Addictive behaviors最新文献

{"title":"Mediation of beneficial effects of an alcohol-specific inhibition training on drinking of patients with alcohol use disorder: The role of cognitive demands and inhibitory performance","authors":"Alessandra Guarriello ,&nbsp;Tim Fleckenstein ,&nbsp;Leila M. Soravia ,&nbsp;Raphaela M. Tschuemperlin ,&nbsp;Hallie M. Batschelet ,&nbsp;Joshua Jaeger ,&nbsp;Reinout W. Wiers ,&nbsp;Franz Moggi ,&nbsp;Maria Stein","doi":"10.1016/j.addbeh.2024.108212","DOIUrl":"10.1016/j.addbeh.2024.108212","url":null,"abstract":"<div><h3>Background</h3><div>A cognitively demanding, alcohol-specific inhibition training (Alc-IT) might enhance treatment success in patients with severe alcohol use disorder (AUD; Stein et al., 2023). An inhibitory working mechanism for Alc-IT has been discussed, but compelling evidence supporting this hypothesis is yet lacking. The present study investigates inhibitory performance during Alc-IT and examines whether inhibitory parameters mediate drinking outcome.</div></div><div><h3>Methods</h3><div>Patients with AUD (<em>N</em> = 232) completed six sessions of either a standard or improved Alc-IT, differing in their inhibitory demands determined by Go/NoGo-ratios in a modified Go-NoGo-task, or a control training. During these training sessions, data on inhibitory performance was collected. To assess differences in inhibitory performance and its improvement, <em>alcohol-related errors of commission</em> and <em>relative performance,</em> integrating accuracy and speed, were analyzed with hierarchical linear contrast models. Mediation analyses tested whether inhibitory performance predicted drinking outcome (percent days abstinent at 3-month follow-up).</div></div><div><h3>Results</h3><div>Patients in improved Alc-IT started with higher <em>errors of commission</em> (γ_01(standard) =  −2.74, <em>p</em> &lt; 0.001, R² = 0.885) and a lower <em>relative performance</em> in the first training session compared to standard Alc-IT (γ_01(standard) = 0.51, <em>p</em> = 0.004). They showed a steeper increase in <em>relative performance</em> until the final sixth session (γ_{1(s6),(standard)} = −0.37, <em>p</em> = 0.024, R² = 0.882). The effect of improved Alc-IT on drinking outcome was mediated by <em>relative performance</em> increase (bootstrap-CI [0.15, 7.11]).</div></div><div><h3>Conclusion</h3><div>Higher inhibitory demands enable larger improvements across sessions. Mediation analysis supports an inhibitory working mechanism. Tailoring inhibitory demands to individual performance capacity could optimize future Alc-IT.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"161 ","pages":"Article 108212"},"PeriodicalIF":3.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding US adolescents’ and emerging adults’ overestimation of their cannabis use quantity","authors":"Ruschelle M. Leone ,&nbsp;Rachel L. Tomko ,&nbsp;Chandni Hindocha ,&nbsp;Loren Hardeman ,&nbsp;Jade Tuttle ,&nbsp;Kevin M. Gray","doi":"10.1016/j.addbeh.2024.108206","DOIUrl":"10.1016/j.addbeh.2024.108206","url":null,"abstract":"<div><div>Cannabis is the most used federally illicit drug in the United States (U.S). Understanding how accurate adolescents and emerging adults are at estimating their cannabis use quantity is important, as this lays the groundwork for understanding and studying the outcomes associated with cannabis use. This study aimed to assess the accuracy of cannabis quantity in grams for a typical joint and identify predictors of accuracy among U.S. adolescents and emerging adults. Participants (n = 50; aged 14–21) who reported using joints in the past 30 days completed measures of cannabis use characteristics and problems, were asked to “eyeball” the amount of cannabis in their average joint using a cannabis substitute and estimated the number of grams. The cannabis substitute was then weighed in grams. Paired samples t-tests indicated that participants <em>estimated</em> significantly more grams in a joint (<em>M=</em>.82; <em>SD</em> = 0.46) than the <em>actual</em> amount of the surrogate substance (<em>M=</em>.47; <em>SD</em> = 0.21; <em>t</em>(49) = 6.32, <em>p</em> &lt; 0.001, <em>d</em> = 0.89). A linear regression analysis indicated that the age of cannabis initiation (<em>B =</em> -0.13<em>, p=</em>.002) and cannabis use problems (<em>B =</em> -0.03<em>, p=</em>.009) were negatively and significantly associated with discrepancies in estimated grams. Specifically, being older when first using cannabis and reporting more cannabis use problems were linked to less overestimation of grams per joint. These findings align with previous research demonstrating a tendency to overestimate cannabis quantity and contribute novel insights by identifying predictors of estimation accuracy. This study underscores the importance of considering age and cannabis-related problems when assessing the reliability of self-reported cannabis use quantities among adolescents and emerging adults.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"161 ","pages":"Article 108206"},"PeriodicalIF":3.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The transition from cigarette smoking to the exclusive or partial use of e-cigarettes: A multi-stage mixed methods study among French university students","authors":"Shérazade Kinouani ,&nbsp;Héléna Da Cruz ,&nbsp;Maximilien Simon ,&nbsp;Maëlys Abraham ,&nbsp;Garance Perret ,&nbsp;Emmanuel Langlois ,&nbsp;Christophe Tzourio","doi":"10.1016/j.addbeh.2024.108205","DOIUrl":"10.1016/j.addbeh.2024.108205","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have estimated the frequency of e-cigarette use by smoking status among French young adults, and how those who smoke tobacco start and continue to use e-cigarettes. Our aim was to describe e-cigarette use among students who smoked tobacco.</div></div><div><h3>Methods</h3><div>A multi-stage, mixed methods study was conducted at the University of Bordeaux between September 2018 and March 2020. The study consisted of three different sub-studies: 1) a cross-sectional study across five campuses (n = 211), 2) a qualitative study (n = 30), and 3) an online cross-sectional study (n = 415). These were combined to form an explanatory sequential design (stage 1) and then a convergent parallel design (stage 2).</div></div><div><h3>Results</h3><div>Although 41 % of students had tried e-cigarettes at least once in their lifetime, only 7 % were current users. Both e-cigarette experimentation and current use (i.e. occasional or daily use) were mainly found among current and former smokers. Student smokers started using e-cigarettes out of curiosity, with other vapers. Two main factors were identified as intervening in the transition from smoking to sustained vaping: the perception of smoking as problematic and personal commitment to e-cigarette use (i.e. by buying their own device, acquiring technical skills, and increasing the frequency of use). Among current vapers, exclusive vapers and dual users differed in terms of their smoking goals, the role they attributed to e-cigarettes, their identity development and their perceived social or personal benefits.</div></div><div><h3>Conclusion</h3><div>This study highlighted the complexity of the decision-making process for transitioning from smoking to sustained vaping among university students. This required a socially supportive environment and some intrinsic factors, of which the problematization of smoking and personal commitment to vaping were key factors.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"161 ","pages":"Article 108205"},"PeriodicalIF":3.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing the transitions in poly-tobacco use among young adults: A latent transition analysis of a smoking reduction intervention trial","authors":"Lisbeth Lund,&nbsp;Christian Ritz,&nbsp;Lotus Sofie Bast,&nbsp;Marie Pil Jensen,&nbsp;Susan Andersen","doi":"10.1016/j.addbeh.2024.108195","DOIUrl":"10.1016/j.addbeh.2024.108195","url":null,"abstract":"<div><h3>Objective</h3><div>The escalating trends in poly-tobacco use among young people are worrying due to the heightened health consequences associated with use. This study aims to re-analyze data from a smoking reduction intervention applying latent transition analysis (LTA) to explore the effect of a smoking reduction intervention on the transition between tobacco and nicotine use behavior patterns, particularly poly-tobacco use, over time. Additionally, the effect of sociodemographic variables on transition patterns was explored.</div></div><div><h3>Methods</h3><div>From 2018 to 2020, a two-armed randomized controlled trial was conducted to evaluate a smoking reduction intervention focusing on a comprehensive school tobacco policy across 14 vocational schools in Denmark. Baseline and five-month follow-up surveys assessed self-reported use of cigarettes, e-cigarettes, smokeless tobacco, and waterpipe. This study was a secondary data analysis using latent transition analysis (LTA). The primary analysis of the trial did not find a significant overall effect of the intervention on tobacco use.</div></div><div><h3>Results</h3><div>A total of 2,158 students completed the baseline and/or follow-up surveys (mean age: 20.8 years, 49.5 % female). At both time points, three latent classes of tobacco and nicotine use behavior emerged (<em>non-users</em>, <em>cigarette users</em>, and <em>poly-tobacco users</em>). Intervention school students had 36 % lower odds of transitioning from cigarette use at baseline to poly-tobacco use at follow-up (OR = 0.64; 95 % CI 0.41,0.99, p = 0.047) compared to control school students. Males and younger students had increased odds of transitioning from cigarette use to poly-tobacco. In contrast, students of non-Danish origins had increased odds of transitioning from poly-tobacco use to non-use.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the effectiveness of a smoking reduction intervention in reducing the progression toward poly-tobacco use among vocational school students.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"161 ","pages":"Article 108195"},"PeriodicalIF":3.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations and mediating factors between adverse childhood experiences and substance use behaviours in early adulthood: A population-based longitudinal study","authors":"Deirdre Mongan ,&nbsp;Seán R Millar ,&nbsp;Margaret M Brennan ,&nbsp;Anne Doyle ,&nbsp;Brian Galvin ,&nbsp;Noel McCarthy","doi":"10.1016/j.addbeh.2024.108194","DOIUrl":"10.1016/j.addbeh.2024.108194","url":null,"abstract":"<div><h3>Background</h3><div>Research has demonstrated positive associations between adverse childhood experiences (ACEs) and substance use behaviours in young adults. However, many of these are based on cross-sectional data. The pathway between ACEs and substance misuse among emerging adults is also not fully understood and few studies have investigated potential mediating factors.</div></div><div><h3>Methods</h3><div>We analysed data from the Child Cohort of the Growing Up in Ireland study, a nationally representative longitudinal sample of children recruited at 9 years of age (n = 4,729). Logistic regression was used to examine individual and cumulative ACE exposure relationships with substance use at age 20 years. Mediation analyses were used to assess whether parental and peer relationships and school engagement mediate ACE history associations with substance use behaviours.</div></div><div><h3>Results</h3><div>ACE exposure relationships with current cannabis use, other illicit drug use and problematic drug use were observed. In particular, young adults who had experienced 2 ACEs or 3 + ACEs had an approximate two-fold (OR=1.80, 95 % CI: 1.29, 2.51) and approximate three-fold (OR=2.94, 95 % CI: 2.06, 4.19) increased odds of problematic drug use, respectively, when compared to participants who had experienced no ACEs during the study period. Mediation analyses suggested that parent and peer attachment and liking school partially mediate relationships between ACEs and substance use behaviours.</div></div><div><h3>Conclusions</h3><div>Children who have experienced ACEs are at higher risk of future substance use and problematic drug use. In supporting these children, identified mediators such as interpersonal relationships and school engagement may help guide selection of prevention interventions.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"161 ","pages":"Article 108194"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis use and associated longitudinal transitions in electronic nicotine delivery systems use among young adults in the United States","authors":"Alexandra Loukas ,&nbsp;C. Nathan Marti ,&nbsp;Melissa B. Harrell ,&nbsp;Keryn E. Pasch ,&nbsp;Anna V. Wilkinson","doi":"10.1016/j.addbeh.2024.108191","DOIUrl":"10.1016/j.addbeh.2024.108191","url":null,"abstract":"<div><h3>Objective</h3><div>Cannabis is increasingly the first substance used by young people and research indicates that cannabis use may precede the onset of tobacco use. Little is known, however, about the role of cannabis use in stages of electronic nicotine delivery systems (ENDS) uptake and progression across young adulthood. This study examined the associations between past 30-day (P30D) cannabis use frequency and transitions in ENDS use among young adults. <em>Methods</em>: 5,018 18–29-year-olds (64.2% female) were recruited from 24 Texas colleges to participate in a multi-wave study across a 4.5-year period from 2014 to 2019. A continuous time, multi-state Markov model was used to assess associations between P30D cannabis use frequency and three ENDS use transitions, spanning at least six months 1) never to P30D use (initiation); 2) P30D to non-P30D use (desistance); and 3) non-P30D to P30D use (re-uptake). The model also included socio-demographic and time-varying intrapersonal (other tobacco use, alcohol use, sensation seeking, depressive symptoms) and interpersonal (peer ENDS use) confounding factors. <em>Results</em>: Past 30-day cannabis use frequency was associated with an increased probability of ENDS initiation and decreased probability of desistance in the model adjusted for socio-demographic and confounding factors. Past 30-day cannabis use frequency was not associated with an increased probability of ENDS re-uptake in the adjusted model. <em>Conclusions</em>: Cannabis use is associated with the uptake and continuation of ENDS use. Findings are concerning given that the most popular ENDS devices used by young adults contain high concentrations of nicotine that increase the risk for nicotine dependence and lifelong use.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"160 ","pages":"Article 108191"},"PeriodicalIF":3.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel smoking cessation behavior based on quit attempts may identify new genes associated with long-term abstinence","authors":"Adriana Lori,&nbsp;Alpa V. Patel,&nbsp;J. Lee Westmaas,&nbsp;W. Ryan Diver","doi":"10.1016/j.addbeh.2024.108192","DOIUrl":"10.1016/j.addbeh.2024.108192","url":null,"abstract":"<div><h3>Background</h3><div>Smoking cessation at any age has been shown to improve quality of life, decrease illness, and reduce mortality. About half of smokers attempt to quit each year, but only ∼ 7 % maintain long-term abstinence unaided. Few genetic factors have been consistently associated with smoking cessation, possibly due to poor phenotype definition.</div></div><div><h3>Methods</h3><div>We performed a genome-wide association study (GWAS) with an alternative phenotype based on the difficulty of quitting smoking (DQS) in the Cancer Prevention Study-3 cohort. Difficult quitters were defined as having made at least ten quit attempts, whether successful or not, and easy quitters as having quit after only one attempt. Only individuals of European ancestry were selected for the study. Among 10,004 smokers (5,071 difficult quitters, 4,933 easy quitters), we assessed the genetic heritability of DQS and evaluated associations between DQS and each genome-wide variant using logistic regression while adjusting for confounders, including smoking intensity (cigarettes per day).</div></div><div><h3>Results</h3><div>The genetic heritability of the DQS phenotype was 13 %, comparable to, or higher than, the reported heritability of other smoking behaviors (e.g., smoking intensity, cessation). Although no variants were genome-wide significant, several genes were identified at a subthreshold level (p &lt; 10^-4). A variant in <em>MEGF9</em> (rs149760032)<em>,</em> a transmembrane protein largely expressed in the central nervous system, showed the strongest association with DQS (OR = 0.60, p = 1.3x10^-7). Additional variants associated with DQS independently by smoking intensity were also detected in <em>GLRA3</em> (rs73006492, OR = 0.77, p = 5.6x10^-7) and <em>FOCAD</em> (rs112251973, OR = 1.96, p = 1.8x10^-6) and are plausibly related to smoking cessation through pathways in the brain and respiratory system.</div></div><div><h3>Conclusions</h3><div>The use of an alternative cessation phenotype based on difficulty quitting smoking facilitated the identification of new pathways that could lead to unique smoking treatments.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"161 ","pages":"Article 108192"},"PeriodicalIF":3.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocrates in addiction and the need for transdiagnostic phenotypes to address evidence-based interventions","authors":"Mauro Pettorruso,&nbsp;Francesco Di Carlo,&nbsp;Giorgio Di Lorenzo,&nbsp;Giovanni Martinotti","doi":"10.1016/j.addbeh.2024.108190","DOIUrl":"10.1016/j.addbeh.2024.108190","url":null,"abstract":"","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"160 ","pages":"Article 108190"},"PeriodicalIF":3.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of intentional self-regulation in the constructive and pathological compensation processes of problematic social networking use","authors":"Qianqian Li ,&nbsp;Tianlong Chen ,&nbsp;Shujing Zhang ,&nbsp;Chuanhua Gu ,&nbsp;Zongkui Zhou","doi":"10.1016/j.addbeh.2024.108188","DOIUrl":"10.1016/j.addbeh.2024.108188","url":null,"abstract":"<div><div>Perceived social isolation is a key predictor of college students’ problematic social networking site use (PSNSU). According to the Fear-Driven/Compensation-Seeking Hypothesis, reducing the fear of social isolation and compensating for social deficits serve as negative reinforcement motivations for SNS use, which may potentially result in PSNSU. This study investigated the association between perceived social isolation and PSNSU through the mediating roles of intentional self-regulation and parasocial relationships from a compensatory perspective. Additionally, gender differences in the mediating model were examined. Findings from an online survey of 893 college students in China revealed a positive relationship between perceived social isolation and PSNSU. The serial mediation model showed that intentional self-regulation and parasocial relationships both had positive individual mediating effects, as well as a negative serial mediating effect. Moreover, these mediating effects were only significant among women. The findings suggest that in the association between perceived social isolation and PSNSU, the mediating role of intentional self-regulation forms a constructive compensatory process, while its serial mediating role through parasocial relationships forms a pathological compensatory process. Interventions for PSNSU should take the mediating role of intentional self-regulation in constructive compensation process and the gender difference into consideration.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"160 ","pages":"Article 108188"},"PeriodicalIF":3.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol and cannabis co-use: Probing subjective response in eliciting cross-substance craving","authors":"Kaitlin R. McManus ,&nbsp;Alexandra Venegas ,&nbsp;Ziva D. Cooper ,&nbsp;Lara A. Ray","doi":"10.1016/j.addbeh.2024.108189","DOIUrl":"10.1016/j.addbeh.2024.108189","url":null,"abstract":"<div><div>The co-use of alcohol and cannabis is rising in prevalence, yet the mechanisms driving individuals to co-use are not well understood. Subjective response to alcohol or cannabis may predict the desire to use either substance. However, which specific facets of subjective response predict cross-substance craving remains unclear. The present study investigated whether acute administration of alcohol or cannabis facilitates cue-induced craving for the other substance, with an emphasis on the underlying subjective response mechanisms contributing to co-use. This is a secondary analysis of a behavioral pharmacology study that combined alcohol/cannabis administration with a cross-substance cue-reactivity paradigm in individuals who were heavy alcohol and heavy cannabis co-users. Over two sessions, twenty-nine individuals (17M/12F) self-administered alcohol or cannabis (in a crossover design), and then completed a cue-reactivity exercise with the other substance. Analyses tested how changes in subjective response variables following substance administration predicted cross-substance cue-induced craving. Following alcohol administration, greater subjective ratings of positive mood predicted significantly greater cue-induced cannabis craving (β = 1.14, SE = 0.41, t = 2.80, <em>p</em> = 0.010). Following cannabis administration, lower subjective effects ratings of positive mood/arousal predicted significantly greater cue-induced alcohol craving (β = −1.08, SE = 0.38, t = −2.85, p = 0.009; β = −2.38, SE = 1.13, t = −2.10, p = 0.047). This study identified subject response mechanisms contributing to cross-substance cue induced craving. These mechanisms include increases in positive mood following alcohol use and decreases in positive mood and arousal, akin to increases in relaxation, following cannabis use.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"160 ","pages":"Article 108189"},"PeriodicalIF":3.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}