Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2025-01-06 DOI:10.1007/s13659-024-00494-4

Dong-Yang Wang, Ming-Xing Li, Yan-Chao Xu, Peng Fu, Wei-Ming Zhu, Li-Ping Wang

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Abstract

A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1–11). Notably, the newly identified dibohemamines I–O (1–7) have not been previously reported. Their structures were elucidated through detailed spectroscopic analysis, encompassing high-resolution electrospray ionization mass, nuclear magnetic resonance, infrared radiation, ultraviolet–visible, and electronic circular dichroism spectroscopy. Dibohemamine I (1) exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated, with the half-inhibitory concentration values of 3.24 ± 0.20 and 7.36 ± 0.41 μM, respectively.

Graphical Abstract

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来自药用和食用植物鱼腥草的内生放线菌链霉菌sp. GZWMJZ-662中的二波西米亚胺I-O。

鱼腥草内生放线菌Streptomyces sp. GZWMJZ-662的化学性质研究得到了11个波西米亚二聚体（1-11）。值得注意的是，新发现的二波西米亚胺I-O（1-7）以前没有报道过。通过详细的光谱分析，包括高分辨率电喷雾电离质量、核磁共振、红外辐射、紫外可见和电子圆二色光谱，阐明了它们的结构。Dibohemamine I(1)对18株肿瘤细胞系786-O和GBC-SD表现出选择性的细胞毒作用，其半抑制浓度分别为3.24±0.20 μM和7.36±0.41 μM。图形抽象

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.