Erica Cruvinel , Alexandra Brown , Amanda Pritchard , Matthew S. Mayo , Lisa Sanderson Cox , Eleanor L.S. Leavens , Nicole L. Nollen
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Medication adherence was defined as taking at least 80 % of the prescribed medication for the entire treatment. Characteristics associated with 18-week adherence included demographic, psychosocial, smoking characteristics, substance use, medication experience, early treatment response, and adverse events. A best-subsets regression analyses were performed with all characteristics, and descriptive statistics were used to summarize the reasons for non-adherence to medication.</div></div><div><h3>Results</h3><div>One hundred seventy-seven participants were compliant with their medication. Participants randomized to the ADT (OR = 2.40, 95 % CI = 1.52–3.81, p < 0.001) and with more positive medication experience (OR = 1.28, 95 % CI = 1.14–1.45, p < 0.001) were more likely to be adherent to study medications. The most common reason for non-adherence was “forgetting or losing the medication” (49.1 %).</div></div><div><h3>Conclusions</h3><div>Over half of our sample were adherent to their pharmacotherapy, and those randomized to adaptive therapy, coupled with a positive experience with their medication, exhibited better overall compliance with their long-term pharmacotherapy. Reasons for not taking medications were similar to the existing literature.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"170 ","pages":"Article 108431"},"PeriodicalIF":3.6000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characteristics associated with medication adherence in a randomized clinical trial of multiple pharmacotherapy adaptations based on treatment response in black adults who smoke\",\"authors\":\"Erica Cruvinel , Alexandra Brown , Amanda Pritchard , Matthew S. Mayo , Lisa Sanderson Cox , Eleanor L.S. Leavens , Nicole L. Nollen\",\"doi\":\"10.1016/j.addbeh.2025.108431\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Pharmacotherapy is a key component of evidence-based smoking cessation treatment and a major predictor of success in quitting. 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A best-subsets regression analyses were performed with all characteristics, and descriptive statistics were used to summarize the reasons for non-adherence to medication.</div></div><div><h3>Results</h3><div>One hundred seventy-seven participants were compliant with their medication. Participants randomized to the ADT (OR = 2.40, 95 % CI = 1.52–3.81, p < 0.001) and with more positive medication experience (OR = 1.28, 95 % CI = 1.14–1.45, p < 0.001) were more likely to be adherent to study medications. The most common reason for non-adherence was “forgetting or losing the medication” (49.1 %).</div></div><div><h3>Conclusions</h3><div>Over half of our sample were adherent to their pharmacotherapy, and those randomized to adaptive therapy, coupled with a positive experience with their medication, exhibited better overall compliance with their long-term pharmacotherapy. 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引用次数: 0
摘要
药物治疗是循证戒烟治疗的关键组成部分,也是戒烟成功的主要预测因素。然而,大多数在临床试验中试图戒烟的人都不能完全坚持他们的药物治疗。目的和方法评估参与临床试验的黑人成年人坚持戒烟药物治疗的相关因素,并了解不坚持治疗的原因。数据来自333名参与者,他们参加了一项针对戒烟的适应疗法(ADT)或强化常规护理(UC)的随机临床试验。药物依从性被定义为在整个治疗过程中至少服用处方药物的80%。与18周依从性相关的特征包括人口统计学、社会心理、吸烟特征、物质使用、用药经历、早期治疗反应和不良事件。对所有特征进行最佳子集回归分析,并使用描述性统计来总结不遵守药物治疗的原因。结果177名受试者的服药依从性良好。随机分配到ADT组的参与者(OR = 2.40, 95% CI = 1.52-3.81, p <;0.001)和更积极的用药经历(OR = 1.28, 95% CI = 1.14-1.45, p <;0.001)更有可能坚持服用研究药物。最常见的原因是“忘记或丢失药物”(49.1%)。我们的样本中有超过一半的人坚持他们的药物治疗,而那些随机接受适应性治疗的人,加上他们对药物的积极体验,表现出更好的长期药物治疗的总体依从性。不服药的原因与已有文献相似。
Characteristics associated with medication adherence in a randomized clinical trial of multiple pharmacotherapy adaptations based on treatment response in black adults who smoke
Introduction
Pharmacotherapy is a key component of evidence-based smoking cessation treatment and a major predictor of success in quitting. However, most people attempting to quit in clinical trials fail to fully adhere to their pharmacological treatments.
Aims and methods
To assess factors associated with adherence to smoking cessation pharmacotherapies among Black adults participating in a clinical trial and to understand reasons for non-adherence to treatment. Data came from 333 participants enrolled in a randomized clinical trial of adapted therapy (ADT) or enhanced usual care (UC) for smoking cessation. Medication adherence was defined as taking at least 80 % of the prescribed medication for the entire treatment. Characteristics associated with 18-week adherence included demographic, psychosocial, smoking characteristics, substance use, medication experience, early treatment response, and adverse events. A best-subsets regression analyses were performed with all characteristics, and descriptive statistics were used to summarize the reasons for non-adherence to medication.
Results
One hundred seventy-seven participants were compliant with their medication. Participants randomized to the ADT (OR = 2.40, 95 % CI = 1.52–3.81, p < 0.001) and with more positive medication experience (OR = 1.28, 95 % CI = 1.14–1.45, p < 0.001) were more likely to be adherent to study medications. The most common reason for non-adherence was “forgetting or losing the medication” (49.1 %).
Conclusions
Over half of our sample were adherent to their pharmacotherapy, and those randomized to adaptive therapy, coupled with a positive experience with their medication, exhibited better overall compliance with their long-term pharmacotherapy. Reasons for not taking medications were similar to the existing literature.
期刊介绍:
Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings.
Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.