光疗是一种有效且温和的治疗青少年化脓性汗腺炎的方法:来自96例患者使用真实世界数据的结果。

IF 3.7 4区 医学 Q1 DERMATOLOGY
Alexandra Strobel, Michael Schultheis, Petra Staubach, Stephan Grabbe, Katharina Hennig, Jacek Szepietowski, Łukasz Matusiak, Esther Von Stebut, Uwe Kirschner, Hans Bayer, Georgios Nikolakis, Simone Garcovich
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引用次数: 0

摘要

化脓性汗腺炎(HS)是一种慢性皮肤病,以疼痛结节、脓肿和隧道的形成为特征,通常发生在三叉区。虽然HS主要影响成年人,但当它影响青少年患者时,会引起特别严重的痛苦。由于潜在的副作用、心理负担和长期后果,医生倾向于避免对儿童使用全身药物和手术。基于设备的LAight®疗法结合了强脉冲光和射频,并于2017年获得欧盟范围内的批准,用于治疗所有严重程度的成人HS。自2017年以来,德国和奥地利已有96名青少年患者接受了LAight的非适应症治疗。在36周内重复测量化脓性皮炎严重程度评分系统(IHS4)、NRS疼痛和皮肤病生活质量指数(DLQI)终点的混合模型显示,高负担开始治疗的患者显著受益于治疗,而低负担开始治疗的患者可以有效地稳定在低水平。HS及其管理会给儿童及其家庭带来相当大的压力和焦虑。温和和耐受性良好的治疗,如光疗,可以为患者带来更积极的体验,从而提高他们的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
LAight Therapy is an Effective and Gentle Treatment in Adolescents Suffering from Hidradenitis Suppurative: Results from 96 Patients Using Real-world Data.

Hidradenitis suppurativa (HS) is a chronic skin condition characterized by the formation of painful nodules, abscesses, and tunnels, typically in intertriginous areas. While HS primarily affects adults, it causes in particular severe distress when it affects adolescent patients. Physicians prefer to avoid the use of systemic medications and surgery in children due to the potential side effects, psychological burden, and long-term consequences. The device-based LAight® therapy combines intense pulsed light and radiofrequency and received EU-wide approval in 2017 for the treatment of adults with all severities of HS. Since 2017, 96 adolescent patients in Germany and Austria have been treated off-label with LAight. A mixed model for repeated measures over 36 weeks on the endpoints Hidradenitis Suppurativa Severity Score System (IHS4), NRS Pain, and Dermatology Life Quality Index (DLQI) showed that patients starting treatment with a high burden significantly benefited from treatment, while those starting with a low burden could be effectively stabilized at a low level. HS and its management can cause considerable stress and anxiety for children and their families. Gentle and well-tolerated treatments, such as LAight therapy, can contribute to a more positive experience for patients and consequently improve their quality of life.

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来源期刊
Acta dermato-venereologica
Acta dermato-venereologica 医学-皮肤病学
CiteScore
4.90
自引率
2.80%
发文量
210
审稿时长
6-12 weeks
期刊介绍: Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.
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