Natural Products and Bioprospecting最新文献_第3页

5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer’s disease mice model 从大叶桉树中提取的 5α-Epoxyalantolactone 可减轻东莨菪碱诱导的阿尔茨海默病小鼠模型的认知缺陷。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-07-02 DOI: 10.1007/s13659-024-00462-y

Rui Ma, Xu-Yao Feng, Jiang-Jiang Tang, Wei Ha, Yan-Ping Shi

{"title":"5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer’s disease mice model","authors":"Rui Ma, Xu-Yao Feng, Jiang-Jiang Tang, Wei Ha, Yan-Ping Shi","doi":"10.1007/s13659-024-00462-y","DOIUrl":"10.1007/s13659-024-00462-y","url":null,"abstract":"<div><p>Alzheimer’s disease (AD) is a complex neurodegenerative condition. 5<i>α</i>-epoxyalantolactone (5<i>α</i>-EAL), a eudesmane-type sesquiterpene isolated from the herb of <i>Inula macrophylla</i>, has various pharmacological effects. This work supposed to investigate the improved impact of 5<i>α</i>-EAL on cognitive impairment. 5<i>α</i>-EAL inhibited the generation of nitric oxide (NO) in BV-2 cells stimulated with lipopolysaccharide (LPS) with an EC<sub>50</sub> of 6.2 μM. 5<i>α</i>-EAL significantly reduced the production of prostaglandin E2 (PGE<sub>2</sub>) and tumor necrosis factor-α (TNF-α), while also inhibiting the production of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins. The ability of 5<i>α</i>-EAL to penetrate the blood–brain barrier (BBB) was confirmed via a parallel artificial membrane permeation assay. Scopolamine (SCOP)-induced AD mice model was employed to assess the improved impacts of 5<i>α</i>-EAL on cognitive impairment in vivo. After the mice were pretreated with 5<i>α</i>-EAL (10 and 30 mg/kg per day, <i>i.p.</i>) for 21 days, the behavioral experiments indicated that the administration of the 5<i>α</i>-EAL could alleviate the cognitive and memory impairments. 5<i>α</i>-EAL significantly reduced the AChE activity in the brain of SCOP-induced AD mice. In summary, these findings highlight the beneficial effects of the natural product 5<i>α</i>-EAL as a potential bioactive compound for attenuating cognitive deficits in AD due to its pharmacological profile.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689 Paragliomastix luzulae（原名 Acremonium striatisporum）KMM 4401 及其与西班牙青霉 KMM 4689 的共培养物的代谢物图谱

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-06-18 DOI: 10.1007/s13659-024-00459-7

Sofya S. Starnovskaya, Liliana E. Nesterenko, Roman S. Popov, Natalya N. Kirichuk, Viktoria E. Chausova, Ekaterina A. Chingizova, Artur R. Chingizov, Marina P. Isaeva, Ekaterina A. Yurchenko, Anton N. Yurchenko

{"title":"Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689","authors":"Sofya S. Starnovskaya, Liliana E. Nesterenko, Roman S. Popov, Natalya N. Kirichuk, Viktoria E. Chausova, Ekaterina A. Chingizova, Artur R. Chingizov, Marina P. Isaeva, Ekaterina A. Yurchenko, Anton N. Yurchenko","doi":"10.1007/s13659-024-00459-7","DOIUrl":"10.1007/s13659-024-00459-7","url":null,"abstract":"<div><p>The marine holothurian-derived fungal strain KMM 4401 has been identified as <i>Paragliomastix luzulae</i> using 28S rDNA, ITS regions and the partial <i>TEF1</i> gene sequences. The metabolite profile of the fungal culture was studied by UPLC-MS technique. The strain KMM 4401 is a source of various virescenoside-type isopimarane glycosides suggested as chemotaxonomic feature for this fungal species. Also <i>Px. luzulae</i> KMM 4401 was proposed as possible source of new bioactive secondary metabolites especially antimicrobials. Moreover, the co-cultures of <i>Px. luzulae</i> KMM 4401 with another marine fungus <i>Penicillium hispanicum</i> KMM 4689 inoculated simultaneously or after two weeks were investigated by same way. It was shown, that <i>P. hispanicum</i> KMM 4689 suppressed the production of most of <i>Px. luzulae</i> KMM 4401 metabolites. On the other hand, the co-cultivation of <i>P. hispanicum</i> KMM 4689 and <i>Px. luzulae</i> KMM 4401 resulted in increasing of production of main deoxyisoaustamide alkaloids of <i>P. hispanicum</i> KMM 4689 on 50–190%.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00459-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products 在含环丁烷天然产物的化学合成中应用 [2 + 2] 环加成法的最新进展。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-06-11 DOI: 10.1007/s13659-024-00457-9

Song-Yu Hou, Bing-Chao Yan, Han-Dong Sun, Pema-Tenzin Puno

引用次数: 0

Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway 关于 Adenosma buchneroides Bonati 通过调节 TLR4/MyD88/NF-κB 信号通路抑制炎症的民族药理学研究。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-06-04 DOI: 10.1007/s13659-024-00458-8

Yuru Shi, Xiaoqian Zhang, Shengji Pei, Yuhua Wang

{"title":"Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway","authors":"Yuru Shi, Xiaoqian Zhang, Shengji Pei, Yuhua Wang","doi":"10.1007/s13659-024-00458-8","DOIUrl":"10.1007/s13659-024-00458-8","url":null,"abstract":"<div><p><i>Adenosma buchneroides</i> Bonati, also known as fleagrass, is an important medicinal plant used by the Akha (Hani) people of China for treating inflammation-related skin swelling, acne, and diarrhoea, among other conditions. In this study, we aimed to evaluate the anti-inflammatory activities and explore the molecular mechanisms of fleagrass on treating skin swelling and acne. The results demonstrated that fleagrass inhibited the enzymatic activities of 5-LOX and COX-2 in vitro, and decreased the release of NO, IL-6, TNF-α, and IL-10 in the LPS-induced RAW264.7 macrophages. The levels of proteins associated with the nuclear factor-kappa B (NF-κB) pathway were examined by western blotting and immunofluorescence, demonstrating that fleagrass downregulated the expression of TLR4, MyD88, NF-κB/p65, and iNOS and blocked the nuclear translocation of NF-κB/p65. Furthermore, fleagrass exhibited acute anti-inflammatory activity in paw oedema models. The results confirm that fleagrass exhibits remarkable anti-inflammatory activity and can be used in alleviating inflammation, suggesting that fleagrass has the potential to be a novel anti-inflammatory agent.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11150230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration 在无溶剂条件下通过硫氰酸法制备的化学工程精油：化学和生物活性的改变。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-06-01 DOI: 10.1007/s13659-024-00456-w

Liz E. Lescano, Mario O. Salazar, Ricardo L. E. Furlan

{"title":"Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration","authors":"Liz E. Lescano, Mario O. Salazar, Ricardo L. E. Furlan","doi":"10.1007/s13659-024-00456-w","DOIUrl":"10.1007/s13659-024-00456-w","url":null,"abstract":"<div><p>The generation of chemically engineered essential oils (CEEOs) prepared from bi-heteroatomic reactions using ammonium thiocyanate as a source of bioactive compounds is described. The impact of the reaction on the chemical composition of the mixtures was qualitatively demonstrated through GC–MS, utilizing univariate and multivariate analysis. The reaction transformed most of the components in the natural mixtures, thereby expanding the chemical diversity of the mixtures. Changes in inhibition properties between natural and CEEOs were demonstrated through acetylcholinesterase TLC autography, resulting in a threefold increase in the number of positive events due to the modification process. The chemically engineered <i>Origanum vulgare</i> L. essential oil was subjected to bioguided fractionation, leading to the discovery of four new active compounds with similar or higher potency than eserine against the enzyme. The results suggest that the directed chemical transformation of essential oils can be a valuable strategy for discovering new acetylcholinesterase (AChE) inhibitors.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells 从Phyllanthus acidus中分离出的Pacidusin B能引发HT1080细胞的铁性细胞死亡。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-05-23 DOI: 10.1007/s13659-024-00454-y

Guangyu Zhu, Dian Luo, Yueqin Zhao, Zhengrui Xiang, Chao Chen, Na Li, Xiaojiang Hao, Xiao Ding, Yingjun Zhang, Yuhan Zhao

{"title":"Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells","authors":"Guangyu Zhu, Dian Luo, Yueqin Zhao, Zhengrui Xiang, Chao Chen, Na Li, Xiaojiang Hao, Xiao Ding, Yingjun Zhang, Yuhan Zhao","doi":"10.1007/s13659-024-00454-y","DOIUrl":"10.1007/s13659-024-00454-y","url":null,"abstract":"<div><p>Cancer cells generally exhibit ‘iron addiction’ phenotypes, which contribute to their vulnerability to ferroptosis inducers. Ferroptosis is a newly discovered form of programmed cell death caused by iron-dependent lipid peroxidation. In the present study, pacidusin B, a dichapetalin-type triterpenoid from <i>Phyllanthus acidus</i> (L.) Skeels (Euphorbiaceae), induces ferroptosis in the HT1080 human fibrosarcoma cell line. Cells treated with pacidusin B exhibited the morphological characteristic ‘ballooning’ phenotype of ferroptosis. The biochemical hallmarks of ferroptosis were also observed in pacidusin B-treated cells. Both oxidative stress and ER stress play significant roles in pacidusin B-induced ferroptosis. The activation of the PERK-Nrf2-HO-1 signaling pathway led to iron overload, while inhibition of GPX4 further sensitized cancer cells to ferroptosis. Furthermore, the molecular docking study showed that pacidusin B docked in the same pocket in xCT as the ferroptosis inducer erastin. These results revealed that pacidusin B exerts anticancer effects via inducing ER-mediated ferroptotic cell death.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method 利用 LC-MS 方法分析海洋肺癌候选药物 N-hydap 的代谢特征和毒性。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-05-21 DOI: 10.1007/s13659-024-00455-x

Jindi Lu, Weimin Liang, Yiwei Hu, Xi Zhang, Ping Yu, Meiqun Cai, Danni Xie, Qiong Zhou, Xuefeng Zhou, Yonghong Liu, Junfeng Wang, Jiayin Guo, Lan Tang

{"title":"Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method","authors":"Jindi Lu, Weimin Liang, Yiwei Hu, Xi Zhang, Ping Yu, Meiqun Cai, Danni Xie, Qiong Zhou, Xuefeng Zhou, Yonghong Liu, Junfeng Wang, Jiayin Guo, Lan Tang","doi":"10.1007/s13659-024-00455-x","DOIUrl":"10.1007/s13659-024-00455-x","url":null,"abstract":"<div><p><i>N</i>-Hydroxyapiosporamide (<i>N</i>-hydap), a marine product derived from a sponge-associated fungus, has shown promising inhibitory effects on small cell lung cancer (SCLC). However, there is limited understanding of its metabolic pathways and characteristics. This study explored the in vitro metabolic profiles of <i>N</i>-hydap in human recombinant cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs), as well as human/rat/mice microsomes, and also the pharmacokinetic properties by HPLC–MS/MS. Additionally, the cocktail probe method was used to investigate the potential to create drug-drug interactions (DDIs). <i>N</i>-Hydap was metabolically unstable in various microsomes after 1 h, with about 50% and 70% of it being eliminated by CYPs and UGTs, respectively. UGT1A3 was the main enzyme involved in glucuronidation (over 80%), making glucuronide the primary metabolite. With a favorable bioavailability of 24.0%, <i>N</i>-hydap exhibited a higher distribution in the lungs (26.26%), accounting for its efficacy against SCLC. Administering <i>N</i>-hydap to mice at normal doses via gavage did not result in significant toxicity. Furthermore, <i>N</i>-hydap was found to affect the catalytic activity of drug metabolic enzymes (DMEs), particularly increasing the activity of UGT1A3, suggesting potential for DDIs. Understanding the metabolic pathways and properties of <i>N</i>-hydap should improve our knowledge of its drug efficacy, toxicity, and potential for DDIs.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy 通过 OSMAC（一种菌株多种化合物）策略从海洋源真菌 Penicillium velutinum ZK-14 中发现新的哌嗪衍生物 helvamides B-C。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-05-21 DOI: 10.1007/s13659-024-00449-9

Gleb V. Borkunov, Elena V. Leshchenko, Dmitrii V. Berdyshev, Roman S. Popov, Ekaterina A. Chingizova, Nadezhda P. Shlyk, Andrey V. Gerasimenko, Natalya N. Kirichuk, Yuliya V. Khudyakova, Viktoria E. Chausova, Alexandr S. Antonov, Anatoly I. Kalinovsky, Artur R. Chingizov, Ekaterina A. Yurchenko, Marina P. Isaeva, Anton N. Yurchenko

{"title":"New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy","authors":"Gleb V. Borkunov, Elena V. Leshchenko, Dmitrii V. Berdyshev, Roman S. Popov, Ekaterina A. Chingizova, Nadezhda P. Shlyk, Andrey V. Gerasimenko, Natalya N. Kirichuk, Yuliya V. Khudyakova, Viktoria E. Chausova, Alexandr S. Antonov, Anatoly I. Kalinovsky, Artur R. Chingizov, Ekaterina A. Yurchenko, Marina P. Isaeva, Anton N. Yurchenko","doi":"10.1007/s13659-024-00449-9","DOIUrl":"10.1007/s13659-024-00449-9","url":null,"abstract":"<div><p>Four extracts of the marine-derived fungus <i>Penicillium velutinum</i> J.F.H. Beyma were obtained via metal ions stress conditions based on the OSMAC (One Strain Many Compounds) strategy. Using a combination of modern approaches such as LC/UV, LC/MS and bioactivity data analysis, as well as in silico calculations, influence metal stress factors to change metabolite profiles <i>Penicillium velutinum</i> were analyzed. From the ethyl acetate extract of the <i>P. velutinum</i> were isolated two new piperazine derivatives helvamides B (<b>1</b>) and C (<b>2</b>) together with known saroclazin A (<b>3</b>) (4<i>S</i>,5<i>R</i>,7<i>S</i>)-4,11-dihydroxy-guaia-1(2),9(10)-dien (<b>4</b>). Their structures were established based on spectroscopic methods. The absolute configuration of helvamide B (<b>1</b>) as 2<i>R</i>,5<i>R</i> was determined by a combination of the X-ray analysis and by time-dependent density functional theory (TD-DFT) calculations of electronic circular dichroism (ECD) spectra. The cytotoxic activity of the isolated compounds against human prostate cancer PC-3 and human embryonic kidney HEK-293 cells and growth inhibition activity against yeast-like fungi <i>Candida albicans</i> were assayed.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023) 抗癌真菌代谢物的研究进展：过去十年（2012-2023 年）的来源、化学和生物活性。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-05-14 DOI: 10.1007/s13659-024-00452-0

Antonio Evidente

{"title":"Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)","authors":"Antonio Evidente","doi":"10.1007/s13659-024-00452-0","DOIUrl":"10.1007/s13659-024-00452-0","url":null,"abstract":"<div><p>Among microorganisms, fungi are the ones that have the most imagination in producing secondary metabolites with the most varied structural differences, which are produced through different biosynthetic pathways. Therefore, they synthesize secondary metabolites classifiable into numerous families of natural compounds such as amino acids, alkaloids, anthraquinones, aromatic compounds, cyclohexene epoxides, furanones, macrolides, naphthoquinones, polyketides, pyrones, terpenes, etc. They also produced metabolites with very complex structures that can not be classified in the known families of natural compounds. Many fungal metabolites show different biological activities with potential applications in agriculture, food chemistry, cosmetics, pharmacology and medicine. This review is focused on the fungal secondary metabolites with anticancer activity isolated in the last ten years. For some metabolites, when described, their biosynthetic origin, the mode of action and the results of structure activity relationships studies are also reported.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling 通过基于 LC-MS 的代谢轮廓分析法对瓜蒌子器官进行代谢物比较分析。

IF 4.8 3区化学

Natural Products and Bioprospecting Pub Date : 2024-05-14 DOI: 10.1007/s13659-024-00453-z

Ismail Ware, Katrin Franke, Andrej Frolov, Kseniia Bureiko, Elana Kysil, Maizatulakmal Yahayu, Hesham Ali El Enshasy, Ludger A. Wessjohann

{"title":"Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling","authors":"Ismail Ware, Katrin Franke, Andrej Frolov, Kseniia Bureiko, Elana Kysil, Maizatulakmal Yahayu, Hesham Ali El Enshasy, Ludger A. Wessjohann","doi":"10.1007/s13659-024-00453-z","DOIUrl":"10.1007/s13659-024-00453-z","url":null,"abstract":"<div><p><i>Piper sarmentosum</i> Roxb. (Piperaceae) is a traditional medicinal and food plant widely distributed in the tropical and subtropical regions of Asia, offering both health and culinary benefits. In this study the secondary metabolites in different organs of <i>P. sarmentosum</i> were identified and their relative abundances were characterized. The metabolic profiles of leaves, roots, stems and fruits were comprehensively investigated by liquid chromatography high-resolution mass spectrometry (LC-HR-MS) and the data subsequently analyzed using multivariate statistical methods. Manual interpretation of the tandem mass spectrometric (MS/MS) fragmentation patterns revealed the presence of 154 tentatively identified metabolites, mostly represented by alkaloids and flavonoids. Principle component analysis and hierarchical clustering indicated the predominant occurrence of flavonoids, lignans and phenyl propanoids in leaves, aporphines in stems, piperamides in fruits and lignan-amides in roots. Overall, this study provides extensive data on the metabolite composition of <i>P. sarmentosum</i>, supplying useful information for bioactive compounds discovery and patterns of their preferential biosynthesis or storage in specific organs. This can be used to optimize production and harvesting as well as to maximize the plant’s economic value as herbal medicine or in food applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0