Acta Poloniae Pharmaceutica - Drug Research最新文献_第6页

Evaluation of immune status and selected sirtuins in people living with HIV after fully vaccinating for COVID-19 评估完全接种 COVID-19 疫苗后艾滋病毒感染者的免疫状态和选定的 sirtuins

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2024-02-01 DOI: 10.32383/appdr/175542

Beata Szymańska, Monika Stępień, B. Knysz, Małgorzata Zalewska, Dawid Radziszewski, Hubert Ciepłucha, B. Szetela, Aleksandra Szymczak, A. Piwowar

{"title":"Evaluation of immune status and selected sirtuins in people living with HIV after fully vaccinating for COVID-19","authors":"Beata Szymańska, Monika Stępień, B. Knysz, Małgorzata Zalewska, Dawid Radziszewski, Hubert Ciepłucha, B. Szetela, Aleksandra Szymczak, A. Piwowar","doi":"10.32383/appdr/175542","DOIUrl":"https://doi.org/10.32383/appdr/175542","url":null,"abstract":"The introduction of protective vaccination against COVID-19 was a turning point in the fight against the pandemic. Expectations also concerned the effectiveness of vaccines in inducing a strong immune response against the SARS-CoV-2 virus and the length of post-vaccination immunity. This topic seems to be especially important in the case of immunocompromised people such as those living with HIV (PLWH). The aim of the study was to examine the concentration of anti-SARS-CoV-2 IgG antibodies against the S1 subunit of the virus’spike protein as a marker of humoral response and the concentration of interferon-gamma (IFN-γ) as an indicator of cellular response in PLWH undergoing combination antiretroviral therapy (cART) and uninfected people (control group) several months after the COVID-19 booster. Concentrations of selected enzymes from the group of sirtuins (SIRT1,-3,-6) that participate in the course of HIV infection were also examined. Concentrations of IgG and IFN-γ were statistically significantly lower in PLWH compared to the control group. Correlations between IgG and IFN-γ concentrations were found both in PLWH and in the control group. Only the concentration of SIRT-6 was significantly lower in PLWH compared to the control group. Vaccination for COVID-19 enabled good long-term humoral and cellular immunity in both HIV positive and uninfected people. The CD4/CD8 ratio and T CD8+ T lymphocytes count played a role in the long-term immune response to booster vaccination. The introduction of optimal cART stabilized the immune status of PLWH and had a positive effect on the humoral and cellular response against infection SARS-CoV- 2.","PeriodicalId":7135,"journal":{"name":"Acta Poloniae Pharmaceutica - Drug Research","volume":"40 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139686876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polish physicians' views on compounded medicines and factors related to the frequency of their prescription 波兰医生对复方药物的看法及其处方频率的相关因素

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2024-02-01 DOI: 10.32383/appdr/178181

Piotr Guzy, Andrzej Porębski, Sławomir Łudzik, Natalia Obajtek, Anna Gołda

{"title":"Polish physicians' views on compounded medicines and factors related to the frequency of their prescription","authors":"Piotr Guzy, Andrzej Porębski, Sławomir Łudzik, Natalia Obajtek, Anna Gołda","doi":"10.32383/appdr/178181","DOIUrl":"https://doi.org/10.32383/appdr/178181","url":null,"abstract":"The aim of this study was to verify if there is a relationship between physicians' specialization, place of practice, or views on issues related to compounded medicines and the frequency of prescribing such formulations. Additionally, the study aimed to determine the factors that influence these views. The study also examined the barriers and encouragements, according to physicians, in the use of compounded medicines. The original questionnaire was developed specifically for this study. Included sample consisted of Polish-speaking physicians whose main specialization was gynaecology, gastroenterology, dermatology, family medicine, internal medicine, otorhinolaryngology, paediatric otorhinolaryngology, paediatrics. Answers were gathered using computer-assisted telephone interview. The majority of surveyed physicians believed that every Polish patient receives treatment tailored to their personal needs (68,7%) and agreed that compounded medicines are a way to facilitate individualization of pharmacotherapy (79,3%). Frequency of prescribing of magistral formulations, as well as views on quality of compounded medicines, ease of prescribing, and filling a prescription vary between specializations and places of practice. The problem that negatively affects the practice of the largest group of respondents was complicated and frequently changing legal regulations (63.3%), while the least frequently indicated problems were concerns about the quality of preparation (16.7%). Based on opinion of surveyed physicians, a simplification of the regulations for prescribing and liberalization of reimbursement rules are main changes to consider in order to improve clinical practice in the areas where it relates to the prescription of compounded medicines.","PeriodicalId":7135,"journal":{"name":"Acta Poloniae Pharmaceutica - Drug Research","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139892486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the consumption of potentially goitrogenic food products in various models of plant-based diets in Poland 对波兰各种植物性膳食模式中可能含有甲状腺素的食品消费量的评估

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2024-02-01 DOI: 10.32383/appdr/176361

Jadwiga Kryczyk-Kozioł, P. Zagrodzki, Robert Podsiadły, A. Galanty, P. Paśko

{"title":"Evaluation of the consumption of potentially goitrogenic food products in various models of plant-based diets in Poland","authors":"Jadwiga Kryczyk-Kozioł, P. Zagrodzki, Robert Podsiadły, A. Galanty, P. Paśko","doi":"10.32383/appdr/176361","DOIUrl":"https://doi.org/10.32383/appdr/176361","url":null,"abstract":"The aim of this study was to evaluate the consumption frequency of the selected examples of goitrogenic foods in four different groups of people in Poland, who used traditional, vegetarian, vegan and pescovegetarian diets. The validated consumption frequency questionnaire of the examples of goitrogenic foods in four groups of people (n=365) on afore-mentioned diets, was performed in Poland in 2022. The statistical correspondence analysis model (CAM) was used to quantify and reveal potential relations between dietary habits and thyroid dysfunction, family history of thyroid disease, use of thyroid drugs (L-thyroxine, propylthiouracil, thiamazole), or iodine dietary supplements/drugs. Statistical analyses revealed an increased odds ratio more than 3, 8, and 6 times higher for tofu; plant-based meat; and soy beverages, respectively, by vegetarian’s vs traditional diet. Respondents with diagnosed hypothyroidism consumed soy, flax products, but avoided iodine-rich products. All respondents on traditional diet used iodine-rich products while 22% vegetarian and 23% vegan excluded them. CAM analysis did not show any relation between brassica vegetables and thyroid dysfunction. Despite the results obtained using food questionnaire were not combined with biochemicals data, some tendencies in food behavior among Polish vegans, vegetarians, and pescovegetarians appeared. Apart from some interesting correlations and tendencies, revealed in our study, further in-depth research, combined with biochemical analysis, will allow to better understand, and explain these observations. Still, the effort should be made in the future in equalizing the proportions of female and male participants of such studies, what should bring some additional data on the gender influence.","PeriodicalId":7135,"journal":{"name":"Acta Poloniae Pharmaceutica - Drug Research","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139687748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Content of selected polyphenolic compounds in four Sambucus nigra l. cultivars in relation to their antimicrobial activity 四种黑三叶草栽培品种中某些多酚化合物的含量与其抗菌活性的关系

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2024-02-01 DOI: 10.32383/appdr/175051

I. Korona-Głowniak, Martyna Kasela, Barbara Pliszka, D. Zalewski, Anna Malm

{"title":"Content of selected polyphenolic compounds in four Sambucus nigra l. cultivars in relation to their antimicrobial activity","authors":"I. Korona-Głowniak, Martyna Kasela, Barbara Pliszka, D. Zalewski, Anna Malm","doi":"10.32383/appdr/175051","DOIUrl":"https://doi.org/10.32383/appdr/175051","url":null,"abstract":"European elderberry (Sambucus nigra L.) fruits constitute a valuable source of biologically active compounds useful in the pharmaceutical industry. We aimed to determine the content of chosen polyphenolic compounds in fruit extracts from four cultivars of elderberry (Alleso, Korsor, Sampo, Samyl) and their relation to antibacterial and antifungal activity. The content of polyphenols was determined with the use of high-performance liquid chromatography (HPLC), while antimicrobial activity, including minimum inhibitory concentration (MIC), minimum bactericidal (MBC) or fungicidal (MFC) concentration, was studied with the use of microbroth dilution method. HPLC analysis revealed the presence of concentrations of cyanidin glycosides, caffeic and quercetin derivatives depending on the plant cultivar. The extracts exhibited the highest antibacterial activity against Staphylococcus spp. (MIC = 0.313 – 0.625 mg/mL) and Helicobacter pylori (MIC = 0.313 – 1.25 mg/mL) and antifungal against Candida albicans and C. parapsilosis (MIC = 0.313 – 2.5 mg/mL). Results showed that the concentration of cyanidin glycosides, caffeic and quercetin derivatives depended on the analyzed S. nigra L. cultivar and pointed towards a correlation between their high content and antimicrobial activity. These results support the idea that elderberry fruits contain bioactive compounds providing them significant antimicrobial potential.","PeriodicalId":7135,"journal":{"name":"Acta Poloniae Pharmaceutica - Drug Research","volume":"15 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139815928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emulsions, their quality and importance in food, cosmetic, and pharmaceutical industries 乳液及其质量和在食品、化妆品和制药业中的重要性

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2024-01-30 DOI: 10.32383/appdr/174249

Magdalena Wozniak, M. Kowalska, Piotr Ludwiński

引用次数: 0

Monoterpenes as Medicinal Agents: Exploring the Pharmaceutical Potential of p-Cymene, p-Cymenene, and γ-Terpinene 作为药剂的单萜类化合物：探索对伞花烯、对伞花烯和γ-萜品烯的药用潜力

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2024-01-30 DOI: 10.32383/appdr/178242

Sylwia Bagińska, Aleksandra Golonko, R. Świsłocka, W. Lewandowski

{"title":"Monoterpenes as Medicinal Agents: Exploring the Pharmaceutical Potential of p-Cymene, p-Cymenene, and γ-Terpinene","authors":"Sylwia Bagińska, Aleksandra Golonko, R. Świsłocka, W. Lewandowski","doi":"10.32383/appdr/178242","DOIUrl":"https://doi.org/10.32383/appdr/178242","url":null,"abstract":"This review highlights the therapeutic propeties of monoterpenes, particularly γ-terpinene, p-cymene, and p-cymenene, found in essential oils derived from various plants. These compounds are known for their analgesic, anticancer, anti-inflammatory, and antimicrobial properties. γ-Terpinene is recognized for its potent antioxidant propeties and is a constituent of oils from plants such as cumin and thyme. p-cymene, found in over 100 plant species, is noted for its antiviral and antibacterial properties and is considered safe by IFRA standards. p-Cymenene, with its distinct aroma, is detected in parsley and turmeric oils and is known for its antibacterial and antioxidant activities. The antimicrobial properties of γ-terpinene and p-cymene are highlighted, demonstrating their effectiveness in treating various skin conditions and reducing airborne microbes. Their selective antimicrobial activity preserves the integrity of the microbiome, offering a balanced approach to infection control. The anti-inflammatory properties of γ-terpinene are emphasized, with studies indicating its role in modulating cytokine production, underscoring its potential in the treatment of inflammation. Additionally, its antinociceptive effects suggest that it is a safe analgesic. In cancer treatment, the antiproliferative effects of γ-terpinene and p-cymene are being explored, highlighting their potential for targeted cancer therapy. This review aims to consolidate knowledge about these monoterpenes and promote a deeper understanding of their medical applications and safety. The knowledge gained is expected to stimulate further research, potentially leading to innovative applications in pharmaceutical and medical fields and harnessing the potential of -terpinene, p-cymene, and p-cymenene.","PeriodicalId":7135,"journal":{"name":"Acta Poloniae Pharmaceutica - Drug Research","volume":"129 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140482078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural polymorphism research of alverine citrate 柠檬酸阿尔维林的结构多态性研究

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2024-01-30 DOI: 10.32383/appdr/175084

Magdalena Janczura, N. Rosiak, Marta Gromek, J. Cielecka‐Piontek

{"title":"Structural polymorphism research of alverine citrate","authors":"Magdalena Janczura, N. Rosiak, Marta Gromek, J. Cielecka‐Piontek","doi":"10.32383/appdr/175084","DOIUrl":"https://doi.org/10.32383/appdr/175084","url":null,"abstract":"The study compares the active substance alverine citrate from three commercial sources in order to demonstrate polymorphic forms using the XRPD, SEM, and ATR-FTIR techniques. Based on the solubility tests of alverine citrate, a hard capsule was prepared with the highest possible dose of the active substance. The release profiles of alverine citrate and its stability were also investigated. XRPD and ATR-FTIR analysis shows that all alverine citrate samples (despite differences in the synthesis process) are in the same polymorphic Form I. Scanning electron micrographs of alverine citrate from each manufacturer show differences in morphology (texture). The solubility studies confirmed the complete solubility of the highest dose of alverine citrate in media with a pH of 1.2-6.8. The release studies show that the release of the active substance, regardless of the manufacturer type, meets the immediate release requirement. Accelerated stability studies confirm the stability of the alverine citrate from selected manufacturers. As a result, the manufacturer of the final medicinal product may allow their inter-changeability during production without compromising the safety or efficacy of the medicinal product.","PeriodicalId":7135,"journal":{"name":"Acta Poloniae Pharmaceutica - Drug Research","volume":"66 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140483334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BIOINFORMATICS-ASSISTED SELECTION AND ASSOCIATION OF MATRIX MEATLLOPROTEINASE-9 (MMP-9) POLMORPHISM rs17576 WITH DIABETIC RETINOPATHY 经生物分析鉴定的肉毒蛋白酶-9 (MMP-9)多态性 rs17576 与糖尿病性视网膜病变的分离与相关性研究

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2024-01-30 DOI: 10.32383/appdr/174802

F. K. Alswailmi

{"title":"BIOINFORMATICS-ASSISTED SELECTION AND ASSOCIATION OF MATRIX MEATLLOPROTEINASE-9 (MMP-9) POLMORPHISM rs17576 WITH DIABETIC RETINOPATHY","authors":"F. K. Alswailmi","doi":"10.32383/appdr/174802","DOIUrl":"https://doi.org/10.32383/appdr/174802","url":null,"abstract":"Abstract\u0000Purpose: Components of inflammatory pathways had a major role in the development of diabetic induced complications including the retinopathy. Therefore, in the present study bioinformatics assisted predicted the role of polymorphism of genes in the coding sequence of inflammatory pathway mediator matrix metallopeptidase 9 (MMP9) was determined in the development of diabetic retinopathy among the population of south Asian countries. \u0000Methods: Non-synonymous single nucleotide polymorphisms (SNP) rs17576 in MMP9 (c.836A>G; p.Q279R) was bioinformatically analyzed as well as genotyping was done in 419 individuals with type 2 diabetes (219 individuals with diabetic retinopathy (DR) and 200 individuals with diabetic non-retinopathic (DNR) while 200 healthy individuals were recruited as control for both DR and DNR patients.\u0000Results: In silico assisted functional effect due to kinetic changes in protein structure was observed for MMP9 rs17576 (p.Q279R). In addition, genetic analysis revealed significant association of the “G” allele with diabetic individuals most prominently females (χ²=12.65, p<0.05, OR=0.47 [95% CI=0.30-0.73, p<0.05])\u0000Conclusion: The rs17576 (c.836A>G; p.Q279R) polymorphism of MMP9 was found to influence protein structure and functional and was observed to provide protection, dominantly in females, against the diabetic retinopathy.","PeriodicalId":7135,"journal":{"name":"Acta Poloniae Pharmaceutica - Drug Research","volume":"101 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soft Gelatine Capsules- Critical Quality Attributes of Chosen Excipients and Capsules Parameters Following the Quality by Design Concept 明胶软胶囊--按照设计质量理念选择辅料和胶囊参数的关键质量属性

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2023-11-27 DOI: 10.32383/appdr/172348

Barbara Owczarek, E. Łukowska-Chojnacka

{"title":"Soft Gelatine Capsules- Critical Quality Attributes of Chosen Excipients and Capsules Parameters Following the Quality by Design Concept","authors":"Barbara Owczarek, E. Łukowska-Chojnacka","doi":"10.32383/appdr/172348","DOIUrl":"https://doi.org/10.32383/appdr/172348","url":null,"abstract":"Soft gel capsules are a common form of medicine and food supplements. Quality, productivity and manufacturing time is crucial for producers during their development and industrial operations. To ensure the best quality of the product, it is necessary to know all critical process steps and parameters. The use of QbD elements is to ensure the quality of the drug product throughout its \"life cycle\". Quality by design (QbD) and its elements are described by the International Council of Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and in their guideline - chapter ICH Q8 (Pharmaceutical Development). One of the first steps in pharmaceutical product development is to prepare Quality Target Product Profile (QTPP) and analyse Critical Material Attributes (CMAs) and Critical Quality Attributes (CQAs) of excipients, active pharmaceutical ingredient (API) and final product. During this research, we investigated the CQAs of the excipients used in vitamin D3 soft gelatin capsules containing high doses of cholecalciferol, from 10 000 to 200 000 IU per capsule. We considered the viscosity of the gelatin mass, the effect of the addition of dye on the viscosity, and the impact of the colour of the gelatin mass on the active substance content in the final capsules. It was also investigated oily carriers (medium chain triglycerides and safflower oil) and antioxidants (alpha-tocopherol acetate vs butylhydroxytoluene), and their effect on API concentration in the capsule.","PeriodicalId":7135,"journal":{"name":"Acta Poloniae Pharmaceutica - Drug Research","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139232019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salidroside Enhances Aerobic Swimming to Improve Oxidative Aging Induced by D-Galactose in Mice 水杨梅甙增强有氧游泳能力，改善小鼠由 D-半乳糖诱发的氧化衰老

Acta Poloniae Pharmaceutica - Drug Research Pub Date : 2023-11-27 DOI: 10.32383/appdr/172999

Jing Zhang, Xiankun Dai, Mengwei Wang, Jing Song, X. Long, Y. Qian, Xin Zhao

{"title":"Salidroside Enhances Aerobic Swimming to Improve Oxidative Aging Induced by D-Galactose in Mice","authors":"Jing Zhang, Xiankun Dai, Mengwei Wang, Jing Song, X. Long, Y. Qian, Xin Zhao","doi":"10.32383/appdr/172999","DOIUrl":"https://doi.org/10.32383/appdr/172999","url":null,"abstract":"This study observed the effect of salidroside on improving oxidative aging induced by D-galactose in mice by enhancing aerobic swimming. In this study, the oxidative aging model of mice was established by D-galactose, and the changes of organ index, histopathological changes, and mRNA expression in serum and tissue of oxidative aging mice after aerobic swimming and aerobic swimming+salidroside were detected. The results showed that aerobic swimming and aerobic swimming+salidroside inhibited the decline of heart index, liver index, spleen index and kidney index caused by oxidative aging in mice. Aerobic swimming and aerobic swimming+salidroside increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione (GSH) in serum, liver and spleen of oxidative aging mice, and decreased the level of malondialdehyde (MDA). The study also found that aerobic swimming and aerobic swimming+salidroside can reduce the damage of oxidative aging to liver and spleen tissues. Quantitative polymerase chain reaction (qPCR) showed that aerobic swimming and aerobic swimming+salidroside could up-regulate the mRNA expression of CAT, GSH, Cu/Zn-SOD, Mn-SOD and GSH-PX in mouse liver tissue. The results showed that aerobic swimming could effectively inhibit the oxidative aging of mice induced by D-galactose, and the effect of aerobic swimming+salidroside was better than that of aerobic swimming alone. It can be seen that salidroside can enhance the improvement of aerobic swimming on oxidative aging and can be used as a sports supplement.","PeriodicalId":7135,"journal":{"name":"Acta Poloniae Pharmaceutica - Drug Research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0