β - iii微管蛋白（TUBB3）作为肿瘤转移侵袭性分子标志物的预后意义的实验体内证据

IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2025-09-04 DOI:10.3103/S0027131425700336

A. N. Grishanina, T. A. Bogush, S. A. Kaliuzhny, A. M. Scherbakov, E. A. Bogush, M. Ya. Melnikov, V. S. Kosorukov

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引用次数: 0

摘要

对移植小鼠肿瘤原发组织和转移组织中TUBB3表达的比较免疫荧光分析显示，相对于转移较少的LC-67肿瘤，高转移的Lewis肺癌中TUBB3的表达水平和强度均显著增加。这些体内研究结果提供了实验证据，证明肿瘤相关蛋白TUBB3有助于转移潜力，并强调了其作为肿瘤侵袭性预后标志物的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Experimental In Vivo Evidence of the Prognostic Significance of Beta-III Tubulin (TUBB3) as a Molecular Marker of Tumor Metastatic Aggressiveness

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Experimental In Vivo Evidence of the Prognostic Significance of Beta-III Tubulin (TUBB3) as a Molecular Marker of Tumor Metastatic Aggressiveness

Comparative immunofluorescence analysis of TUBB3 expression in primary and metastatic tissues from transplanted mouse tumors demonstrates a marked increase in both the level and intensity of TUBB3 expression in highly metastatic Lewis lung carcinoma, relative to the less metastatic LC-67 tumor. These in vivo findings give experimental evidence that the tumor-associated protein TUBB3 contributes to metastatic potential and underscore its relevance as a prognostic marker of tumor aggressiveness.

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.