Acta clinica Croatica最新文献_第2页

CLEAR CELL VARIANT OF AMELOBLASTIC CARCINOMA OF THE MAXILLA: A CASE REPORT AND REVIEW OF DIFFERENTIAL DIAGNOSTIC AND THERAPEUTIC APPROACH. 上颌骨成釉细胞癌的透明细胞变异：1例报告及鉴别诊断和治疗方法综述。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.24

Luka Manojlović, Daniel Jerković, Davor Brajdić, Predrag Knežević, Spomenka Manojlović

引用次数: 0

CHANGING PATTERNS IN PEDIATRIC BURNS IN CROATIA - DATA FROM THE NATIONAL REFERRAL CENTER DURING THE 2010-2019 PERIOD. 克罗地亚儿科烧伤模式的变化——2010-2019年期间国家转诊中心的数据。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.06

Rok Kralj, Zoran Barčot, Mario Kurtanjek, Ivan Petračić, Karlo Tadić, Igor Bumči, Stjepan Višnjić, Rado Žic

{"title":"CHANGING PATTERNS IN PEDIATRIC BURNS IN CROATIA - DATA FROM THE NATIONAL REFERRAL CENTER DURING THE 2010-2019 PERIOD.","authors":"Rok Kralj, Zoran Barčot, Mario Kurtanjek, Ivan Petračić, Karlo Tadić, Igor Bumči, Stjepan Višnjić, Rado Žic","doi":"10.20471/acc.2025.64.02.06","DOIUrl":"https://doi.org/10.20471/acc.2025.64.02.06","url":null,"abstract":"The aim of this study was to assess changes during the past decade in the overall number, as well as patterns of burn injuries according to age at the time of injury, total body surface area (TBSA) affected, and burn injury mechanisms. We also wanted to evaluate the average length of stay to TBSA ratio and seasonal variations according to burn injury mechanism. We performed a review of 402 patients hospitalized at our institution during a 10-year period and divided them into subgroups as follows: scalds, contact burns, flame and electrical burns, and massive thermal injuries (>40% TBSA regardless of burn injury mechanism). The peak incidence of burn injuries was recorded between the first and second year of life, and scalds predominated as the burn injury mechanism. During the observed period, the average TBSA declined and scalds became even more dominant as the burn injury mechanism. Seasonal variations could be confirmed for contact burns which occurred most commonly during autumn and winter, and for flame and electrical burns that occurred most often during summer. Given the fact that we recorded a decline in the number of patients with burn injuries, we believe that it is of highest importance for the management of burn injury pathology to be concentrated in a center with greatest experience in the treatment of burn injuries in children. Based on the characteristics of patients with burn injuries, small children and preadolescents and young adolescents should be targets of prevention campaigns.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 2","pages":"225-231"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ULTRASOUND AND SHEAR WAVE ELASTOGRAPHY FOR DISTINGUISHING BENIGN AND MALIGNANT AXILLARY LYMPH NODES IN BREAST CANCER PATIENTS. 超声与横波弹性成像鉴别乳腺癌患者腋窝淋巴结良恶性的价值。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.19

Cihan Kalkan, Ilkay Koray Bayrak, Mesut Ozturk, Ahmet Veysel Polat

{"title":"ULTRASOUND AND SHEAR WAVE ELASTOGRAPHY FOR DISTINGUISHING BENIGN AND MALIGNANT AXILLARY LYMPH NODES IN BREAST CANCER PATIENTS.","authors":"Cihan Kalkan, Ilkay Koray Bayrak, Mesut Ozturk, Ahmet Veysel Polat","doi":"10.20471/acc.2025.64.02.19","DOIUrl":"10.20471/acc.2025.64.02.19","url":null,"abstract":"This study aimed to assess the diagnostic efficacy of ultrasound (US) and shear wave elastography (SWE) in distinguishing benign and malignant axillary lymph nodes in patients with breast cancer. A total of 121 axillary lymph nodes from 61 breast cancer patients (mean age, 52.4±14.6 years) were enrolled between May 2019 and August 2020. Lymph nodes were histopathologically diagnosed through core needle biopsy or surgical excision. B-mode US features (short axis diameter, short-to-long axis diameter ratio, presence of echogenic hilum, presence of asymmetric cortical thickening, cortex thickness) were assessed and SWE measurements (maximum shear wave velocity (SWVmax), minimum SWV (SWVmin), median SWV (SWVmedian), mean SWV (SWVmean)) were performed. There were 45 (37.2%) benign and 76 (62.8%) malignant lymph nodes. The short axis diameter, short-to-long axis diameter ratio, and mean cortical thickness of malignant lymph nodes were significantly higher compared to benign lymph nodes (p<0.001 all). SWVmean, SWVmedian, SWVmax, and SWVmin of malignant lymph nodes were significantly higher than those of benign lymph nodes (p<0.001 for all). Both US and SWE were useful in discriminating between benign and malignant axillary lymph nodes.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 2","pages":"354-361"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NON-HDL-C MIGHT PREDICT MAJOR ADVERSE CARDIOVASCULAR EVENT OCCURRENCE IN STATIN-NAÏVE PATIENTS FOLLOWING FIRST-TIME MYOCARDIAL INFARCTION - A PRELIMINARY REPORT. 非hdl - c可能预测statin-naÏve患者首次心肌梗死后主要不良心血管事件的发生——一项初步报告。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.13

Lamija Ferhatbegović, Farid Ljuca, Zumreta Kušljugić, Katarina Kovačević, Denis Mršić, Sabina Kušljugić, Mirsad Selimović

{"title":"NON-HDL-C MIGHT PREDICT MAJOR ADVERSE CARDIOVASCULAR EVENT OCCURRENCE IN STATIN-NAÏVE PATIENTS FOLLOWING FIRST-TIME MYOCARDIAL INFARCTION - A PRELIMINARY REPORT.","authors":"Lamija Ferhatbegović, Farid Ljuca, Zumreta Kušljugić, Katarina Kovačević, Denis Mršić, Sabina Kušljugić, Mirsad Selimović","doi":"10.20471/acc.2025.64.02.13","DOIUrl":"10.20471/acc.2025.64.02.13","url":null,"abstract":"The aim of this study was to examine the effect of the lipid parameter non-high-density lipoprotein cholesterol (non-HDL-C) on the occurrence of major cardiovascular event (MACE) in patients after first-time ST-elevation myocardial infarction (STEMI) treated with primary percutaneous intervention (pPCI) and implantation of drug-eluting stent (DES). Seventy-eight patients (54 male and 24 female, median age 58.62±11.14 years) with the diagnosis of first-time STEMI who were treated with pPCI with DES implantation in the period from January 2018 until January 2020 were included in the study. Patients were followed for two years of the intervention for the occurrence of MACE and its association with baseline non-HDL-C, as well as total cholesterol, LDL-C, HDL-C and triglycerides. During 2-year follow-up, 20 (25.6%) patients had MACE. There was no significant difference in baseline parameters such as age, hypertension, presence of diabetes mellitus, and post-interventional use of statin therapy between patients with and without MACE. The levels of baseline lipid parameters were significantly higher in patients who experienced MACE, as follows: total cholesterol (p=0.009), LDL-C (p=0.028) and non-HDL-C (p=0.007). Pearson χ2-test showed that both non-HDL-C and LDL-C were significant predictors of MACE occurrence during 2-year follow-up, but non-HDL-C had a more significant correlation than LDL-C (p=0.007 vs. p=0.028). Our initial report shows that baseline non-HDL-C was a more significant predictor of the occurrence of MACE after first-time STEMI than LDL-C, which reflects the importance of the residual risk of MACE occurrence while enabling identification and close monitoring of high-risk patients.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 2","pages":"291-300"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE EFFECTIVENESS OF HIGH FLOW OXYGEN THERAPY AND NONINVASIVE MECHANICAL VENTILATION TREATMENT IN ACUTE RESPIRATORY FAILURE DUE TO CHRONIC OBSTRUCTIVE PULMONARY DISEASE - A RANDOMIZED STUDY. 高流量氧疗和无创机械通气治疗慢性阻塞性肺疾病急性呼吸衰竭的疗效——一项随机研究

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.05

Dilek Atik, Basar Cander, Ramiz Yazici, Bensu Bulut, Ramazan Unal, Ramazan Guven

{"title":"THE EFFECTIVENESS OF HIGH FLOW OXYGEN THERAPY AND NONINVASIVE MECHANICAL VENTILATION TREATMENT IN ACUTE RESPIRATORY FAILURE DUE TO CHRONIC OBSTRUCTIVE PULMONARY DISEASE - A RANDOMIZED STUDY.","authors":"Dilek Atik, Basar Cander, Ramiz Yazici, Bensu Bulut, Ramazan Unal, Ramazan Guven","doi":"10.20471/acc.2025.64.02.05","DOIUrl":"https://doi.org/10.20471/acc.2025.64.02.05","url":null,"abstract":"Hypercapnic acute respiratory failure (ARF) is a common complication of chronic obstructive pulmonary disease (COPD). Respiratory support is required in ARF, which usually has a high mortality risk. The objective was to compare the effectiveness of noninvasive mechanical ventilation (NIV), which is the traditional treatment protocol for COPD, with high-flow nasal cannula oxygen therapy (HFNT) as an emerging treatment method. This study was performed between August 20, 2019 and December 20, 2019, as a prospective randomized controlled study. Patients who were admitted with ARF due to COPD were included in the study. With randomization, 30 patients were treated with HFNT, whereas 31 patients were treated with NIV. The pH value of the HFNT group was significantly higher at the 1st hour of treatment (p=0.001). While there were no significant differences in subsequent pH values in the HFNT group (p=0.130), the pH value in the NIV group was found to have changed significantly (p=0.030). Compared to the NIV group, the 1st hour PaCO2 value in the HFNT group was significantly higher (p<0.001). The PaCO2 value decreased and PaO2 value increased significantly during follow-up in both groups (p<0.001). There were no significant differences in intra-group lactate and HCO3 values in the HFNT group, whereas the corresponding changes in the NIV group were significant (p=0.002). Compared to the HFNT group, the NIV group length of stay in the intensive care unit (ICU) was significantly longer (p=0.039). The use of HFNT, especially in more serious COPD patients, can be described as an intervention that could be beneficial in the acute period and could reduce the frequency of nosocomial infections by shortening ICU stay.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 2","pages":"216-224"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRITERIA FOR PRIMARY OR TWO-STAGE DIVERSION PROCEDURES IN COLON INJURIES: EXPERIENCE FROM A TERTIARY CARE CENTER IN MONTENEGRO. 结肠损伤的初级或两阶段转移程序的标准：黑山三级保健中心的经验。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.16

Ranko Lazović, Batrić Vukčević, Ognjenka Šarenac, Jelena Lazović, Nemanja Vukčević

{"title":"CRITERIA FOR PRIMARY OR TWO-STAGE DIVERSION PROCEDURES IN COLON INJURIES: EXPERIENCE FROM A TERTIARY CARE CENTER IN MONTENEGRO.","authors":"Ranko Lazović, Batrić Vukčević, Ognjenka Šarenac, Jelena Lazović, Nemanja Vukčević","doi":"10.20471/acc.2025.64.02.16","DOIUrl":"10.20471/acc.2025.64.02.16","url":null,"abstract":"Modern literature supports primary repair in a wide array of colon injury presentations. The aim of the study was to evaluate the validity of criteria for primary repair of colon injuries. The analysis involved 96 patients with colon injuries. Group 1 (62 patients) underwent the Stone and Fabian (S/F) criteria for primary repair, whereas group 2 (34 patients) underwent the following exclusion criteria for primary repair: significant peritonitis, edema/ischemia of a large area/multiple colonic segments, latent period >8 h, and intraoperative cardiorespiratory instability. The following variables were analyzed: demographic data, mechanism of injury, latent period, distribution of injuries, macroscopic intraoperative finding, and several trauma indices. The mean latent period was shorter in group 2 (1.3±1.1 h) versus group 1 (4.9±3.7 h). Primary repair was more frequent in group 2. There was no difference in the success rate of the primary procedures between the two groups according to Flint grade or S/F criteria. Primary repair is safe and recommended in the first 8 h after injury in hemodynamically and respiratory stable patients without intra-abdominal sepsis.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 2","pages":"324-331"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CONCURRENT CLOSTRIDIUM DIFFICILE COLITIS AND CYTOMEGALOVIRUS INFECTION AS A CAUSE OF PERSISTENT DIARRHEA AFTER AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR NON-HODGKIN LYMPHOMA FOLLOWING BENDAMUSTINE-BASED CONDITIONING. 并发艰难梭菌结肠炎和巨细胞病毒感染作为非霍奇金淋巴瘤患者自体造血干细胞移植后持续腹泻的原因。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.23

Martina Sedinić Lacko, Zdravko Mitrović, Sandra Šestan Crnek, Ozren Jakšić, Željko Prka, Vlatko Pejša

{"title":"CONCURRENT CLOSTRIDIUM DIFFICILE COLITIS AND CYTOMEGALOVIRUS INFECTION AS A CAUSE OF PERSISTENT DIARRHEA AFTER AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR NON-HODGKIN LYMPHOMA FOLLOWING BENDAMUSTINE-BASED CONDITIONING.","authors":"Martina Sedinić Lacko, Zdravko Mitrović, Sandra Šestan Crnek, Ozren Jakšić, Željko Prka, Vlatko Pejša","doi":"10.20471/acc.2025.64.02.23","DOIUrl":"10.20471/acc.2025.64.02.23","url":null,"abstract":"Diarrhea usually appears early following autologous hematopoietic stem cell transplantation (ASCT) due to toxic mucosal damage and neutropenia. Infectious agents also cause diarrhea in the post-transplantation period, with Clostridium difficile (C. difficile) being most common. In contrast, cytomegalovirus (CMV) enterocolitis is extremely rare after ASCT. We report a case of a 55-year-old male who underwent ASCT for non-Hodgkin lymphoma that was complicated by severe persistent diarrhea resulting in significant hypovolemia and electrolyte imbalance. Prior to transplantation, the patient received rituximab in combination with chemotherapy (R-CHOP/R-DHAP) followed by a bendamustine-based conditioning regimen (BeEAM). After treatment with oral metronidazole, vancomycin and fidaxomicin, diarrhea persisted despite undetectable C. difficile toxin, with elevation of hepatic enzymes. Eventually, CMV infection was diagnosed by real-time polymerase chain reaction and treated with ganciclovir and valganciclovir. Due to hypogammaglobulinemia following previous rituximab treatment, CMV immunoglobulins were also administered. The patient's condition gradually improved with CMV DNA being undetectable in serum. This case shows that diarrhea may be caused by concurrent infection with C. difficile and CMV after ASCT. Bendamustine-induced colitis and prior rituximab treatment may have been additional risk factors in this patient. Therefore, more comprehensive workup of diarrhea is needed in ASCT recipients treated with these agents.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 2","pages":"388-394"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARISON OF ENDOVASCULAR INTERVENTION AND DISTAL-LEG BYPASS FOR BELOW-THE-KNEE CHRONIC LIMB-THREATENING ISCHEMIA. 血管内介入治疗与腿远端旁路治疗膝以下慢性肢体缺血的比较。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.14

Josip Figl, Ivan Škorak, Dino Papeš, Ivan Romić, Suzana Figl, Majda Vrkić Kirhmajer

{"title":"COMPARISON OF ENDOVASCULAR INTERVENTION AND DISTAL-LEG BYPASS FOR BELOW-THE-KNEE CHRONIC LIMB-THREATENING ISCHEMIA.","authors":"Josip Figl, Ivan Škorak, Dino Papeš, Ivan Romić, Suzana Figl, Majda Vrkić Kirhmajer","doi":"10.20471/acc.2025.64.02.14","DOIUrl":"10.20471/acc.2025.64.02.14","url":null,"abstract":"Chronic limb-threatening ischemia (CLTI) is the main cause of major amputation and associated morbidity and mortality. Currently, both endovascular and open surgical methods for below-the-knee (BTK) interventions result in unsatisfactorily short patency rates. The aim of this retrospective single-center study was to evaluate six-month and one-year primary patency and major amputation rate in patients with CLTI treated with distal-leg bypass or BTK endovascular intervention. Overall, 46 patients underwent BTK intervention and 32 were available for follow-up analysis. Nine surgical bypasses and 23 endovascular treatments (balloon angioplasty) were performed. Six-month and one-year primary patency was 5/9 (55%) after bypass and 18/23 (78%) and 16/23 (69%) following endovascular intervention (p=0.20 and p=0.46). Angiography findings, predominantly advanced atherosclerosis, precluded any secondary intervention attempts. At one year post-intervention, the incidence of major amputation was 3/9 (33%) after bypass surgery and 5/23 (22%) following endovascular treatment. Although endovascular intervention for BTK CLTI seems to offer better 12-month patency and lower incidence of major amputation compared to bypass surgery, no statistically significant difference was noted. A randomized trial with more subjects and longer follow-up should be undertaken.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 2","pages":"301-307"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IS THERE A PROGNOSTIC ROLE OF FOCAL ADHESION KINASE AND CD8 IN SQUAMOUS CELL HEAD AND NECK CANCER TREATED WITH RADIOTHERAPY? 局灶黏附激酶和cd8在放疗治疗的鳞状细胞头颈部癌中是否有预后作用？

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.08

Vesna Bišof, Antonija Jakovčević, Anita Škrtić, Zoran Rakušić, Drago Prgomet, Ivica Rak

{"title":"IS THERE A PROGNOSTIC ROLE OF FOCAL ADHESION KINASE AND CD8 IN SQUAMOUS CELL HEAD AND NECK CANCER TREATED WITH RADIOTHERAPY?","authors":"Vesna Bišof, Antonija Jakovčević, Anita Škrtić, Zoran Rakušić, Drago Prgomet, Ivica Rak","doi":"10.20471/acc.2025.64.02.08","DOIUrl":"10.20471/acc.2025.64.02.08","url":null,"abstract":"The prevalence of relapses in advanced squamous cell head and neck cancer (SCHNC) is significant, and so is treatment morbidity. There is persistent need for reliable biomarkers in order to better personalize treatment. The purpose of the present study was to evaluate prognostic significance of focal adhesion kinase (FAK) and CD8 expression in human papillomavirus (HPV) negative SCHNC treated with radiotherapy. FAK and CD8 expression was evaluated by immunohistochemical staining. A total of 62 tissue samples were assessed. High expression of FAK was determined in 37.1% and high expression of CD8 in 25.8% of study patients. Patients with high expression of FAK had significantly more relapses than patients with low FAK expression (p=0.04). FAK and CD8 expression had no significant impact on overall survival (OS) (p=0.44 and p=0.48, respectively) and relapse free survival (RFS) (p=0.21 and p=0.31, respectively). However, patients with high expression of FAK and low expression of CD8 had the worst 5-year OS (38.7%) and 5-year RFS (44.3%). Patients with low expression of FAK had significantly less relapses. The prognostic role of FAK and CD8 expression in SCHNC patients treated with radiotherapy was not proven.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 2","pages":"240-250"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LOCALIZED PIGMENTED VILLONODULAR SYNOVITIS OF THE KNEE: A CONSECUTIVE CASE SERIES AND REVIEW OF THE LITERATURE. 膝关节局部色素性绒毛结节性滑膜炎：连续的病例系列和文献回顾。

IF 0.8 4区医学

Acta clinica Croatica Pub Date : 2025-06-01 DOI: 10.20471/acc.2025.64.02.02

Ivan Bojanić, Ivan Levaj, Damjan Dimnjaković, Tomislav Smoljanović

{"title":"LOCALIZED PIGMENTED VILLONODULAR SYNOVITIS OF THE KNEE: A CONSECUTIVE CASE SERIES AND REVIEW OF THE LITERATURE.","authors":"Ivan Bojanić, Ivan Levaj, Damjan Dimnjaković, Tomislav Smoljanović","doi":"10.20471/acc.2025.64.02.02","DOIUrl":"10.20471/acc.2025.64.02.02","url":null,"abstract":"Pigmented villonodular synovitis is a rare disease that occurs on synovial tissue within and outside a joint. It can be localized or diffuse. Localized pigmented villonodular synovitis (LPVNS) can occur in any compartment of the knee joint. The aim of this study was to retrospectively analyze our consecutive series of LPVNS of the knee. From January 1999 to December 2018, 10 consecutive patients with LPVNS of the knee underwent surgical treatment at our department. All patients were arthroscopically treated by the senior author by removal of the localized mass and partial synovial resection of the area surrounding the bottom of the lesion. The series included four female and six male patients, mean age 29.5 (range, 17-60) years. Their symptoms prior to the operation lasted from 3 months to 3 years (mean, 11.8 months). At the mean follow-up of 110.9 (range, 11-239) months, none of the patients had recurrence of the disease. Our study confirms the consensus in the literature that LPVNS of the knee should be treated arthroscopically by excision of the localized mass and partial synovectomy of the area surrounding the base of the lesion.","PeriodicalId":7072,"journal":{"name":"Acta clinica Croatica","volume":"64 2","pages":"190-199"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0