Natural Products and Bioprospecting最新文献

{"title":"Artificial intelligence-based screening of phytochemicals for targeted cancer therapy","authors":"Livia Ramos Santiago,&nbsp;Estéfani Alves Asevedo,&nbsp;Maria Eduarda Jeunon de Oliveira,&nbsp;Karen Cota Pereira,&nbsp;Maria Fernanda da Silva Trindade,&nbsp;Ana Gabriela Silva Oliveira,&nbsp;Marina Andrade Rocha,&nbsp;Sojin Kang,&nbsp;Amama Rani,&nbsp;Moon Nyeo Park,&nbsp;Michel William Tan,&nbsp;Rony Abdi Syahputra,&nbsp;Bonglee Kim,&nbsp;Rosy Iara Maciel de Azambuja Ribeiro","doi":"10.1007/s13659-026-00599-y","DOIUrl":"10.1007/s13659-026-00599-y","url":null,"abstract":"<div><p>Cancer remains one of the leading causes of death worldwide and continues to pose a serious public health challenge. The limited success of many current treatments—often due to toxicity, poor selectivity, and the development of drug resistance—highlights the need for new and more effective therapeutic options. Phytochemicals have emerged as a valuable source of anticancer agents, offering rich structural diversity and a wide range of biological activities. However, identifying promising compounds from the vast chemical space of natural products remains difficult using conventional screening methods, which are typically slow, costly, and inefficient. In recent years, artificial intelligence (AI) has begun to transform phytochemical-based drug discovery. Machine learning and deep learning approaches are now used to support key steps in the discovery process, including metabolite identification, virtual screening, target prediction, and toxicity assessment. By integrating chemical, biological, and multi-omics data, AI enables a more systematic and data-driven exploration of natural product diversity. Despite these advances, challenges persist, particularly the scarcity of high-quality experimental data, the structural complexity of phytochemicals, and their limited representation in public databases. This review critically examines current AI applications in phytochemical-based anticancer drug discovery and discusses emerging strategies aimed at overcoming these limitations. Overall, AI-driven phytochemical screening represents a promising path toward accelerating the development of next-generation cancer therapies.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00599-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sophflarines F–K: matrine-based alkaloids with a rare aromatic system from Sophora flavescens and their anti-inflammatory and synergistic antibacterial effects","authors":"Ding Luo,&nbsp;Le-Yan Wang,&nbsp;Xiang-Feng Zhao,&nbsp;Xiao-Lin Huang,&nbsp;Yang-Yi Hu,&nbsp;Qiong-Yun Jing,&nbsp;Yan-Jun Chen,&nbsp;He Tian,&nbsp;Si-Yan Chen,&nbsp;Yu-Yan Wang,&nbsp;Xian-Hui Huang,&nbsp;Zhen-Ling Zeng,&nbsp;Xiao-Ping Liao","doi":"10.1007/s13659-026-00595-2","DOIUrl":"10.1007/s13659-026-00595-2","url":null,"abstract":"<div><p>Six new matrine-based alkaloids, sophflarines F–K <b>(1–6)</b>, featuring a rare aromatic system, were obtained from the water-soluble alkaloid fractions of <i>Sophora flavescens</i> by UV-guided separation. Their structures were elucidated by the interpretation of spectroscopic analyses, quantum chemical calculation, and X-ray diffraction data. Compounds <b>1</b> and <b>2</b> represent highly modified 15,16-<i>seco</i>-17-<i>nor</i>-matrine derivatives incorporating a rare 4,5-dihydro-3<i>H</i>-pyrrolo[2,3,4-ij]quinolizine moiety, while compound <b>5</b> possesses an unusual 6/6/6–5 tetracyclic skeleton. A copper sulfate-induced zebrafish assay revealed that compounds <b>1</b>, <b>4</b>, and <b>5</b> exhibited moderate anti-inflammatory activity at non-toxic concentrations. Checkerboard assays demonstrated that compounds <b>5</b> and <b>6</b> potentiated colistin activity against <i>Escherichia coli</i> ATCC25922 and BW25113-<i>mcr</i>-1, reducing colistin MIC values by 16- and 32-fold, respectively. These findings expand the structural diversity of aromatic matrine-type alkaloids and highlight their potential as anti-inflammatory agents and antibacterial adjuvants.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase","authors":"Roland Hellinger,&nbsp;Paula Schwarz,&nbsp;Jonathan Dieringer,&nbsp;Carina Ebermann,&nbsp;Kirtikumar B. Jadhav,&nbsp;Markus Muttenthaler,&nbsp;Christian W. Gruber","doi":"10.1007/s13659-026-00598-z","DOIUrl":"10.1007/s13659-026-00598-z","url":null,"abstract":"<div><p>Peptides from natural sources have often served as valuable leads in drug discovery. Plant-derived protease inhibitors are a notable class, yet their distribution, diversity, and targets remain underexplored. Here, eleven tropical Psychotria species were screened for cyclic cysteine-rich peptides, with extracts showing concentration-dependent inhibition of human prolyl oligopeptidase (POP). Peptidomics combining mass spectrometry and transcriptome mining revealed multiple inhibitory peptides. From <i>Psychotria solitudinum</i>, which contained 37 peptides, a novel peptide (psysol 3) was purified and sequenced. Its synthetic analogue inhibited POP with an IC₅₀ of ~ 1.3 µM. Sequence analysis and synthetic probes identified loop 3 as the inhibitory motif. Psysol 3 is a new probe for POP pharmacology and future structure–activity studies.</p></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limonene and its metabolite perillyl alcohol inhibit Chlamydia trachomatis growth by altering host isoprenoid metabolism","authors":"Pilar Cebollada,&nbsp;Inés Reigada,&nbsp;Maarit Ylätalo,&nbsp;Candela Gerediaga,&nbsp;Víctor López,&nbsp;Leena Hanski","doi":"10.1007/s13659-026-00611-5","DOIUrl":"10.1007/s13659-026-00611-5","url":null,"abstract":"<div><p>The obligate intracellular bacterium <i>Chlamydia trachomatis</i> is the most common bacterial sexually transmitted infection globally, with approximately 131 million new cases each year. It contributes to widespread reproductive health issues, including infertility and chronic pelvic pain. The unique cell morphology and biphasic life cycle pose challenges to their effective eradication. Guided by the identification of essential oils (EOs) capable of suppressing <i>C. trachomatis</i> intracellular growth, this study evaluated the antichlamydial properties of the monoterpene limonene and its metabolites perillyl alcohol and perilic acid. The antichlamydial activity was assessed through qPCR-based quantification of bacterial genome copy numbers and immunofluorescence staining of chlamydial inclusions to monitor bacterial growth and infectious progeny production. Elementary body membrane integrity was assessed with viability PCR. <i>Citrus limon</i> essential oil exhibited dose-dependent inhibition of <i>C. trachomatis</i> growth, decreasing infectious progeny by over 90%. <i>Pinus sylvestris</i> EO displayed consistent but non-dose-dependent effects. Limonene, a major constituent of the EOs, exhibited significant suppression of chlamydial growth and progeny production, particularly for its R-enantiomer. While viability-PCR data indicated that the EOs and limonene affected EB membrane permeability, EB infectivity was not affected by the treatments. Perillyl alcohol suppressed chlamydial growth at a lower concentration (100 µg mL⁻¹) than the parent compound limonene. The antichlamydial activity of both limonene and perillyl alcohol was suppressed when infected cultures were supplemented with farnesyl or geranylgeranyl, indicating that the antichlamydial mechanism of the two monoterpenes involves competitive inhibition of protein prenylation. Hence, targeting host protein prenylation may be an effective antichlamydial strategy.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deacetylforskolin ameliorates bleomycin-induced pulmonary fibrosis by suppressing inflammation and TGF-β1-induced epithelial–mesenchymal transition","authors":"Yan Zhong,&nbsp;Chuang Xiao,&nbsp;Yaping Liang,&nbsp;Peng Wang,&nbsp;Yun Long,&nbsp;Shuyi Li,&nbsp;Na Song,&nbsp;Wenbin Shang,&nbsp;Weimin Yang,&nbsp;Xuan Zhang","doi":"10.1007/s13659-026-00593-4","DOIUrl":"10.1007/s13659-026-00593-4","url":null,"abstract":"<div><p>Pulmonary fibrosis (PF) is a chronic, progressive and irreversible inflammatory disease with limited therapeutic methods in clinic. Deacetylforskolin (DFSK), derived from the plant <i>Coleus forskohlii</i>, is a potent adenylyl cyclase activator with potential anti-inflammatory activity. Herein, we attempted to investigate the therapeutic potential and mechanisms of DFSK against PF in bleomycin (BLM)-induced mouse models and TGF-β1-induced A549 cells. Our results showed that DFSK treatment alleviated lung injury and reduced inflammatory cytokines in a mouse model of BLM-induced acute lung inflammation, an early stage of PF. In a BLM-induced PF mouse model, DFSK attenuated pathological lung injury and collagen deposition, decreased pro-inflammatory cytokines (TNF-α, IL-1β) and profibrotic mediators (TGF-β1, CTGF, hydroxyproline). Upregulation of the epithelial marker E-cadherin and downregulation of the mesenchymal marker α-SMA were observed following DFSK treatment. Furthermore, DFSK significantly restored the pulmonary function of PF mice with decreased Te, f, Penh and increased RT, TV. Mechanistically, DFSK suppressed the phosphorylation of JNK and p38 MAPK, and inhibited TGF-β1-induced epithelial–mesenchymal transition (EMT) in A549 cells. Collectively, our findings demonstrate that DFSK is an effective therapeutic agent against PF by suppressing inflammation and EMT.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GNPS2 molecular networking reveals metabolic diversity in fungi isolated from protease-rich fruits","authors":"Vitor de Souza Mazucato,&nbsp;Winner Duque Rodrigues,&nbsp;Ludmilla Tonani,&nbsp;Marcia Regina von Zeska Kress,&nbsp;Paulo Cezar Vieira","doi":"10.1007/s13659-026-00615-1","DOIUrl":"10.1007/s13659-026-00615-1","url":null,"abstract":"<div><p>Fungi are a rich source of chemical diversity for bioprospecting, yet most of their metabolic potential remains unexplored. This study investigated the metabolic profile of phytopathogenic fungi of the genus <i>Fusarium</i>, isolated from fruits with high protease content, such as papaya and pineapple. Comparative metabolomics was used to evaluate how culture substrates and co-cultivation with the endophyte <i>Neofusicoccum ribis</i> modulate secondary metabolite production. Molecular Networking analysis (GNPS2) revealed an impressive diversity of 173 annotated metabolites, including one previously undescribed compound. Metabolite production was highly dependent on the substrate and fungal strain, showing a strong correlation between phylogeny and metabolic profiles. Several extracts displayed significant inhibitory activity against the protease papain, with some co-cultivation combinations further enhancing this effect. These findings highlight how environmental conditions and microbial interactions activate silent biosynthetic pathways, confirming these fungi as promising sources for bioactive molecule discovery.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00615-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression","authors":"Ziou Zha,&nbsp;Dan He,&nbsp;Jianguo Song,&nbsp;Zhenhua Guan,&nbsp;Jiapei Han,&nbsp;Chang Liu,&nbsp;Xinyu Wang,&nbsp;Yongchun Zhu,&nbsp;Hucheng Zhu,&nbsp;Wencai Ye,&nbsp;Qin Li,&nbsp;Yonghui Zhang,&nbsp;Yuan Zhou","doi":"10.1007/s13659-026-00601-7","DOIUrl":"10.1007/s13659-026-00601-7","url":null,"abstract":"<div><p>Prenylation modifications of natural products typically introduce greater structural complexity and enhance their biological activities. Yet, the modification of piperazine alkaloids by dimethylallyl tryptophan synthases (DMATS) remains unreported. In this study, we identified and activated a silent DMATS-containing piperazine biosynthetic gene cluster (BGC), <i>flz</i>, in <i>Aspergillus flavipes</i> via heterologous expression and in vitro enzymatic assay, leading to the isolation and identification of sixteen metabolites. Among these, twelve are new, including five tryptophan-valine-derived alkaloids (<b>2</b>–<b>6</b>) and seven previously unreported prenylated analogs (<b>8</b>–<b>13</b>, <b>17</b>). Notably, <b>8</b> and <b>9</b> represent novel prenylated piperazines featuring a unique 6-5-5-6 ring system. Most significantly, we uncovered a versatile DMATS, FlzE, capable of catalyzing mono-prenylation on flexible substrates, such as piperazine, pyrazine, and diketopiperazine, at multiple sites in either regular or reverse manners. This study not only expands the chemical space of indole alkaloid derivatives but also provides a versatile and engineerable biocatalyst for the prenylation of both natural and synthetic products.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00601-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147606799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, total synthesis, and biological evaluation of dearomatized isoprenylated acylphloroglucinols from Hypericum przewalskii","authors":"Yong Li,&nbsp;Fei-Fei Xiong,&nbsp;Xiao-Yang Sun,&nbsp;Xing-Ren Li,&nbsp;Dao-Feng Chen,&nbsp;Gang Xu,&nbsp;Yin Nian,&nbsp;Li-Dong Shao","doi":"10.1007/s13659-026-00626-y","DOIUrl":"10.1007/s13659-026-00626-y","url":null,"abstract":"<div><p>New dearomatized isoprenylated acylphloroglucinols hyperprzewones A (<b>1</b>) and B (<b>2</b>) were isolated and characterized from the dried aerial parts of <i>Hypericum przewalskii</i>. The structures of these compounds were confirmed by extensive spectroscopic experiments. A facile synthetic route to <b>1</b> and <b>2</b> was developed via Friedel-Crafts acylation, alkylation, dearomatization, and oxidative [4 + 2] cyclization, giving a 17% overall yield. Moreover, the synthetic derivative <b>8</b> exhibited moderate inhibition on T-type calcium channels Ca_v3.2.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00626-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyridone alkaloids from an Antarctic endolichenic Tolypocladium sp.","authors":"Shasha Li,&nbsp;Ting Yu,&nbsp;Jianju Feng,&nbsp;Yue Shang,&nbsp;Tao Zhang,&nbsp;Shuzhen Chen,&nbsp;Liyan Yu,&nbsp;Maoluo Gan","doi":"10.1007/s13659-026-00607-1","DOIUrl":"10.1007/s13659-026-00607-1","url":null,"abstract":"<div><p>Three new pyridone alkaloids, tolypyrone A (<b>1</b>), tolypyrosides A (<b>2</b>) and B (<b>3</b>), and a new tetramic acid 2<i>′</i>-epitolypoalbin (<b>4</b>), along with ten known compounds, were obtained from <i>Tolypocladium</i> sp. CPCC 401485 isolated from an unidentified Antarctic lichen specimen. Structural elucidation of new compounds was achieved by analyses of HRESIMS and NMR spectroscopic data combined with X-ray crystallography, advanced Marfey’s method, and ECD calculation. Tolypyrone A (<b>1</b>) was the first 4-pyridone alkaloid with an unusual octahydro-1<i>H</i>-isochromeno[3,4-<i>b</i>]pyridin-4-one triheterocyclic ring system. Compounds <b>1</b>, <b>4</b> and <b>6</b> exhibited antimicrobial activities with the minimum inhibition concentration of 16−64 μg/mL.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00607-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in natural coumaronochromones: a comprehensive review of natural occurrence, bioactivities, and chemical synthesis","authors":"Dan Xia,&nbsp;Qin Lv,&nbsp;Wei Wang,&nbsp;Meng-Fan Xie,&nbsp;Jin-Cai Li,&nbsp;Kun Li,&nbsp;Dashan Li,&nbsp;Wen-Jing Wang,&nbsp;Li-Dong Shao","doi":"10.1007/s13659-026-00627-x","DOIUrl":"10.1007/s13659-026-00627-x","url":null,"abstract":"<div><p>Coumaronochromones, characterized by a distinctive benzofuro[2,3-<i>b</i>]chromenone core, constitute a rare subclass of isoflavonoids. Biosynthetically, they are proposed to originate from carbohydrate metabolism and the phenylpropanoid pathway like other isoflavones. To date, 92 natural coumaronochromones have been isolated and characterized from nearly 28 species across 24 genera within 7 families (including one fungal source). These compounds are predominantly distributed in the Fabaceae family, which accounts for over half (64%) of all known derivatives. Notably, approximately 20% of coumaronochromones are derived from the genus <i>Euchresta</i> (Fabaceae). The unique scaffold of coumaronochromones confers a broad spectrum of notable pharmacological activities, including anti-inflammatory, antibacterial, insecticidal, cytotoxic, and immunomodulatory effects, highlighting their potential as valuable natural leads for pharmaceutical and agrochemical development. This review comprehensively summarizes recent advances in the chemistry and biology of coumaronochromones, providing a detailed account of their natural occurrence, documented biological activities, and chemical syntheses.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00627-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}