Natural Products and Bioprospecting最新文献

{"title":"Huanglian-Wendan Decoction alleviates DSS-induced colitis by modulating the gut microbiota and protecting against intestinal injury via suppression of colonic apoptosis and endoplasmic reticulum stress","authors":"Liang Li,&nbsp;Xinyi Zhan,&nbsp;Hidayat Ullah,&nbsp;Wenxian Guo,&nbsp;Ping Gui,&nbsp;Weijie Peng,&nbsp;Quanxi Mei,&nbsp;Weibo Dai,&nbsp;Yuting Duan,&nbsp;Xia Yuan,&nbsp;Xianjing Hu","doi":"10.1007/s13659-026-00636-w","DOIUrl":"10.1007/s13659-026-00636-w","url":null,"abstract":"<div><p>Inflammatory bowel disease (IBD) is a chronic disorder characterized by recurrent intestinal inflammation and gut microbiota dysbiosis. Huanglian-Wendan Decoction (HLWDD) has been clinically used for IBD treatment; however, its underlying mechanisms remain unclear. In this study, a dextran sulfate sodium (DSS, 2.25%)-induced IBD mouse model was established to evaluate the therapeutic effects of HLWDD. The protective mechanisms were investigated in colon tissues of DSS-induced mice using ELISA, immunoblotting, histological, and immunohistochemical analyses. In addition, the impact of HLWDD on gut microbiota dysbiosis was analyzed using 16S rRNA sequencing. Antibiotic treatment was applied before DSS administration to deplete gut microbiota and verify the role of microbial modulation. Furthermore, the phytochemical constituents of HLWDD were characterized using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QTOF-MS/MS). The results demonstrated that HLWDD markedly alleviated DSS-induced colitis, as evidenced by reduced body weight loss, rectal bleeding, colon shortening, and disease activity index (DAI) scores. Mechanistically, HLWDD suppressed inflammatory responses in colon tissues by inhibiting the TLR4/MyD88/NF-κB and IL-6/JAK2/STAT3 signaling pathways, while enhancing epithelial barrier integrity through upregulation of ZO-1, Occludin, Claudin-1, and Mucin-2. In addition, HLWDD attenuated endoplasmic reticulum stress (ERS) and apoptosis by downregulating CHOP, phospho-eIF2α, cleaved caspase-3, and Bax, while increasing Bcl-2 expression in colonic tissues. Microbiota analysis revealed an increased abundance of beneficial bacterial genera such as <i>Akkermansia</i> and <i>Escherichia-Shigella</i>–related commensals, along with enrichment of beneficial bacterial families including <i>Ruminococcaceae</i>, <i>Lachnospiraceae</i>, and <i>Verrucomicrobiaceae</i>, whereas potentially harmful taxa such as <i>Escherichia</i> and <i>Paraprevotella</i> were reduced. HLWDD also increased the production of short-chain fatty acids (SCFAs), including acetate, butyrate, and isobutyrate, thereby promoting intestinal homeostasis. Importantly, the protective effects of HLWDD were largely abolished following antibiotic-mediated gut microbiota depletion, confirming the essential role of microbial modulation in its therapeutic action. Collectively, these findings suggest that HLWDD ameliorates IBD by regulating gut microbiota composition and function, thereby inhibiting colonic ER stress and apoptosis and restoring intestinal barrier integrity. This study provides mechanistic evidence supporting the potential clinical application of HLWDD as a novel therapeutic strategy for IBD.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00636-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational potential of medicinal plants for Alzheimer’s disease: integrated evidence from molecular mechanisms to preclinical and clinical findings","authors":"Shirsendu Nag Saikat,&nbsp;Nawfal Hasan Siam","doi":"10.1007/s13659-026-00621-3","DOIUrl":"10.1007/s13659-026-00621-3","url":null,"abstract":"<div><p>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder driven by amyloid-β accumulation, tau hyperphosphorylation, oxidative stress, neuroinflammation, mitochondrial dysfunction, and cholinergic deficits. Despite extensive research, current FDA-approved therapies provide only modest symptomatic relief, underscoring the urgent need for safe and multi-targeted alternatives. This comprehensive review synthesizes evidence from in vitro, in vivo, and clinical studies on 15 medicinal plants and their 21 active compounds with therapeutic relevance to AD. Studies were included based on defined screening criteria: reported neuroprotective activity in at least one AD-related pathway, mechanistic evidence from preclinical or clinical investigations, and publication between 2015 and 2025. Analysis demonstrates that numerous plant extracts and isolated compounds including those from <i>Allium</i> <i>sativum</i>, <i>Bacopa</i> <i>monnieri,</i> <i>Centella</i> <i>asiatica,</i> <i>Crocus</i> <i>sativus,</i> <i>Curcuma</i> <i>longa,</i> <i>Ginkgo</i> <i>biloba,</i> <i>Hericium</i> <i>erinaceus,</i> <i>Melissa</i> <i>officinalis,</i> <i>Nigella</i> <i>sativa,</i> <i>Salvia</i> <i>miltiorrhiza,</i> <i>Vitis</i> <i>vinifera,</i> and others exert neuroprotective actions through convergent mechanisms. These include attenuation of oxidative and inflammatory pathways, inhibition of acetylcholinesterase and BACE-1, suppression of amyloid and tau pathology, enhancement of synaptic plasticity, mitochondrial support, and activation of neurotrophic signaling such as BDNF, TrkB and NRF2. Several compounds, including crocin, crocetin, curcumin, bilobalide, tanshinone IIA, bacosides, thymoquinone, and salvianolic acid B, demonstrate strong mechanistic activity across multiple AD-related pathways. Clinical trials further validate translational potential, with improvements reported in cognitive performance, behavioral symptoms, biomarker regulation, and daily functioning in individuals with mild cognitive impairment, AD, or age-related cognitive decline. Together, the evidence highlights medicinal plants as promising complementary or alternative strategies for modifying disease-relevant mechanisms and supporting cognitive health. Continued high-quality clinical investigations and optimized formulations are essential to advance these candidates toward therapeutic application.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00621-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel bioactive compounds from marine-derived endosymbiotic Penicillium fungi reported during 2020–2025","authors":"Sarah A. Omran,&nbsp;Mohamed S. Elnaggar,&nbsp;Fadia S. Youssef,&nbsp;Safaa A. El-Moghazy","doi":"10.1007/s13659-026-00633-z","DOIUrl":"10.1007/s13659-026-00633-z","url":null,"abstract":"<div><p>Marine-derived <i>Penicillium</i> fungus gained significant attention in recent years due to their potential as a valuable source of unique natural compounds with a wide range of chemical structures and bioactive capabilities. The primary origins of marine-derived <i>Penicillium</i> fungi are mangroves, sediments, marine shrimps, corals, starfish, algae, and sponges. A total of 390 unique natural compounds were extracted from <i>Penicillium</i> fungi which were found in marine environments. These compounds primarily consist of polyketides, alkaloids, terpenoids, chromone derivatives, anthraquinones, citrinins, steroids, azaphilones, and macrolides. Biological studies demonstrated that these compounds exhibit antimicrobial, anti-inflammatory, cytotoxic, pesticide development, neuroprotective, anti-glioma, anti-proliferative, α-glucosidase inhibitory activities, anti-allergic, photo-protective, anti-angiogenic effect, larvicidal activity, antiviral, anti-diabetic activity, and other activities that could be useful in the development of new drugs. This study shed the light on the recent discovery of bioactive MNPs (marine-derived <i>Penicillium</i>; natural products) derived from <i>Penicillium</i> fungi found in marine environments in the last five years from 2020 to 2025, classified the MNPs based on the sources of the fungi and their specific biological activities. Besides, the results of molecular docking studies recently performed on <i>Penicillium</i> metabolites referring to various biological activities were also compiled in this review. Thus, this review highlighted that <i>Penicillium</i> species obtained from marine organisms act as an everlasting mine of bioactive novel metabolites combating various ailments.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00633-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oligosaccharides from Polygonatum cyrtonema Hua ameliorate colitis-induced lung injury via modulation of the gut-lung axis through NF-κB and Nrf2 pathways","authors":"Jin Xu,&nbsp;Chuankang Tang,&nbsp;Qianyu He,&nbsp;Yu Lu,&nbsp;Pei Luo,&nbsp;Jianbo Wu","doi":"10.1007/s13659-026-00608-0","DOIUrl":"10.1007/s13659-026-00608-0","url":null,"abstract":"<div><h3>Background</h3><p>The gut-lung axis is a bidirectional communication network linking intestinal and pulmonary homeostasis through shared immunological and molecular mechanisms, conceptually consistent with the traditional Chinese medicine theory of “lung-intestine combined treatment.” <i>Polygonatum cyrtonema</i> Hua is an edible medicinal plant with reported anti-inflammatory and antioxidant properties, yet its role in intestinal inflammation-associated lung injury remains unclear.</p><h3>Materials and methods</h3><p>Dextran sulfate sodium (DSS)-induced colitis and lipopolysaccharide (LPS)-induced lung injury models were established in vivo, while LPS-stimulated A549 lung epithelial cells were used in vitro. The protective effects of <i>Polygonatum cyrtonema</i> oligosaccharides (PFOS) were evaluated, with particular focus on NF-κB and Nrf2 signaling pathways. The Nrf2 inhibitor ML385 was applied in vitro to verify pathway involvement. Non-targeted fecal metabolomics was conducted to assess PFOS-mediated metabolic modulation.</p><h3>Results</h3><p>PFOS significantly alleviated DSS-associated lung histopathological damage, reduced inflammatory cell infiltration, and improved epithelial barrier integrity. PFOS suppressed pulmonary proinflammatory cytokines, including TNF-α and IL-6, decreased myeloperoxidase activity, and attenuated oxidative stress by lowering malondialdehyde levels while enhancing antioxidant enzymes such as superoxide dismutase and HO-1. Mechanistically, PFOS inhibited NF-κB activation and promoted Nrf2/HO-1 signaling in lung tissues and LPS-stimulated A549 cells, effects that were partially reversed by ML385. Metabolomics analysis revealed that PFOS corrected DSS-induced disturbances in amino acid and lipid metabolism, with enrichment in cAMP, PPAR, and tryptophan-related pathways.</p><h3>Conclusions</h3><p>PFOS protects against colitis-associated lung injury by modulating the gut-lung axis through coordinated anti-inflammatory and antioxidant mechanisms involving NF-κB inhibition and Nrf2 activation, supporting its potential therapeutic application in gut-lung axis-related diseases.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00608-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolite diversification via halogen salts enhances biocontrol potential of marine-derived Trichoderma virens B211","authors":"Minh Van Nguyen,&nbsp;Yeong Seok Kim,&nbsp;Seung Mok Ryu,&nbsp;Jaeyoung Kwon,&nbsp;Hun Kim,&nbsp;Gyung Ja Choi,&nbsp;Jae Woo Han","doi":"10.1007/s13659-026-00634-y","DOIUrl":"10.1007/s13659-026-00634-y","url":null,"abstract":"<div><p>In the search for natural products with potent activity against plant diseases, we employed the one strain–many compounds (OSMAC) strategy to the marine-derived fungus <i>Trichoderma virens</i> B211 by supplementing cultures with halogen salts such as sodium bromide (NaBr). Both solid and liquid cultures grown under NaBr-supplemented conditions exhibited markedly darker pigmentation of B211, a diversified secondary metabolite profile, and enhanced antibacterial activity against <i>Erwinia amylovora</i>. Bioassay-guided fractionation of these extracts led to the isolation of fourteen compounds (<b>1</b>–<b>14</b>), including two new polycyclic aromatic terpenoids (<b>1</b> and <b>5</b>) belonging to the viridin family. In vitro antimicrobial assays demonstrated that viridin (<b>3</b>) and <i>β</i>-viridin (<b>4</b>), together with gliotoxin (<b>8</b>), displayed broad-spectrum activity against diverse plant pathogenic fungi and bacteria. Notably, viridin derivatives <b>1</b> and<b> 2</b>, which are structural isomers, exhibited distinct bioactivity profiles: compound <b>1</b> exhibited antifungal activity, whereas compound <b>2</b> showed antibacterial activity. Among the isolated metabolites, only gliotoxin (<b>8</b>) and bisdethiobis(methylthio)gliotoxin (<b>9</b>) exhibited direct antibacterial activity against <i>E. amylovora.</i> Furthermore, NaBr-induced crude extracts in which compounds <b>8</b> and <b>9</b> were the major constituents, as well as the purified compounds themselves, effectively suppressed fire blight symptoms. Collectively, these findings highlight the effectiveness of the OSMAC approach in expanding the chemical diversity of metabolites produced by <i>T. virens</i> B211 and enhancing its potential as a biocontrol agent for plant disease management.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00634-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural characterization, rheological properties, and skin bioactivities of a glucomannan from Bletilla striata","authors":"Xuan Li,&nbsp;Qinghui Gu,&nbsp;Qile Hu,&nbsp;Tuo Deng,&nbsp;Lan Luo,&nbsp;Jianping Cai,&nbsp;Xudong Dong,&nbsp;Chunhua Wu,&nbsp;Mingyi Wu","doi":"10.1007/s13659-026-00638-8","DOIUrl":"10.1007/s13659-026-00638-8","url":null,"abstract":"<div><p><i>Bletilla striata</i> is highly regarded in traditional Chinese medicine and has also gained widespread attention as a valuable medicinal plant resource. However, the molecular composition and bioactive potential of its polysaccharides present a significant knowledge gap. Herein, a specific glucomannan fraction, designated as BSP60, was purified from <i>Bletilla striata</i> tubers and subsequently subjected to structural, rheological, and biological evaluations. Comprehensive characterization via methylation-GC–MS, monosaccharide composition analysis, and 1D and 2D NMR techniques demonstrated that BSP60 possesses a β-(1 → 4)-linked backbone featuring alternating mannosyl and glucosyl units, with the mannose moieties exhibiting partial <i>O</i>-acetylation at their C-2 or C-3 positions (with an acetylation rate of 23.54%). Rheological studies showed that BSP60 aqueous solutions exhibit shear-thinning behavior and form an elastic-dominated viscoelastic network, with higher viscosity and storage modulus than dextran of comparable molecular weight, indicating enhanced intermolecular interactions. Biological assays revealed that the BSP60 effectively decreased the level of NO, IL-6, and TNF-α in LPS-triggered macrophages (RAW264.7). Furthermore, the scavenge ability of BSP60 to superoxide anion (O₂^•−) and ABTS^⁺• radicals are significantly higher than that of hyaluronic acid. This study systematically characterizes the structural features of glucomannan derived from <i>Bletilla striata</i>, thereby establishing a robust scientific basis for its expanded utilization in the development of biomedical materials and functional cosmetic ingredients.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00638-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid exploration of anti-MRSA components from plants of Salvia","authors":"Huan Huang,&nbsp;Zhao-Jie Wang,&nbsp;Li-Yu Bai,&nbsp;Yue-Ming Jiang,&nbsp;Yan-Yan Zhu,&nbsp;Yun-Li Zhao,&nbsp;Xiao-Dong Luo","doi":"10.1007/s13659-026-00624-0","DOIUrl":"10.1007/s13659-026-00624-0","url":null,"abstract":"<div><p>Plants of <i>Salvia</i> are frequently used for treatment infections of boils and sores in Traditional Chinese medicine, which might inhibit microbial. In this work, the chemical constituents of the effective fractions were analyzed using UPLC-Q-TOF–MS, and multivariate analysis and network pharmacology were used to predict potential antibacterial substances and their mechanism. Moreover, against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) effect and pathway of bioactive compounds were validated by experiments in vitro and in vivo. Two unreported anti-MRSA compounds, miltirone and przewaquinone A were proposed and then validated by serial experiments. They acted as bactericides and biofilm scavengers, respectively, and both targeted on the cell membrane, causing leakage of contents and affecting intracellular metabolism, leading to bacterial death without significant toxicity. Furthermore, miltirone ameliorated skin wound infection caused by MRSA in mice, roughly equal to vancomycin. The research supported the traditional use of <i>Salvia</i> plants, and presented two potent bactericidal agents for further investigation.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00624-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sesamol derivatives bearing a quinazolin moiety: synthesis, antifungal efficacy against tea plant pathogens, and mechanistic insights","authors":"Haixia Tang,&nbsp;Shiyi Liu,&nbsp;Fali Wang,&nbsp;Chao Gao,&nbsp;Linhong Jin,&nbsp;Dandan Xie","doi":"10.1007/s13659-025-00568-x","DOIUrl":"10.1007/s13659-025-00568-x","url":null,"abstract":"<p><i>Pestalotiopsis</i> sp. and <i>Colletotrichum camelliae</i> are two devastating fungal pathogens that cause significant yield losses and quality degradation in tea plants (<i>Camellia sinensis</i>). The increasing resistance of these pathogens to commercial fungicides necessitates the development of novel fungicidal agents with distinct modes of action. In this study, A series of novel sesamol derivatives incorporating a quinazolin moiety were synthesized and structurally validated by ¹H NMR, ¹³C NMR, and HRMS. In vitro bioassays demonstrated that these derivatives exhibited potent antifungal activity, with compounds <b>4g</b> and <b>4i</b> standing out: against <i>Pestalotiopsis</i> sp., their inhibition rates reached 76.4% and 86.9% (vs. 18.0% for the parent compound sesamol); against <i>C. camelliae</i>, the rates were 57.9% and 70.8% (vs. 42.3% for sesamol). Notably, their in vivo control efficacy significantly surpassed that of azoxystrobin: <b>4g</b> and <b>4i</b> controlled <i>C. camelliae</i> with efficiencies of 66.6% and 51.7% (vs. 25.7% for azoxystrobin) and <i>Pestalotiopsis</i> sp. with 99.0% efficacy (vs. 57.1% for azoxystrobin). Mechanistic investigations revealed dual modes of action: (i) direct disruption of fungal cell membrane integrity; (ii) induction of tea plant resistance via up-regulating activities of defense-related enzymes (PAL, POD, SOD, CAT). Integrated transcriptomic and proteomic analyses further confirmed that <b>4g</b> activates classical defense pathways by coordinately regulating defense gene expression and protein synthesis.</p><p>In summary, these sesamol-quinazolin hybrids demonstrate potent antifungal activities with multiple targets. This study not only expands the application scope of the natural product sesamol but also provides promising lead compounds for the development of eco-friendly fungicides in tea plant protection.</p>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00568-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the global mosaic of medicinal plant databases: unveiling nature’s pharmacopoeia","authors":"Yifei Jiang,&nbsp;Xiaozhuan Jia,&nbsp;Zhenzhong Yang","doi":"10.1007/s13659-026-00614-2","DOIUrl":"10.1007/s13659-026-00614-2","url":null,"abstract":"<div><p>Medicinal plants have long served as an important asset in the treatment of diseases. Recent developments in computer science have enabled the rise of specialized databases cataloging medicinal plant knowledge. However, a systematic comparison of available region-specific medicinal plant databases is lacking. This review summarizes globally available medicinal plant databases that focus on specific geographical regions, aiming to inspire and guide people from specialists to the general public toward fostering innovation and making informed decisions. Through a systematic search of literature and digital resources, 81 regional medicinal plant databases established or updated between 2013 and 2025 were identified. From this pool, 40 core platforms were subjected to detailed statistical characterization regarding their data categories and volume. Our analysis reveals a geographical concentration in Asia (48.1%), dominated by China and India, alongside a notable proliferation of universal databases with a global scope. These databases facilitate critical applications in drug discovery, quality control, biodiversity conservation, and policy-making. By identifying current research gaps and emphasizing the need for interdisciplinary standardization, this review serves as a strategic roadmap for bridging traditional wisdom with modern therapeutic innovation.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00614-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating therapeutic mechanisms of naringin and phloridzin on ulcerative colitis mice by metabolomics-based comparative analysis","authors":"Jing Yang,&nbsp;Chongxin Kang,&nbsp;Chulei Xiao,&nbsp;Yusi Zhang,&nbsp;Yihong Mai,&nbsp;Yinghong Huang,&nbsp;Yi Zhan,&nbsp;Hetong Liu,&nbsp;Xian Wang","doi":"10.1007/s13659-026-00620-4","DOIUrl":"10.1007/s13659-026-00620-4","url":null,"abstract":"<div><p>Naringin and phloridzin are structurally similar flavonoids with anti-inflammatory, antioxidant, and antimicrobial properties, showing considerable potential as natural therapeutic agents. This study demonstrated that naringin and phloridzin exert anti-inflammatory effects and preserve normal intestinal function in UC mice. This protective effect is mediated by inhibition of the NF-κB signalling pathway. To investigate metabolic differences, we employed UPLC-MS/MS-based widely targeted metabolomics alongside targeted analyses of tryptophan (Trp) and short-chain fatty acids (SCFAs). Comparative analysis of metabolic profiles, differential metabolites, and associated pathways revealed regulatory effects on Trp and SCFAs. However, naringin demonstrated superior regulation of Trp metabolism and SCFA levels compared to phloridzin, resulting in more pronounced improvement of gut homeostasis. These findings elucidate the metabolic mechanisms underlying both flavonoid treatments and underscore their potential as complementary therapies for UC.</p><h3>Graphical abstract</h3><p>Naringin and phloridzin exert protective effects against DSS-induced ulcerative colitis by modulating tryptophan metabolism and suppressing inflammation through inhibition of the NF-κB signaling pathway</p>\u0000<div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00620-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}