Natural Products and Bioprospecting最新文献

{"title":"Functional roles and regulatory mechanisms of paeonol in the treatment of liver disease","authors":"Min Shu,&nbsp;Mengzhou Fang,&nbsp;Tao Xu,&nbsp;Qi Yan","doi":"10.1007/s13659-025-00554-3","DOIUrl":"10.1007/s13659-025-00554-3","url":null,"abstract":"<div><p>Liver disease is a serious threat to human health, so its prevention and treatment have been the focus of medical research. In the past few years, natural products have proved to be promising and valuable in the treatment of liver diseases. The bioactive substance paeonol, extracted from the root bark of peony (Paeonia lactiflora) of the buttercup family, is a promising drug candidate because of its low toxicity and multifaceted pharmacological properties. This review comprehensively explored the therapeutic potential of paeonol in different liver pathologies as well as the regulatory mechanisms. Despite its promising potential, the poor solubility and rapid metabolism of paeonol hindered its clinical translation. To improve bioavailability and liver targeting, we highlighted the potential of paeonol as a next-generation therapy for liver diseases by integrating preclinical evidence and technological advances, while exploring key avenues for future research, such as metabolic regulation and smart nanocarrier design.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12770108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First discovery of triterpenoids and sterols from Cotinus coggygria var. cinereus Engl. with anti-inflammatory and antibacterial activities","authors":"Yue-Tong Zhu,&nbsp;Ze-Rui Li,&nbsp;Ren-Hao Chen,&nbsp;Jin-Hao Li,&nbsp;Wei Wang,&nbsp;Yu-Qi Gao,&nbsp;Chun-Huan Li,&nbsp;Jin-Ming Gao","doi":"10.1007/s13659-025-00553-4","DOIUrl":"10.1007/s13659-025-00553-4","url":null,"abstract":"<div><p>This study led to the isolation of 17 triterpenoids, including two lanostane-type (<b>1</b> and <b>2</b>), two dammarane-type (<b>3</b> and <b>7</b>), ten tirucallane-type (<b>4</b> and <b>8</b>−<b>16</b>), and three oleanane-type (<b>17</b>−<b>19</b>) triterpenoids, as well as nine sterols (<b>5</b>, <b>6</b>, and <b>20</b>−<b>26</b>) from <i>Cotinus coggygria</i> var. cinereus Engl, which were first discovered from the genus <i>Cotinus</i>. Among them, coggygrenoids A−D (<b>1</b>−<b>4</b>), coggygrerol A (<b>5</b>), and coggygrerol B (<b>6</b>) are undescribed compounds. Additionally, seven flavonoids (<b>27</b>−<b>33</b>) were also isolated from this plant<i>.</i> Compound <b>15</b> displayed inhibitory activities in LPS-induced RAW 264.7 cells with an IC₅₀ value 6.81 ± 0.15 μM. Molecular docking demonstrated that <b>15</b> exhibited favorable affinity for NLRP3 and iNOS. In vitro and in vivo antibacterial evaluations indicated that coggygrnoid C (<b>3</b>) exhibited significant inhibitory activity against methicillin-resistant <i>Staphylococcus aureus</i> ATCC BAA-1717 (USA300), with An MIC of 8 μg/mL. Further mechanistic investigations demonstrated that <b>3</b> exerted antibacterial activity by compromising the integrity of the cell wall and membrane. Notably, the combination of <b>3</b> with ampicillin exhibited an additive antibacterial effect. In the <i>Galleria mellonella</i> infection model, compound <b>3</b> exhibited comparable activity to that of the positive control at 20 mg/kg. These findings suggest that triterpenoids of <i>C. coggygria</i> are potential antibacterial lead agents.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00553-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145895994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation, physicochemical properties, and immunomodulatory activity of glycoproteins from Syngnathoides biaculeatus","authors":"Xuewei Xia,&nbsp;Jieling Lin,&nbsp;Lihong Yang,&nbsp;Youhong Li,&nbsp;Wenshen Lin,&nbsp;Qingqing Wang,&nbsp;Jun Liu,&nbsp;Riming Huang","doi":"10.1007/s13659-025-00551-6","DOIUrl":"10.1007/s13659-025-00551-6","url":null,"abstract":"<div><p><i>Syngnathoides biaculeatus</i>, a potential functional food from marine sources, was found to enhance nonspecific immunity, but its functional ingredients have rarely been reported. Therefore, this study focused on the preparation and physicochemical properties of its water-soluble natural ingredients with their immunomodulatory activities and potential mechanisms. Firstly, we optimized the extraction method of glycoproteins from <i>S. biaculeatus</i> and prepared the crude glycoprotein SYB, from which the fraction glycoprotein SYB-1 was further purified. The carbohydrates of SYB-1 were 8.46% comprising mannose, glucose, and galactose, with an average molecular weight of 9.423 kDa. Amino acid analysis demonstrated that its major amino acids are glycine, glutamic acid, aspartic acid, and proline, with a total amino acid content of 88.81%. Furthermore, SYB-1 could significantly increase the cell viability of macrophages, and promote the release of NO, TNF-<i>α</i>, and IL-6. Metabolomics revealed that it was associated with arachidonic acid metabolism. The CYP450 enzyme family members and PTGS2 may be key targets for the regulatory role. These results suggested that the glycoprotein of <i>S. biaculeatus</i> may be an attractive functional food supplement from natural sources for immunocompromised populations.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12665643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancement in nanocarrier-mediated delivery of herbal bioactives: from bench to beside","authors":"Fatemeh Najafi,&nbsp;Negar Farrokhzad,&nbsp;Amirhossein Ghaemi,&nbsp;Dorsa Azizi Khezri,&nbsp;Mohammadali Hajiabbas,&nbsp;Amirhossein Khanizadeh,&nbsp;Nasim Kaveh Farsani,&nbsp;Mahsa Khoramipour,&nbsp;Niloofar Fatemipayam,&nbsp;Elham Seyyedi Zadeh,&nbsp;Arash Goodarzi,&nbsp;Behnoosh Khodadadi,&nbsp;Fatemeh Moradbeygi,&nbsp;Ahmad Reza Farmani,&nbsp;Mohammad Tavakkoli Yaraki,&nbsp;Martin Federico Desimone","doi":"10.1007/s13659-025-00550-7","DOIUrl":"10.1007/s13659-025-00550-7","url":null,"abstract":"<div><p>The resurgence of interest in traditional herbal remedies stems from an increasing appreciation for their complex phytochemical profiles and potential for synergistic therapeutic effects. However, the therapeutic potential of plant extracts is often limited by poor absorption and potential toxicity related to conventional delivery methods. This review explores the application of nanocarrier-mediated delivery systems, such as nanoparticles (NPs), liposomes, and nanoemulsions, to address these challenges. These biocompatible carriers offer enhanced stability and targeted delivery of herbal compounds, improving their efficacy and reducing unwanted side effects. By enabling precise distribution, nanotechnology optimizes the potency of herbal medicine across diverse applications, including regenerative medicine, wound healing, anticancer, and infection treatment. This review provides a systematic description of successful applications of nano-delivery technologies, nanoparticles, liposomes, nanoemulsions, and hybrid carriers, for the targeted delivery of some well-characterized herbal bioactives (curcumin, allicin, berberine, resveratrol etc.) and the enhanced therapeutic performance of herbal bioactives across a variety of preclinical models.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00550-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145406059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaemphenolide: a cyclobutane-bearing phenylpropanoid from Kaempferia galanga L. with nitric oxide inhibitory activity","authors":"Syarifatul Mufidah,&nbsp;Yusaku Miyamae,&nbsp;Hiroyuki Fuchino,&nbsp;Nobuo Kawahara","doi":"10.1007/s13659-025-00547-2","DOIUrl":"10.1007/s13659-025-00547-2","url":null,"abstract":"<div><p>An undescribed phenylpropanoid dimer featuring a rare cyclobutane ring was isolated from the rhizomes of <i>Kaempferia galanga</i> L., a medicinal plant traditionally used in Southeast Asia for its anti-inflammatory and therapeutic properties. Kaemphenolide (<b>1</b>), along with five known constituents, was obtained by separations of methanolic extract using chromatography. The presence of a cyclobutane ring within the phenylpropanoid scaffold represents an unusual structural motif among natural products and underscores the chemical uniqueness of this molecule. To evaluate its biological relevance, <b>1</b> was tested for its ability to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The compound exhibited anti-inflammatory activity, with an IC₅₀ value of 23.1 ± 6.40 µM.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00547-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of chemical constituents from Nicotiana tabacum L. in Parkinson’s disease","authors":"Hao-Jing Zang,&nbsp;Xiao-Lin Bai,&nbsp;Xue-Yi Sui,&nbsp;Xiao-Rui Zhai,&nbsp;Yong-Cui Wang,&nbsp;Zhong-Quan Xin,&nbsp;Qiu-Yuan Yin,&nbsp;Xiao-Jiang Hao,&nbsp;Yue-Hu Wang,&nbsp;Xun Liao,&nbsp;Ying-Tong Di","doi":"10.1007/s13659-025-00541-8","DOIUrl":"10.1007/s13659-025-00541-8","url":null,"abstract":"<div><p>Parkinson’s disease (PD), the second most common neurodegenerative disorder globally, arises from selective dopaminergic neuron degeneration. While current therapies address symptoms, disease-modifying agents remain an unmet need. Herein, we investigated <i>Nicotiana tabacum</i> L. (Solanaceae), a plant linked epidemiologically to reduced PD risk, as a source of multi-target neuroprotective compounds. From ultra-low nicotine (&lt; 0.04%) tobacco leaves, we isolated 22 molecules, including a novel 21-norsesterterpenoid (Nicotiazanorpenoid A) and eight previously unreported compounds. Systematic evaluation revealed three synergistic neuroprotective mechanisms: (1) Antioxidant activity: Scopoletin (<b>3</b>) and isoferulic acid (<b>6</b>) showed significant radical scavenging capacity (ABTS assay; IC₅₀ = 27.74, and 18.13 μM, respectively); (2) Neuronal protection: <i>cis</i>-11,14,17-Eicosatrienoic acid methyl ester (<b>14</b>) enhanced survival (93.94% vs. control) in 6-OHDA-induced PC12 cells, surpassing rasagiline (88.36% at equivalent concentrations); (3) MAO-B inhibition: five compounds displayed selective inhibition, with scopoletin (<b>3</b>) exhibiting highest potency (<i>K</i>_i = 20.7 μM). Notably, plant prostaglandins (<b>10/11</b>) were identified as competitive MAO-B inhibitors first time through molecular docking and 100-ns MD simulations, revealing stable binding at the FAD site (ΔG = − 10.42, and − 9.75 kcal/mol, respectively).</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00541-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strophioglandins A–C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.04,13]tridecane core from Strophioblachia glandulosa var. cordifolia","authors":"Jian-Kai Xia,&nbsp;Lei-Ming Wu,&nbsp;Wei-Ye Wu,&nbsp;Dong Huang,&nbsp;Fang-Yu Yuan,&nbsp;Lei Li,&nbsp;Shu-Qi Wu,&nbsp;Yan-Jiang Zhang,&nbsp;Tao Yuan,&nbsp;Xin Chen,&nbsp;Gui-Hua Tang,&nbsp;Jia-Luo Huang,&nbsp;Sheng Yin","doi":"10.1007/s13659-025-00548-1","DOIUrl":"10.1007/s13659-025-00548-1","url":null,"abstract":"<div><p>Strophioglandins A−C (<b>1</b>−<b>3</b>), three highly rearranged norditerpenoids featuring an unusual tricyclo[6.4.1.0^4,13]tridecane core, were isolated from <i>Strophioblachia glandulosa</i> var. <i>cordifolia</i>. Integrated spectroscopic analyses, X-ray crystallography, and ECD calculations synergistically determined their molecular architectures. Remarkably, all compounds manifested potent anti-inflammatory effects in LPS-activated RAW264.7 cells with IC₅₀ values ranging from 7.83 ± 1.11 to 15.09 ± 1.21 μM. Mechanism study revealed that strophioglandin A (<b>1</b>), the most potent compound, could suppress the expression of multiple inflammatory factors by inhibiting the P38 and Erk1/2 MAPK signaling pathways.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00548-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lobetyolin, an anti-AD factor from the diet campanulaceae source, metabolism regulation and target exploration","authors":"Wen Huang,&nbsp;Yihan Liu,&nbsp;Haixin Jiang,&nbsp;Dongxue Guo,&nbsp;Yi Song,&nbsp;Junqi Wang,&nbsp;Luqi Li,&nbsp;Qiang Zhang","doi":"10.1007/s13659-025-00549-0","DOIUrl":"10.1007/s13659-025-00549-0","url":null,"abstract":"<div><p>Bioactive compounds from food-compatible medicinal herbs have shown promise as preventive agents against age-related neurodegenerative conditions, particularly Alzheimer’s disease (AD). The present work aimed to find Lobetyolin as a new suppressor of Aβ aggregation and its interventions on abnormal metabolism in AD. Aβ-expressing <i>Caenorhabditis elegans</i> (strain CL4176) and wild-type worms were employed to evaluate paralysis onset, lifespan, cerebral Aβ deposition, and intracellular reactive oxygen species (ROS) after Lobetyolin administration. Untargeted ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) metabolomics coupled with RNA-seq transcriptomics was carried out to profile systemic metabolic and gene-expression changes. Differential metabolites and transcripts were subjected to Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and pathway-impact analyses; hub targets were prioritized by integrating enrichment scores with in-silico docking. Lobetyolin (12.5–50 µM) markedly protected <i>C. elegans</i> from Aβ-driven toxicity and oxidative stress. In CL2006 worms, β-amyloid deposits fell by 54.8 ± 9.4%, while paralysis in CL4176 was delayed by 20.9 ± 4.5%. Lifespan increased by up to 18.2% in CL4176 and 25.0% in wild-type N2 worms. Concomitantly, intracellular ROS declined maximally by 28.1 ± 8.9% (N2) and 22.4 ± 3.8% (CL4176). Integrative metabolomic–transcriptomic analyses, validated by RT-qPCR, revealed selective remodeling of glutathione metabolism: gst-38 expression was suppressed, whereas gst-1 was elevated. Lobetyolin confers neuroprotective and geroprotective benefits in <i>vivo</i>, primarily through reprogramming glutathione-centered redox metabolism and selectively modulating glutathione-S-transferases (GST) isoforms. These findings position Lobetyolin as a promising dietary lead compound for AD prevention and healthy aging interventions.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00549-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nidulin stimulates glucose uptake in myotubes through the IRS-AKT pathway and alters redox balance and intracellular calcium","authors":"Kanittha Chantarasakha,&nbsp;Arunrat Yangchum,&nbsp;Masahiko Isaka,&nbsp;Surapun Tepaamorndech","doi":"10.1007/s13659-025-00546-3","DOIUrl":"10.1007/s13659-025-00546-3","url":null,"abstract":"<div><p>Nidulin is a secondary metabolite of the depsidone family produced by <i>Aspergillus</i> spp., and has shown promises in pharmacological applications. This study aimed to investigate the effect of nidulin on glucose metabolism in skeletal muscle, the primary site of physiological glucose disposal, and its underlying mechanisms. Using a 2-[³H]-deoxy-glucose (2-DG) uptake assay, nidulin stimulated 2-DG in L6 myotubes in a dose- and time-dependent manner. This effect of nidulin was additive to insulin and metformin, and remained effective under palmitic acid-induced insulin resistance. At the molecular level, nidulin upregulated the mRNA expression and promoted membrane translocation of glucose transporters, GLUT4 and GLUT1. Although nidulin activated AMPK and p38 signaling, pharmacological inhibition of this pathway had minimal effect on nidulin-enhanced 2-DG uptake activity. Notably, nidulin activated key insulin signaling proteins, including IRS1, AKT, and p44/42, and its effect was attenuated by an AKT inhibitor. This study further compared the upstream mechanism of nidulin with that of insulin. While nidulin did not directly activate the insulin receptor β-subunit, it modulated redox homeostasis and intracellular calcium, evidenced by increased cytosolic H₂O₂ and Ca²⁺ levels. The 2-DG uptake-enhancing effect of nidulin and its activation of AKT were suppressed by either an antioxidant or calcium chelator treatment. These findings position nidulin as a promising insulin-sensitizing agent, offering mechanistic insights and therapeutic potential for improving glucose homeostasis in type 2 diabetes.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00546-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chalasoergodimers A–E, heterodimers with multiple polymerization modes from a marine-derived Chaetomium sp. fungus","authors":"Ze-Hong Lin,&nbsp;Han-Wen Shan,&nbsp;Li-Kun Yang,&nbsp;Tian-Tian Sun,&nbsp;Li-Ying He,&nbsp;Hui-Fang Du,&nbsp;Ya-Hui Zhang,&nbsp;Shan Liu,&nbsp;Xu Wang,&nbsp;Du-Qiang Luo,&nbsp;Fei Cao","doi":"10.1007/s13659-025-00544-5","DOIUrl":"10.1007/s13659-025-00544-5","url":null,"abstract":"<div><p>Five new heterodimers, chalasoergodimers A–E (<b>1</b>–<b>5</b>), and three known heterodimers (<b>6</b>–<b>8</b>), along with four chaetoglobosin monomers (<b>9</b>–<b>12</b>), were isolated from a marine-derived <i>Chaetomium</i> sp. fungus. The structures of new compounds <b>1</b>–<b>5</b> were elucidated by HRESIMS, NMR, chemical calculated ¹³C NMR and ECD methods. Among them, compound <b>1</b> was derived from C-2′ substitution of chaetoglobosin Fex (<b>9</b>) with ergosta-4,6,8(14),22-tetraen-3<i>β</i>-ol, representing a new dimerization mode among chaetoglobosin-ergosterol derivative hybrids. Compound <b>2</b> featured substitution at NH-1′ and constituted the first example of this dimeric type bearing an <i>R</i>-configuration at C-3′′. Compounds <b>3</b>–<b>5</b> were formed via a Diels–Alder cycloaddition between chaetoglobosins and 14-dehydroergosterol. Furthermore, it was revealed that compound <b>9</b>–<b>12</b> exhibited the significant cytotoxic activity against the human non-small cell lung cancer cell (A549), with compound <b>12</b> showing the most potent effect at an IC₅₀ of 5.14 μM.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"15 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-025-00544-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}