Acta Chimica Slovenica最新文献_第3页

Design, synthesis, X-ray structure, Hirshfeld surface, and NLO behavior of 3-bromo-2-[(2E)-2-(2-oxonaphthalen-1(2H)-ylidene)hydrazinyl]benzoic acid. 3-溴-2-[(2E)-2-（2-氧萘-1(2H)-酰基）肼基]苯甲酸的设计、合成、x射线结构、Hirshfeld表面和NLO行为。

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2026-01-05 DOI: 10.17344/acsi.2025.9398

Souheyla Chetioui, Mansour Azayez, Ouarda Brihi, Djebar Hadji, Zohra-Douaa Benyahlou, Youcef Megrouss, Abdelkader Chouaih, Mokhtaria Drissi, Jean-Pierre Djukic, Salem Yahiaoui

{"title":"Design, synthesis, X-ray structure, Hirshfeld surface, and NLO behavior of 3-bromo-2-[(2E)-2-(2-oxonaphthalen-1(2H)-ylidene)hydrazinyl]benzoic acid.","authors":"Souheyla Chetioui, Mansour Azayez, Ouarda Brihi, Djebar Hadji, Zohra-Douaa Benyahlou, Youcef Megrouss, Abdelkader Chouaih, Mokhtaria Drissi, Jean-Pierre Djukic, Salem Yahiaoui","doi":"10.17344/acsi.2025.9398","DOIUrl":"https://doi.org/10.17344/acsi.2025.9398","url":null,"abstract":"The crystalline form of the compound, 3-bromo-2-[(2E)-2-(2-oxonaphthalen-1(2H)-ylidene)hydrazinyl]benzoic acid (BOHB), has been synthesized in good yield by diazotization of 2-amino-3-bromobenzoic acid followed by a reaction with β-naphthol. The XRD-crystal measurements and DFT calculations confirmed that the hydrazone was the favored form. The structure of the synthetic product was also examined by IR and NMR spectroscopic methods. Using Hirshfeld surface analysis, interactions in the crystal have been highlighted, where many contributors are identified such as H···H (24.7%), O···H/H···O (20.6%), H···C/C···H (17.0%), and Br···H/H···Br (15.0%). Furthermore, the novel benzoic acid derivative was investigated for its nonlinear optical (NLO) properties. Computational results indicate that the compound shows enhanced first hyperpolarizability values relative to common reference systems. This suggests the benzoic acid derivative might offer a potential structural basis for exploring materials for selected NLO applications.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 1","pages":"140-153"},"PeriodicalIF":1.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, characterization and antimicrobial activity of fluoro-containing aroylhydrazones. 含氟芳基腙的合成、表征及抗菌活性研究。

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2026-01-02 DOI: 10.17344/acsi.2025.9574

Lei Shi, Xiaoniu Hong, Xinyue Zhang, Fu-Ming Wang, Feng Guo

引用次数: 0

Nickel(II) complex derived from 5-phenyl-1,3,4-oxadiazole-2-thiol and dppe ligands: synthesis, crystal structure, cytotoxicity and theoretical studies. 5-苯基-1,3,4-恶二唑-2-硫醇和dppe配体衍生的镍（II）配合物：合成、晶体结构、细胞毒性和理论研究。

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2026-01-01 DOI: 10.17344/acsi.2025.9603

Beriwan Muhamad Hamad Ameen, Karwan Omer Ali, Rezan Ali Saleh

引用次数: 0

Examining the chemical reasoning of pre-service science teachers using a multiple-choice test based on the essential questions-perspectives framework. 运用基于基本问题-视角框架的多项选择测验来检验职前科学教师的化学推理能力。

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2025-12-31 DOI: 10.17344/acsi.2025.9556

Gülen Önal Karakoyun

{"title":"Examining the chemical reasoning of pre-service science teachers using a multiple-choice test based on the essential questions-perspectives framework.","authors":"Gülen Önal Karakoyun","doi":"10.17344/acsi.2025.9556","DOIUrl":"https://doi.org/10.17344/acsi.2025.9556","url":null,"abstract":"The purpose of this study is to examine the chemical reasoning levels of pre-service science teachers. For this purpose, an inventory developed by the researcher in accordance with the Essential Questions-Perspectives Framework (EQ-P) was used as a data collection tool. The inventory consists of thirty-six questions related to three fundamental question types and twelve chemical perspectives. A total of 265 pre-service science teachers from six universities in Turkey participated in the study. A survey model was used in the study. Findings showed that pre-service science teachers performed better on questions related to identification and description. Success was moderate for questions requiring explanation and prediction. Success was lowest for questions requiring transformation and synthesis. When evaluated according to perspectives, high success was observed on questions related to physical properties, structure, composition, and reaction properties. Success was moderate for questions related to particles, interactions, kinetics, and thermodynamics. Success was low for questions related to target molecules, starting materials, addition-removal and process control. The results indicated that the chemical reasoning levels of pre-service science teachers varied significantly depending on the fundamental question types and perspectives. The findings reveal that synthesis and design-oriented thinking should be supported more in chemistry teaching.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 1","pages":"174-182"},"PeriodicalIF":1.3,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, and biological evaluation of N-propionylcysteamine-functionalized calix[n]arenes: antioxidant and enzyme inhibitory activities. n -丙酰半蒸汽碱功能化杯[n]芳烃的设计、合成和生物学评价：抗氧化和酶抑制活性。

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2025-12-18 DOI: 10.17344/acsi.2025.9464

Mürüvvet Kurt, Murat Özer, Gülderen Uysal Akkuş

引用次数: 0

Synthesis, structure and photophysical properties of novel thiazolo[2,3-b]pteridines. 新型噻唑[2,3-b]翼啶化合物的合成、结构及光物理性质

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2025-12-18 DOI: 10.17344/acsi.2025.9557

Daryna Kyrylova, Oleksii Voskoboinik, Anatolii Tatarets, Liubomyr Havryshchuk, Svitlana Shishkina, Sergiy Okovytyy, Serhii Kovalenko

引用次数: 0

Novel hydrazide-hydrazone derivatives containing flurbiprofen 1,2,4-triazole as anticancer agents: design, synthesis and biological evaluation. 以氟比洛芬1,2,4-三唑为抗癌剂的新型酰腙衍生物：设计、合成及生物学评价。

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2025-12-18 DOI: 10.17344/acsi.2025.9452

Ecem Gökoğlan, Çiğdem Çakıcı, Ömer Erdoğan, Özgür Yılmaz, Özge Çevik, Ş Güniz Küçükgüzel

{"title":"Novel hydrazide-hydrazone derivatives containing flurbiprofen 1,2,4-triazole as anticancer agents: design, synthesis and biological evaluation.","authors":"Ecem Gökoğlan, Çiğdem Çakıcı, Ömer Erdoğan, Özgür Yılmaz, Özge Çevik, Ş Güniz Küçükgüzel","doi":"10.17344/acsi.2025.9452","DOIUrl":"https://doi.org/10.17344/acsi.2025.9452","url":null,"abstract":"Hydrazone derivatives are one of the scaffolds frequently used in new drug development studies. Due to the promising pharmacological effects of the hydrazone structure, fifteen new hydrazide-hydrazone compounds containing flurbiprofen 1,2,4-triazole were synthesized in this study and their in vitro anticancer effects were tested. All compounds were tested for cytotoxic effects against breast cancer cell lines (MCF-7 and MDA-MB231), and glioblastoma cell line (U87) by using MTT assay. Among the synthesized compounds, compounds 7a and 7c exhibited the most potent cytotoxic activity with IC50 values of 7.80 ± 1.20 µM and 2.40 ± 0.93 µM against MCF-7 cell line, while compound 7a showed the highest activity with IC50 value of 7.63 ± 1.05 µM against MDA-MB231 cell line. In addition, compounds 7c and 7n presented cytotoxic activity with IC50 values of 10.31 ± 4.63 µM and 10.81 ± 6.11 µM against U87 cell line. The possible cytotoxic effects of compounds on mouse fibroblast cell line (L929) were assessed for their safety and compounds 7a, 7c, and 7n were found less toxic than 5-fluorourasil. Additionally, compound 7c was further studied to investigate its effects on apoptosis and PI3K activity, which play a role in cancer development. The results showed that compound 7c increased apoptosis in MCF-7 cells and it displayed PI3K enzyme inhibitory activity. Our study revealed that the synthesized hydrazone compounds have the potential to be lead compounds for further studies on cancer.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 1","pages":"70-88"},"PeriodicalIF":1.3,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological, electrochemical, molecular docking and DFT studies of the asymmetric Schiff base: synthesis of 2-hydroxy-6-methyl-3-((E)-1-((4-methyl-3-((E)-(pyridin-3-ylmethylene)amino)phenyl)imino)ethyl)-4H-pyran-4-one. 不对称席夫碱的生物学、电化学、分子对接和DFT研究：2-羟基-6-甲基-3-((E)-1-（（4-甲基-3-（E)-（吡啶-3-基亚甲基）氨基）苯基亚胺）乙基）- 4h -吡喃-4-酮的合成。

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2025-12-18 DOI: 10.17344/acsi.2025.9482

Khadidja Boukerche, Djahida Haffar, Chawki Bensouici, Amina Belounis

{"title":"Biological, electrochemical, molecular docking and DFT studies of the asymmetric Schiff base: synthesis of 2-hydroxy-6-methyl-3-((E)-1-((4-methyl-3-((E)-(pyridin-3-ylmethylene)amino)phenyl)imino)ethyl)-4H-pyran-4-one.","authors":"Khadidja Boukerche, Djahida Haffar, Chawki Bensouici, Amina Belounis","doi":"10.17344/acsi.2025.9482","DOIUrl":"https://doi.org/10.17344/acsi.2025.9482","url":null,"abstract":"The asymmetric Schiff base 2-hydroxy-6-methyl-3-((E)-1-((4-methyl-3-((E)-(pyridin-3-ylmethylene)amino)phenyl)imino)ethyl)-4H-pyran-4-one (AL) was synthesized, and characterized by LC-MS, FT-IR, UV-Vis, 1H and 13C NMR techniques as well as cyclic voltammetry. The optimized molecular structures, IR and UV-Vis spectral modeling, stability, reactivity, and specific quantum chemical properties of the synthesized AL were examined using Density Functional Theory (DFT). The theoretical findings were consistent with the experimental results. The results show that compound AL has good antioxidant and anti-inflammatory activity. The electrochemical behavior of AL and BHT in the presence of superoxide radicals shows that the radical reaction is spontaneous. Apro-AL calculations indicated the ability of the AL compound to inhibit the primary protease (4GCA). Finally, the docking studies and ADME-T results showed that the AL compound under investigation could be developed as a therapeutic agent.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 1","pages":"98-117"},"PeriodicalIF":1.3,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid synthesis and antimicrobial evaluation of triazole-modified calix[4]arenes via click chemistry. 三唑修饰杯芳烃的快速合成及抗菌性能评价。

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2025-12-18 DOI: 10.17344/acsi.2025.9503

Murat Özer, Fatma Demir, Safiye Elif Korcan, Gülderen Uysal Akkuş

引用次数: 0

DRUŠTVENE VESTI IN DRUGE AKTIVNOSTI SOCIETY NEWS, ANNOUNCEMENTS, ACTIVITIES. DruŠtvene vesti in drugs activenosti society新闻、公告、活动。

IF 1.3 4区化学

Acta Chimica Slovenica Pub Date : 2025-12-02

引用次数: 0