Experimental In Vivo Evidence of the Prognostic Significance of Beta-III Tubulin (TUBB3) as a Molecular Marker of Tumor Metastatic Aggressiveness

Abstract

Comparative immunofluorescence analysis of TUBB3 expression in primary and metastatic tissues from transplanted mouse tumors demonstrates a marked increase in both the level and intensity of TUBB3 expression in highly metastatic Lewis lung carcinoma, relative to the less metastatic LC-67 tumor. These in vivo findings give experimental evidence that the tumor-associated protein TUBB3 contributes to metastatic potential and underscore its relevance as a prognostic marker of tumor aggressiveness.