{"title":"DRUŠTVENE VESTI IN DRUGE AKTIVNOSTI SOCIETY NEWS, ANNOUNCEMENTS, ACTIVITIES.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"S65-S80"},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syawal Mohd Yusof, Azizul Hakim Lahuri, Nurul Asikin Mijan, Umar Kalmar Nizar, Siti Sarahah Sulhadi, Salma Samidin, Ainil Hafiza Abdul Aziz
{"title":"Fibrous Silica KCC-1 as a Platform for Mn-Based Dual Metal Oxide Adsorbents for CO2 Capture.","authors":"Syawal Mohd Yusof, Azizul Hakim Lahuri, Nurul Asikin Mijan, Umar Kalmar Nizar, Siti Sarahah Sulhadi, Salma Samidin, Ainil Hafiza Abdul Aziz","doi":"10.17344/acsi.2025.9370","DOIUrl":"https://doi.org/10.17344/acsi.2025.9370","url":null,"abstract":"<p><p>The continuous rise in atmospheric CO2 levels due to industrial emissions and fossil fuel combustion has intensified the need for efficient carbon capture. Solid adsorbents are favoured for their reusability and low energy demand, yet often face limitations in thermal stability and adsorption performance. This study examines the effect of co-loading manganese (Mn) with potassium (K), copper (Cu), and calcium (Ca) on fibrous silica KCC-1 for CO2 capture over a wide temperature range. KCC-1 was synthesised via a microemulsion method, and metals were introduced using an ultrasonic-surfactant-assisted impregnation technique. Characterisation using XRD, FTIR, BET, FESEM-EDX, and CO2-TPD confirmed structural integrity, surface functionality, and adsorption behaviour. CaO-MnO@KCC-1 shows the most balanced textural properties and the highest CO2 uptake due to its strong basicity and varied adsorption site strength. This highlights its potential as a temperature-flexible CO2 adsorbent.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"613-621"},"PeriodicalIF":1.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design, synthesis and anticonvulsant activity of 2 and 5-disubstituted 1,3-dioxoisoindoline.","authors":"Asghar Davood, Maryam Yadavar Nikravesh, Mahsa Hadipour Jahromy, Sepideh Taghizad","doi":"10.17344/acsi.2024.9007","DOIUrl":"https://doi.org/10.17344/acsi.2024.9007","url":null,"abstract":"<p><p>The isoindoline scaffold, a rigid analogue of ameltolide, exhibits notable antiepileptic properties. Here we describe the design, synthesis, and evaluation of nine new isoindoline derivatives prepared by condensation of trimellitic anhydride with various arylamines. Anticonvulsant activity of prepared compounds was assessed in maximal electroshock (MES; tonic seizure) and pentylenetetrazole (PTZ; clonic seizure) seizure models. All compounds significantly attenuated both tonic and clonic seizures; in MES they reduced seizure-induced mortality, while in PTZ they improved seizure frequency and latency. Compounds 3 and 4 showed the highest efficacy, surpassing phenytoin. Structure-activity analysis indicates that bulky ortho-substituents on the N-aryl group, combined with a meta-nitro substituent, enhance anticonvulsant potency.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"524-531"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nail Besli, Nilufer Ercin, Ulkan Celik, Yusuf Tutar
{"title":"How to Expedite Drug Discovery: Integrating Innovative Approaches to Accelerate Modern Drug Development.","authors":"Nail Besli, Nilufer Ercin, Ulkan Celik, Yusuf Tutar","doi":"10.17344/acsi.2025.9280","DOIUrl":"https://doi.org/10.17344/acsi.2025.9280","url":null,"abstract":"<p><p>The drug discovery process, traditionally a lengthy and costly endeavor, is being revolutionized by integrating innovative approaches. This review delves into how modern techniques accelerate drug discovery and development, significantly reducing costs. We focus on the robust synergy of bioinformatics, artificial intelligence (AI), and high-throughput screening (HTS). Bioinformatics aids in the identification and validation of drug targets by analyzing vast genomic and proteomic datasets. AI enhances lead compound identification and optimization through predictive modeling and machine learning (ML) algorithms, slashing the time required for these stages. HTS facilitates the rapid screening of vast compound libraries to pinpoint potential drug candidates. AI-based approaches, such as HTS and predictive modeling, enhance early-stage decision-making, minimize trial-and-error experimentation, and contribute to cost-efficiency across the pipeline. Moreover, advancements in computational chemistry and molecular dynamics simulations provide deeper insights into drug-target interactions, further accelerating the design of effective and selective drugs. In drug discovery, drug candidates are tested in laboratory and live animal settings to assess their effectiveness, pharmacokinetics, and safety. By integrating these preclinical methods, the efficiency and success of drug discovery can be significantly improved, leading to more effective and safer drugs. This review underscores the important role of these technologies in contemporary drug development and explores their promising implications for future research and clinical applications.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"581-600"},"PeriodicalIF":1.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"HPLC-DAD analysis, antioxidant and antibacterial properties of fruit extracts from Pistacia atlantica Desf.","authors":"Younes Douffa, Karima Saffidine, Nour Elhouda Belabes, Nadjet Azzi, Haifaa Laroui, Hafsa Silini Cherif, Thoraya Guemmaz, Fatima Zerargui, Abderahmane Baghiani","doi":"10.17344/acsi.2025.9317","DOIUrl":"https://doi.org/10.17344/acsi.2025.9317","url":null,"abstract":"<p><p>Pistacia atlantica is commonly used in traditional medicine to treat various diseases in Algeria. This study was carried out to investigate the antioxidant potential and antibacterial properties of fruit extracts. The results indicated various amounts of polyphenols and flavonoids in different extracts. Quercetin, gallic acid, chlorogenic acid and methyl gallate were the dominant constituents in the ethyl acetate extract (EAE) and crude extract (CrE) quantified by HPLC-DAD. EAE was the most active in scavenging DPPH and hydroxyl (OH.) radicals, hydrogen peroxide (H2O2), reducing power and total antioxidant capacity. All extracts have the ability to inhibit lipid peroxidation. A broad spectrum of antibacterial effects (10.66 to 29.33 mm) was obtained. In addition, the time-kill assay and the MBC/MIC ratio indicated that all extracts were bactericidal against most of the test bacteria and their combination with antibiotics showed remarkable synergistic effect. The findings of this study suggest that medicinal plant is a potential source of natural antioxidant and antibacterial compounds, which could be used where these kind of activities are warranted.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"601-612"},"PeriodicalIF":1.3,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehdi Abaszadeh, Arghavan Arjomand Kermani, Ali Armin, Yasaman Abolhassani, Fatemeh Haghani, Salehe Sabouri, Bagher Amirheidari, Behzad Behnam
{"title":"Evaluating the cytotoxic effects of some chlorinated substituted 2-amino-3-carbonitrile chromene derivatives on 3T3 and MCF-7 cell lines.","authors":"Mehdi Abaszadeh, Arghavan Arjomand Kermani, Ali Armin, Yasaman Abolhassani, Fatemeh Haghani, Salehe Sabouri, Bagher Amirheidari, Behzad Behnam","doi":"10.17344/acsi.2025.9331","DOIUrl":"https://doi.org/10.17344/acsi.2025.9331","url":null,"abstract":"<p><p>Cancer remains a leading cause of death worldwide, necessitating novel therapeutic approaches. In this study we synthesized and characterized 2-amino-3-carbonitrile chromene derivatives and evaluated their cytotoxic effects on 3T3 and MCF-7 cell lines. Characterization included melting point, IR, NMR, and elemental analysis. Cytotoxicity was assessed via MTT assay, with IC50 values calculated, while apoptosis induction was confirmed by flow cytometry using annexin V/propidium iodide staining. Compounds 4f and 4h demonstrated significant cytotoxicity against breast cancer cells, with IC50 values of 4.74 and 21.97 µg/ml and selectivity indices of 3.83 and 2.80, respectively. Increased apoptotic cell populations support their pro-apoptotic potential. These findings indicate that the chromene derivatives, synthesized via a one-pot method, may serve as promising candidates for further anticancer drug development.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"514-523"},"PeriodicalIF":1.3,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, DFT, and Molecular Docking Studies of Anti-cancer Imidazolidine-2,4-dione and Thiazolidine-2,4-dione Derivatives.","authors":"Osama Alharbi","doi":"10.17344/acsi.2025.9326","DOIUrl":"https://doi.org/10.17344/acsi.2025.9326","url":null,"abstract":"<p><p>Novel families of thiazolidine-2,4-dione and imidazolidine-2,4-dione derivatives were synthesized. Thiazolidine-2,4-dione 3 was prepared using chloroacetic acid and thiourea, followed by condensation with terephthalaldehyde to form 4-((2,4-dioxothiazolidine-5-ylidene)methyl)benzaldehyde 4. This compound reacted with 2-aryloxyacetohydrazides 8a-b to yield Schiff bases 9a-b. Imidazolidine-2,4-diones 13a-c were synthesized via cyclizing of anilines 10a-c, urea 11, and chloroacetic acid 12. The compounds 9a-b and 13a-c were evaluated for antitumor activity against the Caco-2 cell line, compounds 13b and 13c exhibiting the highest potency (IC50 values of 41.30 ± 0.07 μM and 109.2 ± 0.027 μM, respectively). DFT calculations, including HOMO-LUMO analysis, energy gap estimation, and molecular docking, were conducted to evaluate and optimize the molecular properties of the target compounds.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"562-572"},"PeriodicalIF":1.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutic potential and in silico evaluation of phytochemicals in the leaves of Eucalyptus globulus, Jasminum officinale and Solanum nigrum.","authors":"Imran Ali, Afshan Kaleem, Farah Akram, Muhammad Talal, Roheena Abdullah, Mehwish Iqtedar, Irfana Iqbal, Xiaoming Chen","doi":"10.17344/acsi.2025.9244","DOIUrl":"https://doi.org/10.17344/acsi.2025.9244","url":null,"abstract":"<p><p>In this study, the plants Eucalyptus globulus (E. globulus), Jasminum officinale (J. officinale), and Solanum nigrum (S. nigrum) are investigated for their antibacterial, antioxidant, and therapeutic properties. The extraction solvents (aqueous, methanol, ethanol, and butanol) were used for phytochemical screening, antibacterial activity while aqueous extracts were specifically used for antioxidant analysis. The quantitative determination showed that the highest phenolic and tannin content was found in J. officinale, while highest flavonoid and alkaloids levels were found in E. globulus among the tested species. The disc diffusion method was followed for assessing the antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). All extracts of E. globulus leaves showed antibacterial activity against E. coli and S. aureus. The aqueous extracts on FTIR showed quercetin, benzoic, salicylic, gallic, ferulic, and ascorbic acid. Furthermore, in silico analysis to assess the interaction of selected bioactive compounds, quercetin and benzoic acid, found in E. globulus, were docked with haemagglutinin and neuraminidase, as these influenza virus surface proteins play an important role in the virus's ability to infect host cells. Salicylic, gallic, ferulic, and ascorbic acid from J. officinale and S. nigrum, were docked with GABA receptor-associated proteins, which are important in synaptic transmission and plasticity.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"532-544"},"PeriodicalIF":1.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adsorption and Corrosion Inhibition Effect of Expired Prednisolone on AISI 1020 Carbon Steel: Electrochemical, Gravimetric, and Surface Studies.","authors":"Sihem Kherraf, Malika Foudia, Zohra Djetoui, Leila Kherraf, Nour El Houda Sobhi","doi":"10.17344/acsi.2025.9289","DOIUrl":"https://doi.org/10.17344/acsi.2025.9289","url":null,"abstract":"<p><p>The present study evaluated the inhibition performance of expired prednisolone against the corrosion of AISI 1020 carbon steel in a 3.5% sodium chloride medium. The inhibition effectiveness was evaluated using electrochemical impedance spectroscopy, potentiodynamic polarization, gravimetric measurements, and surface characterization techniques. Data obtained from the polarization studies indicated that prednisolone acted as mixed-type inhibitor. Electrochemical impedance spectroscopy results revealed an increase in charge transfer resistance with rising inhibitor concentration. The inhibitor showed a maximum inhibition efficiency of 90% at 298 K. The interaction between the steel surface and the inhibitor was determined to be physisorption, consistent with the Langmuir adsorption isotherm model. The corrosion inhibition performance of prednisolone decreased with increasing temperature, reaching 79.42% at 328 K. Surface characterization showed that the inhibitor significantly reduced the corrosion on the metal surface.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"553-561"},"PeriodicalIF":1.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, Characterization, and Theoretical Calculation of a Copper Complex of 3-Hydroxy-2-methylquinolin-4- carboxylate and 1,10-Phenanthroline.","authors":"Yan-Hua Li, Xing-Jian Liu, Jian Huang, Yu Xie, Fei Deng, Xiu-Guang Yi","doi":"10.17344/acsi.2025.9384","DOIUrl":"https://doi.org/10.17344/acsi.2025.9384","url":null,"abstract":"<p><p>A copper complex containing mixed ligands [Cu(MCA)(Phen)·3H2O)] (HMCA = 3-hydroxy-2-methylquinoline-4-carboxylic acid, Phen = 1,10-phenanthroline) was prepared by the hydrothermal method. Structure was characterized by single crystal X-ray diffraction. Solid state fluorescence photoluminescence measurement shows a strong emission peak at 620 nm, which is attributed to the characteristic electronic transitions and molecular stacking effects within the ligand. CIE color difference analysis indicates that the title complex exhibits red photoluminescence (chromaticity coordinates of 0.1256, 0.2418). In addition, solid-state UV-Vis diffuse reflectance experiments revealed that the titled complex has an energy band gap of 1.578 eV.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 3","pages":"573-580"},"PeriodicalIF":1.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}