Natural Products and Bioprospecting最新文献

{"title":"Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core","authors":"Xin-Ting Hu,&nbsp;Qing-Yan Cheng,&nbsp;Yan-Ping Chen,&nbsp;Kun Li,&nbsp;Cai-Xian Yan,&nbsp;Dashan Li,&nbsp;Li-Dong Shao","doi":"10.1007/s13659-024-00450-2","DOIUrl":"10.1007/s13659-024-00450-2","url":null,"abstract":"<div><p>A catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successfully utilized to prepare various 1,3-dioxanes <b>7</b> in 14–88% yields. Take advantage of the synthetic intermediate <b>7h</b>, the key B/C rings in brazilin core could be constructed by the sequential of Friedel–Crafts/Ullmann-Ma rather than Ullmann-Ma/Friedel–Crafts reactions.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural-derived acetophenones: chemistry and pharmacological activities","authors":"Hamid Ahmadpourmir,&nbsp;Homayoun Attar,&nbsp;Javad Asili,&nbsp;Vahid Soheili,&nbsp;Seyedeh Faezeh Taghizadeh,&nbsp;Abolfazl Shakeri","doi":"10.1007/s13659-024-00447-x","DOIUrl":"10.1007/s13659-024-00447-x","url":null,"abstract":"<div><p>Acetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains. They are exist in both free or glycosides form in nature. The biological activities of these compounds have been assayed and reported including cytotoxicity, antimicrobial, antimalarial, antioxidant and antityrosinase activities. Herein, we review the chemistry and biological activity of natural acetophenone derivatives that have been isolated and identified until January 2024. Taken together, it was reported 252 acetophenone derivatives in which the genera <i>Melicope</i> (69) and <i>Acronychia</i> (44) were the principal species as producers of acetophenones.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases","authors":"Nasreddine El Omari,&nbsp;Saad Bakrim,&nbsp;Asaad Khalid,&nbsp;Ashraf N. Abdalla,&nbsp;Mohamed A. M. Iesa,&nbsp;Kawtar El Kadri,&nbsp;Siah Ying Tang,&nbsp;Bey Hing Goh,&nbsp;Abdelhakim Bouyahya","doi":"10.1007/s13659-024-00451-1","DOIUrl":"10.1007/s13659-024-00451-1","url":null,"abstract":"<div><p>Until recently, the main pharmaceuticals used to control cholesterol and prevent cardiovascular disease (CVD) were statin-related drugs, known for their historical side effects. Therefore, there is growing interest in exploring alternatives, such as nutritional and dietary components, that could play a central role in CVD prevention. This review aims to provide a comprehensive understanding of how natural phytosterols found in various diets combat CVDs. We begin with a description of the overall approach, then we explore in detail the different direct and indirect mechanisms that contribute to reducing cardiovascular incidents. Phytosterols, including stigmasterol, <i>β</i>-sitosterol, ergosterol, and fucosterol, emerge as promising molecules within nutritional systems for protection against CVDs due to their beneficial effects at different levels through direct or indirect cellular, subcellular, and molecular mechanisms. Specifically, the mentioned phytosterols exhibit the ability to diminish the generation of various radicals, including hydroperoxides and hydrogen peroxide. They also promote the activation of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione, while inhibiting lipid peroxidation through the activation of Nrf2 and Nrf2/heme oxygenase-1 (HO-1) signaling pathways. Additionally, they demonstrate a significant inhibitory capacity in the generation of pro-inflammatory cytokines, thus playing a crucial role in regulating the inflammatory/immune response by inhibiting the expression of proteins involved in cellular signaling pathways such as JAK3/STAT3 and NF-κB. Moreover, phytosterols play a key role in reducing cholesterol absorption and improving the lipid profile. These compounds can be used as dietary supplements or included in specific diets to aid control cholesterol levels, particularly in individuals suffering from hypercholesterolemia.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11082103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim","authors":"Shi-Yan Feng,&nbsp;Na Jiang,&nbsp;Jia-Ying Yang,&nbsp;Lin-Yao Yang,&nbsp;Jiang-Chao Du,&nbsp;Xuan-Qin Chen,&nbsp;Dan Liu,&nbsp;Rong-Tao Li,&nbsp;Jin-Dong Zhong","doi":"10.1007/s13659-024-00448-w","DOIUrl":"10.1007/s13659-024-00448-w","url":null,"abstract":"<div><p>Seven undescribed compounds, including three flavones (<b>1–3</b>), one phenylpropanoid (<b>19</b>), three monoaromatic hydrocarbons (<b>27–29</b>), were isolated from the twigs of <i>Mosla chinensis</i> Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound <b>20</b> displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC₅₀ = 20.47 <i>μ</i>M) compared to the positive control oseltamivir (IC₅₀ = 6.85 <i>µ</i>M). Further research on the anti-influenza mechanism showed that compound <b>20</b> could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds <b>9</b>, <b>22</b>, <b>23</b>, and <b>25</b> displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC₅₀ values of 22.78, 20.47, 27.66, and 30.14 <i>µ</i>M, respectively.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00448-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway","authors":"Bangrui Huang,&nbsp;Rui Han,&nbsp;Hong Tan,&nbsp;Wenzhuo Zhu,&nbsp;Yang Li,&nbsp;Fakun Jiang,&nbsp;Chun Xie,&nbsp;Zundan Ren,&nbsp;Rou Shi","doi":"10.1007/s13659-024-00446-y","DOIUrl":"10.1007/s13659-024-00446-y","url":null,"abstract":"<div><p>Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb <i>Erigeron breviscapus</i> (Vant.) Hand-Mazz, has demonstrated a promising potential in improving diabetic nephropathy (DN). However, the specific active constituent(s) responsible for its therapeutic effects and the underlying pharmacological mechanisms remain unclear. In this study, we aimed to investigate the impact of scutellarin, a constituent of breviscapine, on streptozotocin-induced diabetic nephropathy and elucidate its pharmacological mechanism(s). Our findings demonstrate that scutellarin effectively ameliorates various features of DN in vivo, including proteinuria, glomerular expansion, mesangial matrix accumulation, renal fibrosis, and podocyte injury. Mechanistically, scutellarin appears to exert its beneficial effects through modulation of the transforming growth factor-β1 (TGF-β1) signaling pathway, as well as its interaction with the extracellular signal-regulated kinase (Erk) and Wnt/β-catenin pathways.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00446-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural compounds proposed for the management of non-alcoholic fatty liver disease","authors":"Théodora Merenda,&nbsp;Florian Juszczak,&nbsp;Elisabeth Ferier,&nbsp;Pierre Duez,&nbsp;Stéphanie Patris,&nbsp;Anne-Émilie Declèves,&nbsp;Amandine Nachtergael","doi":"10.1007/s13659-024-00445-z","DOIUrl":"10.1007/s13659-024-00445-z","url":null,"abstract":"<div><p>Although non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalence, the often-recommended lifestyle interventions mostly lack high-level evidence of efficacy and there are currently no effective drugs proposed for this indication. The present review delves into NAFLD pathology, its diverse underlying physiopathological mechanisms and the available in vitro<i>, </i>in vivo, and clinical evidence regarding the use of natural compounds for its management, through three pivotal targets (oxidative stress, cellular inflammation, and insulin resistance). The promising perspectives that natural compounds offer for NAFLD management underscore the need for additional clinical and lifestyle intervention trials. Encouraging further research will contribute to establishing more robust evidence and practical recommendations tailored to patients with varying NAFLD grades.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others","authors":"Zhe-Wei Yu,&nbsp;Bang-Ping Cai,&nbsp;Su-Zhi Xie,&nbsp;Yi Zhang,&nbsp;Wen-Hui Wang,&nbsp;Shun-Zhi Liu,&nbsp;Yan-Lin Bin,&nbsp;Qi Chen,&nbsp;Mei-Juan Fang,&nbsp;Rong Qi,&nbsp;Ming-Yu Li,&nbsp;Ying-Kun Qiu","doi":"10.1007/s13659-024-00440-4","DOIUrl":"10.1007/s13659-024-00440-4","url":null,"abstract":"<div><p>In this study, two new kaurane diterpenes (1<b>6</b>, <b>17</b>), together with 12 lignans (<b>1–12</b>), a triterpene (<b>15</b>), and two other compounds (<b>13</b>, <b>14</b>) were isolated from the woods of <i>Agathis</i> <i>dammara</i>. The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds <b>5</b>, <b>11</b>, <b>14</b> exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140189342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata","authors":"Shi-Hui Qin,&nbsp;Zhi-Lan Li,&nbsp;Liu Yang,&nbsp;Jiang-Miao Hu","doi":"10.1007/s13659-024-00430-6","DOIUrl":"10.1007/s13659-024-00430-6","url":null,"abstract":"<div><p>Based on the research progress and traditional usage with whole herbal of the TCM \"Tianma\", chemical studies herein on the flower branch of <i>Gastrodia</i> <i>elata</i> were carried out in-depth and got 13 compounds including the gastrodinols (<b>1–4</b>), the flavonoid morins (<b>5–8, 11–12</b>), together with the specialist mulberrofurans (<b>9</b>, <b>13</b>) and gastrodiamide (<b>10</b>) for the first time from the species. The antibacterial and cholinesterase inhibitory activities were then evaluated and the results showed that compounds<b> 5</b>, <b>11</b>, <b>12</b>, <b>13</b> have good activity against anti-methicillin-resistant <i>Staphylococcus</i> <i>aureus</i>, and compounds <b>9</b>, <b>13</b> had good acetylcholinesterase inhibitory activity. All these results provide new chemical composition for better understanding the traditional application of \"Tianma\" and for exploring new pharmacological ingredients.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00430-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which is the optimal choice for neonates’ formula or breast milk?","authors":"Yueqi Hu,&nbsp;Xing Wu,&nbsp;Li Zhou,&nbsp;Jikai Liu","doi":"10.1007/s13659-024-00444-0","DOIUrl":"10.1007/s13659-024-00444-0","url":null,"abstract":"<div><p>The incidence of prematurity has been increasing since the twenty-first century. Premature neonates are extremely vulnerable and require a rich supply of nutrients, including carbohydrates, proteins, docosahexaenoic acid (DHA), arachidonic acid (ARA) and others. Typical breast milk serves as the primary source for infants under six months old to provide these nutrients. However, depending on the individual needs of preterm infants, a more diverse and intricate range of nutrients may be necessary. This paper provides a comprehensive review of the current research progress on the physical and chemical properties, biological activity, function, and structure of breast milk, as well as explores the relationship between the main components of milk globular membrane and infant growth. Additionally, compare the nutritional composition of milk from different mammals and newborn milk powder, providing a comprehensive understanding of the differences in milk composition and detailed reference for meeting daily nutritional needs during lactation.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10942964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation","authors":"Li-Jun Ruan,&nbsp;Zhi-Jun Song,&nbsp;Ren-Wang Jiang","doi":"10.1007/s13659-024-00442-2","DOIUrl":"10.1007/s13659-024-00442-2","url":null,"abstract":"<div><p>Bufadienolides, naturally occurring steroids primarily found in toads, have garnered attention for their pharmacological properties and ecological significance. In this study, we isolated and identified 21 bufadienolides from the gallbladders of <i>Bufo gargarizans</i>, comprising four new compounds and 17 known ones. Notably, the predominance of 15 bufadienolides with a 3α-OH configuration in toad bile differs significantly from the 3β-OH bufadienolides found in venom secreted by toad glands. Moreover, our investigation into the biotransformation of 3β-OH and 3α-OH bufadienolides in the liver and kidney tissues of toads revealed an irreversible conversion from 3β-OH to 3α-OH bufadienolides, suggesting a crucial role in toad self-detoxification. These findings provide valuable insights into the structural diversity of bufadienolides and advance our understanding of their medical and ecological significance.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10912398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140020604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}