Zhong-Lu You, Jia-Yan Dai, Hao-Dong Zhang, Yu-Qun Ye, Jin Mu, Mu-Ji Jike, Yu-Qing Gu
{"title":"3-Hydroxy-N'-(2-hydroxy-4-methoxybenzylidene)benzohydrazide and its isostructural cobalt(II) and nickel(II) complexes: Synthesis, X-ray crystal structures and antibacterial activity.","authors":"Zhong-Lu You, Jia-Yan Dai, Hao-Dong Zhang, Yu-Qun Ye, Jin Mu, Mu-Ji Jike, Yu-Qing Gu","doi":"10.17344/acsi.2026.9841","DOIUrl":"https://doi.org/10.17344/acsi.2026.9841","url":null,"abstract":"<p><p>A new hydrazone compound 3-hydroxy-N'-(2-hydroxy-4-methoxybenzylidene)benzohydrazide (HL) and its isostructural cobalt(II) and nickel(II) complexes [M2Cl2L2(EtOH)2] (M = Co for 1, Ni for 2) were synthesized and characterized by physico-chemical methods such as elemental analysis, infrared and electronic spectroscopy. The free hydrazone HL was also characterized by 1H and 13C NMR spectroscopy. Structures of HL and the two complexes were further confirmed by single crystal X-ray determination. The hydrazone ligand in the complexes coordinates to the metal atoms through phenolate oxygen, imino nitrogen and carbonyl oxygen atoms. The metal atoms in the complexes are in octahedral coordination. The hydrazone and both complexes were assayed for antibacterial activities on the bacterial strains Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and on the fungal strains Candida albicans and Aspergillus niger, and gave interesting results.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 3","pages":"546-553"},"PeriodicalIF":1.2,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aza-Michael approach for the rapid synthesis of 3,5-dimethylpyrazole derivatives with potential biological significance.","authors":"Hasmik Khachatryan, Ruzanna Paronikyan, Ivetta Nazaryan, Hrachik Gasparyan, Hovhannes Attaryan","doi":"10.17344/acsi.2025.9660","DOIUrl":"https://doi.org/10.17344/acsi.2025.9660","url":null,"abstract":"<p><p>A promising strategy for preventing epileptogenic processes involves the development of modified aza-Michael adducts, which demonstrate a range of biological activities, including antioxidant, anti-inflammatory, and antiviral effects. In the present study, compound 3, administered at a dose of 50 mg/kg, prevented pentylenetetrazole-induced clonic seizures in 60% of mice (ED50 = 37.5 mg/kg), while compound 4 achieved seizure prevention in 40% of mice. With an ED50 value of 155.5 mg/kg, compound 3 was approximately four times more potent than ethosuximide. Importantly, neither the tested compounds nor ethosuximide (50-500 mg/kg) produced muscle relaxation or impaired motor coordination. Furthermore, derivatives of compound 3 exhibited not only anticonvulsant activity but also anxiolytic and antidepressant effects, surpassing ethosuximide in the conducted assays. Ongoing research aims to further explore and optimize this series of compounds for potential therapeutic use.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 3","pages":"522-526"},"PeriodicalIF":1.2,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photoinactivation of MRSA ATCC 33591 by antimicrobial photodynamic therapy using coumarin-functionalized zinc(II) phthalocyanine.","authors":"Merve Bilgin, Tuğba Elgün, Çiğdem Aktaş, Onur Olgaç Karagülle, Kamil Çınar, Asiye Yurttaş","doi":"10.17344/acsi.2025.9638","DOIUrl":"https://doi.org/10.17344/acsi.2025.9638","url":null,"abstract":"<p><p>This study evaluates the photodynamic inactivation potential of a coumarin-functionalized zinc(II) phthalocyanine derivative against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 33591. The antimicrobial and cytotoxic effects of the derivative were assessed under dark and laser-irradiated (658 nm) conditions. Minimum inhibitory concentration (MIC) values were determined, and the photodynamic response was further explored in MRSA-infected HT-29 (human colorectal adenocarcinoma) and HUVEC (human umbilical vein endothelial) cell models. While the derivative exhibited dose-dependent antibacterial activity, the light-induced reduction in colony-forming units (CFU) was moderate, remaining below a tenfold (1-log10) under the tested conditions. In cell-based assays, the compound showed detectable dark cytotoxicity, which was further enhanced upon laser irradiation. The photodynamic cytotoxic response was more pronounced in infected HT-29 cells than in infected HUVEC cells, with flow-cytometric profiles consistent with predominantly necrotic/late apoptotic cell-death patterns. These findings indicate that the compound exhibits light-enhanced effects in complex infection models; however, further optimization of formulation, photophysical properties, and light dosimetry is required to improve antimicrobial efficacy and selectivity.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 3","pages":"515-521"},"PeriodicalIF":1.2,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149102668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DRUŠTVENE VESTI IN DRUGE AKTIVNOSTI SOCIETY NEWS, ANNOUNCEMENTS, ACTIVITIES.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 2","pages":"S21-S56"},"PeriodicalIF":1.2,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, crystal structures and urease inhibition of isostructural tetranuclear nickel(II)-zinc(II) complexes derived from 2-(((2-hydroxyphenyl)imino)methyl)-6-methoxyphenol.","authors":"Peng Liang, Hai-Bo Niu","doi":"10.17344/acsi.2026.9781","DOIUrl":"https://doi.org/10.17344/acsi.2026.9781","url":null,"abstract":"<p><p>Three isostructural tetranuclear nickel(II)-zinc(II) complexes with the general formula [Ni2Zn2(CH3OH)2L2(N3)2X2]·2CH3OH (X = Cl for 1, Br for 2, I for 3, and L is the dianionic form of 2-(2-hydroxy-3-methoxybenzylideneamino)phenol (H2L)) were prepared. H2Land the complexes have been characterized by elemental analysis, IR and UV-Vis spectroscopy. Molecular structures of H2L and the three complexes have been confirmed by single crystal X-ray diffraction. The three complexes are isostructural. The Schiff base ligand L coordinates to the Ni and Zn atoms through all the donor atoms including two phenolate oxygens, imine nitrogen and ether oxygen. The Ni atoms are in octahedral coordination, and the Zn atoms are in square pyramidal coordination. The azide ligand adopts interesting µ1,1,1-bridging mode. Cl, Br and I ligands adopt terminal coordination mode. The methanol molecules act both as terminal ligand and solvate in the crystals. The complexes have interesting inhibitory activity on Jack bean urease, with IC50 values of 3.2-3.6 μmol L-1.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 2","pages":"489-495"},"PeriodicalIF":1.2,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"N'-(2-Hydroxy-4-methoxybenzylidene)-4-methylbenzohydrazide and its dinuclear nickel(II) and cadmium(II) complexes: Synthesis, crystal structures and urease inhibition.","authors":"Chi Liu, Liu-Xiu Chen, Zi-Fu Hu, Wu Chen","doi":"10.17344/acsi.2026.9766","DOIUrl":"https://doi.org/10.17344/acsi.2026.9766","url":null,"abstract":"<p><p>Hydrazone compounds and their nickel(II) and cadmium(II) complexes have interesting biological activities. To explore new and efficient urease inhibitors, in this work an aroylhydrazone compound N'-(2-Hydroxy-4-methoxybenzylidene)-4-methylbenzohydrazide (HL) and two complexes [Ni2L2(CH3OH)2(OH2)2]Cl2·2CH3OH (1) and [Cd2L2(CH3COO)2] (2) have been prepared and characterized by elemental analysis, infrared and electronic spectroscopy, as well as single crystal X-ray determination. In addition, 1H and 13C NMR spectroscopy was used for HL. Both complexes are dinuclear compounds. The Ni atoms in complex 1 are in octahedral coordination, and the Cd atoms in complex 2 are in square pyramidal coordination. The Cl- in 1 acts as a counter anion, while the NO3- in 2 coordinates to the metal atoms with bidentate form. The urease inhibitory assay reveals that HL has weak activity, while complexes 1 and 2 have IC50 values of 18.2 ± 1.1 μmol L-1 and 0.38 ± 0.12 μmol L-1, respectively. Both complexes have higher activity than the standard drug acetohydroxamic acid (IC50 = 28.1 μmol L-1).</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 2","pages":"436-443"},"PeriodicalIF":1.2,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predicting mutagenicity of aromatic and heteroaromatic amine mutagens using a newly developed set of laplacian matrix-based graph invariants.","authors":"Igor Kuzmanovski, Subhash C Basak","doi":"10.17344/acsi.2026.9757","DOIUrl":"10.17344/acsi.2026.9757","url":null,"abstract":"<p><p>This paper presents an effort for development of predictive quantitative structure-activity relationship (QSAR) models to assess mutagenicity of a set of 95 aromatic and heteroaromatic amines using newly developed set of Laplacian matrix-based molecular descriptors using graph convolution. In order to calculate these descriptors we used (1) properties of isolated atoms, (2) properties of the atoms, which arise from their molecules, and (3) properties derived from the graphs that represent the molecules. The QSAR models developed are based on counter-propagation artificial neural network algorithm. The optimization was performed in automated manner using genetic algorithm for (1) selection of the most suitable descriptors as well as for (2) selection of the most suitable parameters of the neural networks. Results presented in this study show that this new type of descriptors, reported in this paper, encode structural information capable of predicting TA98 Ames' mutagenicity of the amines.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 2","pages":"425-435"},"PeriodicalIF":1.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
De-Jun Meng, Yan-Chun Hou, Ning Wang, Ming-Jie Ding, Yin-Feng Li
{"title":"Syntheses, characterization, crystal structures and antibacterial activity of pyridine containing hydrazones.","authors":"De-Jun Meng, Yan-Chun Hou, Ning Wang, Ming-Jie Ding, Yin-Feng Li","doi":"10.17344/acsi.2026.9807","DOIUrl":"10.17344/acsi.2026.9807","url":null,"abstract":"<p><p>Three new hydrazone compounds derived from 3-pyridinecarboxaldehyde with hydrazides, and two new hydrazone compounds derived from nicotinohydrazide with aldehydes were prepared and characterized by elemental analyses, IR and 1H NMR spectroscopy, and single crystal X-ray diffraction. They are 3,4-dihydroxy-N'-(pyridin-3-ylmethylene)benzohydrazide (1), 4-bromo-N'-(pyridin-3-ylmethylene)benzohydrazide (2), 4-methoxy-N'-(pyridin-3-ylmethylene)benzohydrazide (3), N'-(4-bromo-2-fluorobenzylidene)nicotinohydrazide (4) and N'-(2,5-dimethoxybenzylidene)nicotinohydrazide (5). The five compounds and a published compound N'-(4-hydroxybenzylidene)nicotinohydrazide (6) were assayed for their antibacterial activities against E. coli, P. aeruginosa, S. typhi and S. aureus.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 2","pages":"444-451"},"PeriodicalIF":1.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, characterization, crystal structures and urease inhibitory activity of new acylhydrazone complex materials.","authors":"Feng-Qian Zou, De-Wen Dong","doi":"10.17344/acsi.2026.9815","DOIUrl":"https://doi.org/10.17344/acsi.2026.9815","url":null,"abstract":"<p><p>In this work, four new oxidovanadium(V) complexes with the general formula [VOLL'] were prepared. L is the dianionic form of 2-hydroxy-5-methyl-N'-(3-methylbenzylidene)benzohydrazide (H2L1) for complexes 1 and 2, and 2-hydroxy-4-methoxy-N'-(3-methylbenzylidene)benzohydrazide (H2L2) for complexes 3 and 4. L' is the deprotonated form of methyl maltol (HLa) for complexes 1 and 3, and ethyl maltol (HLb) for complexes 2 and 4. The structural features of the complexes were assigned using the single crystal X-ray diffraction and other physicochemical techniques. The V atoms in the complexes are in octahedral coordination. Inhibitory activities of the acylhydrazones and complexes were evaluated on Helicobacter pylori urease. All the complexes show effective activity with IC50 values of 15.3-27.2 μmol L-1.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 2","pages":"452-458"},"PeriodicalIF":1.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mirela Dragomir, Tadej Rojac, Juan José Sáenz de la Torre, Leyre Flamarique, Fernando Gomollon-Bel, Evelina Colacino
{"title":"Mehanokemija v Evropi: od kod prihajamo in kje smo danes.","authors":"Mirela Dragomir, Tadej Rojac, Juan José Sáenz de la Torre, Leyre Flamarique, Fernando Gomollon-Bel, Evelina Colacino","doi":"10.17344/acsi.2026.9964","DOIUrl":"https://doi.org/10.17344/acsi.2026.9964","url":null,"abstract":"<p><p>Mehanokemija je stara več tisoč let, vendar je bila dolgo časa zapostavljena v korist kemije v raztopinah. Šele v zadnjem času so se mehanokemijske metode uveljavile za razvoj zelene kemije, saj ponujajo alternativo tradicionalnim kemijskim procesom, kjer se običajno uporabljajo organska topila. Mehanokemija se že uspešno uporablja v metalurški industriji, farmacevtskih industriji, za pretvorbo biomase, recikliranje in razgradnjo polimerov. Na področju mehanokemije so se v zadnjih letih razvile številne pobude, ki so nastale kot rezultat skupnih prizadevanj znanstvenikov v Mednarodnem mehanokemijskem združenju. Odobritev projekta COST Action MechSustInd je omogočil pridobivanje sredstev za projekt EU Horizon IMPACTIVE in za ustanovitev Delovne skupine za mehanokemijo pri EuChemS, organizacijo projekta Round Robin na področju mehanokemijskih transformacij ter odobritev projekta IUPAC, namenjenega terminologiji. Vse te pobude postavljajo Evropo v ospredje mehanokemijskih inovacij.</p>","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"73 2","pages":"S33-S41"},"PeriodicalIF":1.2,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}