枸杞叶化学成分及其体外抗类风湿关节炎活性研究。

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2025-05-30 DOI:10.1007/s13659-025-00516-9

Zi-Jiao Wang, Bang-Yin Tan, Yun Zhao, Chang-Bin Wang, Yun-Li Zhao, Xiao-Dong Luo

{"title":"枸杞叶化学成分及其体外抗类风湿关节炎活性研究。","authors":"Zi-Jiao Wang, Bang-Yin Tan, Yun Zhao, Chang-Bin Wang, Yun-Li Zhao, Xiao-Dong Luo","doi":"10.1007/s13659-025-00516-9","DOIUrl":null,"url":null,"abstract":"Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1-34 were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (LPS)-induced MH7A cells inflammatory model. As a result, compounds 1-3, 6, 8, 10, 14, 17-19, 29 and 31 inhibited the activity of lactate dehydrogenase (LDH) and nitric oxide (NO) at concentrations 20 μM. Among them, compound 1 showed the best effectiveness, with inhibition rates of 46.7% for NO and 32.8% for LDH.","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":"35"},"PeriodicalIF":4.8000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125459/pdf/","citationCount":"0","resultStr":"{\"title\":\"Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro.\",\"authors\":\"Zi-Jiao Wang, Bang-Yin Tan, Yun Zhao, Chang-Bin Wang, Yun-Li Zhao, Xiao-Dong Luo\",\"doi\":\"10.1007/s13659-025-00516-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1-34 were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (LPS)-induced MH7A cells inflammatory model. As a result, compounds 1-3, 6, 8, 10, 14, 17-19, 29 and 31 inhibited the activity of lactate dehydrogenase (LDH) and nitric oxide (NO) at concentrations 20 μM. Among them, compound 1 showed the best effectiveness, with inhibition rates of 46.7% for NO and 32.8% for LDH.\",\"PeriodicalId\":718,\"journal\":{\"name\":\"Natural Products and Bioprospecting\",\"volume\":\"15 1\",\"pages\":\"35\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125459/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Products and Bioprospecting\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s13659-025-00516-9\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s13659-025-00516-9","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

从枸杞叶中分离出2个新化合物和32个已知化合物。它们的结构通过一维和二维NMR， hresms和ECD光谱技术进行了鉴定。化合物1-34在脂多糖（LPS）诱导的MH7A细胞炎症模型中评估其抗类风湿关节炎的活性。结果表明，化合物1-3、6、8、10、14、17-19、29和31在浓度为20 μM时均能抑制乳酸脱氢酶（LDH）和一氧化氮（NO）的活性。其中化合物1对NO的抑制率为46.7%，对LDH的抑制率为32.8%，效果最好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro.

Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1-34 were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (LPS)-induced MH7A cells inflammatory model. As a result, compounds 1-3, 6, 8, 10, 14, 17-19, 29 and 31 inhibited the activity of lactate dehydrogenase (LDH) and nitric oxide (NO) at concentrations 20 μM. Among them, compound 1 showed the best effectiveness, with inhibition rates of 46.7% for NO and 32.8% for LDH.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.