{"title":"苯磺酸氨氯地平在不同温度下在聚乙二醇400 +乙醇中的溶解度：热力学分析和数据建模","authors":"Taher Sayad, Milad Moradi, Parisa Jafari, Elaheh Rahimpour, Abolghasem Jouyban","doi":"10.3103/S0027131425700282","DOIUrl":null,"url":null,"abstract":"<p>In the present study, the solubility values of amlodipine besylate (AMB) in the binary mixtures of polyethylene glycol 400 and ethanol were determined using the shake-flask method at 293.2 to 313.2 K under atmospheric pressure (≈85 kPa) and correlated to some cosolvency and activity coefficient models. Additionally, the density of saturated mixtures was also measured and represented by the Jouyban–Acree model at various temperatures. The accuracy of each model was marked by the mean relative deviations (<i>MRD</i>%) of the back-calculated solubility and density data. The generated data in this work could be useful in the different steps of discovery and development of various formulations of AMB.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 4","pages":"265 - 272"},"PeriodicalIF":0.5000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Amlodipine Besylate Solubility in Polyethylene Glycol 400 + Ethanol at Different Temperatures: Thermodynamic Analysis and Data Modeling\",\"authors\":\"Taher Sayad, Milad Moradi, Parisa Jafari, Elaheh Rahimpour, Abolghasem Jouyban\",\"doi\":\"10.3103/S0027131425700282\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In the present study, the solubility values of amlodipine besylate (AMB) in the binary mixtures of polyethylene glycol 400 and ethanol were determined using the shake-flask method at 293.2 to 313.2 K under atmospheric pressure (≈85 kPa) and correlated to some cosolvency and activity coefficient models. Additionally, the density of saturated mixtures was also measured and represented by the Jouyban–Acree model at various temperatures. The accuracy of each model was marked by the mean relative deviations (<i>MRD</i>%) of the back-calculated solubility and density data. The generated data in this work could be useful in the different steps of discovery and development of various formulations of AMB.</p>\",\"PeriodicalId\":709,\"journal\":{\"name\":\"Moscow University Chemistry Bulletin\",\"volume\":\"80 4\",\"pages\":\"265 - 272\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Moscow University Chemistry Bulletin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.3103/S0027131425700282\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moscow University Chemistry Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.3103/S0027131425700282","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Amlodipine Besylate Solubility in Polyethylene Glycol 400 + Ethanol at Different Temperatures: Thermodynamic Analysis and Data Modeling
In the present study, the solubility values of amlodipine besylate (AMB) in the binary mixtures of polyethylene glycol 400 and ethanol were determined using the shake-flask method at 293.2 to 313.2 K under atmospheric pressure (≈85 kPa) and correlated to some cosolvency and activity coefficient models. Additionally, the density of saturated mixtures was also measured and represented by the Jouyban–Acree model at various temperatures. The accuracy of each model was marked by the mean relative deviations (MRD%) of the back-calculated solubility and density data. The generated data in this work could be useful in the different steps of discovery and development of various formulations of AMB.
期刊介绍：
Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.
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