Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2025-04-24 DOI:10.1007/s13659-025-00512-z

Hongyan Wen, Sheng Li, Yu Zhang

引用次数: 0

Abstract

Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (1) and B (2), and a new phthalide monomer (3), were obtained from the rhizomes of Angelica sinensis. Their structures were established through spectroscopic methods, quantum calculations, and chiral HPLC analysis. Compounds 1 and 2 were [2 + 2] and [4 + 2] cycloadducts of phthalide monomers, and their hypothetical biogenetic origin was proposed. Compounds 2, (+)-2, (−)-2, 4, (+)-4, and (−)-4 exhibited significant inhibitory activity against NO production with IC₅₀ values range from 1.23 to 5.55 μM.

Graphical Abstract

查看原文本刊更多论文

当归根状茎中邻苯酞单、二聚体及其抗炎活性

从当归根状茎中分离得到3对苯酞对映体二聚体，包括两个新化合物：当归内酯A(1)和B(2)，以及一个新的苯酞单体(3)。通过光谱方法、量子计算和手性高效液相色谱分析确定了它们的结构。化合物1和2分别为邻苯酞单体的[2 + 2]和[4 + 2]环加合物，并提出了它们的生物成因假说。化合物2、(+)-2、(−)-2、4、(+)-4和(−)-4对NO的生成具有显著的抑制活性，IC50值在1.23 ~ 5.55 μM之间。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.