Acta biochimica Polonica最新文献_第4页

MicroRNA-221-3p promotes post-burn HUVEC proliferation, migration, and angiogenesis by regulating CDKN1B. MicroRNA-221-3p通过调节CDKN1B促进烧伤后HUVEC的增殖、迁移和血管生成。

IF 1.7 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-22 DOI: 10.18388/abp.2020_6295

Kun Miao, Fei Xie, JinGui Lin

{"title":"MicroRNA-221-3p promotes post-burn HUVEC proliferation, migration, and angiogenesis by regulating CDKN1B.","authors":"Kun Miao, Fei Xie, JinGui Lin","doi":"10.18388/abp.2020_6295","DOIUrl":"10.18388/abp.2020_6295","url":null,"abstract":"Background and objective: Previous studies have shown that miR-221-3p plays an important role in vascular remodeling, but it is unclear whether it contributes to angiogenesis after burn injury. The purpose of this study was to investigate the effect of miR-221-3p on angiogenesis in HUVECs after burn injury and to reveal its underlying molecular mechanism.Methods: The burn HUVECs model was established by heat treatment. Plasmid or oligonucleotide transfection altered the expression of miR-221-3p and CDKN1B in HUVECs. MTT, colony formation, Transwell, flow cytometry, and tube formation experiments were applied to assess the proliferation, migration, apoptosis, cell cycle, and tube formation capacity of HUVECs. miR-221-3p, CDKN1B, Ki-67, and PCNA expression was assessed by RT-qPCR or Western blot. The dual-luciferase reporter assay verified the targeting relationship between miR-221-3p and CDKN1B.Results: miR-221-3p was lowly expressed and CDKN1B was highly expressed in burn HUVECs. Overexpression of miR-221-3p promoted the proliferation, migration, and tube formation ability of burn HUVECs and inhibited apoptosis and the proportion of cells in the G0/G1 phase, whereas overexpression of CDKN1B had the opposite effect. Knockdown of miR-221-3p further inhibited the angiogenic capacity of burn HUVECs, but this effect was reversed by knockdown of CDKN1B. Mechanistically, miR-221-3p targeted CDKN1B.Conclusion: miR-221-3p improves the angiogenesis of burn HUVECs by targeting CDKN1B expression, and the miR-221-3p/CDKN1B axis may serve as a potential molecular target for future burn therapy.","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":" ","pages":"785-790"},"PeriodicalIF":1.7,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138290031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and biochemical mechanisms of diabetic encephalopathy. 糖尿病性脑病的分子生化机制。

IF 1.7 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-22 DOI: 10.18388/abp.2020_6953

Igor Belenichev, Olena Aliyeva, Olena Popazova, Nina Bukhtiyarova

引用次数: 0

Imiquimod-induced psoriasis model: induction protocols, model characterization and factors adversely affecting the model. 吡喹莫德诱导的银屑病模型:诱导方案、模型特性和影响模型的不利因素。

IF 1.7 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-22 DOI: 10.18388/abp.2020_6426

Manahel Mahmood Alsabbagh

引用次数: 0

MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein. MicroRNA-508-3p 通过靶向 G1 到 S 期转变 1 (GSPT1) 蛋白调节人类肺癌细胞的增殖。

IF 1.7 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-22 DOI: 10.18388/abp.2020_6660

Xingyou Chen, Chen Feng, Jiliang Zha, Zihao Shen, Wei Ji

{"title":"MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein.","authors":"Xingyou Chen, Chen Feng, Jiliang Zha, Zihao Shen, Wei Ji","doi":"10.18388/abp.2020_6660","DOIUrl":"10.18388/abp.2020_6660","url":null,"abstract":"Purpose: Due to its crucial cancer regulatory role, microRNA-508-3p has been reported as a potential therapeutic anticancer molecular target. The present work encompassed the molecular characterization of microRNA-508-3p in lung cancer emphasizing on understanding the possible mechanism of its regulatory action.Methods: qRT-PCR was performed to estimate the relative gene expression of microRNA-508-p in the tissue samples. The proliferation of cancer cells was determined by cell counting kit-8. The colony formation from cancer cells was analyzed by clonogenic assay. Mitotic phase distribution was understood by employing the flow cytometric technique. Edu-Hoechst staining was used for the assessment of cell viability. In silico analysis and dual-luciferase assay were used for target identification of microRNA-508-3p in lung cancer. Immunofluorescence and western blotting studies were carried out for relative protein expression. The rat models were used for performing the in vivo experimental procedures.Results: The study showed the significant down-regulation of microRNA-508-3p in lung cancer. The lower expression levels of microRNA-508-3p were shown to be associated with poor survival of lung cancer patients. The over-expression of microRNA-508-3p was found to decline the proliferation and viability of cancer cells together with the induction of mitotic cell cycle arrest at G1 by targeting G1 to S phase transition 1 (GSPT1) protein. MicroRNA-508-3p up-regulation inhibited the in vivo tumor growth in rat models.Conclusion: Our study identifies miR-508-3p as a pivotal regulator of lung cancer cell proliferation by targeting the GSPT1 protein. This highlights its potential as a tumor suppressor and a therapeutic target for lung cancer. Our findings offer mechanistic insights into miRNA-mediated cancer progression, prompting further research in this intricate regulatory network.","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":"70 4","pages":"835-841"},"PeriodicalIF":1.7,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of microbiological safety of dry cat foods marketed in Poland. 波兰市售干猫食品微生物安全性调查。

IF 1.7 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-15 DOI: 10.18388/abp.2020_6921

Joanna Ziętara-Wysocka, Olga Sierawska, Cansel Taskin, Agata Poniewierska-Baran, Dominika Bębnowska, Rafał Hrynkiewicz, Filip Lewandowski, Paulina Niedźwiedzka-Rystwej

{"title":"Investigation of microbiological safety of dry cat foods marketed in Poland.","authors":"Joanna Ziętara-Wysocka, Olga Sierawska, Cansel Taskin, Agata Poniewierska-Baran, Dominika Bębnowska, Rafał Hrynkiewicz, Filip Lewandowski, Paulina Niedźwiedzka-Rystwej","doi":"10.18388/abp.2020_6921","DOIUrl":"10.18388/abp.2020_6921","url":null,"abstract":"Pets are inhabiting more and more human homes every year. In 2020, the cat population in Europe was 110 million, including 6.8 million in Poland. Dry food is the most popular dietary model for cats because of its easy storage and efficient satisfaction of pet needs. The high processing temperature of dry food reduces the chance of microbial contamination, but this can occur later, during post-production or storage in the pet's caregiver's home or, in the case of weighed foods, in the store. The purpose of this study was to investigate the microbiological safety of dry feed sold in the original manufacturer's packaging and the same feed from the same manufacturers sold in a retail store by weight. Six discriminants, presence of Salmonella spp., number of coliforms, number of coagulase-positive staphylococci, determination of yeast and mould counts, Enterobacteriaceae count, Listeria monocytogenes and determination of total aerobic microbial count were used for the analysis. Then, cat food was then stored for 45 days according to the manufacturer's recommendations. Based on the samples tested both after opening and after storage, it was concluded that the dry cat food analyzed posed a law microbiological risk to animals and humans.","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":" ","pages":"971-977"},"PeriodicalIF":1.7,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134648145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relative expression levels of growth hormone gene and growth rate in Indian major carp species. 印度主要鲤鱼种生长激素基因的相对表达量与生长速率。

IF 1.7 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-14 DOI: 10.18388/abp.2020_6864

Shahid Sherzada, Muhammad Nauman Sharif, Qurban Ali, Saeed Akram Khan, Tawaf Ali Shah, Mohamed A M El-Tabakh, Tariq Aziz, Ghulam Nabi, Metab Alharbi, Thamer H Albekairi, Abdullah F Alasmari

{"title":"Relative expression levels of growth hormone gene and growth rate in Indian major carp species.","authors":"Shahid Sherzada, Muhammad Nauman Sharif, Qurban Ali, Saeed Akram Khan, Tawaf Ali Shah, Mohamed A M El-Tabakh, Tariq Aziz, Ghulam Nabi, Metab Alharbi, Thamer H Albekairi, Abdullah F Alasmari","doi":"10.18388/abp.2020_6864","DOIUrl":"10.18388/abp.2020_6864","url":null,"abstract":"The phenomenon of growth is a leading factor for aquaculture success. The uneven growth of major Indian carps (Labeo rohita, Catla catla, and Cirrhinus mrigala) is a serious issue in fish culture from an economic point of view. The growth hormone (GH) gene is crucial for selection in commercially cultivated fish species for better growth and production. Indian major carp (L. rohita, C. catla, and C. mrigala) are commonly cultured in Pakistan. The GH expression was examined using qPCR to understand growth in fish species better. Muscle tissue samples (n=480) from 160 individuals of the same age were collected from three species (L. rohita, C. catla, and C. mrigala). Individuals were divided into two groups (high-weight and low-weight groups), cultured under normal conditions. The housekeeping gene β-actin validated GH expression in fast and slow-growing fishes from the same species. Results showed that GH expression varies across species and fish specimens that overweight their counterpart feature have higher GH expression. A selection for overweight fish in the aquaculture breeding systems is preferable as those fish could inherit their genomics to the future cohort, enhancing production, and commercial profit for farmers. Comprehensive research about different growth genes and the environmental aspects that influence fish growth is mandatory. No work has been reported regarding the growth gene analysis of fish from Pakistan. This report was Pakistan's first and baseline study regarding growth analysis of main culturable fish species at the molecular level.","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":" ","pages":"943-949"},"PeriodicalIF":1.7,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107589943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, preparation and investigation of leaf extracts of Aloe barbadensis for its remedial effects on tumor necrosis factor alpha (TNF-α) and interleukin (IL-6) by in vivo and in silico approaches in experimental rats. 芦荟叶提取物的分离、制备及其对实验大鼠肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的治疗作用。

IF 1.7 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-08 DOI: 10.18388/abp.2020_6827

Iram Khurshaid, Sobia Ilyas, Nureen Zahra, Suhail Ahmad, Tariq Aziz, Fahad Al-Asmari, Sanaa Almowallad, Rehab F Al-Massabi, Yasmene F Alanazi, Aminah A Barqawi, Roaa Mohammed Tahir Kassim, Abdulhakeem S Alamri, Majid Alhomrani, Manal Y Sameeh

{"title":"Isolation, preparation and investigation of leaf extracts of Aloe barbadensis for its remedial effects on tumor necrosis factor alpha (TNF-α) and interleukin (IL-6) by in vivo and in silico approaches in experimental rats.","authors":"Iram Khurshaid, Sobia Ilyas, Nureen Zahra, Suhail Ahmad, Tariq Aziz, Fahad Al-Asmari, Sanaa Almowallad, Rehab F Al-Massabi, Yasmene F Alanazi, Aminah A Barqawi, Roaa Mohammed Tahir Kassim, Abdulhakeem S Alamri, Majid Alhomrani, Manal Y Sameeh","doi":"10.18388/abp.2020_6827","DOIUrl":"10.18388/abp.2020_6827","url":null,"abstract":"Aloe barbadensis is a stemless plant with a length of 60-100 cm with juicy leaves which is used for its remedial and healing properties in different suburbs of various countries. The present study was conducted to investigate the effect of A. barbadensis leaf extract (aqueous and ethanolic) in yeast induced pyrexia and acetic acid induced writhing in rat model to evaluate the antipyretic biomarkers and its phytochemical screening with computational analysis. For analgesic activity model 60 Albino rats (160-200 kg) were divided into four groups. Of the 4 groups, control consisted of 6 rats (Group I) treated with normal saline, standard comprised of 6 rats treated with drug diclofenac (Group I). Experimental groups consisted of 48 rats, treated with A. barbadensis ethanolic and aqueous leaf extracts at doses of 50 mg/kg, 100 mg/kg, 200 mg/kg, and 400 mg/kg (Group III. IV). For antipyretic activity group division was same as in analgesic activity. All groups were treated the same as in the analgesic activity except for the second group which was treated with paracetamol. In both antipyretic and analgesic activity at the dose of 400 mg/kg, group III showed significant inhibition. TNF-α and IL-6 showed significant antipyretic activity at a dose of 400 mg/kg. For molecular docking aloe emodin and cholestanol were used as ligand molecules to target proteins Tnf-α and IL-6. Acute oral toxicity study was performed. There was no mortality even at the dose of 2000 mg/kg. Quantitative and qualitative phytochemical screening was performed for the detection of various phytochemicals. Hence, A. barbadensis leaf extracts can be used in the form of medicine for the treatment of pain and fever.","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":" ","pages":"927-933"},"PeriodicalIF":1.7,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects. circCCDC6与microRNA-128-3p的竞争性结合激活TXNIP/NLRP3通路并促进脑缺血再灌注缺陷。

IF 1.4 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-07 DOI: 10.18388/abp.2020_6552

ChongShu Wang, MingMing Dong, XiaoYi Zhang, XiaoYu Wang, Yan Zhao, Yunpeng Cao

{"title":"Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.","authors":"ChongShu Wang, MingMing Dong, XiaoYi Zhang, XiaoYu Wang, Yan Zhao, Yunpeng Cao","doi":"10.18388/abp.2020_6552","DOIUrl":"10.18388/abp.2020_6552","url":null,"abstract":"Objective: Circular RNAs (circRNAs) are enriched in the brain and involved in various central nervous system diseases. The potential role of circCCDC6 in cerebral ischemia-reperfusion defects was partly elucidated in the work.Methods: A middle cerebral artery occlusion/reperfusion (MCAO/R) rat model and an oxygen-glucose deprivation and re-oxygenation (OGD/R)-treated SH-SY5Y cell model were constructed. CircCCDC6 expression in the two models was examined, and circCCDC6-involved mechanisms in neuronal pyroptosis and inflammation were analyzed through loss- and gain-of-function assays.Results: MCAO/R rat brain tissues and OGD/R-treated SH-SY5Y cells exhibited upregulated circCCDC6. Silencing circCCDC6 attenuated neuronal pyroptosis and inflammation in the brain tissue of MCAO/R rats. Overexpressing circCCDC6 or inhibiting miR-128-3p stimulated OGD/R-induced pyroptosis and inflammation in SH-SY5Y cells, while upregulating miR-128-3p attenuated OGD/R injury. CircCCDC6 silencing-induced effects on SH-SY5Y cells were antagonized by TXNIP overexpression.Conclusion: Mechanistically, circCCDC6 mediates miR-128-3p and activates TXNIP/NLRP3, thereby promoting OGD/R-induced neuronal pyroptosis and inflammation. CircCCDC6 may provide a new strategy for the treatment of MCAO/R.","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":" ","pages":"807-815"},"PeriodicalIF":1.4,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71476845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic Mcpip1 regulates adaptation to food restriction in mice. 肝Mcpip1调节小鼠对食物限制的适应。

IF 1.7 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-06 DOI: 10.18388/abp.2020_6819

Olga Mucha, Bozena Skupien-Rabian, Alicja Slota, Katarzyna Trzos, Natalia Pydyn, Bartosz Podlewski, Jolanta Jura, Jerzy Kotlinowski

{"title":"Hepatic Mcpip1 regulates adaptation to food restriction in mice.","authors":"Olga Mucha, Bozena Skupien-Rabian, Alicja Slota, Katarzyna Trzos, Natalia Pydyn, Bartosz Podlewski, Jolanta Jura, Jerzy Kotlinowski","doi":"10.18388/abp.2020_6819","DOIUrl":"10.18388/abp.2020_6819","url":null,"abstract":"Monocyte-chemoattractant protein-induced protein 1 (MCPIP1, or Regnase-1) is an endoribonuclease that degrades translationally active mRNA molecules. MCPIP1 is mostly known for its anti-inflammatory actions, but it is also an important regulator of adipogenesis and lipid metabolism. Its overexpression impairs adipogenesis by reducing mRNA levels of C/EBPβ and PPARγ, key transcription factors regulating this process. Although adipocytes overexpressing MCPIP1 are characterised by impaired glucose uptake, the function of MCPIP1 in hepatocyte metabolism remains unknown. In this study, conditional deletion of Zc3h12a in murine liver epithelial cells was used to characterise the role of Mcpip1 in adaptation to 24-hour food restriction. We found that Mcpip1 deficiency in liver epithelial cells (Mcpip1fl/flAlbCre mice) resulted in higher blood glucose levels in response to fasting in comparison to Mcpip1fl/fl counterparts. Hepatic proteome analysis showed 26 down-regulated and 117 up-regulated proteins in Mcpip1fl/flAlbCre animals that were involved in cellular adhesion, extracellular matrix and metabolic processes. In conclusion, our studies provide new insight into the hepatic function of Mcpip1 and its involvement in metabolic control.","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":" ","pages":"919-925"},"PeriodicalIF":1.7,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71476846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel ferroptosis-related gene signature associated with cuproptosis for predicting overall survival in breast cancer patients. 一种与铜中毒相关的新型铁中毒相关基因标记用于预测癌症患者的总生存率。

IF 1.7 4区生物学

Acta biochimica Polonica Pub Date : 2023-11-06 DOI: 10.18388/abp.2020_6722

Xiaoyu Zhang, Qunchen Zhang

{"title":"A novel ferroptosis-related gene signature associated with cuproptosis for predicting overall survival in breast cancer patients.","authors":"Xiaoyu Zhang, Qunchen Zhang","doi":"10.18388/abp.2020_6722","DOIUrl":"10.18388/abp.2020_6722","url":null,"abstract":"Purpose Ferroptosis and cuproptosis are both metal-dependent regulated cell death that play an important role in cancer. However, the expression patterns and the prognostic values of ferroptosis-related genes (FRGs) associated with cuproptosis in breast cancer (BC) are largely unknown. This study aims to explore the prognostic value of cuproptosis-related FRGs and their relationship with tumor microenvironments in BC. Methods The clinical and RNA sequencing data of BC patients from TCGA, METABRIC and GEO databases were analyzed. The least absolute shrinkage and selection operator regression analysis was used to establish prognostic signatures based on cuproptosis-related FRGs. The overall survival between risk subgroups was assessed by Kaplan-Meier analysis. The changes in risk score during neoadjuvant chemotherapy, and differences in immune cells, immune checkpoints, and drug sensitivity between risk subgroups were also analyzed in this study. Results A successful development of a prognostic signature based on cuproptosis-related FRGs in the TCGA cohort was achieved and it was validated in the METABRIC cohort. Gene set enrichment analysis results revealed the enrichment of steroid biosynthesis and ABC transporters in the high-risk group. Moreover, the signature was also found to be associated with immune cells and immune checkpoints. Lower risk score in patients after neoadjuvant chemotherapy and higher sensitivity of the high-risk group to AKT inhibitor VIII and cisplatin was also observed. Conclusion Cuproptosis-related FRGs can be used as a novel prognostic signature for predicting the overall survival of BC patients. This can provide meaningful insights into the selection of immunotherapy and antitumor drugs for BC.","PeriodicalId":6984,"journal":{"name":"Acta biochimica Polonica","volume":" ","pages":"875-884"},"PeriodicalIF":1.7,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71476844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0