Natural Products and Bioprospecting最新文献

{"title":"Calabanones A‒H, chromanone derivatives from the stem bark of Calophyllum calaba and their cytotoxic activities against cancer cells","authors":"Sutin Kaennakam,&nbsp;Fadjar Mulya,&nbsp;Manussada Ratanasak,&nbsp;Kitiya Rassamee,&nbsp;Pongpun Siripong,&nbsp;Yasuteru Shigeta,&nbsp;Preecha Phuwapraisirisan,&nbsp;Edwin R. Sukandar","doi":"10.1007/s13659-026-00603-5","DOIUrl":"10.1007/s13659-026-00603-5","url":null,"abstract":"<div><p>The genus <i>Calophyllum</i> (Calophyllaceae), distributed mainly in tropical regions, is rich in chromanone derivatives with diverse molecular structures that exhibit potential antimicrobial and anticancer effects. Phytochemical investigation of the stem bark of <i>C. calaba</i> collected in Thailand led to the discovery of eight previously undescribed chromanones, calabanones A–H (<b>1</b>‒<b>8</b>), and two known analogs, (‒)-isocalomembranone P (<b>9</b>) and (‒)-calomembranone P (<b>10</b>). The chemical structures of undescribed compounds were elucidated using spectroscopic analyses, particularly NMR and HRESIMS, while their absolute configurations were determined through ECD and NMR calculations combined with DP4+ probability analysis. Compounds <b>7</b> and <b>8</b> were identified as chromanone–steroid hybrids linked via an ester bond, representing the first report of such structures in plants. Cytotoxic evaluation of the isolated specialized metabolites revealed that compounds <b>6</b> and <b>9</b> displayed moderate activity against KB and HeLa S3 cancer cell lines, with IC₅₀ values ranging from 12.71 to 25.50 μM, while compounds <b>3</b>‒<b>5</b> selectively inhibited the growth of KB cells, with IC₅₀ values in the range of 18.77‒27.06 μM.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00603-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147337069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008","authors":"Yuan Chen,&nbsp;Fei Zhang,&nbsp;Zi-Kang Zhao,&nbsp;Lin-Fang Tang,&nbsp;Yu-Xin Sun,&nbsp;Mi-Mi Tian,&nbsp;Xing-Tao Li,&nbsp;Qian Zhao,&nbsp;Xiao-Jiang Hao,&nbsp;Mingming Cao,&nbsp;Duozhi Chen","doi":"10.1007/s13659-026-00591-6","DOIUrl":"10.1007/s13659-026-00591-6","url":null,"abstract":"<div><p>Three new naphthomycin derivatives were isolated and identified from <i>Streptomyces</i> sp<i>.</i> HKIB0008, and were designated as naphthomycin R (<b>1</b>), naphthomycin S (<b>2</b>), and naphthomycin T (<b>3</b>). Their structures were elucidated using a combination of spectroscopic techniques, including high-resolution mass spectrometry, and NMR. The naphthoquinone core of <b>1</b> underwent carbon–carbon bond cleavage, resulting in a novel structural feature, and a corresponding Baeyer–Villiger oxidation mechanism was proposed. Compounds <b>2</b> and <b>3</b> possess a complex side chain when compared to known cystine modification on the naphthalenoid core as in the case of naphthomycins I and J. In addition, the minimum inhibitory concentration (MIC) assays for these compounds were conducted.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00591-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peniexpansones A–F: polyketides from Penicillium expansum DWS880 capable of enhancing the activity of fluconazole against Candida albicans","authors":"Wen-Yu Lu,&nbsp;Qing-Hui Xiao,&nbsp;Ai-Lin Liang,&nbsp;Peng-Ju Xu,&nbsp;Jing Li,&nbsp;Wen-Xuan Wang","doi":"10.1007/s13659-026-00592-5","DOIUrl":"10.1007/s13659-026-00592-5","url":null,"abstract":"<div><p>Six new polyketides, peniexpansones A–F (<b>1</b>–<b>4</b>,<b> 6</b>,<b> 7</b>), along with an additional novel compound, (2<i>E</i>,4<i>E</i>,6<i>E</i>)-8-methyldeca-2,4,6-trienoic acid (<b>5</b>), and a known naphthopyrone, were isolated from the ethyl acetate extract of rice fermented with the soil fungus <i>Penicillium expansum</i> DWS880. Structurally, peniexpansones A–D feature a highly oxygenated tetrahydronaphthalene moiety linked to an acyl chain. The structures of the new compounds were elucidated by extensive spectroscopic analysis (1D/2D NMR and HRESIMS) and further supported by quantum chemical calculations. Peniexpansone C showed weak cytotoxicity against HCT116 cells (IC₅₀ 22.81 ± 0.42 μM) and moderate antimicrobial activity against pathogens including <i>Staphylococcus aureus</i> and <i>Candida albicans</i>. Moreover, peniexpansones A and B, can significantly improve the anti-fungal activity of fluconazole against resistant <i>Candida albicans</i>. Our results provided new structures for the future development of efficiency enhancement agents for anti-fungal drugs.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00592-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colloidal lignin particles for Pickering emulsion stabilization: multifunctional properties and prospects for cosmetic applications","authors":"Giovana Colucci,&nbsp;Alírio Egídio Rodrigues,&nbsp;Maria Filomena Barreiro","doi":"10.1007/s13659-026-00594-3","DOIUrl":"10.1007/s13659-026-00594-3","url":null,"abstract":"<div><p>Lignin, the most abundant aromatic biopolymer on Earth, is abundantly found as a by-product of biomass processing industries. Lignin presents remarkable properties, including antioxidant, UV-blocking, thermal stability, and antimicrobial; thus being considered a valuable feedstock to replace synthetic and fossil-based resources. Colloidal lignin particles (CLPs) are a promising strategy to overcome technical barriers in lignin valorization and have attracted increasing interest to be applied as multifunctional ingredients into several fields, including agriculture, biomedical, construction, and more recently, cosmetics. For this latter, CLPs stand out as promising Pickering stabilizers, creating opportunities for the development of surfactant-free cosmetic formulations. This review provides a current state of lignin research, focusing on the production of CLPs and Pickering emulsions and the key factors influencing their formation and stability. Recent progress in CLPs-stabilized Pickering emulsions is thoroughly addressed. Furthermore, it highlights advances on the multifunctional attributes of CLPs, including antioxidant activity, UV shielding, and demonstrated safety for cosmetic applications. The review concludes by discussing current challenges and future research directions for advancing the use of CLPs as sustainable materials in cosmetic science.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00594-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147336860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nature meets machine: the AI renaissance in natural product drug discovery","authors":"Rajesh Muthuraj,&nbsp;Jaikanth Chandrasekaran","doi":"10.1007/s13659-025-00589-6","DOIUrl":"10.1007/s13659-025-00589-6","url":null,"abstract":"<div><p>Natural products (NPs) have long served as a cornerstone of drug discovery, yielding landmark therapeutics such as paclitaxel and artemisinin and providing sustained access to biologically relevant chemical space. Despite this legacy, NP-based discovery has gradually declined with the rise of synthetic chemistry and high-throughput screening, even as many contemporary “synthetic” drugs remain structurally inspired by natural scaffolds. Classical NP workflows—centered on phenotypic screening and bioassay-guided fractionation—continue to face persistent bottlenecks, including structural complexity, low bioactive yield, frequent rediscovery, and limited scalability. Rather than competing with NP research, artificial intelligence (AI) offers a complementary methodological framework to address these longstanding challenges. This review critically examines the bottlenecks inherent to traditional NP discovery and outlines how AI can be systematically integrated across the pipeline. We discuss AI-enabled advances ranging from natural language processing for mining ethnopharmacological knowledge to machine learning–driven dereplication, cheminformatics, and genome mining, with platforms such as GNPS2 exemplifying scalable progress. Case studies in antibiotic and anticancer discovery, as well as the modernization of traditional medicine, illustrate how AI–NP integration can accelerate early-stage discovery while enhancing translational relevance. Looking ahead, we examine emerging paradigms—including quantum machine learning, federated data ecosystems, and AI-assisted molecular design—that may further expand the scope of NP-based research. Collectively, this review presents a forward-looking framework in which AI functions not as a replacement for NP science, but as a synergistic discipline that enables more efficient, scalable, and informed exploration of nature-derived chemical diversity.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00589-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nematode-trapping fungus Arthrobotrys oligospora is hungry for iron-chelating agent COQ7 of nematodes","authors":"Qunfu Wu,&nbsp;Jiao Zhou,&nbsp;Donglou Wang,&nbsp;Songhan Xue,&nbsp;Ling Li,&nbsp;Li Wu,&nbsp;Junxian Yan,&nbsp;Xuemei Niu","doi":"10.1007/s13659-026-00590-7","DOIUrl":"10.1007/s13659-026-00590-7","url":null,"abstract":"<div><p>Iron homeostasis is critical for the survival of almost all organisms, yet its dysregulation is often caused by a synergistic effect of genetic and environmental factors. Previous studies have shown that trapping devices of the predominant nematode-trapping fungus (NTF) <i>Arthrobotrys oligospora</i> serve as an unprecedented iron sequestration system compensatory for lack of the crucial fungal vacuolar iron detoxification mechanism. Here, we found that among the Ascomycota phylum, only NTFs lacked gene <i>coq7</i>, which encodes COQ7 responsible for ubiquinol (UQ) biosynthesis and efficient iron chelation. Addition of exogenous UQ₁₀ or heterologous expression of yeast gene <i>coq7</i> in <i>A. oligospora</i> inhibited the formation of fungal trapping devices<i>.</i> Interestingly, mutant nematodes with disruption of gene <i>coq7</i> can greatly reduce nematode-capturing ability of fungal trapping devices. Exogenous COQ7s exhibit significant adsorption effects on fungal trapping devices both in vitro and in vivo. Transcriptional, metabolic, mutational, and phenotypic analyses indicated that <i>A. oligospora</i> utilized a chemotaxonomic class of highly oxygenated arthrobotrisins with similar characteristics to UQ₃, instead of UQs, in response to elevated oxygen levels. Loss of arthrobotrisin biosynthesis led to a delayed growth of the mutant Δ<i>art</i> but enhanced UQ₈ biosynthesis, trapping device formation, and nematicidal activity. Time-calibrated evolutionary analyses, combined with geological data, indicated that the NTF ancestor lost the <i>coq7</i> gene after acquiring the <i>art</i> gene cluster during the cold “superoligotrophy” period, characterized by dramatic shifts in global oxygen levels and temperature changes. Our findings indicated that the trapping devices of NTF capture nematodes primarily for iron chelation therapy, rather than solely for food, which addresses the long-standing issue regarding the limited carnivorous ability of trapping devices.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00590-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De novo synthesis of plant polyketide plumbagin in yeast: a platform for sustainable production of naphthoquinones","authors":"Arati P. Vasav,&nbsp;Vitthal T. Barvkar","doi":"10.1007/s13659-025-00588-7","DOIUrl":"10.1007/s13659-025-00588-7","url":null,"abstract":"<div><p>Plumbagin is a natural naphthoquinone with different pharmacological properties and abundantly present in the roots of <i>Plumbago zeylanica</i> L. In spite of its therapeutic anti-cancerous potential, its limited availability from plant sources has slowed down its large scale production. In the present study, we report the heterologous reconstruction of the complete plumbagin biosynthetic pathway in <i>Saccharomyces cerevisiae</i> using six functionally characterized genes from <i>P. zeylanica</i> viz. <i>Polyketide synthase</i> (<i>PKS</i>), <i>Polyketide cyclase</i>, <i>Aldo–keto reductase</i> (<i>AKR1</i>), two <i>cytochrome P450 monooxygenases</i> (<i>CYP81B140</i> and <i>CYP81B141</i>), and a <i>cytochrome P450 reductase</i> (<i>CPR</i>). Stepwise pathway engineering was performed to evaluate the necessity and sufficiency of individual and combined gene sets. The expression of PKS alone was not able to synthesize measurable products, while the co-expression of <i>PKS</i>, <i>cyclase</i>, and <i>AKR1</i> (PCA) enabled the biosynthesis of 3-methyl-1,8-naphthalenediol which is a key intermediate and also confirmed by LC–MS/MS. The addition of <i>CYP81B140</i> and <i>CPR</i> (PCACC) led to the production of 3-methyl-1,8-naphthalenediol and isoshinanolone, and further addition of <i>CYP81B141</i> (PCACCC) in yeast effectively biosynthesized plumbagin. These results confirm the functional roles of all six genes and demonstrate full pathway reconstruction in yeast from the primary precursors acetyl-CoA and malonyl-CoA. The present study establishes a microbial production platform for plumbagin and provides valuable insights into the biosynthesis of plant-derived naphthoquinones as well as paving the way for the sustainable and scalable production of medicinally important compounds.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00588-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Hsp70 triggers ferroptosis: a novel anti-cancer mechanism of a marine natural product in prostate cancer","authors":"Qiuyu Liu,&nbsp;Mengjing Cong,&nbsp;Chenghai Gao,&nbsp;Yonghong Liu,&nbsp;Junfeng Wang,&nbsp;Xueni Wang","doi":"10.1007/s13659-025-00586-9","DOIUrl":"10.1007/s13659-025-00586-9","url":null,"abstract":"<div><p>Prostate cancer (PCa) remains one of the most common malignant tumors among men worldwide, typically relying on the androgen receptor (AR) signaling pathway. Inducing ferroptosis, a novel form of iron-dependent cell death, represents a promising strategy; however, its regulation by AR signaling is complex. The molecular chaperone heat shock protein 70 (HSP70) is critical for AR stability and function, yet its role as a therapeutic target in this context is underexplored. The anti-proliferative effect of the compound nidurufin (Nid) was assessed across PCa cell lines using MTT, clonogenic, and 3D spheroid assays. Ferroptosis was evaluated by transmission electron microscopy, reactive oxygen species (ROS) detection, and lipid peroxidation analysis. Mechanistic insights were gained through Western blot, qPCR, immunofluorescence, ChIP-qPCR, molecular docking, and cellular thermal shift assay (CETSA). In vivo efficacy was validated in a zebrafish xenograft model. Nid exhibited potent, selective anti-proliferative activity against AR-positive PCa cells, particularly 22Rv1 (IC₅₀ = 10.30 μM), and induced ferroptosis characterized by mitochondrial shrinkage and ROS accumulation. Mechanistically, Nid did not bind to AR, but it directly bound to HSP70, disrupting its chaperone function and leading to AR protein destabilization and transcriptional downregulation. This consequently suppressed the expression of the AR-target gene membrane-associated O-acyltransferase domain protein 2 (MBOAT2), a key ferroptosis suppressor enzyme. ChIP-qPCR confirmed AR directly binds the MBOAT2 promoter, and Nid treatment reduced this enrichment. In vivo, Nid significantly inhibited tumor growth and metastasis in a zebrafish xenograft model. Our study identifies Nid as a novel HSP70-targeted compound that triggers ferroptosis by disrupting the HSP70-AR-MBOAT2 axis. This work not only reveals a previously unrecognized connection between protein chaperone function and ferroptotic susceptibility but also positions HSP70 as a compelling therapeutic target for overcoming AR-pathway dependency in PCa.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revitalizing actinobacteria research: an urgent response to the antimicrobial resistance crisis","authors":"Samuel Paulo Cibulski,&nbsp;Valnês da Silva Rodrigues-Junior","doi":"10.1007/s13659-025-00587-8","DOIUrl":"10.1007/s13659-025-00587-8","url":null,"abstract":"<p>The crisis of antimicrobial resistance (AMR) is escalating while the antibiotic pipeline remains stagnant. Our bibliometric analysis of eight decades of literature reveals a critical imbalance: research on AMR has grown, yet fundamental research on antibiotic discovery has declined. Most strikingly, research attention to <i>Actinomycetota</i>, the source of most clinical antibiotics, has sharply decreased since its mid-twentieth-century peak. This therapeutic disinvestment coincides with the intensifying AMR crisis. We argue for a strategic reinvestment in natural product discovery, now enabled by advances in genomics, artificial intelligence, and synthetic biology. These tools can unlock the vast, silent biosynthetic potential of actinobacteria, transforming discovery into a targeted and efficient endeavor. Rebalancing research priorities by coupling this historically proven source with modern technology is essential to revive the antibiotic pipeline. We urge funding agencies and industry to bridge the growing gap between a well characterized problem and a neglected solution.</p>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced delivery of natural bioactive compounds for atopic dermatitis: a review of polymeric conjugates and nanocarriers","authors":"Jigar Vyas,&nbsp;Nensi Raytthatha,&nbsp;Puja Vyas,&nbsp;Sudarshan Singh,&nbsp;Bhupendra G. Prajapati","doi":"10.1007/s13659-025-00585-w","DOIUrl":"10.1007/s13659-025-00585-w","url":null,"abstract":"<div><p>Atopic dermatitis (AD) is a persistent, relapsing skin inflammatory disorder characterised by epidermal barrier dysfunction, immune system anomalies, and microbial dysbiosis. Current therapies encompass calcineurin inhibitors, topical corticosteroids, and synthetic drugs such as JAK inhibitors and biologics, which, despite their efficacy, have safety issues and constraints on prolonged use. Recently, natural bioactive compounds namely flavonoids, polyphenols, and terpenoids have garnered interest for their anti-inflammatory, antioxidant, and skin-barrier-repairing characteristics. Recent studies emphasise the incorporation of these bioactive compounds into hydrophilic/hydrophobic polymeric conjugates and nanocarrier systems to promote skin distribution, increase efficacy, and minimise systemic adverse effects. This study encapsulates traditional and innovative medicines, highlights the promise of polymer-conjugated herbal formulations, and examines recent developments in nanotechnology and delivery technologies for AD management. The increasing interest in bioactive ingredient formulations and polymeric nanocarriers indicates a favourable shift towards safer, more effective, and patient-compliant treatment methodologies.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12873061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}