{"title":"Using Eye-Movements to Explain Processing Triple Level of Chemical Information: Systematic Review.","authors":"Miha Slapničar, Luka Ribič, Iztok Devetak","doi":"10.17344/acsi.2024.9049","DOIUrl":"10.17344/acsi.2024.9049","url":null,"abstract":"<p><p>The focus of this systematic literature review was to examine eye-tracking studies in the chemistry classroom and to evaluate the usefulness of eye-tracking in studying students' learning of complex chemical concepts. The reviewed studies primarily used small samples of students, with undergraduate students being the most studied population, and measured variables such as eye movements, fixation time, pupil dilation, and others. The results show that higher performing students have shorter fixation time and learn better with models, with prior knowledge being an important factor. However, both students rely mainly on the symbolic level of presentations with better performing students being more successful at giving explanations. Problems with the complexity of data analysis were reported in the studies.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 1","pages":"1-14"},"PeriodicalIF":1.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulrahaman Mahmoud Dogara, Sawsan Sadiq Al-Rawi, Ateeq Ahmed Al-Zahrani, Abubakar Abdullahi Lema, Aisha Abdullahi Mahmud, Hasan Nudin Nur Fatihah, Iliyasu Uwaisu, Hussain Daifallah Almalki
{"title":"Biological activities, chemical composition and molecular docking of Urelytrum giganteum Pilg.","authors":"Abdulrahaman Mahmoud Dogara, Sawsan Sadiq Al-Rawi, Ateeq Ahmed Al-Zahrani, Abubakar Abdullahi Lema, Aisha Abdullahi Mahmud, Hasan Nudin Nur Fatihah, Iliyasu Uwaisu, Hussain Daifallah Almalki","doi":"10.17344/acsi.2024.9077","DOIUrl":"10.17344/acsi.2024.9077","url":null,"abstract":"<p><p>This study analyzed solvent extractions of Urelytrum giganteum Pilg, a perennial wild tufted grass in dry tropical African countries, to determine its antioxidant potential, chemical composition, proximate analysis, antimicrobial efficacy, and molecular docking. The ethanolic extract showed the highest antioxidant activity across various assays and showed the most substantial antibacterial activity against all tested bacterial strains. The phytochemicals identified included alkaloids, flavonoids, saponins, phenolic substances, tannins, carbohydrates, terpenes, and C-glycosides. The majority of the phytochemicals demonstrated notable inhibitory activity, with Stigmasterol showing the highest inhibition score.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 1","pages":"107-118"},"PeriodicalIF":1.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pham M Tuan, Danh C Vu, Sy Vo Van, Ngo Thi Thuy, Vo Mong Tham, Nguyen Ngan
{"title":"Phytochemical composition, antioxidant and enzyme inhibitory effects of Stahlianthus thorelii Gagnep. rhizomes.","authors":"Pham M Tuan, Danh C Vu, Sy Vo Van, Ngo Thi Thuy, Vo Mong Tham, Nguyen Ngan","doi":"10.17344/acsi.2024.9043","DOIUrl":"10.17344/acsi.2024.9043","url":null,"abstract":"<p><p>Stahlianthus thorelii Gagnep. is used in traditional medicine to treat various diseases. In this study, ethyl acetate (EtOAc) extract of S. thorelii rhizomes was analyzed for its phychemicals, antioxidant activity and inhibition against enzymes (acetylcholinesterase, α-amylase, α-glucosidase, and tyrosinase). The EtOAc extract showed the presence of ferulic acid, catechin, epicatechin, epigallocatechin gallate, quercetin, and kaempferol, with average levels ranging from 169.29 to 2449.60 μg/g. Analysis of the volatile components of the extract revealed that β-patchoulene (23.1%), (E)-nerolidyl isobutyrate (11.9%), and aristolene (10.8%) were the major compounds. The antioxidant potential of the extract measured by DPPH (IC50 = 86.94 ± 2.87 μg/mL) and ABTS (IC50 = 743.60 ± 56.52 μg/mL) assays showed promising results. The inhibitory effects against acetylcholinesterase and α-amylase demonstrated potential with IC50 values of 246.43 ± 11.39 and 789.84 ± 8.27 µg/mL, respectively. The findings above suggest that the EtOAc extract of S. thorelii could contribute to supporting the treatment of certain diseases such as diabetes and Alzheimer's.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 1","pages":"63-70"},"PeriodicalIF":1.2,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biomarkers of neuroinflammation in abdominal cancer surgery with optimised anaesthesia.","authors":"Matej Jenko, Aleš Jerin, Alenka Spindler Vesel","doi":"10.17344/acsi.2024.8901","DOIUrl":"10.17344/acsi.2024.8901","url":null,"abstract":"<p><p>Neurocognitive decline during the perioperative period represents a risk of significant complications, including dementia and even death. Our prospective study included high-risk surgical patients who underwent large intestinal resections. Balanced anaesthesia was used to maximize cerebral protection. The release of NSE, protein S-100, matrix metalloproteinase-9 (MMP-9) and other biomarkers of cerebral injury and inflammation were measured during and after surgery to obtain the perioperative concentration profile and to identify possible clinically useful markers. Profiles of proteins MMP-9 and S-100 showed perioperative increase, which was in accordance with intraoperative cerebral injury. The S-100 and NSE plasma levels remained within normal values. The level of NSE even decreased, probably due to intraoperative fluid infusion. Our study showed that the use of neuroprotective anesthesia can reduce neuroinflammation. The study also highlights the perioperative expression of proteins MMP-9 and S-100, which might be useful as biomarkers of cerebral injury in the context of balanced anesthesia during major abdominal surgery.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 1","pages":"45-51"},"PeriodicalIF":1.2,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cennet Ozay, Nuray Sarac Deveci, Fadime Aydin Kose, Ramazan Mammadov
{"title":"Two unexplored Saponaria species from Türkiye: Phenolic composition and a pharmacologic potential.","authors":"Cennet Ozay, Nuray Sarac Deveci, Fadime Aydin Kose, Ramazan Mammadov","doi":"10.17344/acsi.2024.9076","DOIUrl":"10.17344/acsi.2024.9076","url":null,"abstract":"<p><p>To investigate the total secondary metabolite amounts, phenolic profile, antioxidant activity, acute toxicity, cytotoxic, and wound-healing effects of the aerial parts of Saponaria kotschyi (endemic) and Saponaria pumilio extracts. The total phenolic, flavonoid, saponin, and tannin contents; antioxidant activity (via six different methods, including β-carotene/linoleic acid, DPPH, ABTS, FRAP, phosphomolybdenum, and metal chelating assays); phenolic constituents in the extracts (HPLC method); acute toxicity (brine shrimp lethality test); antiproliferative effects on human cervical carcinoma (HeLa) and human neuroblastoma (SH-SY5Y) cancer cell lines (MTT assay); and the effects on wound healing in healthy mouse fibroblast cells (NIH-3T3) through an in vitro scratch assay were evaluated. The methanol extract of S. kotschyi demonstrated higher concentrations of secondary metabolites and antioxidant activity than S. pumilio. Both species predominantly contained caffeic acid, 2,5-dihydroxybenzoic acid, and epicatechin, though S. pumilio had a notably higher caffeic acid content. Additionally, S. kotschyi extract showed greater cytotoxicity against HeLa and SH-SY5Y cancer cells, while S. pumilio exhibited greater wound-healing efficacy. Two previously unexplored Saponaria species reveal a remarkable richness in secondary metabolites and potent antioxidant activity. Given their diverse phenolic constituents, these species emerge as promising candidates for therapeutic applications in cervical cancer and neuroblastoma, as well as playing a potentially critical role in tissue repair and regeneration-areas that merit further in-depth investigation.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 1","pages":"96-106"},"PeriodicalIF":1.2,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merve Argon, Temine Sabudak, Buse Nur Yildirim, Bahadır Batar, Hakime Hulya Orak, Mehmet Yabas, Ayten Bostanci, Hilmican Caliskan
{"title":"Chemical profile, antiproliferative and antioxidant activities of Genista januensis subsp. lydia (Boiss.) Kit Tan & Ziel (Fabaceae).","authors":"Merve Argon, Temine Sabudak, Buse Nur Yildirim, Bahadır Batar, Hakime Hulya Orak, Mehmet Yabas, Ayten Bostanci, Hilmican Caliskan","doi":"10.17344/acsi.2024.8957","DOIUrl":"10.17344/acsi.2024.8957","url":null,"abstract":"<p><p>The aim of this study was to investigate the anticancer and antioxidant activities of the G. januensis subsp. lydia (Fabaceae) and to isolate the phytochemical compounds responsible for these activities. In this study, the G. januensis plant was extracted by maceration with increasing polarity and the anticancer activity of the crude extracts was investigated by performing cytotoxicity, apoptosis and cell cycle analyses. In addition, the total phenolic/flavonoid content was determined in crude extracts and antioxidant activity. According to the results of anticancer and antioxidant activities, the EtOAc extract was found to have the highest activity and this extract was selected for an isolation study. All purified flavonoid compounds from the EtOAc extract were elucidated using 1D and 2D NMR and mass spectroscopy methods and compared with the literature data. A new biflavonoid (4) was isolated together with three known isoflavonoids (Genistein (1), Genistin (2) and 4'-hydroxy isoflavon (3)) from Genista januensis subsp. lydia (Fabaceae). MTT analysis of the compounds 2, 3, and 4 was utilized to evaluate the anticancer activity. Moreover, compound 4 had antioxidant activities determined. These findings suggest that G. januensis subsp. lydia has potential for further study as a natural source of antiproliferative and antioxidant agents.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"72 1","pages":"52-62"},"PeriodicalIF":1.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DRUŠTVENE VESTI IN DRUGE AKTIVNOSTI SOCIETY NEWS, ANNOUNCEMENTS, ACTIVITIES.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 3","pages":"S75-S91"},"PeriodicalIF":1.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ekaterina Arzyamova, Olga Mazhukina, Alevtina Yegorova
{"title":"Synthesis of (E)-3-{[2-oxo-5-arylfuran-3(2H)-ylidene]methyl}-4H-1-benzopyran-4-ones, crystal structure, quantum chemical substantiation.","authors":"Ekaterina Arzyamova, Olga Mazhukina, Alevtina Yegorova","doi":"10.17344/acsi.2024.8791","DOIUrl":"https://doi.org/10.17344/acsi.2024.8791","url":null,"abstract":"<p><p>A directed method for the preparation of hybrid compounds based on furan-2(3H)-ones and chromen-4(4H)-one, (E)-3-{[2-oxo-5-arylfuran-3(2H)-ylidene]methyl}-4H-1-benzopyran-4-ones, the structure of which was confirmed by elemental analysis, IR, UV, NMR spectroscopy, and X-ray single crystal analysis, was developed. The molecular geometry of the synthesized compound (E)-3-((2-oxo-5-phenylfuran-3(2H)-ylidene)methyl)-4H-chromen-4-one (3a) was analyzed and compared with X-ray diffraction data, DFT calculations were performed using 6-311G split-valence basis functions.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 3","pages":"528-539"},"PeriodicalIF":1.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extraction System for the Spectrophotometric Determination of Tungsten(VI) with 4-Nitrocatechol and Benzalkonium Chloride.","authors":"Vidka Vassileva Divarova, Kirila Trifonova Stojnova, Ivelina Dobromirova Radkovska, Antoaneta Dimitrova Saravanska, Galya Kostadinova Toncheva, Vassil Borisov Delchev, Kiril Blazhev Gavazov","doi":"10.17344/acsi.2024.8835","DOIUrl":"https://doi.org/10.17344/acsi.2024.8835","url":null,"abstract":"<p><p>A novel chromogenic system for the liquid-liquid extraction and determination of trace amounts of tungsten(VI) was investigated. The system comprises 4-nitrocatechol (4NC) as a chromogenic reagent, sulfuric acid as a complexing medium, and benzalkonium chloride (BAC) as a source of bulky cations (BA+), which readily form chloroform-extractable ion-association complexes. The impact of foreign ions and reagents was studied, and the optimal conditions for the sensitive, selective, and inexpensive determination of tungsten(VI) were identified. The limit of detection, linear working range, and molar absorptivity at lmax (422 nm) were determined to be 31 ng cm-3, 0.1-4.4 µg cm-3, and 5.49 × 104 dm3 mol-1 cm-1, respectively. The composition of the extracted complex was 1:2:2 (W:4NC:BA). Two potential structures of its anionic component, [WO2(4NC)2]2-, were discussed based on optimizations at the B3LYP/CEP-4G theoretical level and comparison between theoretical and experimental spectra.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 3","pages":"519-527"},"PeriodicalIF":1.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shao-Peng Yan, Zhi-Yu Zhu, Qi-Ke Jia, Rui-Ying Ji, Ya-Pin Wang, Dan He, Rong Wang, Yang Zhou
{"title":"Synthetic optimization and antibacterial activity of novel benzodioxepine-biphenyl amide derivatives.","authors":"Shao-Peng Yan, Zhi-Yu Zhu, Qi-Ke Jia, Rui-Ying Ji, Ya-Pin Wang, Dan He, Rong Wang, Yang Zhou","doi":"10.17344/acsi.2024.8784","DOIUrl":"10.17344/acsi.2024.8784","url":null,"abstract":"<p><p>The biosynthesis of fatty acids constitutes a critical metabolic pathway in bacterial organisms. Prior investigations have highlighted the synthesis of antimicrobial compounds anchored in the benzodioxepin scaffold, noted for their pronounced antibacterial properties. Leveraging this foundational knowledge, the current research endeavors to meticulously engineer and synthesize a series of eight innovative benzodioxepin amide-biphenyl derivatives. This achievement was realized through the sophisticated optimization of synthetic methodologies. The scope of this study extends to a rigorous evaluation of the antibacterial prowess and biocompatibility of the aforementioned novel derivatives. Notably, Compound E4 emerged as a supremely potent antimicrobial agent. A detailed elucidation of the crystalline architecture of Compound E4 was conducted, alongside a thorough docking study to explore its interactions with the FabH enzyme.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"71 3","pages":"509-518"},"PeriodicalIF":1.2,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}