中国针灸最新文献

{"title":"[<i>Jiuci renmai</i> therapy combined with bladder function training for post-stroke neurogenic bladder: a randomized controlled trial].","authors":"Qiang Huang, Chunning Li, Hongyu Xie, Baoguo Wang, Zhenya Wang, Yi Cao","doi":"10.13703/j.0255-2930.20250302-0001","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20250302-0001","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To observe the clinical effect and safety of &lt;i&gt;Jiuci renmai&lt;/i&gt; therapy (moxibustion and acupuncture on the conception vessel) combined with bladder function training in treatment of post-stroke neurogenic bladder (PSNB).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Sixty patients with PSNB were randomly divided into an observation group and a control group, 30 cases in each group. On the basis of conventional treatment with western medication, bladder function training was delivered in the control group, once a day for 4 weeks. In the observation group, &lt;i&gt;Jiuci renmai&lt;/i&gt; therapy was supplemented besides the regimen as the control group. The main acupoints were Guanyuan (CV4), Zhongji (CV3), Qihai (CV6) and Qugu (CV2); and the supplementary acupoints were Henggu (KI11), Zhongwan (CV12), Xiawan (CV10) and Shuifen (CV9). Warm needling and moxibustion were operated, once every other day, for 4 weeks. Separately, before treatment and in 2 and 4 weeks of treatment, the urodynamic parameters were detected in the two groups, including maximal urine flow rate (Qmax), maximal detrusor pressure (PdetQmax), residual urine volume (RUV), maximal bladder capacity in the filling phase (MCC), and maximal intravesical pressure in the voiding phase (Pvesmax); the voiding parameters (the average daily number of micturition, urinary leakage episodes, and single voiding volume) were recorded; neurogenic bladder symptom score (NBSS), lower urinary tract symptom score (LUTS) and the score of quality of life scale for incontinence of urine (I-QoL) were evaluated, as well as the clinical effect and safety in the two groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In 2 and 4 weeks of treatment, Qmax, PdetQmax, MCC, Pvesmax, and average daily single voiding volume were increased compared with the levels before treatment in each group (&lt;i&gt;P&lt;/i&gt;&lt;0.05), and the above indexes in the observation group were higher than those of the control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). RUV, the average daily number of micturition, urinary leakage episode, NBSS and LUTS scores of the two groups were reduced in comparison with those before treatment (&lt;i&gt;P&lt;/i&gt;&lt;0.05 ), and these indexes in the observation group were lower than those of the control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). In 4 weeks of treatment, the average urinary leakage episode was reduced largely in comparison with the control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05); and the improvement in RUV for the patients with retention of urine in the observation group was superior to the control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). In 4 weeks of treatment, the score of each dimension in I-QoL and the total score were elevated compared with those before treatment in the two groups (&lt;i&gt;P&lt;/i&gt;&lt;0.05), and the scores in the observation were higher when compared with the control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The total effective rate in the observation group was 90.0% (27/30) which was higher than 70.0% (21/30) of the control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The incidence of adverse reactions was 3.3% (1/3","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 10","pages":"1427-1433"},"PeriodicalIF":0.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of clinical studys on acupuncture and moxibustion therapy for urticaria: an evidence map].","authors":"Meng Li, Xiaoyi Hu, Zhen Luo, Jie Ma, Tianyu Ming, Weijuan Gang, Shihao DU, Xianghong Jing","doi":"10.13703/j.0255-2930.20240906-0002","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20240906-0002","url":null,"abstract":"<p><p>Through collecting the existing clinical evidences on acupuncture and moxibustion for urticaria, the distribution of evidence in this field was mapped. A systematic search of Chinese and English literature was conducted in CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, and Cochrane Library for treatment of urticaria with acupuncture and moxibustion, published up to December 31, 2023 since inception of each database. The research status in this field was summarized using an evidence mapping approach, and methodological quality was assessed. A total of 323 randomized controlled trials (RCTs) and 22 systematic reviews were included. The number of studies on acupuncture and moxibustion for urticaria has been increasing, with a significant rise in recent years. In most RCTs, the study scale was small, and the subjects focused on chronic spontaneous urticaria in adolescents and middle-aged adults, aged 14 to 60 years. Regarding the intervention measures, the single therapy of acupuncture and moxibustion was predominant such as acupoint injection, acupoint embedding thread, and filiform needling. In acupuncture with filiform needles, the commonly used acupoints were Quchi (LI11), Xuehai (SP10), Sanyinjiao (SP6), Zusanli (ST36) and Hegu (LI4). The main outcome measures referred to effectiveness rate, score of disease severity, recurrence rate, laboratory indexes, and score of quality of life; and the short-term effect was evaluated specifically. The overall methodological quality of the included studies was relatively low. It is suggested that the future research should focus on large-scale, multi-center, high-quality clinical trials, optimize the protocols for acupuncture and moxibustion intervention, standardize the outcomes, and draw the attention to the evaluation of long-term efficacy, so as to provide clinical evidences of high certainty for urticaria treated with acupuncture and moxibustion.</p>","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 10","pages":"1519-1526"},"PeriodicalIF":0.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Herbal cake-separated moxibustion at <i>Baliao</i> acupoints for erectile dysfunction with kidney deficiency and blood stasis: a randomized controlled trial].","authors":"Junge DU, Pengchao Li, Zixue Sun","doi":"10.13703/j.0255-2930.20240924-0001","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20240924-0001","url":null,"abstract":"<p><strong>Objective: </strong>To compare the clinical efficacy of herbal cake-separated moxibustion at <i>Baliao</i> acupoints combined with western medication versus western medication alone in treating erectile dysfunction (ED) with kidney deficiency and blood stasis.</p><p><strong>Methods: </strong>A total of 108 ED patients were randomly divided into a combination group (54 cases, 2 cases dropped out) and a western medication group (54 cases, 1 case was eliminated, 2 cases dropped out). The western medication group received oral tadalafil tablets 5 mg a time, once daily. The combination group received additional herbal cake-separated moxibustion at <i>Baliao</i> acupoints (Shangliao [BL31], Ciliao [BL32], Zhongliao [BL33], Xialiao [BL34]) twice weekly (administered on Tuesdays and Fridays). Both groups were treated for 4 weeks. The 5-question international index of erectile function (IIEF-5) score, erectile hardness assessment (EHS) score, TCM syndrome score, serum sex hormone levels (follicle-stimulating hormone [FSH], luteinizing hormone [LH], prolactin [PRL], testosterone [T]), penile hemodynamic parameters [peak systolic velocity (PSV) of penile cavernosal artery, end-diastolic velocity (EDV), resistance index (RI)] were compared before and after treatment between the two groups, and the safety and clinical efficacy were evaluated.</p><p><strong>Results: </strong>After treatment, the IIEF-5 scores, EHS scores, serum T levels, PSV and RI of penile cavernosal artery were increased compared with those before treatment in the two groups (<i>P</i><0.05). Except for RI, the combination group exhibited significantly higher improvements in the above indexes than those in the western medication group (<i>P</i><0.05). After treatment, the TCM syndrome scores, the serum FSH, LH levels, and EDV in the two groups and the serum PRL level in the combination group were decreased compared with those before treatment (<i>P</i><0.05), while the above indexes in the combination group were lower than those in the western medication group (<i>P</i><0.05). The total effective rate of the combination group was 88.5% (46/52), which was superior to 72.5% (37/51) in the western medication group (<i>P</i><0.05). No significant adverse reactions occurred in either group.</p><p><strong>Conclusion: </strong>Herbal cake-separated moxibustion at <i>Baliao</i> acupoints combined with western medicine can regulate sex hormone levels, improve penile blood supply, enhance erectile function and hardness, and is superior to western medication alone, with no observed adverse reactions.</p>","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 10","pages":"1434-1439"},"PeriodicalIF":0.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intelligent education of acupuncture and moxibustion: perspective of knowledge graph].","authors":"Tiancheng Xu, Chengbiao Yang, Wanling Mao, Guanhu Yang, Youbing Xia","doi":"10.13703/j.0255-2930.20250120-0001","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20250120-0001","url":null,"abstract":"<p><p>With the development and the application of intelligent acupuncture and moxibustion equipment such as moxibustion robot and acupuncture robot, intelligent technology is constantly involved in the innovation of education. Computer technology represented by knowledge graph is re-constructing, in a structured form, including the fragmented information of the knowledge of acupuncture and moxibustion at all times and in all countries. Its application in the education scene further promotes the optimization of the technology itself. The knowledge fusion for the vertical scene of acupuncture-moxibustion knowledge has impelled us to develop universal entity and relationship extraction techniques. With the help of knowledge graph, the four-diagnosis equipment and acupuncture and moxibustion treatment equipment can be deeply integrated, and the wise information technology be thoroughly applied in the whole process of acupuncture and moxibustion education, so as to give full play to the \"emergence\" effect of knowledge and thinking, and drive the development of the theories of acupuncture and moxibustion in traditional Chinese medicine.</p>","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 10","pages":"1391-1395"},"PeriodicalIF":0.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Exploration on <i>JI Laixi</i>'s academic philosophy: \"making use of various therapeutic methods, taking effectiveness as the first priority\"].","authors":"Nixuan Gu, Yaohui Cui, Zhen Gao, Jinji Zhao, Dingjun Cai, Laixi Ji","doi":"10.13703/j.0255-2930.20250328-k0002","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20250328-k0002","url":null,"abstract":"<p><p>The paper introduces the reconstruction of Professor <i>JI Laixi</i>'s modern paradigm of thought, \"making use of various therapeutic methods\". Professor <i>JI Laixi</i> reveres the concept of \"integration of western medicine and TCM\" and advocates the \"combination of advantageous techniques of acupuncture and moxibustion\". Guided by the concept of \"combination of superiority, and coordinated adjustment\", a multi-mode intervention is delivered in treatment, including the operation with the nine needles, relaxation with acupotomy, acupoint thread-embedding, Chinese herbal compounds and adjuvant therapy with western medicines, so as to obtain dynamic adjustment of multiple targets and levels, \"taking effectiveness as the first priority\". The pathway of clinical practice is determined and clear, which provides a paradigm of \"upholding the right and innovating\" for the modernization of acupuncture and moxibustion.</p>","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 10","pages":"1470-1476"},"PeriodicalIF":0.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research on machine-learning quantitative evaluative model of manual acupuncture manipulation based on three-dimensional motion tracking technology].","authors":"Jiayao Wan, Binggan Wang, Tianai Huang, Fan Wang, Wenchao Tang","doi":"10.13703/j.0255-2930.20241209-0002","DOIUrl":"10.13703/j.0255-2930.20241209-0002","url":null,"abstract":"<p><strong>Objective: </strong>To develop an objective quantitative evaluative model of manual acupuncture manipulation (MAM) using three-dimensional motion tracking technology and machine learning, so as to provide a new approach to the study on acupuncture and moxibustion education and manipulation standardization.</p><p><strong>Methods: </strong>A total of 120 undergraduate students in the major of acupuncture-moxibustion and <i>tuina</i> were recruited. The Simi Motion Ver.8.5 motion tracking system was used to collect the data of three types of MAM, balanced reinforcing and reducing by twisting, reinforcing technique by twisting and reducing technique by twisting. Eight quantitative parameters covering movement performance and stability were established. With 5 types of machine learning algorithms (logistic regression, random forest, support vector machine, K-nearest neighbor, and decision tree) adopted, the evaluative model was constructed, and the feature importance analyzed.</p><p><strong>Results: </strong>In the evaluation of different types of MAM, the support vector machine presented the best for the effects of the balanced reinforcing and reducing by twisting, and the reducing by twisting (accuracy rates were both 0.88); and the logistic regression algorithm showed the optimal performance in evaluating the reinforcing by twisting (1.00 of accuracy rate). Feature importance analysis revealed that twisting velocity was the dominant parameter for evaluating the balanced reinforcing-reducing manipulation. The reinforcing and reducing of acupuncture techniques were more dependent on the left-hand twisting parameters and comprehensive performances, respectively.</p><p><strong>Conclusion: </strong>The objective evaluative model of MAM based on three-dimensional motion tracking technology and machine learning demonstrates a reliable evaluative performance, providing a new technical approach to standardized assessment in acupuncture and moxibustion education.</p>","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 9","pages":"1201-1208"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[<i>FAN Gangqi</i>'s experience in \"four-dimensional\" diagnosis and treatment of migraine with acupuncture and moxibusition].","authors":"Sixuan Chen, Chang Sun, Xiaomeng Hu, Xitong Mo, Yan Li, Peng Yan, Yuxin Zhang, Gangqi Fan","doi":"10.13703/j.0255-2930.20250220-k0008","DOIUrl":"10.13703/j.0255-2930.20250220-k0008","url":null,"abstract":"<p><p>The paper introduces Professor <i>FAN Gangqi</i>'s clinical experience in treatment of migraine. Regarding the syndrome/pattern differentiation of TCM, a four-approach framework is established, identifying the nature of illness, analyzing the syndrome/pattern and pathogenesis, determining the stage of illness, and identifying body constitution. In treatment, the principle of treatment is determined in line with syndrome/pattern differentiation, so as to ensure the therapeutic effect by means of \"four dimensions\". The acupuncture regimens are formulated in terms of the illness stages, \"strong needling stimulation in acute stage for analgesia, and needle retaining in chronic stage for long-term effect\". \"Focusing on neuovascular pathway\" is the effective approach to treatment of migraine with acupuncture and moxiubstion. The clinical holistic model by combining acupuncture with medication is advocated because that \"the single acupuncture is weak in therapeutic effect, but with medication combined, the effect is enhanced\". The different acupuncture techniques are provided comprehensively in treatment of migraine such as horizontal and row-like needling, collateral needling at Taiyang (EX-HN5), acupuncture at Sankong (Yuyao [EX-HN4], Sibai [ST2] and Jiachengjiang [Extra]), acupoint injection at Tianyou (TE16) and Renying (ST9), and acupoint embedding therapy at Fengchi (GB20).</p>","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 9","pages":"1299-1304"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[<i>JI Laixi</i>'s clinical experience in treating primary open angle glaucoma through \"nape-eight-needles\" acupotomy as main treatment].","authors":"Shuoxin Yang, Fang Gao, Gaofeng Liu, Qi Dong, Aiai Dong, Laixi Ji","doi":"10.13703/j.0255-2930.20250422-k0007","DOIUrl":"10.13703/j.0255-2930.20250422-k0007","url":null,"abstract":"<p><p>The paper introduces Professor <i>JI Laixi</i>'s academic thought and clinical experience in treatment of primary open angle glaucoma with \"nape-eight-needle\" acupotomy. Professor <i>JI Laixi</i> believes that the key pathogenesis lies in \"occlusion of <i>xuanfu</i> (subtle orifices) within the eyes and obstruction of meridian pathways\". Using the unblocking principle of treatment, taking meridian theory of traditional acupuncture as the core and based on the anatomical principles of structural acupuncture, Professor <i>JI</i> has proposed his academic thought, \"treating eye diseases from the nape\". In treatment, \"nape-eight-needle\" acupotomy is adopted, combined with filiform needle acupuncture. It is the advantageous compound therapeutic method, aiming to open <i>xuanfu</i>, restore brain-eye meridian connectivity, harmonize body, <i>qi</i> and mind through systemic regulation, address both the causative factors and symptoms and prevent from blindness. This therapeutic approach provides a new idea for clinical treatment of primary open angle glaucoma.</p>","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 9","pages":"1305-1310"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[<i>ZHANG Ren</i>'s academic characteristics of acupuncture for refractory eye diseases in modern times with \"homotherapy for heteropathy\"].","authors":"Yue Ma, Yanmei Hu, Xiaolan Shi, Xiaoying Hu, Wenqiang Hong, Ren Zhang","doi":"10.13703/j.0255-2930.20240812-k0002","DOIUrl":"10.13703/j.0255-2930.20240812-k0002","url":null,"abstract":"<p><p>This paper introduces the academic characteristics of Professor <i>ZHANG Ren</i> in treatment with acupuncture for refractory eye diseases in modern times, guided by \"homotherapy for heteropathy\" (same therapy for different diseases sharing the same pathogenesis). The refractory eye diseases in modern times include a variety of conditions such as glaucoma, macular degeneration, diabetic retinopathy, high myopia and its complications, dry eye, cortical visual impairment and genetic eye diseases. The same therapy is used because these diseases share the similar location and pathogenesis. Professor <i>ZHANG</i> optimizes the methods of acupoint selection and provides the comprehensive prescriptions, \"basic prescription, prescription based on disease differentiation, and supplementary prescription\". A variety of acupuncture manipulation techniques are operated in clinical practice, such as compound needling methods, penetration needling, manipulations for promoting <i>qi</i> movement and conducting <i>qi</i> flow. \"Early, regular and persistent\" treatment is the common requirement with \"the same acupoints, the same prescription and the same acupuncture method\" as well as at \"the same time\". It is also proposed that the treatment should be provided flexibly according to the different symptoms, \"identifying the differences within similarities\".</p>","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 9","pages":"1311-1317"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Inhibitory effect of electroacupuncture on microglial activation via Notch1/Hes1 pathway in Parkinson's disease mice].","authors":"Jinxu Jiang, Yang Liu, Huijie Fan, Tiansheng Zhang, Liran Wang, Lei Xu, Lixia Yang, Yunfei Song, Cungen Ma, Chongyao Hao, Zhi Chai","doi":"10.13703/j.0255-2930.20240528-0002","DOIUrl":"https://doi.org/10.13703/j.0255-2930.20240528-0002","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To observe the effects of electroacupuncture (EA) on improving motor function and regulating microglial activation based on Notch receptor 1 (Notch1)/Hes family bHLH transcription factor 1 (Hes1) pathway in mice with Parkinson's disease (PD).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Thirty-six male C57BL/6 mice were randomly divided into a control group, a model group and an EA group, 12 mice in each group. PD model was established by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 7 consecutive days in the model group and the EA group. From the 1st day of modeling, EA was applied at \"Baihui\" (GV20) and bilateral \"Shenshu\" (BL23) in the EA group, with continuous wave, in frequency of 2 Hz and current of 2 mA, 15 min a time, once a day for 14 days continuously. The behavioral performance was evaluated by gait test, pole climbing test and hanging test, the number of positive cells of tyrosine hydroxylase (TH) and the co-expression positive cells of Notch1/ionized calcium binding adaptor molecule 1 (Iba-1) in the substantia nigra of midbrain was assessed by immunofluorescence, the protein expression of TH, α-synuclein (α-syn), Notch1, Hes1, Iba-1, inducible nitric oxide synthase (iNOS), Arginase-1 (ARG1), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and IL-10 was detected by Western blot, the mRNA expression of Notch1 and Hes1 was detected by real-time PCR.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared with the control group, in the model group, the stride frequency was accelerated (&lt;i&gt;P&lt;/i&gt;&lt;0.001) and the stride length was shortened (&lt;i&gt;P&lt;/i&gt;&lt;0.001) for the four limbs, the pole climbing test time was prolonged (&lt;i&gt;P&lt;/i&gt;&lt;0.01) and the grip level was reduced (&lt;i&gt;P&lt;/i&gt;&lt;0.01); in the substantia nigra of midbrain, the number of positive cells of TH was decreased (&lt;i&gt;P&lt;/i&gt;&lt;0.001), the number of co-expression positive cells of Notch1/Iba-1 was increased (&lt;i&gt;P&lt;/i&gt;&lt;0.001), the protein expression of α-syn, Notch1, Hes1, Iba-1, iNOS, TNF-α, IL-1βand IL-6 was increased (&lt;i&gt;P&lt;/i&gt;&lt;0.01, &lt;i&gt;P&lt;/i&gt;&lt;0.05, &lt;i&gt;P&lt;/i&gt;&lt;0.001), the protein expression of TH, ARG1 and IL-10 was decreased (&lt;i&gt;P&lt;/i&gt;&lt;0.01, &lt;i&gt;P&lt;/i&gt;&lt;0.001), the mRNA expression of Notch1 and Hes1 was increased (&lt;i&gt;P&lt;/i&gt;&lt;0.01). Compared with the model group, in the EA group, the stride frequency was decelerated (&lt;i&gt;P&lt;/i&gt;&lt;0.001) and the stride length was increased (&lt;i&gt;P&lt;/i&gt;&lt;0.05, &lt;i&gt;P&lt;/i&gt;&lt;0.01, &lt;i&gt;P&lt;/i&gt;&lt;0.001) for the four limbs, the pole climbing test time was shortened (&lt;i&gt;P&lt;/i&gt;&lt;0.05) and the grip level was increased (&lt;i&gt;P&lt;/i&gt;&lt;0.05); in the substantia nigra of midbrain, the number of positive cells of TH was increased (&lt;i&gt;P&lt;/i&gt;&lt;0.01), the number of co-expression positive cells of Notch1/Iba-1 was decreased (&lt;i&gt;P&lt;/i&gt;&lt;0.001), the protein expression of α-syn, Notch1, Hes1, Iba-1, iNOS, TNF-α, IL-6 and IL-1β was decreased (&lt;i&gt;P&lt;/i&gt;&lt;0.05, &lt;i&gt;P&lt;/i&gt;&lt;0.01), the protein expression of TH, ARG1 and IL-10 was increased (&lt;i&gt;P&lt;/i&gt;&lt;0.05, &lt;i&gt;P&lt;/i&gt;&lt;0.001, &lt;i&gt;P&lt;/","PeriodicalId":69903,"journal":{"name":"中国针灸","volume":"45 9","pages":"1290-1298"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}