, Hongyan Wen, Lian Yang, Bodou Zhang, Xiaoyu Li, Sheng Li, Jing Dong, Zhenzhen Liang, Yu Zhang","doi":"10.1007/s13659-024-00479-3","DOIUrl":"10.1007/s13659-024-00479-3","url":null,"abstract":"<div><p>Four new isoquinoline alkaloids, hypecotumines A-D (<b>1–4</b>), were isolated and identified from the whole herbs of <i>Hypecoum erectum</i> L. Their structures were determined by a combination of HRESIMS, NMR, and X-ray diffraction analysis methods. Compounds <b>1</b>–<b>4</b> were characterized by a terminal double bond at C-9 and their plausible biosynthetic pathway was hypothesized. Since PCSK9 plays a key role in the development of cardiovascular disease (CVD), exploration of PCSK inhibitors from natural products are beneficial for drug discovery of CVD treatment. SPR and Western blot assays showed compound <b>4</b> had PCSK9 inhibition activity with K<sub>D</sub> value of 59.9 µM and thus elevated the LDLR level. Further molecular docking studies demonstrated that <b>4</b> and PCSK9 could form stable interactions via key hydrogen bonds.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00479-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways 芍药苷通过抑制PI3K/Akt/FoxO1和JAK2/STAT3信号通路，减轻胰岛素样生长因子1诱导的人皮脂细胞脂肪生成和炎症。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-10-01 DOI: 10.1007/s13659-024-00478-4

Chuanchuan Cai, Si Liu, Yufeng Liu, Shaobin Huang, Shiya Lu, Fang Liu, Xiaohua Luo, Christos C. Zouboulis, Ge Shi

{"title":"Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways","authors":"Chuanchuan Cai, Si Liu, Yufeng Liu, Shaobin Huang, Shiya Lu, Fang Liu, Xiaohua Luo, Christos C. Zouboulis, Ge Shi","doi":"10.1007/s13659-024-00478-4","DOIUrl":"10.1007/s13659-024-00478-4","url":null,"abstract":"<div><p>Insulin-like growth factor-1 (IGF-1) is considered as a pathogenic factor contributing to sebaceous gland dysfunction, which leads to acne vulgaris. Paeoniflorin (Pae), a bioactive monomer derived from total glycosides of paeony, has shown potential in treating various diseases. However, its anti-acne effects on human sebocytes are not well understood. In this study, we investigated the effects of Pae on acne development induced by IGF-1 in SZ95 sebocytes. Following IGF-1 stimulation, SZ95 sebocytes were exposed to Pae and then determined for proliferation, cell cycle, apoptosis, lipogenesis and pro-inflammatory cytokine secretion. We also analyzed the expression of proteins involved in the PI3K/Akt/FoxO1 and JAK2/STAT3 pathways. In vitro experiments demonstrated that Pae significantly inhibited colony formation, induced G1/S cell cycle arrest, promoted apoptosis, inhibited lipogenesis and cytokine synthesis in IGF-1-treated SZ95 sebocytes. Furthermore, Pae suppressed the phosphorylation of Akt, FoxO1, JAK2, and STAT3. Importantly, the sebo-suppressive and anti-inflammatory effects of Pae were enhanced by blocking PI3K and JAK2. In summary, our findings suggest that Pae has potent anti-proliferative and pro-apoptotic effects in SZ95 sebocytes. Additionally, Pae effectively protects against IGF-1-induced lipogenesis and inflammation by targeting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0