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Application of Matrix Solid-Phase Dispersion Combined with Gas Chromatography-Mass Spectrometry for the Determination of Bisphenol A in Fresh-Water Fishes 应用基质固相分散结合气相色谱-质谱法测定淡水鱼类中的双酚 A
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-10-16 DOI: 10.3103/S0027131424700391
A. S. Gubin, A. A. Kushnir, P. T. Sukhanov
{"title":"Application of Matrix Solid-Phase Dispersion Combined with Gas Chromatography-Mass Spectrometry for the Determination of Bisphenol A in Fresh-Water Fishes","authors":"A. S. Gubin,&nbsp;A. A. Kushnir,&nbsp;P. T. Sukhanov","doi":"10.3103/S0027131424700391","DOIUrl":"10.3103/S0027131424700391","url":null,"abstract":"<p>Matrix solid-phase dispersion using a humate-based magnetic sorbent is proposed as an efficient method for the concentration of bisphenol A from fish muscular and hepatic tissue samples followed by the chromatography-mass spectrometry determination of an analyte prederivatized with acetic anhydride. Under the optimum concentration conditions (the stirring time is 10 min and the sorbent weight is 0.05 g), the recovery of bisphenol A upon single sorption reaches 85%. The percentage desorption exceeds 99% (the eluate is methanol, the time is 3 min, and the volume is 1 mL). The maximum enrichment factor is 718. The limit of the detection of bisphenol A is 0.15 μg/kg (on a dry basis) for muscular tissue and 0.25 μg/kg for liver.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 5","pages":"351 - 357"},"PeriodicalIF":0.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryochemical Synthesis of Hybrid Nanoforms Based on Silver and Antibacterial Drug Dioxidine by the Low-Temperature Condensation of Vapor from the Gas Phase 通过气相蒸汽的低温凝结低温化学合成基于银和抗菌药物二氧六环的混合纳米形式
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-10-16 DOI: 10.3103/S0027131424700317
A. V. Soloviev, S. A. Gromova, Ya. A. Gromova, A. V. Shabatin, Yu. N. Morosov, T. I. Shabatina
{"title":"Cryochemical Synthesis of Hybrid Nanoforms Based on Silver and Antibacterial Drug Dioxidine by the Low-Temperature Condensation of Vapor from the Gas Phase","authors":"A. V. Soloviev,&nbsp;S. A. Gromova,&nbsp;Ya. A. Gromova,&nbsp;A. V. Shabatin,&nbsp;Yu. N. Morosov,&nbsp;T. I. Shabatina","doi":"10.3103/S0027131424700317","DOIUrl":"10.3103/S0027131424700317","url":null,"abstract":"<p>Hybrid nanoforms based on silver and the antibacterial drug dioxidine (2,3-bis-(hydroxymethyl)quinoxaline 1,4-di-<i>N</i>-oxide) are prepared by the method of joint cocondensation of metal and ligand vapors on a liquid nitrogen-cooled surface. The samples obtained are characterized by FTIR-, UV-Vis, and XPS-spectroscopy, as well as ТЕМ, SEM, and powder X-ray phase analysis (ХРА). It is shown that cryomodified nanoforms preferably consist of the anhydrous triclinic (T-phase) crystal phase of dioxidine. The dimensions of dioxidine particles ranged from 50 to 300 nm and the average size of doping silver nanoparticles is 15 ± 3 nm. The broadening of the diffraction patterns belonging to silver shows the transition of metallic silver to the nanoscale state. The FTIR results indicate hybrid nanoforms stabilized by the donor-acceptor interactions of surface silver atoms with the hydroxyl groups and with the donor N-atoms of quinoxaline cycles of dioxidine molecules.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 5","pages":"301 - 306"},"PeriodicalIF":0.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Structure and Dynamics of the Enzyme–Substrate Complex of N-Acetylaspartylglutamate Synthase According to the Computer Simulation Data 计算机模拟数据显示的 N-乙酰天冬氨酰谷氨酸合成酶酶-底物复合物的结构和动力学特征
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-10-16 DOI: 10.3103/S0027131424700238
I. V. Polyakov, A. V. Krivitskaya, M. G. Khrenova
{"title":"The Structure and Dynamics of the Enzyme–Substrate Complex of N-Acetylaspartylglutamate Synthase According to the Computer Simulation Data","authors":"I. V. Polyakov,&nbsp;A. V. Krivitskaya,&nbsp;M. G. Khrenova","doi":"10.3103/S0027131424700238","DOIUrl":"10.3103/S0027131424700238","url":null,"abstract":"<p><i>N</i>-Acetylaspartylglutamate (NAAG) is the most common dipeptide in brain cells, which is synthesized using the enzyme <i>N</i>-acetylaspartylglutamate synthase. In this study, we utilize bioinformatics methods to predict the protein structure based on the primary sequence of the coding gene, classical molecular dynamics to obtain a stable protein complex with <i>N</i>-acetylaspartate and glutamate ligands within the trajectory, and machine learning methods to analyze, describe, and select potential reactive and nonreactive conformations of the model system describing the enzyme–substrate complex. Molecular dynamics trajectories are obtained for a set of selected conformations within the framework of the method of combined quantum and classical molecular mechanics, and the active site of the protein–ligand complex and potential reaction mechanism are characterized.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 4","pages":"239 - 245"},"PeriodicalIF":0.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of Copper Clusters with Dioxidine 铜簇与二氧六环的相互作用
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-10-16 DOI: 10.3103/S0027131424700226
A. Yu. Ermilov, A. V. Soloviev, Yu. N. Morosov, T. I. Shabatina
{"title":"Interaction of Copper Clusters with Dioxidine","authors":"A. Yu. Ermilov,&nbsp;A. V. Soloviev,&nbsp;Yu. N. Morosov,&nbsp;T. I. Shabatina","doi":"10.3103/S0027131424700226","DOIUrl":"10.3103/S0027131424700226","url":null,"abstract":"<p>The configurations of small copper clusters (Cu<sub>2</sub>, Cu<sub>3</sub>, Cu<sub>13</sub>) and their complexes including a complex containing a copper atom with dioxidine (Dx) are calculated by density functional theory modeling with B3LYP5 parametrization. The trends of the changes in the geometry configuration and metal cluster–dioxidine ligand interaction energy depending on the size of the metal cluster are assessed. The dissociation energy of the complexes increases with the metal cluster size but the maximum value (55.1 kcal/mol) is implemented for a Cu<sub>3</sub>–Dx complex. There is coordination of the metal atom to one or two oxygen atoms of the dioxidine molecule for all the complexes.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 4","pages":"233 - 238"},"PeriodicalIF":0.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modification of the Process of Cesium Separation from the Product of the High-Temperature Treatment of Spent Fuel with Molybdenum Trioxide 改进用三氧化钼高温处理乏燃料产品的铯分离工艺
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-10-16 DOI: 10.3103/S0027131424700378
V. A. Boldakov, S. S. Poglyad, A. S. Kornilov, O. S. Dmitrieva, V. N. Momotov, N. O. Pozigun, A. A. Telnova
{"title":"Modification of the Process of Cesium Separation from the Product of the High-Temperature Treatment of Spent Fuel with Molybdenum Trioxide","authors":"V. A. Boldakov,&nbsp;S. S. Poglyad,&nbsp;A. S. Kornilov,&nbsp;O. S. Dmitrieva,&nbsp;V. N. Momotov,&nbsp;N. O. Pozigun,&nbsp;A. A. Telnova","doi":"10.3103/S0027131424700378","DOIUrl":"10.3103/S0027131424700378","url":null,"abstract":"<p>The technological scheme of cesium extraction from spent fuel before hydrometallurgical reprocessing is developing in order to reduce the heat dissipation and specific activity of spent fuel. The scheme includes the joint high temperature treatment of spent fuel and molybdenum trioxide, flushing the product with an alkali solution to remove cesium, and then dissolving the fuel in nitric acid. Implementation of this technology will allow reducing the cooling time of the spent fuel and reduce the radiation impact on personnel, equipment, and technological environment. This article presents the results of the experimental substantiation of the choice of temperature of the high-temperature treatment, comparative analysis of the efficiency of flushing solutions of different compositions, and determining the duration of the cesium fractionation process. The research was conducted in laboratory conditions with the use of spent fuel imitators and radionuclide markers.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 5","pages":"338 - 344"},"PeriodicalIF":0.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Study of the Dynamic Behavior of Bacterial Photoregulated Adenylate Cyclases bPAC and OaPAC 细菌光调节腺苷酸环化酶 bPAC 和 OaPAC 的动态行为比较研究
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-10-16 DOI: 10.3103/S0027131424700251
M. S. Kuryshkina, A. M. Kulakova, A. A. Moskovsky, M. G. Khrenova
{"title":"A Comparative Study of the Dynamic Behavior of Bacterial Photoregulated Adenylate Cyclases bPAC and OaPAC","authors":"M. S. Kuryshkina,&nbsp;A. M. Kulakova,&nbsp;A. A. Moskovsky,&nbsp;M. G. Khrenova","doi":"10.3103/S0027131424700251","DOIUrl":"10.3103/S0027131424700251","url":null,"abstract":"<p>Photoregulated adenylate cyclases bPAC and OaPAC are compared using methods of classical molecular dynamics in the states before and after irradiation with light. The pathways of signal transduction from the photoreceptor domain to the catalytic domain are determined. The more pronounced acceleration of the catalytic reaction as a result of irradiation with light in the case of bPAC is determined both by a shift of the equilibrium towards a closed conformation and a more significant increase in the number of suboptimal pathways of allosteric signal transduction from one domain to another.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 4","pages":"257 - 261"},"PeriodicalIF":0.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-Destructive Analysis of Tetracycline Drugs by the Digital Colormetric Method Using a Smartphone and the Photometrix Pro® Software 使用智能手机和 Photometrix Pro® 软件以数字比色法对四环素药物进行无损分析
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-10-16 DOI: 10.3103/S0027131424700354
V. G. Amelin, G. M. Beschastnova, Z. A. Ch. Shogah, A. V. Tretyakov, L. K. Kish
{"title":"Non-Destructive Analysis of Tetracycline Drugs by the Digital Colormetric Method Using a Smartphone and the Photometrix Pro® Software","authors":"V. G. Amelin,&nbsp;G. M. Beschastnova,&nbsp;Z. A. Ch. Shogah,&nbsp;A. V. Tretyakov,&nbsp;L. K. Kish","doi":"10.3103/S0027131424700354","DOIUrl":"10.3103/S0027131424700354","url":null,"abstract":"<p>A nondestructive analysis of tetracyclines in drugs by their own fluorescence using a smartphone and a device printed on a 3D printer is proposed. The possibility of using chemometric methods, which reduce the analysis time and visualize the obtained data, is shown. The dataset is processed by principal component analysis (PCA), hierarchical cluster analysis (HCA), partial least squares (PLS) regression, and least squares using the PhotoMetrix PRO<sup>®</sup> software. The use of chemometric methods of analysis to determine the concentration of the active substance and identify the manufacturer of medicinal products is considered.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 5","pages":"325 - 333"},"PeriodicalIF":0.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Modification of Minerals Surfaces: Brief Sketch of Formation and Development 矿物表面的化学修饰：形成与发展简述
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-10-16 DOI: 10.3103/S0027131424700366
G. V. Lisichkin
{"title":"Chemical Modification of Minerals Surfaces: Brief Sketch of Formation and Development","authors":"G. V. Lisichkin","doi":"10.3103/S0027131424700366","DOIUrl":"10.3103/S0027131424700366","url":null,"abstract":"<p>This article succinctly outlines the key points of the emergence and development of methods for chemical modification of the surface of inorganic substrates. It is shown that the assumption of the presence of chemically active functional groups on such surfaces arose relatively recently, although the first experience of practical application was carried out in the middle of the 19th century. The main stages in the development of the chemistry of surface compounds are traced.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 5","pages":"334 - 337"},"PeriodicalIF":0.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Huntingtin, the Major Factor in Huntington’s Disease Development. Main Functions and Intracellular Proteolysis 亨廷顿症发病的主要因素亨廷廷蛋白。主要功能和细胞内蛋白质分解
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-07-11 DOI: 10.3103/S0027131424700160
N. N. Gotmanova, A. V. Bacheva
{"title":"Huntingtin, the Major Factor in Huntington’s Disease Development. Main Functions and Intracellular Proteolysis","authors":"N. N. Gotmanova,&nbsp;A. V. Bacheva","doi":"10.3103/S0027131424700160","DOIUrl":"10.3103/S0027131424700160","url":null,"abstract":"<p>This review is devoted to the consideration of pathological intracellular mechanisms characteristic of Huntington’s disease and the central role of huntingtin protein in these processes. The features of mutant huntingtin aggregates utilization by the ubiquitin–proteasome system and autophagy, as well as the possibilities of polyglutamine-containing substrates hydrolysis by proteasome are discussed.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 3","pages":"189 - 194"},"PeriodicalIF":0.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141609442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopolymer Controlled Release Systems Based on Hydrolyzed Collagen: Cryoforming, Structure, and Properties 基于水解胶原蛋白的生物聚合物控释系统：冷冻成型、结构和特性
IF 0.7
Moscow University Chemistry Bulletin Pub Date : 2024-07-11 DOI: 10.3103/S0027131424700147
A. A. Makeeva, A. S. Shumilkin, A. S. Ryzhkova, O. I. Vernaya, A. V. Shabatin, A. M. Semenov, T. I. Shabatina
{"title":"Biopolymer Controlled Release Systems Based on Hydrolyzed Collagen: Cryoforming, Structure, and Properties","authors":"A. A. Makeeva,&nbsp;A. S. Shumilkin,&nbsp;A. S. Ryzhkova,&nbsp;O. I. Vernaya,&nbsp;A. V. Shabatin,&nbsp;A. M. Semenov,&nbsp;T. I. Shabatina","doi":"10.3103/S0027131424700147","DOIUrl":"10.3103/S0027131424700147","url":null,"abstract":"<p>Biopolymer materials based on natural collagen (gelatin, hydrolyzed collagen) are widely used in the food, pharmaceutical, and cosmetic industries due to their low toxicity, high biocompatibility, low antigenicity, and unique mechanical and technological properties. Hydrolyzed collagen, unlike gelatin, is formed by peptides with a lower molecular weight. Its advantages are higher bioavailability and biodegradability in comparison with gelatin. In this study, biopolymer matrices containing a dioxidine antibacterial drug are obtained based on hydrolyzed collagen using low-temperature technologies. It is shown that, varying synthesis parameters such as the concentration of hydrolyzed collagen in the precursor solution (from 1 to 10%), matrix crosslinking time (0.1–24 h), and cryoforming temperature (–30 and –196°C), it is possible to change the morphology and structure of the matrix, its degradation time, and drug release time. The composition and structure of dioxidine/hydrolyzed collagen systems are characterized by SEM and IR and UV spectroscopy. The antibacterial activity of the resulting dioxidine/hydrolyzed collagen systems against <i>E. coli</i> and <i>S. aureus</i> is characterized by the disk diffusion method.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"79 3","pages":"175 - 181"},"PeriodicalIF":0.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141609520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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