{"title":"Effect of Biphenyl Derivative of Coumarin Compounds Photodynamic Therapy on The Expression of Carcinoma-Associated Genes.","authors":"Asiye Yurttaş, Tuğba Elgün, Burçin Erkal Çam, Melike Kefeli, Kamil Çınar","doi":"10.17344/acsi.2024.8948","DOIUrl":"https://doi.org/10.17344/acsi.2024.8948","url":null,"abstract":"<p><p>Photodynamic Therapy (PDT) is a cancer treatment. Singlet oxygen is produced as a result of the photochemical reaction between light, photosensitizer (PS), and molecular oxygen, which kills cells. Colon cancer, affecting 1.23 million people worldwide, often requires surgery but has high recurrence and metastasis rates. Photodynamic therapy (PDT) is an alternative treatment for colon cancer. This study used MTT assays to evaluate cell viability and applied Zinc(II) Phthalocyanine photosensitizers to the colorectal adenocarcinoma (HT-29) cell line to investigate cancer pathways via flow cytometry and q-PCR. The results showed that PDT with Zinc(II) Phthalocyanine significantly reduced cell viability in HT-29 cells and induced apoptosis at a rate of 53%. According to q-PCR results, CT values of ten out of thirty genes were found to be significant and their association with cancer was evaluated.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"696-704"},"PeriodicalIF":1.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kuldeepak Sharma, Irena Zajc, Alen Albreht, Lovro Ziberna
{"title":"INHIBITION OF BILIVERDIN REDUCTASE DIMINISHED THE PROTECTIVE ACTIVITY OF BILIRUBIN AND BILIVERDIN AGAINST OXIDATIVE STRESS-INDUCED INJURY IN HUMAN VASCULAR ENDOTHELIUM.","authors":"Kuldeepak Sharma, Irena Zajc, Alen Albreht, Lovro Ziberna","doi":"10.17344/acsi.2024.8964","DOIUrl":"https://doi.org/10.17344/acsi.2024.8964","url":null,"abstract":"<p><p>Endothelial dysfunction, a key factor in cardiovascular diseases, is further aggravated by oxidative stress. Biliverdin (BV) and bilirubin (BR) are potent antioxidants that protect endothelial cells, with biliverdin reductase (BVR) converting BV to BR to maintain redox balance. This study explored BVR's role in mediating these protective effects under normoxic and hypoxia-reoxygenation conditions. Pharmacological inhibition of BVR reduced the protective effects of BV and BR, as evidenced by decreased cell viability, cellular antioxidant activity, and intracellular bilirubin levels. Activation of ERK1/2 reduced BVR's protective function, while its inhibition enhanced it. Additionally, disruption of the BVR-ERK interaction further modulated these effects, highlighting the BVR-ERK1/2 interaction sites as potential therapeutic targets for oxidative stress-induced endothelial dysfunction.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"627-645"},"PeriodicalIF":1.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Elimination of Cadmium using Silica Gel Prepared from Blast Furnace Slag.","authors":"Toufik Chouchane, Mohamed Tayeb Abedghars, Sabiha Chouchane, Atmane Boukari","doi":"10.17344/acsi.2024.8692","DOIUrl":"https://doi.org/10.17344/acsi.2024.8692","url":null,"abstract":"<p><p>In this work, the silica gel recovered from the blast furnace slag was exploited for the elimination of cadmium in batch mode under the action of different factors. Physico-chemical analyzes revealed that the modified slag is only composed of silica (96.14%). Its specific surface area is 484 m2g-1 and the pH corresponding to PZC is 4.2. The experiment revealed that the effect of the determining factors contributed considerably to the progression of the adsorption capacity (154.11 mg/g). Adsorption isotherms demonstrated that the removal of cadmium on modified slag was accomplished on a homogeneous monolayer surface (R2= 099; qmax= 153.84 mg/g). Kinetic analysis revealed that this process agreed with the pseudo-second-order kinetic model (R2 ≥ 0.99). In addition, it was indicated that the diffusion of the pollutant is ensured by external and intraparticle diffusion. The values of thermodynamic variables clarified that cadmium sorption is spontaneous, exothermic, less entropic and physically executed under the effect of electrostatic interaction. The desorption process revealed that the reuse of Silica gel was feasible over five consecutive cycles.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"646-659"},"PeriodicalIF":1.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microwave Asisted Synthesis of Methylene Bisthiazolo Arylvinyl Pyrazoles as Potential Biological Agents.","authors":"Avula Sri Nivas","doi":"10.17344/acsi.2024.8876","DOIUrl":"https://doi.org/10.17344/acsi.2024.8876","url":null,"abstract":"<p><p>(2E,2'E)-1,1'-(5,5'-(5,5'-methylenebis(2-methoxy-5,1-phenylene))bis(3-(4-fluorophenyl)-6-phenyl-3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazole-5,2-diyl))bis(3-phenylprop-2-en-1-one) were synthesized from (5Z,5'Z)-2,2'-(5,5'-methylenebis(2-methoxy-5,1-phenylene))bis(5-(4-fluorobenzylidene)-3-phenylthiazolidin-4-one)through cycloaddition reaction with Cinnamic acid hydrazide and evaluated its anti bacterial, fungal and nematicidal activity against. Among the tested compounds 5b and 5d containing chloro and Nitro are the most effective against Dietylenchus myceliophagus, Caonorbitis elegans with LD 50 between 160 and 190 ppm, 190 and 210 ppm respectively, . Compounds 5b, 5e showed good zone of inhibition against B. subtiles compounds 5c and 5d were active against S.aureus compounds 5a, 5c &5e were active against C. Violaceum and compounds 5b, 5a and 5d were the most active against K. aerogenes, P. aeruginosa and B. sphaericus. Compounds 5b and 5d showed good inhibition towards C. albicans at the concentration of 3.12 μg/mL which is less than Amphotericin B standard.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"660-667"},"PeriodicalIF":1.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inhibition Effect of Benzimidazole Derivatives on the Corrosion of Mild Steel in Acidic Medium: Experimental and Theoretical Studies.","authors":"Sonia Benabid, Linda Toukal","doi":"10.17344/acsi.2024.8922","DOIUrl":"https://doi.org/10.17344/acsi.2024.8922","url":null,"abstract":"<p><p> The effect of heterocyclic compounds, derived from benzimidazole (BnZ), namely1-Benzyl-2-phenyl 1H-benzimidazole (BI) and1-(4-Nitrobenzyl)-2-(4-nitrophenyl)-1H-benzimidazole(NNBI),on the carbon corrosion steel in 1M HCl medium was assessed by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP). The effects of the concentration and the temperature were studied. The determined electrochemical parameters showed that the two inhibitors are of mixed type. The inhibitory effect of NNBI was lesser compared to that of BI. The most electron-withdrawing substituent offers the lowest efficiency. The mechanism of action of these inhibitors has been defined by the thermodynamic study. Calculated,, and values confirmed that BI and NNBI adsorb through a chemical and physical process. The adsorption process was found to be spontaneous and followed the Langmuir adsorption isotherm. The quantum chemical parameters calculated by density functional theory (DFT) and molecular dynamics simulation (MDS) corroborate with both the experimental data and those of the literature. Keywords: Corrosion; steel; organic inhibitors; benzimidazole; DFT; MDS.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"668-684"},"PeriodicalIF":1.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yurii Chumakov, Vasilii Graur, Ianina Graur, Victor Tsapkov, Olga Garbuz, Aurelian Gulea
{"title":"Insights into Antiradical Behavior: Crystal Structures and DFT Analysis of 2-Formylpyridine N4-Allylthiosemicarbazone Salts.","authors":"Yurii Chumakov, Vasilii Graur, Ianina Graur, Victor Tsapkov, Olga Garbuz, Aurelian Gulea","doi":"10.17344/acsi.2024.8728","DOIUrl":"https://doi.org/10.17344/acsi.2024.8728","url":null,"abstract":"<p><p>In this paper, six new salts of 2-formylpyridine N4-allylthiosemicarbazone ([H2L]X⸱nH2O, where X is NO3- (1), NH2SO3- (2), Cl- (3), Cl3CCOO- (4), Cl2CHCOO- (5), ClCH2COO- (6); n = 0 (1, 3, 5, 6), 1 (2, 4)) were synthesized and physico-chemically characterized by elemental analysis, molar conductivity measurements, FT-IR studies, 1H and 13C NMR. The crystal structures of compounds 1-5 were determined by single-crystal X-ray diffraction. Analysis of crystal data shows that the structures of these compounds consist of protonated thiosemicarbazone H2L+, anions of acid residue and water molecules in 2 and 4. These compounds manifest antiradical activity toward ABTS•+ cation radicals that exceeds the activity of non-protonated thiosemicarbazone HL and trolox, that is used in medicine. The most active one is compound [H2L]Cl (3) with IC50 value 9.9 μmol/L. Density Functional Theory calculations showed that the electronic structure of cation H2L+ is more favorable for electron acceptation if compared with HL.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"609-618"},"PeriodicalIF":1.3,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, Characterization and Crystal Structures of Aroylhydrazones Derived from 2-Chlorobenzaldehyde with Various Benzohydrazides.","authors":"Jiaxue Liu, Shi-Yu Zhang, Wei Li, Zhonglu You","doi":"10.17344/acsi.2024.8967","DOIUrl":"https://doi.org/10.17344/acsi.2024.8967","url":null,"abstract":"<p><p>Reaction of 2-chlorobenzaldehyde with 3-trifluoromethylbenzohydrazide, 3,5-dimethoxybenzohydrazide, 4-trifluoromethylbenzohydrazide and 2-bromobenzohydrazide, respectively, in methanol afforded four new aroylhydrazones. The newly synthesized compounds were characterized by means of elemental analysis, IR and 1H NMR spectroscopy, and their structures were further confirmed by X-ray single crystal determination. The compounds were assayed for their antibacterial activities against E. coli, P. aeruginosa, B. subtilis, and S. aureus and show interesting results.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"587-594"},"PeriodicalIF":1.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, Characterization and X-Ray Crystal Structures of Schiff Base Zinc(II) Complexes with Antibacterial Activity.","authors":"Yu-Hui Wu, Wanlin Wei, Wei Li, Zhonglu You","doi":"10.17344/acsi.2024.8928","DOIUrl":"https://doi.org/10.17344/acsi.2024.8928","url":null,"abstract":"<p><p>Two mononuclear zinc(II) complexes [ZnCl2(HL)] (1) and [ZnBr2(HL)] (2), and a polymeric zinc(II) complex [Zn(dca)L] (3), where HL is the zwitterionic form of the Schiff base 2,4-difluoro-6-(((2-pyrrolidin-1-yl)ethylimino)methyl)phenol (HL), L is the monoanionic form of HL, and dca is dicyanoamide, were prepared and characterized by elemental analysis and infrared spectroscopy, as well as X-ray single crystal determination. Complexes 1 and 2 are isostructural, in which the Zn atoms are in tetrahedral coordination. The Schiff base ligands in both complexes are coordinate to the Zn atoms through phenolate oxygen and imino nitrogen. The zinc atoms in complex 3 are in tetrahedral coordination and are bridged by dicyanoamide ligands. The Schiff base ligand in this complex is coordinates to the zinc atom through phenolate oxygen, imino nitrogen and pyrrolidine nitrogen. Molecules of the three complexes are stabilized by hydrogen bonds. The biological assay indicates that the complexes have good antimicrobial activities on the bacteria strains Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Staphylococcus aureus.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"580-586"},"PeriodicalIF":1.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of an anionic surfactant on electrochemical response of Leuprolide used in the treatment of precocious puberty: A reliable voltammetric method.","authors":"Begüm Evranos Aksöz, Burcu Dogan-Topal","doi":"10.17344/acsi.2021.7194","DOIUrl":"https://doi.org/10.17344/acsi.2021.7194","url":null,"abstract":"<p><p>In this study, the rapid, simple and sensitive voltammetric method has been developed for the quantification of leuprolide acetate in the presence of anionic surfactant on a glassy carbon electrode. The effect of surfactant types, pH of the medium, scan rate on the voltammetric response of leuprolide acetate were evaluated. The oxidation peak currents of leuprolide acetate were enhanced in the presence of 8.0 x 10-5 M sodium dodecyl sulfate. The monomer structure of sodium dodecyl sulfate can be attracted to amino moieties in drug structure via the electrostatic interaction. The voltammetric behavior of leuprolide acetate exhibited irreversible and diffusion-adsorption mix controlled processes by cyclic voltammetry. Under optimized conditions, the proposed method exhibits linearity in the concentration range of 3.64 x 10-9 - 2.00 x 10-7 M with a nano-level detection limit of 4.70 x 10-10 M by adsorptive stripping square wave voltammetry. The developed method was applied to an injectable dosage form for the determination of leuprolide acetate with satisfactory accuracy and precision.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"558-565"},"PeriodicalIF":1.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivo Bardarov, Desislava Apostolova, Maris Minna Mathew, Miha Nosan, Pedro Farinazzo Bergamo Dias Martins, Bostjan Genorio
{"title":"Flash graphene: a sustainable prospect for electrocatalysis.","authors":"Ivo Bardarov, Desislava Apostolova, Maris Minna Mathew, Miha Nosan, Pedro Farinazzo Bergamo Dias Martins, Bostjan Genorio","doi":"10.17344/acsi.2024.8794","DOIUrl":"https://doi.org/10.17344/acsi.2024.8794","url":null,"abstract":"<p><p>The increasing demand for sustainable and efficient energy conversion technologies requires ongoing exploration of new materials and methods. Flash Joule Heating (FJH) emerges as a promising technique for large-scale graphene production, boasting advantages over conventional methods. FJH rapidly heats carbon-based precursors to extreme temperatures using high electric currents, forming flash graphene upon rapid cooling. This approach offers rapid processing, high throughput, and can utilize diverse carbon sources, including biomass and waste, making it sustainable and cost-effective. Moreover, it generates minimal waste and yields flash graphene with enhanced conductivity, crucial for energy applications. FJH's scalability, versatility, and efficiency position it as a key method for commercializing graphene across industries, particularly in energy conversion. This review comprehensively discusses FJH synthesis principles, emphasizing efficiency, scalability, and sustainability. Additionally, it analyzes recent advancements in flash graphene-based electrocatalysts, exploring their impact on renewable energy and sustainable electrocatalysis. Challenges and opportunities are addressed, outlining future research directions. Continued advancements hold immense potential to revolutionize graphene production and integrate it into next-generation energy systems, driving the transition towards cleaner energy solutions.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 4","pages":"541-557"},"PeriodicalIF":1.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}