Salidroside Enhances Aerobic Swimming to Improve Oxidative Aging Induced by D-Galactose in Mice

Abstract

This study observed the effect of salidroside on improving oxidative aging induced by D-galactose in mice by enhancing aerobic swimming. In this study, the oxidative aging model of mice was established by D-galactose, and the changes of organ index, histopathological changes, and mRNA expression in serum and tissue of oxidative aging mice after aerobic swimming and aerobic swimming+salidroside were detected. The results showed that aerobic swimming and aerobic swimming+salidroside inhibited the decline of heart index, liver index, spleen index and kidney index caused by oxidative aging in mice. Aerobic swimming and aerobic swimming+salidroside increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione (GSH) in serum, liver and spleen of oxidative aging mice, and decreased the level of malondialdehyde (MDA). The study also found that aerobic swimming and aerobic swimming+salidroside can reduce the damage of oxidative aging to liver and spleen tissues. Quantitative polymerase chain reaction (qPCR) showed that aerobic swimming and aerobic swimming+salidroside could up-regulate the mRNA expression of CAT, GSH, Cu/Zn-SOD, Mn-SOD and GSH-PX in mouse liver tissue. The results showed that aerobic swimming could effectively inhibit the oxidative aging of mice induced by D-galactose, and the effect of aerobic swimming+salidroside was better than that of aerobic swimming alone. It can be seen that salidroside can enhance the improvement of aerobic swimming on oxidative aging and can be used as a sports supplement.