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IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-09-25

引用次数: 0

Preliminary in vitro evaluation of anti-leukemic and antimalarial activities of pyrrolo[1,2-a]quinoxaline-carboxylic acid hydrazone derivatives. 吡咯[1,2-a]喹啉-羧酸腙衍生物抗白血病和抗疟疾活性的体外初步评价。

IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-09-11 DOI: 10.17344/acsi.2026.9975

Jean Gullion, Noel Pinaud, Lindita Lari, Luisa Ronga, Patrice Agnamey, Céline Damiani, Solène Savrimoutou, Elise Si Ahmed Charrier, Tshering Zangmo, Stéphane Moreau, Mathieu Marchivie, Sandra Albenque, Vanessa Desplat, Pascal Sonnet

{"title":"Preliminary in vitro evaluation of anti-leukemic and antimalarial activities of pyrrolo[1,2-a]quinoxaline-carboxylic acid hydrazone derivatives.","authors":"Jean Gullion, Noel Pinaud, Lindita Lari, Luisa Ronga, Patrice Agnamey, Céline Damiani, Solène Savrimoutou, Elise Si Ahmed Charrier, Tshering Zangmo, Stéphane Moreau, Mathieu Marchivie, Sandra Albenque, Vanessa Desplat, Pascal Sonnet","doi":"10.17344/acsi.2026.9975","DOIUrl":"https://doi.org/10.17344/acsi.2026.9975","url":null,"abstract":"New pyrrolo[1,2-a]quinoxaline-2-carboxylic acid hydrazone derivatives were synthesized from nitroaniline using a multi-step pathway. Structure characterization of these novel substituted pyrrolo[1,2-a]quinoxaline-carboxylic acid hydrazones was achieved by using FT-IR, 1H NMR, 13C NMR, X-Ray and HRMS spectral analysis. These pyrroloquinoxaline hydrazone compounds were then evaluated in vitro for their potential on the human acute myeloid leukemia cell line MV4-11, in which (N'-pyridin-2-ylmethylene)pyrrolo[1,2-a]quinoxaline-2-carboxylic acid hydrazone 1a showed an IC50 value of 15.51 µM. Given the structural similarities between our hydrazone derivatives 1 and some recently published quinoline-type hydrazone compounds for antimalarial use, our compounds were also evaluated for their antimalarial activity. Among them, compound 1c demonstrated promising antiplasmodial activity, with an IC50 of 0.02 μM against the 3D7 strain of Plasmodium falciparum, exhibiting a selectivity index (SI) exceeding 5000 against this strain. Against the chloroquine-resistant Plasmodium falciparum W2 strain, hydrazone 1e emerged as the most potent and promising antimalarial candidate (IC50 = 0.03 mM), demonstrating a cytotoxicity to-antiprotozoal activity ratio exceeding 3333.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 3","pages":"713-723"},"PeriodicalIF":1.2,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical constituents and anticancer properties of bioactive compounds from Macrosphyra longistyla (DC.) Hiern. 长柱头草（Macrosphyra longstyla）生物活性化合物的化学成分及抗癌特性Hiern。

IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-09-07 DOI: 10.17344/acsi.2025.9684

Patricia Akpomedaye Onocha, Michael Gabriel Ibok, Sasidhar B Somappa, Oluwakayode Olubunmi Odeja, Ejike Onwudiegwu Okpala, Sarah Oyenibe Nwozo, Ganiyat Kehinde Oloyede

引用次数: 0

Chemical composition and bioactivities of Macaranga trichocarpa essential oil. 毛菖蒲精油的化学成分及生物活性研究。

IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-09-02 DOI: 10.17344/acsi.2026.9883

Nguyen Thi Kim Anh, Nguyen Thi Trang, Danh C Vu, Hieu Tran-Trung, Le Duc Giang, Sy Vo Van, Dao Huynh Minh, Nguyen Ngan

{"title":"Chemical composition and bioactivities of Macaranga trichocarpa essential oil.","authors":"Nguyen Thi Kim Anh, Nguyen Thi Trang, Danh C Vu, Hieu Tran-Trung, Le Duc Giang, Sy Vo Van, Dao Huynh Minh, Nguyen Ngan","doi":"10.17344/acsi.2026.9883","DOIUrl":"https://doi.org/10.17344/acsi.2026.9883","url":null,"abstract":"The present study investigated chemical composition and in vitro bioactivities of the essential oil (EO) of Macaranga trichocarpa leaves. The EO was analyzed using gas chromatography-mass spectrometry. The results showed the identification of 61 volatile constituents representing 97.54% of the total oil content. Sesquiterpene hydrocarbons were the predominant class (52.58%), with (E)-β-caryophyllene (17.66%), α-curcumene (16.04%), β-pinene (13.83%), linalool (9.52%), and β-caryophyllene epoxide (5.19%), identified as the major constituents. The EO showed weak antioxidant activity in both DPPH and ABTS radical scavenging assays. The EO demonstrated potent α-amylase inhibitory activity (IC50 = 120.70 ± 0.47 µg/mL), comparable to acarbose. Cytotoxicity evaluation using the MTT assay revealed that the EO exerted a dose-dependent inhibitory effect against the human hepatocellular carcinoma (HepG2) cell line. These findings provide the first report on the chemical composition of M. trichocarpa leaf EO, along with preliminary in vitro screening of its enzymatic and cytotoxic properties.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 3","pages":"686-693"},"PeriodicalIF":1.2,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, molecular docking, anti-inflammatory and antioxidant activity of novel 2-(1-(4-(4-chlorophenyl)thiazol-2-yl)-1H-pyrazol-4-yl)benzo[d]oxazoles. 新型2-（1-（4-（4-氯苯基）噻唑-2-基）- 1h -吡唑-4-基）苯并恶唑的设计、合成、分子对接、抗炎和抗氧化活性

IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-09-02 DOI: 10.17344/acsi.2026.9704

Nirmala Darekar, Hemantkumar Akolkar, Sushama Takate, Dilip Thube, Dipak Raut, Vijay Khedkar, Dnyaneshwar Sirsat, Sadhana Mhaske

引用次数: 0

Synthesis and characterization of PVA-co-acrylic acid incorporating magnesium nanoparticles and their application in sweetening of natural gas. 含镁纳米粒子pva -共丙烯酸的合成、表征及其在天然气脱硫中的应用。

IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-09-02 DOI: 10.17344/acsi.2025.9474

Mallikarjunagouda B Patil, Priya A Hoskeri, Shridhar N Mathad, Mahanada B Math, Rajendraprasad S

{"title":"Synthesis and characterization of PVA-co-acrylic acid incorporating magnesium nanoparticles and their application in sweetening of natural gas.","authors":"Mallikarjunagouda B Patil, Priya A Hoskeri, Shridhar N Mathad, Mahanada B Math, Rajendraprasad S","doi":"10.17344/acsi.2025.9474","DOIUrl":"https://doi.org/10.17344/acsi.2025.9474","url":null,"abstract":"Natural gas sweetening, involving removal of CO2 and H2S from CH4, is conventionally carried out by amine scrubbing, which is highly energy intensive. In the present study, we report the synthesis of poly(vinyl alcohol-co-acrylic acid) (PVA-co-AAc) based nanocomposite membranes incorporated with surface-stabilized magnesium nanoparticles (MgNPs) through a simple aqueous route. The MgNPs act as Lewis basic sites providing reversible chemisorption for CO2/H2S, while the polymer matrix ensures hydrophilic pathways for solution-diffusion along with mechanical robustness. The prepared membranes were characterized by FTIR, XRD, SEM, TEM, AFM, TGA/DSC, DMA and tensile strength. Gas permeation studies at 25-60 °C and 1-10 bar revealed improved CO2/CH4 and H2S/CH4 selectivity, with CO2/CH4 selectivity reaching 20.8, without loss in permeance. The synergistic effect of polymer-nanoparticle interaction enhanced both stability and separation performance. Process analysis indicates potential energy savings compared to conventional amine processes, showing promise for industrial scale natural gas sweetening.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 3","pages":"702-712"},"PeriodicalIF":1.2,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A validated UV spectrophotometric method for simultaneous determination of ascorbic acid and resveratrol using isosbestic point approach. 一种有效的紫外分光光度法同时测定抗坏血酸和白藜芦醇的方法。

IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-09-01 DOI: 10.17344/acsi.2025.9651

Rizwan Ahamad, Nazreen Tabassum, Rama K P, Prerna Saxena, Mohd Akhtar, Mohd Aqil, Mohd Mujeeb

{"title":"A validated UV spectrophotometric method for simultaneous determination of ascorbic acid and resveratrol using isosbestic point approach.","authors":"Rizwan Ahamad, Nazreen Tabassum, Rama K P, Prerna Saxena, Mohd Akhtar, Mohd Aqil, Mohd Mujeeb","doi":"10.17344/acsi.2025.9651","DOIUrl":"https://doi.org/10.17344/acsi.2025.9651","url":null,"abstract":"A simple, precise UV-spectroscopy method using isosbestic point detection was developed for simultaneous analysis. The developed method exhibited good linearity over the concentration range of 0-12 μg/mL at both 269.7 nm and 252 nm. At 269.7 nm, the R2 values were 0.9963 and 0.9964 for ascorbic acid and resveratrol, with LOD/LOQ values of 1.597/4.838 μg/mL and 1.563/4.737 μg/mL, respectively. At 252 nm, the corresponding R2 values were 0.9922 and 0.9995, while the LOD/LOQ values were 2.537/7.688 μg/mL for ascorbic acid and 0.584/1.771 μg/mL for resveratrol. Percentage recovery rates of 50%, 100%, and 150% ranged from 98.6% to 100.6%, 98.5% to 100.4%, and 100.1% to 99.9%, respectively, with low %RSD values. %RSD of ascorbic acid and resveratrol combination, obtained during intra-day analysis, was 0.866% at λ1 and 0.486% at λ2. Inter-day test revealed a %RSD of 0.976% at λ1 and 0.664% at λ2, while repeatability was measured at 0.879 for λ1 and 0.411 for λ2, respectively. The developed UV method was simple, precise, and accurate for quantifying ascorbic acid and resveratrol in pure drugs in methanolic solution.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 3","pages":"661-668"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical composition, biological activities, and molecular docking analysis of Ozoroa insignis Delile leaf extracts. 小木犀叶提取物的植物化学成分、生物活性及分子对接分析

IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-09-01 DOI: 10.17344/acsi.2025.9205

Abdulkadir Yunusa, Abubakar Bawa, Misbahu Sambo, Magret Samuel Nadro, Abdulrahman Mahmoud Dogara, Ateeq Ahmed Al-Zahrani, Hussain Daifallah Almalki, Hemn Star

引用次数: 0

Anion induced synthesis, crystal structures and urease inhibition of copper(II) complexes derived from N'-(3-bromo-5-chloro-2-hydroxybenzylidene)-4-methylbenzohydrazide. 阴离子诱导的N'-（3-溴-5-氯-2-羟基苄基）-4-甲基苯并肼铜（II）配合物的合成、晶体结构和脲酶抑制作用

IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-08-31 DOI: 10.17344/acsi.2026.10000

Zhong-Lu You, Ling-Yu Wang, Fei-Yang Xie, Zi-Han Pu, Yao-Yao Cao, Da-Hua Shi

{"title":"Anion induced synthesis, crystal structures and urease inhibition of copper(II) complexes derived from N'-(3-bromo-5-chloro-2-hydroxybenzylidene)-4-methylbenzohydrazide.","authors":"Zhong-Lu You, Ling-Yu Wang, Fei-Yang Xie, Zi-Han Pu, Yao-Yao Cao, Da-Hua Shi","doi":"10.17344/acsi.2026.10000","DOIUrl":"https://doi.org/10.17344/acsi.2026.10000","url":null,"abstract":"Aroylhydrazones have attracted considerable attention owing to their diverse biological properties and strong coordination ability toward metal ions. In the present study, two novel copper(II) complexes, [CuL(MeOH)]NO3·MeOH (1) and [CuBrL(MeOH)]·MeOH (2), derived from the aroylhydrazone ligand N'-(3-bromo-5-chloro-2-hydroxybenzylidene)-4-methylbenzohydrazide (HL), were successfully synthesized and comprehensively characterized using various physicochemical techniques. Single-crystal X-ray diffraction analyses revealed that the ligand coordinates to the copper(II) center in its deprotonated form (L⁻). Complex 1 exhibits a square planar geometry, and complex 2 exhibits a distorted square-pyramidal geometry around the Cu(II) ions. In complex 1, the coordination polyhedron is formed by the three donor atoms of the aroylhydrazone ligand and one methanol oxygen. In complex 2, the basal plane is defined by the three donor atoms of the aroylhydrazone ligand and one methanol oxygen, and the axial position is occupied by a bromide ligand. In addition, one methanol molecule is present as a solvent of crystallization in each complex. The supramolecular architectures of the complexes are further reinforced through intermolecular hydrogen-bonding interactions. Biological evaluation demonstrated that both copper(II) complexes possess remarkable inhibitory activity against Jack bean urease, with IC50 values of 0.5 and 1.1 μmol L⁻1 for complexes 1 and 2, respectively, indicating their potential as potent urease inhibitors.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 3","pages":"694-701"},"PeriodicalIF":1.2,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting ruthenium scorpionate chemistry: Reactivity of bis(3,5-dimethylpyrazol-1-yl)acetic acid toward organoruthenium(II) precursors. 重述天蝎酸钌化学：双（3,5-二甲基吡唑-1-基）乙酸对有机钌（II）前体的反应性。

IF 1.2 4区化学

Acta Chimica Slovenica Pub Date : 2026-08-28 DOI: 10.17344/acsi.2026.9999

Mihaela Rebernik Gracej, Nives Kitanovski, Jakob Kljun

引用次数: 0