Moscow University Chemistry Bulletin最新文献

{"title":"Tungsten(VI) Complexes with 2-Hydroxy-5-chlorothiophenol in the Presence of Aminophenols and Their Application","authors":"Zalov Ali Zal","doi":"10.3103/S0027131425700361","DOIUrl":"10.3103/S0027131425700361","url":null,"abstract":"<p>In the present paper, we report results from liquid–liquid extraction-spectrophotometric studies on two different systems, each containing W(VI), a 2-hydroxy-5-chlorothiophenol (H₂L), and aminophenols (AP_1,2), namely, 2(<i>N</i>,<i>N</i>-dimethylaminomethyl)-4-chlorphenol (АP₁) and 2(<i>N</i>,<i>N</i>-dimethylaminomethyl)-4-bromphenol (AP₂)}. Extraction of mixed-ligand complexes is maximal at pH 4.1–5.2. The absorption maxima of the mixed-ligand complexes (MLCs) W(V)–L–AP_1,2 lie in the range of 476–480 nm. The molar absorption coefficients are (2.3–2.4) × 10⁴. The proposed method were applied to the determination of tungsten in steel and soil samples.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 5","pages":"330 - 339"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Manganese and Aluminum on Sorption Properties of Type AB5 Alloys for Their Use under Arctic Conditions","authors":"S. V. Mitrokhin,&nbsp;E. A. Movlaev,&nbsp;M. A. Prokhorenkov","doi":"10.3103/S0027131425700312","DOIUrl":"10.3103/S0027131425700312","url":null,"abstract":"<p>The interaction between hydrogen and AB5 alloys, intended for their use under arctic conditions, is studied. The thermodynamic parameters of hydrogen absorption and desorption reactions are found, and the influence of alloying with manganese and aluminum on them is studied. The experimental data are compared with those calculated with a statistical forecast model.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 5","pages":"293 - 297"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Synthetic Food Dyes in Carbonated Beverages by Digital Image Colorimetry","authors":"O. V. Monogarova,&nbsp;K. V. Oskolok,&nbsp;V. S. Milkina,&nbsp;A. V. Garmay","doi":"10.3103/S0027131425700324","DOIUrl":"10.3103/S0027131425700324","url":null,"abstract":"<p>A simple and cheap method for the simultaneous determination of two dyes by digital image colorimetry using a smartphone camera is developed. A prototype of a specialized box that allows reducing the contribution of scattered radiation to the measured signal to the noise level of the digital image sensor is created. The proposed approach is tested in determining synthetic food dyes in carbonated beverages. The accuracy of the results of determining dyes in beverages by digital image colorimetry and spectrophotometry differs insignificantly.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 5","pages":"298 - 305"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of Astaxanthin with Iron Salts Fe2+ and Fe3+ in Organic Solvents","authors":"N. V. Zhdanova,&nbsp;N. Yu. Lotosh,&nbsp;E. A. Kulikov,&nbsp;S. V. Lukashevich,&nbsp;S. N. Malakhov,&nbsp;Yu. A. Koksharov,&nbsp;A. A. Selishcheva","doi":"10.3103/S0027131425700348","DOIUrl":"10.3103/S0027131425700348","url":null,"abstract":"<p>The carotenoid astaxanthin has a variety of biological activities and antioxidant properties. Due to its lipophilic nature, astaxanthin can be used to protect against lipid peroxidation, in which iron ions play an important role. The effect of Fe²⁺ ions on the oxidative degradation of astaxanthin in phospholipid liposomes was previously studied. In this paper, we study the interaction of astaxanthin with Fe³⁺ and Fe²⁺ in organic solvents of various polarities in the absence of lipids. It is shown that in the presence of Fe³⁺, astaxanthin oxidation and degradation occurs in methanol and dichloromethane. The formation of an intermediate product with an absorption maximum at 876 nm is recorded spectrophotometrically. Electron paramagnetic resonance (EPR) proves the radical nature of the intermediate product, whose signal intensity decreased over time, with the signal remaining for up to 3 days. Based on the obtained results, it can be assumed that the radical product formed in the reaction with Fe³⁺ is the radical cation of astaxanthin. At the same time, no changes are detected when astaxanthin is incubated with Fe²⁺: the absorption spectrum does not change and no radical product is formed.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 5","pages":"311 - 320"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Description of Polymer Systems in the Field of Linear Viscoelasticity","authors":"V. N. Matveenko,&nbsp;E. A. Kirsanov","doi":"10.3103/S0027131425700300","DOIUrl":"10.3103/S0027131425700300","url":null,"abstract":"<p>A structural rheological model is presented, including kinetic equations of the processes of formation and destruction of aggregates of particles or associates of macromolecules. The shape of rheological curves is determined by the state of the matter’s structure and the change in the structure as a result of an oscillating shear flow. An integral characteristic of the structure is the number of meshes or contacting particles-macromolecules per unit volume. Rheological equations contain three (or two) coefficients (parameters) that have a clear physical meaning; their value is determined by the physicochemical and structural state of the system during the flow. The viscous and elastic properties of polymers are considered independently of each other. The rheological equations of the model are used to interpret the frequency dependences of the dynamic modules of some melts and polymer solutions. The existing relationship between the coefficients of rheological equations that describe viscosity, and elasticity is explained by their common structural nature.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 5","pages":"281 - 292"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Kinetic Model of the Functioning of the Glutamatergic Synapse: A Key Synaptic Contact in the Human Brain","authors":"S. D. Varfolomeev,&nbsp;S. B. Tsybenova","doi":"10.3103/S0027131425700294","DOIUrl":"10.3103/S0027131425700294","url":null,"abstract":"<p>A kinetic model of the functioning of the glutamate excitatory synapse with glutamate and <i>N</i>‑acetylaspartylglutamate as neurotransmitters in a three-component system, taking into account neuroglial astrocytic cells and the enzyme glutamate carboxypeptidase, is developed. The model is based on structural and chemical data and describes the dynamic behavior of the coupled metabolites of <i>N</i>-acetylaspartic and <i>N</i>‑acetylaspartyl glutamic acids, the most highly concentrated low-molecular agents in the human brain. Within the framework of the simulation, the biphasic nature of the process that provides amplification of the excitation signal is shown, the dynamics of the increase in the number of excited cells (the basis of the blood-oxygen-level-dependent (BOLD) signal) is presented, and the dynamics of a pulsed decrease in the concentration of <i>N</i>-acetylaspartate in the excitation zone is described.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 5","pages":"273 - 280"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chloroacetylation of Substituted Methoxyphenols: Synthesis and Subsequent Transformations","authors":"A. U. Choriev,&nbsp;A. K. Abdushukurov","doi":"10.3103/S002713142570035X","DOIUrl":"10.3103/S002713142570035X","url":null,"abstract":"<p>The synthesis and rearrangement reactions of 2-methoxyphenyl chloroacetate in the presence of low amounts of catalysts to form <i>o</i>- and <i>p-</i>hydroxy-3-methoxyphenacyl chlorides are described in this study. A method for obtaining <i>m</i>-methoxyphenyl chloroacetate is developed, based on the chloroacetylation of <i>m</i>‑methoxyphenol in benzene solution.. The reactions of <i>m</i>-methoxyphenyl chloroacetate are rearranged for the first time in the presence of low amounts of FeCl₃, MoCl₅, WCl₆, ZnCl₂, SnCl₄, VCl₃, FeCl₃⋅6H₂O, Fe₂(SO₄)₃, iron acetylacetonate (IAA), and iron salicylate (ISA). The reaction leads to the formation of 2‑hydroxy-4-methoxyphenacyl chlorides and 4-hydroxy-2-methoxyphenacyl chlorides. The percentage ratio of isomers depends on the reaction conditions. The synthesis of 4-methoxyphenyl chloroacetate via reaction with diphenylthiocarbazone in the presence of dimethylformamide is studied. The structure of the substances is elucidated with UV, IR, and NMR spectroscopies.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 5","pages":"321 - 329"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of the Mesalazine Solubility at Biorelevant Temperature","authors":"Ekin Güler,&nbsp;Kader Poturcu,&nbsp;Elaheh Rahimpour,&nbsp;Abolghasem Jouyban","doi":"10.3103/S0027131425700373","DOIUrl":"10.3103/S0027131425700373","url":null,"abstract":"<p>Physicochemical properties of drug/drug candidates are still key inputs for drug discovery and development studies. The most important physicochemical properties of these substances are lipophilicity, solubility, acid/base character, permeability, and bio-accessibility. Among them, the knowledge about solubility is a crucial physicochemical property of drugs and is of high demand both in industry and academia. The aims of the current study are: to determine the solubility of mesalazine in the non-aqueous propylene glycol (PG) + 2-propanol and aqueous 1,4-dioxane binary mixtures at biorelevant temperature (310.2 K) by using co-solvency method, to perform density analysis in non-aqueous and aqueous binary mixtures for saturated systems, to characterize mesalazine equilibrated in the saturated solutions by XRD analyses. In this research, the solubility values of mesalazine were determined in the non-aqueous (propylene glycol (PG) + 2-propanol) and aqueous (1,4-dioxane + water) binary mixtures at biorelevant temperature (310.2 K) using the common shake-flask method. The experimental molar solubility (<i>C</i>_M) of mesalazine values in the diluted solutions was determined in the PG + 2-propanol and 1,4-dioxane + water binary mixtures using a plotted calibration curve (<i>R</i>² = 0.999) at 310.2 K. The maximum solubility in the molarity scale was obtained in neat PG (<i>C</i>_M = 1.03  ×  10^– 2 mol/L), and the minimum solubility in the neat 2-propanol (<i>C</i>_M = 5.14  ×  10^–4 mol/L) in non-aqueous binary mixtures. The maximum solubility value was obtained in 0.4 mass fraction (<i>C</i>_M = 1.68 ×  10^–2 mol/L) of 1,4-dioxane + water and the minimum solubility was obtained in neat 1,4-dioxane (<i>C</i>_M = 3.34 × 10^–3 mol/L) at 310.2 K. Density data were also determined and correlated with Jouyban–Acree model for saturated systems in non-aqueous and aqueous binary mixtures. The characterization tests of mesalazine equilibrated in saturated solutions were performed by X-ray diffraction (XRD) analyses from 10° to 70°. XRD analysis showed that the crystallinity of mesalazine remained unchanged and did not show any polymorphic transformation during the drug dissolution in the investigated binary mixture. Up to now, no data was reported for mesalazine solubility in these binary mixtures at biorelevant temperature.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 5","pages":"340 - 347"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental In Vivo Evidence of the Prognostic Significance of Beta-III Tubulin (TUBB3) as a Molecular Marker of Tumor Metastatic Aggressiveness","authors":"A. N. Grishanina,&nbsp;T. A. Bogush,&nbsp;S. A. Kaliuzhny,&nbsp;A. M. Scherbakov,&nbsp;E. A. Bogush,&nbsp;M. Ya. Melnikov,&nbsp;V. S. Kosorukov","doi":"10.3103/S0027131425700336","DOIUrl":"10.3103/S0027131425700336","url":null,"abstract":"<p>Comparative immunofluorescence analysis of TUBB3 expression in primary and metastatic tissues from transplanted mouse tumors demonstrates a marked increase in both the level and intensity of TUBB3 expression in highly metastatic Lewis lung carcinoma, relative to the less metastatic LC-67 tumor. These in vivo findings give experimental evidence that the tumor-associated protein TUBB3 contributes to metastatic potential and underscore its relevance as a prognostic marker of tumor aggressiveness.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 5","pages":"306 - 310"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the Protein Environment on Two-Photon Absorption Cross-Sections of Type I and Type II Retinal-Containing Proteins","authors":"P. A. Kusochek,&nbsp;V. I. Nazarova,&nbsp;S. A. Kazantsev,&nbsp;V. R. Aslopovsky,&nbsp;A. V. Scherbinin,&nbsp;A. V. Bochenkova","doi":"10.3103/S0027131425700208","DOIUrl":"10.3103/S0027131425700208","url":null,"abstract":"<p>The prediction and optimization of properties of retinal-containing proteins under two-photon excitation conditions is an important issue for the practical application of channelrhodopsins in optogenetics. Nonlinear two-photon absorption can also lead to photoactivation of visual rhodopsins in the IR range within 950–1000 nm. The factors that influence the two-photon absorption cross section of type I and type II retinal-containing proteins during transition to the first singlet electronically excited state are analyzed in this study with high-level quantum chemistry methods. It is shown that two channels through permanent dipole moments of the initial and final states make the main contribution to the two-photon absorption cross section during the <i>S</i>₀ → <i>S</i>₁ transition in the case of rhodopsins. A fast numerical convergence of the sum-over-states formalism provides direct evidence for the applicability of the two-level model for calculating TPA cross-sections in rhodopsins. This is due to the high transition dipole moment and significant redistribution of electron density during the <i>S</i>₀ → <i>S</i>₁ transition. An unambiguous correlation between the calculated cross section values and the difference in average dipole moments of the initial and final states makes it possible to explain the strong dependence of the cross section on the protein environment of the chromophore group in various rhodopsins (340–610 GM). It also allows us to predict the influence of the protein electrostatic field on the nonlinear photophysical properties of retinal.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"80 4","pages":"205 - 213"},"PeriodicalIF":0.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}