Acta dermato-venereologica最新文献_第3页

Chronic Spontaneous Urticaria in Finland - A Nationwide Registry Study on Epidemiology and Treatment Patterns in Secondary Care. 芬兰的慢性自发性荨麻疹——一项关于二级护理流行病学和治疗模式的全国性登记研究。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-22 DOI: 10.2340/actadv.v106.adv-2026-0509

Suvi-Päivikki Sinikumpu, Emma Heikkinen, Jari Jokelainen, Stina Roth, Maija Wolf, Laura Huilaja

{"title":"Chronic Spontaneous Urticaria in Finland - A Nationwide Registry Study on Epidemiology and Treatment Patterns in Secondary Care.","authors":"Suvi-Päivikki Sinikumpu, Emma Heikkinen, Jari Jokelainen, Stina Roth, Maija Wolf, Laura Huilaja","doi":"10.2340/actadv.v106.adv-2026-0509","DOIUrl":"10.2340/actadv.v106.adv-2026-0509","url":null,"abstract":"Chronic spontaneous urticaria (CSU) is a burdensome skin disease characterized by recurrent wheals and/or angioedema without identifiable external triggers, with symptoms lasting for six weeks or longer, and impairs patients' quality of life and work productivity. This nationwide registry-based study examined epidemiology of CSU in Finland and its treatment patterns. Using secondary care data from 2001 to 2023, we identified 8,784 adult patients with CSU; 70% were female and the mean age was 45.3 years. Point prevalence of CSU was 0.21% in 2022 and an age-standardized incidence 9.34 per 100,000 person-years. A total of 85.8% of patients received antihistamines and 36.1% of all patients required concurrent corticosteroids, suggesting suboptimal disease control. Only 8.5% of patients received omalizumab, and the median time from antihistamine initiation to omalizumab was 9 Comorbidities such as asthma, hypertension, and depression were common. The low recorded of angioedema (5.9%) likely reflects limitations in registry coding. Overall, these findings highlight gaps in CSU management, including delayed initiation of omalizumab and a high proportion of systemic corticosteroid use. These patterns may partly reflect omalizumab reimbursement restrictions and delays in patient pathways, and suggest opportunities to improve clinical practice and patient outcomes.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Accuracy of Dermoscopy for Spitzoid Tumours in Adults. 成人Spitzoid肿瘤的皮肤镜诊断准确性。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-22 DOI: 10.2340/actadv.v106.adv-2026-0513

Nadia Vega, Sebastián Podlipnik, Daniel Morgado, Natalia Espinosa, Natalia Castrejon-de-Anta, Llucia Alòs, Josep Malvehy, Susana Puig, Cristina Carrera

{"title":"Diagnostic Accuracy of Dermoscopy for Spitzoid Tumours in Adults.","authors":"Nadia Vega, Sebastián Podlipnik, Daniel Morgado, Natalia Espinosa, Natalia Castrejon-de-Anta, Llucia Alòs, Josep Malvehy, Susana Puig, Cristina Carrera","doi":"10.2340/actadv.v106.adv-2026-0513","DOIUrl":"10.2340/actadv.v106.adv-2026-0513","url":null,"abstract":"Spitzoid tumours (ST) represent a diagnostic chal-lenge and the accuracy of dermoscopy in these cases remains unclear. This retrospective study evaluated dermoscopic images collected from 2011 to 2016. Two dermatologists, blinded to clinical/ histopathological data, identified lesions with spitzoid dermoscopic patterns, using histopathology as the gold standard. Of 4,337 dermoscopic images, 240 (5.5%) showed spitzoid dermoscopic patterns (221 patients; median age 40; 57.9 % female). Histopathology revealed 23 % (55/240) ST, 62 % (149/240) non--spitzoid melanocytic lesions and 15 % (36/240) non--melanocytic lesions. Overall, 25.4 % (61/240) were malignant, mainly melanoma/melanoma metastases (50/240). Across excised tumours, 1.5 % (67/4,337) were ST. Sensitivity and specificity were 82.1 % (95% CI 70.8%-90.4%) and 95.7 % (95% CI 95%-96.3%), with an AUC of 0.88 (95% CI 0.84-0.93). Positive predictive value (PPV) was 22.9 % (95% CI 17.8%-28.8%), and nega-tive predictive value (NPV) was 99.7 % (95% CI 99.5%-99.9%). Starburst pattern was more frequent in ST (p=0.007). Linear vessels (OR 5.12; 95% CI 2.08-13.1) and glomerular vessels (OR 3.03; 95% CI 1.37-6.69) correlated with malignancy. Dermoscopy demonstrated high diagnostic accuracy and NPVnegative predictive value. However, low PPVpositive predictive value highlights limited specificity in adults; since one1 in four4 lesions with a spitzoid dermoscopic pattern was malignant, any spitzoid lesion in adults warrants high clinical suspicion.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anifrolumab in Refractory Discoid Lupus Erythematosus without Systemic Involvement: A Case Series of Five Patients. 单克隆抗体治疗难治性盘状红斑狼疮，无全身累及：5例病例。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-17 DOI: 10.2340/actadv.v106.adv-2026-0559

Jasmin Marschner, Franziska Schauer

引用次数: 0

Periocular Primary Cutaneous Mucinous Carcinoma in a Young Asian Male: A Rare Presentation. 年轻亚洲男性眼周原发性皮肤黏液癌一例罕见病例。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-16 DOI: 10.2340/actadv.v106.adv-2026-0591

Cuirong Xiao, Zhixun Xiao, Qiuyun Xu, Jiawen Chen, Bo Cheng

引用次数: 0

Primary Hyperhidrosis: A Review of Epidemiology, Pathophysiology and Management. 原发性多汗症：流行病学、病理生理学和治疗的综述。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-16 DOI: 10.2340/actadv.v106.adv-2026-0770

Alexander Shayesteh

{"title":"Primary Hyperhidrosis: A Review of Epidemiology, Pathophysiology and Management.","authors":"Alexander Shayesteh","doi":"10.2340/actadv.v106.adv-2026-0770","DOIUrl":"10.2340/actadv.v106.adv-2026-0770","url":null,"abstract":"Primary hyperhidrosis is termed as excessive sweating exceeding the physiological needs of thermoregulation. This review provides an updated overview focusing on epidemiology, quality of life, pathophysiology, economic impacts, diagnostic approaches and current management strategies. A literature search was conducted in June 2026 across PubMed and the Cochrane Central Register of Controlled Trials. Additional references were identified through manual searches of relevant bibliographies. Reported prevalence of hyperhidrosis varied widely, likely reflecting differences in methodology and disease recognition. Primary hyperhidrosis is associated with autonomic dys-regulation involving sympathetic pathways. Emerging evidence suggests that molecular alterations in eccrine glands may represent secondary adap-tations to sustained cholinergic stimulation, while genetic variability in receptor expression may contribute to interindividual differences in disease severity. Hyperhidrosis has a strong negative impact on the economy and quality of life, adversely affecting both mental and physical health. Multiple treatment options are available, including topical therapies, systemic agents, device-based interventions, botulinum toxin injections, and surgery. Despite increasing recognition of the clinical burden, comprehensive economic evaluations remain limited, with indirect costs and long-term societal impact insufficiently characterized. In conclusion, primary hyperhidrosis imposes a substantial burden on affected individuals, requiring improved re-cognition, standardized diagnostic frameworks, and individualized management strategies supported by high-quality and longitudinal research.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connecting Skin and Gut in Dermatitis Herpetiformis: Insights from Gluten Challenge Transcriptomics. 疱疹样皮炎中连接皮肤和肠道：来自谷蛋白挑战转录组学的见解。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-09 DOI: 10.2340/actadv.v106.adv-2026-0792

Helka Kaunisto, Esko Kemppainen, Teea Salmi, Katarzyna Leskinen, Heli Pessa, Rebecka Ventin-Holmberg, Päivi Saavalainen, Kaisa Hervonen, Tuire Ilus, Katri Kaukinen, Katri Lindfors

{"title":"Connecting Skin and Gut in Dermatitis Herpetiformis: Insights from Gluten Challenge Transcriptomics.","authors":"Helka Kaunisto, Esko Kemppainen, Teea Salmi, Katarzyna Leskinen, Heli Pessa, Rebecka Ventin-Holmberg, Päivi Saavalainen, Kaisa Hervonen, Tuire Ilus, Katri Kaukinen, Katri Lindfors","doi":"10.2340/actadv.v106.adv-2026-0792","DOIUrl":"10.2340/actadv.v106.adv-2026-0792","url":null,"abstract":"Dermatitis herpetiformis (DH) is a dietary gluten -induced autoimmune blistering skin disease. It is hypothesized to be initiated by a small intestinal mucosal immune response. Gluten-free diet (GFD) is the primary treatment for DHdermatitis herpetiformis and effectively resolves skin lesions. Previous studies show that after gluten reintroduction, peripheral cell responses are detectable already in six6 days, and most patients relapse clinically within months. The relapse presentation may differ between patients, with some experiencing both rash and small intestinal mucosal damage and some only one of these. Here, RNA transcriptomics were utilized to characterize temporal systemic and small intestinal mucosal responses to gluten in DH,dermatitis herpetiformis and to identify transcriptomic profiles specific for rash or villous atrophy as relapse presentations. The cohort consisted of 19 DHdermatitis herpetiformis patients on GFDgluten-free diet who underwent a gluten challenge. Gluten challenge elicited pronounced gene expression changes related to inflammation in the small intestine. In patients relapsing with rash, DOCK8 expression was significantly upregulated, while IL10RB was downregulated at end of follow-up. These patients also had significantly increased frequency of intraepithelial lymphocytes. Our findings show that prolonged gluten exposure alters duodenal transcriptomic profiles considerably. Moreover, patterns related to rash could be detected and present interesting candidates for future studies.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13558545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Narrow-band UV-B (TL-01) Phototherapy Exposure and Skin Cancer Risk: A Nested Case-control Study. 窄带UV-B （TL-01）光疗暴露与皮肤癌风险：一项巢式病例对照研究。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-09 DOI: 10.2340/actadv.v106.adv-2025-0274

Petra Åkerla, Eero Pukkala, Mika Helminen, Niina Korhonen, Toni Karppinen

{"title":"Narrow-band UV-B (TL-01) Phototherapy Exposure and Skin Cancer Risk: A Nested Case-control Study.","authors":"Petra Åkerla, Eero Pukkala, Mika Helminen, Niina Korhonen, Toni Karppinen","doi":"10.2340/actadv.v106.adv-2025-0274","DOIUrl":"10.2340/actadv.v106.adv-2025-0274","url":null,"abstract":"Narrow-band TL-01 ultraviolet B phototherapy (TL-01) is generally considered a relatively safe treatment for skin diseases, although conflicting findings have also been reported. This study aimed to evaluate the association between TL-01 exposure and skin cancer risk using a nested case-control design within a Finnish cohort of 4,815 patients treated with TL-01 monotherapy, with subsequent 38 cases of basal cell carcinoma, 13 cases of cutaneous melanoma, and 9 cases of cutaneous squamous cell carcinoma. Four matched controls were selected for each skin cancer case. Personal TL-01 exposure data were obtained from hospital records. Conditional logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs). An increased risk for basal cell carcinoma was observed with higher TL-01 exposure (OR per 20 sessions 1.36, 95% CI 1.08-1.72), whereas no association was found for cutaneous melanoma or cutaneous squamous cell carcinoma. In a categorical analysis, with category of 1-29 TL-01 sessions as the reference, the risk of basal cell carcinoma was markedly elevated among patients who received ≥60 sessions (OR 4.16, 95% CI 1.49-11.6). Occupational outdoor work was considered a potential confounder, but it had no effect. Further studies with larger cohorts and longer follow-up are needed to confirm these findings.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficacy of Different Treatment Options in Cutaneous Sarcoidosis: A Meta-analysis of RCTs. 不同治疗方案对皮肤结节病的疗效：随机对照试验的荟萃分析。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-08 DOI: 10.2340/actadv.v106.adv-2026-0490

Felicia C Thianich, Katharina M Wörgötter, Linda Bruckner, Martin R Grübler, Christian Posch

{"title":"The Efficacy of Different Treatment Options in Cutaneous Sarcoidosis: A Meta-analysis of RCTs.","authors":"Felicia C Thianich, Katharina M Wörgötter, Linda Bruckner, Martin R Grübler, Christian Posch","doi":"10.2340/actadv.v106.adv-2026-0490","DOIUrl":"10.2340/actadv.v106.adv-2026-0490","url":null,"abstract":"Cutaneous sarcoidosis is a granulomatous skin disease associated with significant quality-of-life impairment. Evidence from randomized controlled trials (RCTs) guiding systemic or targeted therapy remains limited. To assess the efficacy and safety of pharmacological therapies for cutaneous sarcoidosis in randomized placebo-controlled trials PubMed, the Cochrane Library, and ClinicalTrials.gov were searched through January 2025. Eligible studies were RCTs including adults with cutaneous sarcoidosis randomized to pharmacological therapy versus placebo. Outcomes were clinical response, quality of life, and serious adverse events (SAEs). Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated using random-effects models. Six RCTs including 156 participants were analyzedanalysed. Pharmacological therapies did not significantly improve clinical response compared with placebo (OR 2.24; 95% CI, 0.73-6.90; p=0.16). A non-significant trend toward improved quality of life was observed (OR 2.23; 95% CI, 0.87-5.73; p=0.09). No significant difference in SAEsserious adverse events was found between groups (OR 0.97; 95% CI, 0.48-1.96; p=0.93). Risk of bias ranged from moderate to high, with low statistical heterogeneity. Pharmacological add-on therapies showed no significant efficacy beyond corticosteroids but may improve quality of life. Larger, well-designed RCTs are needed.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Evidence on IL-17 and IL-(12)/23 Inhibitor Safety during Pregnancy in Psoriasis: A Call for Harmonized Data Collection. 银屑病妊娠期IL-17和IL-(12)/23抑制剂安全性的现有证据：对统一数据收集的呼吁

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-08 DOI: 10.2340/actadv.v106.adv-2026-0797

Liana Barenbrug, Julia Van Praag, Marleen M H J Van Gelder, Renate G Van der Molen, Elke M G J De Jong, Juul M P A Van den Reek

引用次数: 0

Panniculitis-like T-cell Lymphoma: Two Different Diseases and Same Imitator. 泛膜炎样t细胞淋巴瘤：两种不同的疾病和同一模仿者。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-08 DOI: 10.2340/actadv.v106.adv-2026-0439

Ferdi Öztürk, Yunus Toso, Fazıl Çağrı Hunutlu, Şaduman Balaban Adım, Hayriye Sarıcaoğlu

引用次数: 0