Natural Products and Bioprospecting最新文献

{"title":"Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration","authors":"Liz E. Lescano,&nbsp;Mario O. Salazar,&nbsp;Ricardo L. E. Furlan","doi":"10.1007/s13659-024-00456-w","DOIUrl":"10.1007/s13659-024-00456-w","url":null,"abstract":"<div><p>The generation of chemically engineered essential oils (CEEOs) prepared from bi-heteroatomic reactions using ammonium thiocyanate as a source of bioactive compounds is described. The impact of the reaction on the chemical composition of the mixtures was qualitatively demonstrated through GC–MS, utilizing univariate and multivariate analysis. The reaction transformed most of the components in the natural mixtures, thereby expanding the chemical diversity of the mixtures. Changes in inhibition properties between natural and CEEOs were demonstrated through acetylcholinesterase TLC autography, resulting in a threefold increase in the number of positive events due to the modification process. The chemically engineered <i>Origanum vulgare</i> L. essential oil was subjected to bioguided fractionation, leading to the discovery of four new active compounds with similar or higher potency than eserine against the enzyme. The results suggest that the directed chemical transformation of essential oils can be a valuable strategy for discovering new acetylcholinesterase (AChE) inhibitors.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells","authors":"Guangyu Zhu,&nbsp;Dian Luo,&nbsp;Yueqin Zhao,&nbsp;Zhengrui Xiang,&nbsp;Chao Chen,&nbsp;Na Li,&nbsp;Xiaojiang Hao,&nbsp;Xiao Ding,&nbsp;Yingjun Zhang,&nbsp;Yuhan Zhao","doi":"10.1007/s13659-024-00454-y","DOIUrl":"10.1007/s13659-024-00454-y","url":null,"abstract":"<div><p>Cancer cells generally exhibit ‘iron addiction’ phenotypes, which contribute to their vulnerability to ferroptosis inducers. Ferroptosis is a newly discovered form of programmed cell death caused by iron-dependent lipid peroxidation. In the present study, pacidusin B, a dichapetalin-type triterpenoid from <i>Phyllanthus acidus</i> (L.) Skeels (Euphorbiaceae), induces ferroptosis in the HT1080 human fibrosarcoma cell line. Cells treated with pacidusin B exhibited the morphological characteristic ‘ballooning’ phenotype of ferroptosis. The biochemical hallmarks of ferroptosis were also observed in pacidusin B-treated cells. Both oxidative stress and ER stress play significant roles in pacidusin B-induced ferroptosis. The activation of the PERK-Nrf2-HO-1 signaling pathway led to iron overload, while inhibition of GPX4 further sensitized cancer cells to ferroptosis. Furthermore, the molecular docking study showed that pacidusin B docked in the same pocket in xCT as the ferroptosis inducer erastin. These results revealed that pacidusin B exerts anticancer effects via inducing ER-mediated ferroptotic cell death.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method","authors":"Jindi Lu,&nbsp;Weimin Liang,&nbsp;Yiwei Hu,&nbsp;Xi Zhang,&nbsp;Ping Yu,&nbsp;Meiqun Cai,&nbsp;Danni Xie,&nbsp;Qiong Zhou,&nbsp;Xuefeng Zhou,&nbsp;Yonghong Liu,&nbsp;Junfeng Wang,&nbsp;Jiayin Guo,&nbsp;Lan Tang","doi":"10.1007/s13659-024-00455-x","DOIUrl":"10.1007/s13659-024-00455-x","url":null,"abstract":"<div><p><i>N</i>-Hydroxyapiosporamide (<i>N</i>-hydap), a marine product derived from a sponge-associated fungus, has shown promising inhibitory effects on small cell lung cancer (SCLC). However, there is limited understanding of its metabolic pathways and characteristics. This study explored the in vitro metabolic profiles of <i>N</i>-hydap in human recombinant cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs), as well as human/rat/mice microsomes, and also the pharmacokinetic properties by HPLC–MS/MS. Additionally, the cocktail probe method was used to investigate the potential to create drug-drug interactions (DDIs). <i>N</i>-Hydap was metabolically unstable in various microsomes after 1 h, with about 50% and 70% of it being eliminated by CYPs and UGTs, respectively. UGT1A3 was the main enzyme involved in glucuronidation (over 80%), making glucuronide the primary metabolite. With a favorable bioavailability of 24.0%, <i>N</i>-hydap exhibited a higher distribution in the lungs (26.26%), accounting for its efficacy against SCLC. Administering <i>N</i>-hydap to mice at normal doses via gavage did not result in significant toxicity. Furthermore, <i>N</i>-hydap was found to affect the catalytic activity of drug metabolic enzymes (DMEs), particularly increasing the activity of UGT1A3, suggesting potential for DDIs. Understanding the metabolic pathways and properties of <i>N</i>-hydap should improve our knowledge of its drug efficacy, toxicity, and potential for DDIs.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy","authors":"Gleb V. Borkunov,&nbsp;Elena V. Leshchenko,&nbsp;Dmitrii V. Berdyshev,&nbsp;Roman S. Popov,&nbsp;Ekaterina A. Chingizova,&nbsp;Nadezhda P. Shlyk,&nbsp;Andrey V. Gerasimenko,&nbsp;Natalya N. Kirichuk,&nbsp;Yuliya V. Khudyakova,&nbsp;Viktoria E. Chausova,&nbsp;Alexandr S. Antonov,&nbsp;Anatoly I. Kalinovsky,&nbsp;Artur R. Chingizov,&nbsp;Ekaterina A. Yurchenko,&nbsp;Marina P. Isaeva,&nbsp;Anton N. Yurchenko","doi":"10.1007/s13659-024-00449-9","DOIUrl":"10.1007/s13659-024-00449-9","url":null,"abstract":"<div><p>Four extracts of the marine-derived fungus <i>Penicillium velutinum</i> J.F.H. Beyma were obtained via metal ions stress conditions based on the OSMAC (One Strain Many Compounds) strategy. Using a combination of modern approaches such as LC/UV, LC/MS and bioactivity data analysis, as well as in silico calculations, influence metal stress factors to change metabolite profiles <i>Penicillium velutinum</i> were analyzed. From the ethyl acetate extract of the <i>P. velutinum</i> were isolated two new piperazine derivatives helvamides B (<b>1</b>) and C (<b>2</b>) together with known saroclazin A (<b>3</b>) (4<i>S</i>,5<i>R</i>,7<i>S</i>)-4,11-dihydroxy-guaia-1(2),9(10)-dien (<b>4</b>). Their structures were established based on spectroscopic methods. The absolute configuration of helvamide B (<b>1</b>) as 2<i>R</i>,5<i>R</i> was determined by a combination of the X-ray analysis and by time-dependent density functional theory (TD-DFT) calculations of electronic circular dichroism (ECD) spectra. The cytotoxic activity of the isolated compounds against human prostate cancer PC-3 and human embryonic kidney HEK-293 cells and growth inhibition activity against yeast-like fungi <i>Candida albicans</i> were assayed.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)","authors":"Antonio Evidente","doi":"10.1007/s13659-024-00452-0","DOIUrl":"10.1007/s13659-024-00452-0","url":null,"abstract":"<div><p>Among microorganisms, fungi are the ones that have the most imagination in producing secondary metabolites with the most varied structural differences, which are produced through different biosynthetic pathways. Therefore, they synthesize secondary metabolites classifiable into numerous families of natural compounds such as amino acids, alkaloids, anthraquinones, aromatic compounds, cyclohexene epoxides, furanones, macrolides, naphthoquinones, polyketides, pyrones, terpenes, etc. They also produced metabolites with very complex structures that can not be classified in the known families of natural compounds. Many fungal metabolites show different biological activities with potential applications in agriculture, food chemistry, cosmetics, pharmacology and medicine. This review is focused on the fungal secondary metabolites with anticancer activity isolated in the last ten years. For some metabolites, when described, their biosynthetic origin, the mode of action and the results of structure activity relationships studies are also reported.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling","authors":"Ismail Ware,&nbsp;Katrin Franke,&nbsp;Andrej Frolov,&nbsp;Kseniia Bureiko,&nbsp;Elana Kysil,&nbsp;Maizatulakmal Yahayu,&nbsp;Hesham Ali El Enshasy,&nbsp;Ludger A. Wessjohann","doi":"10.1007/s13659-024-00453-z","DOIUrl":"10.1007/s13659-024-00453-z","url":null,"abstract":"<div><p><i>Piper sarmentosum</i> Roxb. (Piperaceae) is a traditional medicinal and food plant widely distributed in the tropical and subtropical regions of Asia, offering both health and culinary benefits. In this study the secondary metabolites in different organs of <i>P. sarmentosum</i> were identified and their relative abundances were characterized. The metabolic profiles of leaves, roots, stems and fruits were comprehensively investigated by liquid chromatography high-resolution mass spectrometry (LC-HR-MS) and the data subsequently analyzed using multivariate statistical methods. Manual interpretation of the tandem mass spectrometric (MS/MS) fragmentation patterns revealed the presence of 154 tentatively identified metabolites, mostly represented by alkaloids and flavonoids. Principle component analysis and hierarchical clustering indicated the predominant occurrence of flavonoids, lignans and phenyl propanoids in leaves, aporphines in stems, piperamides in fruits and lignan-amides in roots. Overall, this study provides extensive data on the metabolite composition of <i>P. sarmentosum</i>, supplying useful information for bioactive compounds discovery and patterns of their preferential biosynthesis or storage in specific organs. This can be used to optimize production and harvesting as well as to maximize the plant’s economic value as herbal medicine or in food applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core","authors":"Xin-Ting Hu,&nbsp;Qing-Yan Cheng,&nbsp;Yan-Ping Chen,&nbsp;Kun Li,&nbsp;Cai-Xian Yan,&nbsp;Dashan Li,&nbsp;Li-Dong Shao","doi":"10.1007/s13659-024-00450-2","DOIUrl":"10.1007/s13659-024-00450-2","url":null,"abstract":"<div><p>A catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successfully utilized to prepare various 1,3-dioxanes <b>7</b> in 14–88% yields. Take advantage of the synthetic intermediate <b>7h</b>, the key B/C rings in brazilin core could be constructed by the sequential of Friedel–Crafts/Ullmann-Ma rather than Ullmann-Ma/Friedel–Crafts reactions.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural-derived acetophenones: chemistry and pharmacological activities","authors":"Hamid Ahmadpourmir,&nbsp;Homayoun Attar,&nbsp;Javad Asili,&nbsp;Vahid Soheili,&nbsp;Seyedeh Faezeh Taghizadeh,&nbsp;Abolfazl Shakeri","doi":"10.1007/s13659-024-00447-x","DOIUrl":"10.1007/s13659-024-00447-x","url":null,"abstract":"<div><p>Acetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains. They are exist in both free or glycosides form in nature. The biological activities of these compounds have been assayed and reported including cytotoxicity, antimicrobial, antimalarial, antioxidant and antityrosinase activities. Herein, we review the chemistry and biological activity of natural acetophenone derivatives that have been isolated and identified until January 2024. Taken together, it was reported 252 acetophenone derivatives in which the genera <i>Melicope</i> (69) and <i>Acronychia</i> (44) were the principal species as producers of acetophenones.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases","authors":"Nasreddine El Omari,&nbsp;Saad Bakrim,&nbsp;Asaad Khalid,&nbsp;Ashraf N. Abdalla,&nbsp;Mohamed A. M. Iesa,&nbsp;Kawtar El Kadri,&nbsp;Siah Ying Tang,&nbsp;Bey Hing Goh,&nbsp;Abdelhakim Bouyahya","doi":"10.1007/s13659-024-00451-1","DOIUrl":"10.1007/s13659-024-00451-1","url":null,"abstract":"<div><p>Until recently, the main pharmaceuticals used to control cholesterol and prevent cardiovascular disease (CVD) were statin-related drugs, known for their historical side effects. Therefore, there is growing interest in exploring alternatives, such as nutritional and dietary components, that could play a central role in CVD prevention. This review aims to provide a comprehensive understanding of how natural phytosterols found in various diets combat CVDs. We begin with a description of the overall approach, then we explore in detail the different direct and indirect mechanisms that contribute to reducing cardiovascular incidents. Phytosterols, including stigmasterol, <i>β</i>-sitosterol, ergosterol, and fucosterol, emerge as promising molecules within nutritional systems for protection against CVDs due to their beneficial effects at different levels through direct or indirect cellular, subcellular, and molecular mechanisms. Specifically, the mentioned phytosterols exhibit the ability to diminish the generation of various radicals, including hydroperoxides and hydrogen peroxide. They also promote the activation of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione, while inhibiting lipid peroxidation through the activation of Nrf2 and Nrf2/heme oxygenase-1 (HO-1) signaling pathways. Additionally, they demonstrate a significant inhibitory capacity in the generation of pro-inflammatory cytokines, thus playing a crucial role in regulating the inflammatory/immune response by inhibiting the expression of proteins involved in cellular signaling pathways such as JAK3/STAT3 and NF-κB. Moreover, phytosterols play a key role in reducing cholesterol absorption and improving the lipid profile. These compounds can be used as dietary supplements or included in specific diets to aid control cholesterol levels, particularly in individuals suffering from hypercholesterolemia.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11082103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim","authors":"Shi-Yan Feng,&nbsp;Na Jiang,&nbsp;Jia-Ying Yang,&nbsp;Lin-Yao Yang,&nbsp;Jiang-Chao Du,&nbsp;Xuan-Qin Chen,&nbsp;Dan Liu,&nbsp;Rong-Tao Li,&nbsp;Jin-Dong Zhong","doi":"10.1007/s13659-024-00448-w","DOIUrl":"10.1007/s13659-024-00448-w","url":null,"abstract":"<div><p>Seven undescribed compounds, including three flavones (<b>1–3</b>), one phenylpropanoid (<b>19</b>), three monoaromatic hydrocarbons (<b>27–29</b>), were isolated from the twigs of <i>Mosla chinensis</i> Maxim together with twenty-eight known compounds. The structures were characterized by HRESIMS, 1D and 2D NMR, and ECD spectroscopic techniques. Compound <b>20</b> displayed the most significant activity against A/WSN/33/2009 (H1N1) virus (IC₅₀ = 20.47 <i>μ</i>M) compared to the positive control oseltamivir (IC₅₀ = 6.85 <i>µ</i>M). Further research on the anti-influenza mechanism showed that compound <b>20</b> could bind to H1N1 virus surface antigen HA1 and inhibit the early attachment stage of the virus. Furthermore, compounds <b>9</b>, <b>22</b>, <b>23</b>, and <b>25</b> displayed moderate inhibitory effects on the NO expression in LPS inducing Raw 264.7 cells with IC₅₀ values of 22.78, 20.47, 27.66, and 30.14 <i>µ</i>M, respectively.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"14 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-024-00448-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}