Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2025-01-02 DOI:10.1007/s13659-024-00485-5

Jiaojiao Ji, Lanlan Zang, Tingting Lu, Cheng Li, Xiaoxu Han, Soo-Rang Lee, Li Wang

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Abstract

Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies have focused on the metabolomic differences among the Angelica species. In this study, widely targeted metabolomics based on gas chromatography-tandem mass spectrometry was employed to analyze the metabolomes of four Angelica species (Angelica sinensis (Oliv.) Diels (A. sinensis), Angelica biserrata (R.H.Shan & Yuan) C.Q.Yuan & R.H.Shan (A. biserrata), Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. (A. dahurica) and Angelica keiskei Koidz. (A. keiskei)). A total of 698 volatile metabolites were identified and classified into fifteen different categories. The metabolomic analysis indicated that 7-hydroxycoumarin and Z-ligustilide accumulated at significantly higher levels in A. sinensis, whereas bornyl acetate showed the opposite pattern. Furthermore, a high correspondence between the dendrogram of metabolite contents and phylogenetic positions of the four species. This study provides a comprehensive biochemical map for the exploitation, application and development of the Angelica species as medicinal plants or health-related dietary supplements.

Graphical Abstract

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广泛靶向代谢组学分析揭示了四种当归挥发物的差异

当归因其传统的药用价值和商业价值而吸引了全球的兴趣。然而，很少有研究关注当归物种之间的代谢组学差异。本研究采用基于气相色谱-串联质谱的代谢组学方法对当归(Angelica sinensis (Oliv.)；白芷（A. sinensis），白芷(R.H.Shan &；袁志强&；单仁辉（A. biserrata），白芷（Hoffm.）Benth。,Hook.f。练习法语。,干腊肠。（A. dahurica）和当归。(答:keiskei))。共鉴定出698种挥发性代谢物，并将其分为15类。代谢组学分析表明，7-羟基香豆素和z -藁本内酯在中华白杨体内的积累量显著高于其他品种，而乙酸龙脑酯的积累量则相反。此外，这四个物种的代谢物含量的树状图与系统发育位置高度对应。本研究为当归作为药用植物或健康膳食补充剂的开发、应用和开发提供了全面的生物化学图谱。图形抽象

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.