Acta clinica Croatica最新文献

{"title":"SMOKING EFFECT ON OXIDATIVE STRESS AND ANTIOXIDANT CAPACITY OF CERVICAL MUCUS IN WOMEN WITH PRIMARY IDIOPATHIC STERILITY - OBSERVATIONAL CASE-CONTROL STUDY.","authors":"Gordana Planinić Radoš, Željko Duić, Boris Lovrić, Josip Juras","doi":"10.20471/acc.2024.63.03-04.15","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.15","url":null,"abstract":"<p><p>The aim of the study was to determine the effects of smoking on cervical mucus in women with primary idiopathic sterility. A prospective, case-control, observational, quantitative, and analytical study was carried out over a five-year period through ambulatory care. The first part of the study involved 140 healthy women (85 smokers and 55 non-smokers). The second part included 90 women (58 healthy, 32 suffering from sterility), grouped according to their smoking status. Concentrations of total proteins in cervical mucus solutions and homogenates of cervical surface cells and their mitochondria, thiocyanate and ascorbic acid, rhodanese activity, concentrations of cytochrome P-450 (mitochondria), lipid peroxidation and the total antioxidant capacity in homogenates of cervical surface cells, concentrations of superoxide O2, reduced gluthatione (GSH), advanced oxidation protein products (AOPP), and ferric reducing ability of plasma (FRAP) were measured. The measurements showed higher concentrations of thiocyanate, cytochrome P-450 and lipid peroxidation values, and lower concentrations of ascorbic acid, cytochrome P-450 activity and FRAP in smokers. Higher concentrations of superoxide O2, GSH, AOPP, and lower FRAP were found among smokers and women suffering from sterility. In conclusion, changes in oxidative stress and antioxidant capacity caused by smoking indicate that the quality of cervical mucus among patients suffering from sterility is lower compared to healthy women.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"568-577"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SUBCLINICAL HYPOTHYROIDISM PREVALENCE AND SELENIUM LEVELS IN WOMEN OF NORTH KHORASAN, IRAN: A CROSS-SECTIONAL STUDY.","authors":"Kimiya Hadavi, Ali Esmaeili, Zeynab Moallemi, Javad Hashemi","doi":"10.20471/acc.2024.63.03-04.35","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.35","url":null,"abstract":"<p><p>Individuals with subclinical hypothyroidism have an increased risk of developing clinical hypothyroidism. The thyroid gland, which has the highest concentration of selenium per gram of tissue among adults, plays a crucial role in the metabolism of thyroid hormones. This study aimed to investigate the prevalence of subclinical hypothyroidism in the North Khorasan province of Iran and assess the serum selenium levels in affected individuals. We conducted a prospective study involving 550 females aged 20-55. Serum samples were collected from individuals based on the study's inclusion and exclusion criteria. We measured the serum levels of thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3). Subsequently, individuals with high TSH but normal T4 and T3 levels were selected for further analysis (group I). The serum levels of TSH, T4, T3 (using the ELISA method), and selenium (using the atomic absorption method) were measured and compared with those of a control group comprising healthy women matched to group I in terms of number, age, and body mass index. The overall prevalence of subclinical hypothyroidism in the study population was 6.48%. Significant differences were observed in serum TSH and selenium levels between the subclinical hypothyroidism group and the control group. Furthermore, a positive correlation between TSH and selenium levels was found exclusively within the subclinical hypothyroidism group. The occurrence of subclinical hypothyroidism was positively correlated with serum selenium levels.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"745-750"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SUPERFICIAL VESSEL DENSITY, RETINAL NERVE FIBER LAYER THICKNESS, AND VISUAL FIELD LOSS IN PRIMARY OPEN-ANGLE AND PSEUDOEXFOLIATIVE GLAUCOMA.","authors":"Ante Prpić, Iva Ferček, Kim Kasa, Armin Kasumović, Ines Matoc, Idoia Goñi Guarro, Vedrana Vukić, Katia Novak-Lauš, Ivan Sabol, Zoran Vatavuk","doi":"10.20471/acc.2024.63.03-04.36","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.36","url":null,"abstract":"<p><p>The aim was to examine peripapillary and macular superficial vessel density, peripapillary thickness of the nerve fiber layer, and inner thickness of the macula in eyes with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG) depending on the visual field impairment. A total of 50 eyes were diagnosed as POAG and 50 as PXG. Both groups were divided into 3 subgroups according to HAP2 criteria of visual field impairment. All eyes underwent optical coherence tomography angiography (OCT-A). Radial peripapillary capillary (RPC) density, peripapillary retinal nerve fiber layer (pRNFL) thickness, superficial macular vessel density (SMVD), and macular thickness between the inner limiting membrane and inner plexiform layer (ILM-IPL) were compared. The overall mean measured values did not show a statistically significant difference between the groups. All measured parameters were statistically significantly lower with more extensive visual field damage within the group. The strongest positive correlation was found between the pRNFL thickness and RPC density values (p=0.893), and strongest negative correlation between the mean defect of visual field and ILM-IPL (p=-0.824). No statistically significant difference was found between POAG and PXG in all values measured on OCT-A. In conclusion, visual field loss is more strongly correlated with the loss of nerve fiber layer thickness than the superficial vessel density, which may suggest that the loss of RNFL precedes the loss of superficial vessel density.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"751-757"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIFFERENCES IN CLINICAL CHARACTERISTICS OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) IN OSIJEK AND ZADAR AND POSSIBLE ASSOCIATION WITH GLOBAL DNA METHYLATION AS AN EPIGENETIC BIOMARKER.","authors":"Eugenia Basioli Kasap, Ljubica Glavaš Obrovac, Marijana Jukić, Ivica Mihaljević, Ana Posavi, Sanda Škrinjarić Cincar","doi":"10.20471/acc.2024.63.03-04.16","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.16","url":null,"abstract":"<p><p>Environmental factors play an important role in the onset and development of chronic obstructive pulmonary disease (COPD). Previous studies have shown that global DNA methylation could be a useful biomarker in COPD. We hypothesized that COPD patients from two different Croatian regions might have clinical characteristics, quality of life, and global DNA methylation, which could be used as a possible epigenetic marker. The study included 136 COPD patients with an average age of 70 years, of whom about 70% were men. Among them, 37% were active smokers, 58% ex-smokers, and 5% non-smokers. There were 69 patients in Osijek and 67 in Zadar. The control group consisted of 64 subjects who were not diagnosed with COPD or other respiratory diseases, 32 from each center. We analyzed risk factors, severity and type of symptoms, exacerbations, comorbidities, and numerous parameters of lung function, phenotypic characteristics, quality of life, and global DNA methylation. We found that COPD patients in Zadar had more pronounced emphysema (P<0.001), while COPD patients from Osijek had more severe symptoms of cough and expectoration (P<0.001 for both). Patients from Osijek had more cardiovascular comorbidities (P<0.001) and depression (P=0.01) than patients from Zadar. Analysis of global DNA methylation found that patients with COPD had lower values than the control group, but the difference was not statistically significant.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"578-587"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THYROID-ASSOCIATED OPHTHALMOPATHY IN A HYPOTHYROID PATIENT.","authors":"Dorotea Filipan, Renata Iveković, Tomislav Gregurić, Zvonko Kusić, Tomislav Jukić","doi":"10.20471/acc.2024.63.03-04.46","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.46","url":null,"abstract":"<p><p>Thyroid-associated ophthalmopathy (TAO) is an autoimmune disorder of the orbit that occurs predominantly in Grave's hyperthyroidism, while it is an uncommon clinical finding in patients with Hashimoto's thyroiditis (HT) and hypothyroidism. We report the case of a 62-year-old female patient who presented with left eyelid edema, proptosis, diplopia, and lateral paralysis of the left eye. Magnetic resonance imaging of the orbits showed retrobulbar mass in the left orbit with hyperintense signals within left medial rectus muscle, offsetting but not infiltrating the optic nerve. An ¹⁸F-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) scan revealed pathological ¹⁸F-FDG uptake of expansive mass within rectus medialis muscle of the left eye (SUVmax=11.0) and similar findings in the right eye (SUVmax=7.1). It also displayed increased glucose metabolism in the thyroid gland (SUVmax=6.4). Laboratory findings showed increased thyrotropin level, while thyroid-stimulating-hormone-receptor antibodies were negative. The patient was diagnosed with HT and TAO, so levothyroxine therapy was introduced. Gradual improvement of TAO symptoms was attained a year later. Diplopia subsided and the patient regained complete eye movements. In conclusion, correction of hypothyroidism can significantly improve symptoms of TAO. Additional value of this case report lies in ¹⁸F-FDG PET/CT images displaying increased metabolic activity, which can advance clinical evaluation; however, further research is needed.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"822-827"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF USING TOPICAL ANESTHETIC DURING HIGH-SPEED DIGITAL IMAGING ON PHONATION ASSESSED BY DIGITAL KYMOGRAPHY PARAMETERS.","authors":"Mario Bilić, Juraj Slipac, Lana Kovač Bilić","doi":"10.20471/acc.2024.63.03-04.18","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.18","url":null,"abstract":"<p><p>High-speed digital imaging (HSDI) is a contemporary method of the phonation process assessment. It records laryngeal images at a rate of up to 8000 frames <i>per</i> second. Digital kymography (DK) extracts high-speed images sampled at a single point along the vocal folds and enables objective quantification of the vocal fold movements. According to the literature, usage of topical anesthetic (TA) in oral cavity, oropharynx and laryngopharynx prior to examination, in order to reduce pain and discomfort level, is optional but the effect of using TA on the phonation process is not well investigated. The aim of this study was to investigate the effect of using TA during HSDI on DK parameters. We performed a prospective double-blind randomized controlled study on 58 healthy subjects. All subjects were examined on 2 consecutive days using TA and using saline solution (placebo) by the same experienced examiner. DK images, made on the middle of the vocal folds, were obtained from HSDI. Vocal folds were examined across glottal cycles and glottal width and period irregularities, left-right phase asymmetry, and the open, closed, opening and closing quotient were calculated. Our data showed that using TA during HSDI did not induce statistically significant changes of DK parameters in healthy subjects.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"595-603"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MASS QUARANTINE EXPERIENCE AFTER UMRAH VISIT.","authors":"Burak Bekgöz, İshak Şan, Eren Usul","doi":"10.20471/acc.2024.63.03-04.05","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.05","url":null,"abstract":"<p><p>This study aimed to determine demographic characteristics, COVID-19 positivity rates of the quarantined individuals, and risk factors between those developing and not developing disease symptoms. The individuals who returned from Mecca, Saudi Arabia to Turkey on March 15, 2020 were transported from the airport to the campus of dormitories and quarantined for 14 days. This study included 2941 passengers who returned from Umrah visit to Turkey and were quarantined between March 15, 2020 and April 2, 2020. There were 1828 (62.2%) women. The polymerase chain reaction (PCR) test was positive in 295 (10%) of those in quarantine, 196 (66.4%) of them women. Among the patients with a positive PCR test result, there was no significant difference between women and men in terms of age and comorbidity. Of the 295 COVID-19 patients detected, 37 (12.5%) had symptoms. There was no significant difference between symptomatic individuals and asymptomatic individuals in terms of age, gender, and comorbidity. Quarantining everyone who has come from risky areas ensures that patients are isolated from the community, which can prevent the spread of the disease.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"487-493"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHEOCHROMOCYTOMA CRISIS TREATED WITH URAPIDIL: A CASE REPORT.","authors":"Miro Bakula, Lea Tomašić, Ivana Kokan, Katarina Mucić, Nikolina Marić, Maja Bakula","doi":"10.20471/acc.2024.63.03-04.45","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.45","url":null,"abstract":"<p><p>Pheochromocytomas are rare tumors that present with a broad spectrum of symptoms and signs, making differential diagnosis broad. They can cause a pheochromocytoma crisis that manifests with arterial blood pressure oscillations, and subsequent symptoms and signs of catecholamine overproduction. There are many potential triggers of this condition. This report presents a 33-year-old man with an obvious pheochromocytoma crisis that occurred due to beta-blocker application without a concomitant alpha-blocker. The crisis was treated with high doses of urapidil, and once permanent hemodynamic stabilization was achieved, urapidil was replaced with phenoxybenzamine. This report demonstrates that pheochromocytoma crisis can be successfully treated with urapidil but further consideration is needed on the use of urapidil both in pheochromocytoma crisis and preoperative management of pheochromocytoma patients.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"816-821"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TEN-YEAR OUTCOMES AFTER ACUTE STEMI TREATED WITH PRIMARY PCI - THE ROLE OF ACUTE BIOMARKERS AND OTHER PARAMETERS IN PREDICTING CLINICAL SEVERITY AND PROGNOSIS.","authors":"Marko Mornar Jelavić, Zdravko Babić, Dorijan Babić, Diana Balenović, Ronald Lipovšćak, Hrvoje Pintarić","doi":"10.20471/acc.2024.63.03-04.34","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.34","url":null,"abstract":"<p><p>This rare prospective study investigated 10-year outcomes of acute ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI), and evaluated the role of acute biomarkers and other parameters in predicting clinical severity and prognosis. We included 250 patients and analyzed their baseline (cardiovascular risk factors), laboratory (maximal CK/TnT, acute inflammatory (white blood cells (WBC), hs-CRP), and liver biomarkers (AST/LDH), glomerular filtration rate (eGFR)) and clinical severity parameters (length of hospital stay, in-hospital complications, coronary angiography, and echocardiography (LVEF)). After hospital discharge, 229 patients were followed-up (2011-2022) and grouped according to the presence of major adverse cardiovascular events (MACE). In the acute phase, WBC, hs-CRP, LDH and AST positively correlated with maximal CK/cTnT and total in-hospital complications, and negatively with LVEF; WBC positively correlated with cardiogenic shock and stent diameter, hs-CRP with cardiac arrest and length of hospital stay, and LDH with stent diameter; total in-hospital complications increased the risk of in-hospital mortality and number of significantly stenosed coronary arteries, risk of heart failure, whereas the length of hospital stay negatively correlated with LVEF (p<0.05 all). During 10-year follow-up, LDH and clinical severity parameters (stenosis of LAD/ACx, multivessel CAD, proximal coronary stenosis, Gensini score, in-hospital complications) increased, while the others (normal eGFR and LVEF) reduced the risk of total MACE (p<0.05). In conclusion, acute biomarkers have a role in predicting clinical severity but they have no role in predicting long-term prognosis (except for LDH). Total in-hospital complications, more severe CAD, systolic dysfunction, and worse kidney function may lead to worse in-hospital and long-term outcomes.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"733-744"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPLICATED POSTERIOR STERNOCLAVICULAR JOINT DISLOCATION WITH AORTIC ARCH IMPINGEMENT.","authors":"Domagoj Lemac, Ivo Dumić-Čule, Ante Legac, Tomislav Čengic, Igor Nikolić, Igor Čikara, Boris Brkljačić, Gordana Ivanac","doi":"10.20471/acc.2024.63.03-04.43","DOIUrl":"https://doi.org/10.20471/acc.2024.63.03-04.43","url":null,"abstract":"<p><p>Posterior sternoclavicular dislocation accompanied by clavicular end fracture is an extremely rare injury according to the available literature. We present a case of a young male with this injury, resulting from a vehicle accident, and additionally complicated by a clavicular bone fragment in the proximity of the aortic arch. An initial X-ray showed no signs of bone trauma, which was, however, revealed on a CT scan. Stable fixation of the fragment and sternoclavicular joint was achieved utilizing a plate and screws. The osteosynthetic material was removed after eight weeks due to the plate breaking. There were no complications in the 5-year follow-up period, and a full range of motion was accomplished. We aimed to emphasize the importance of early diagnosis and appropriate surgical management of complicated posterior sternoclavicular dislocations to avoid life-threatening events.</p>","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"63 3-4","pages":"808-811"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}