Acta Neuropathologica Communications最新文献

{"title":"CX3CL1/CX3CR1 axis dysregulation contributes to epileptogenic mechanisms in focal cortical dysplasia.","authors":"Lei Lei, Shengyu Yang, Yinchao Li, Jiahao Tian, Yubao Fang, Tiancai Huang, Shuda Chen, Liemin Zhou","doi":"10.1186/s40478-026-02274-2","DOIUrl":"10.1186/s40478-026-02274-2","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA-HLX-2-7/HLX axis-dependent metabolic reprogramming drives cancer progression in group 3 medulloblastoma.","authors":"Keisuke Katsushima, Yohei Sanada, David A Scott, Stacie Stapleton, George Jallo, Charles G Eberhart, Ranjan J Perera","doi":"10.1186/s40478-026-02266-2","DOIUrl":"https://doi.org/10.1186/s40478-026-02266-2","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiling of rare immune cell populations and integrative analysis identify immune ecotypes in newly diagnosed meningiomas.","authors":"Catharina Lotsch, Nicoletta Giuliani Canizales, Lena Jassowicz, Carmen Rommel, Mandy Barthel, Katrin Lamszus, Almuth F Kessler, Niels Grabe, Mario Loehr, Ralf Ketter, Christian Senft, Sybren L N Maas, Philipp Sievers, Manfred Westphal, Matthias Simon, Andreas von Deimling, Andreas Unterberg, Sandro M Krieg, Felix Sahm, Rolf Warta, Christel Herold-Mende","doi":"10.1186/s40478-026-02276-0","DOIUrl":"10.1186/s40478-026-02276-0","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of [¹⁸F]MK-6240 binding to tau protein in postmortem human brains of Down syndrome and Alzheimer's disease and assessment of off-target (non-tau) binding.","authors":"Fariha Karim, Agnes P Biju, Christopher Liang, Camryn J Santos, Maharishi Rajarethenam, Jogeshwar Mukherjee","doi":"10.1186/s40478-026-02267-1","DOIUrl":"10.1186/s40478-026-02267-1","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single cell protein profiling of focal cortical dysplasia in a patient requiring multiple resections.","authors":"Nada A Elsayed, Robert P Naftel, Bret C Mobley, Allyson L Alexander, Angus M Toland, Asa A Brockman, Jonathan M Irish, Rebecca A Ihrie, Kevin C Ess","doi":"10.1186/s40478-026-02273-3","DOIUrl":"10.1186/s40478-026-02273-3","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid arteries in cerebral small vessel disease and dementia.","authors":"Erika Kitajima, Ashley Suwanda, Dan Jobson, Louise Allan, Kian Paydar, Gan Han, Kazuo Washida, Masafumi Ihara, Pazhanichamy Kalailingam, Yoshiki Hase, Siu Kwan Sze, Tuomo Polvikoski, Raj N Kalaria","doi":"10.1186/s40478-026-02250-w","DOIUrl":"10.1186/s40478-026-02250-w","url":null,"abstract":"<p><p>Carotid artery disease (CAD) is a recognised cause of stroke. However, the relationships between CAD, cerebral small vessel disease (SVD) and dementia remain unclear. We hypothesised that CAD in older individuals contributes to cerebral SVD pathology by altering cerebral perfusion. We performed a clinicopathological study in patients from the Cognitive Function After Stroke (CogFAST) study and prospectively recruited patients with various dementia diagnoses and evidence of cerebral SVD. In addition to brain tissues, we collected postmortem samples of the internal carotid arteries (ICA) from these cohorts in the Newcastle Brain Tissue Resource. Standard neuropathological examination was performed for diagnosis and assignment of the cases per current diagnostic criteria for vascular and neurodegenerative dementias, which were assessed for the presence of vascular pathology including the degree of stenosis and sclerosis in vascular tissues. We evaluated a total of 159 ICA samples and brain tissues from all cases with evidence of SVD. Severity of ICA stenosis and sclerotic index correlated strongly with both clinical stroke and brain infarction (P < 0.001). More than 90% of the subjects had one subtype of ICA lesion in the order: intimal thickening > fibrocalcific > fibrous cap (thick) > fibrous cap (thin) > thrombus group with a strong inflammatory reaction in fibrocalcific atheromas. Regression analyses showed that ICA stenosis was positively correlated to both SVD pathology scores (P < 0.034) and the total number of vascular lesions (P < 0.001). ICA stenosis was also related to dementia caused by cerebrovascular disease (P < 0.001) and by mixed pathologies characterised by Alzheimer's disease and SVD (P = 0.025). Severity of stenosis was related to subcortical and white matter (WM) vascular lesions within the anterior circulation. ICA stenosis and sclerosis were moreover correlated with the total intracranial artery pathology scores (P < 0.001). In the CogFAST group analysis, we observed that MMSE and CAMCOG scores were lower in subjects with moderate to severe stenosis scores compared to the mild stenosis group (P < 0.05). In these CogFAST cases, by far the majority of lesions in the WM were small in size (< 5 mm, range 72-91%) but not in the cortex or basal ganglia and thalamus. Linear regression analysis further indicated that there were greater numbers of these small lesions in the WM with increasing severity of ICA stenosis (P < 0.05). Our observations suggest carotid atherosclerosis promotes cerebral SVD types of change within the intracerebral arteries. It is conceivable that extracranial ICA pathology may influence perfusion and integrity of subcortical structures including the deep WM.</p>","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of chemogenetic inhibition of serotonergic raphe-striatal neurons on L-DOPA-induced behaviors and neurochemistry in a rat model of Parkinson's disease.","authors":"Carla N Budrow, Luis-Daniel Bernal-Conde, Ivette M Sandoval, Ashley Galfano, Han Grezenko, Angela Velazquez, David J Marmion, Eden Flores-Barrera, Shruti Venkatesh, Michael Coyle, Kimberly Meyers, Kayla Nguyen, Hannah Holden, Kuei Yuan Tseng, Christopher R Bishop, Fredric P Manfredsson","doi":"10.1186/s40478-026-02221-1","DOIUrl":"10.1186/s40478-026-02221-1","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-grade peripheral inflammation accelerates retinal amyloid pathology and dysfunction in an Alzheimer's disease mouse model.","authors":"Lien Cools, Yasmin Dahdouh-Guebas, Iene Kemps, Steven Bergmans, Jonas Castelein, Roosmarijn E Vandenbroucke, Lien Van Hoecke, Lies De Groef","doi":"10.1186/s40478-026-02249-3","DOIUrl":"https://doi.org/10.1186/s40478-026-02249-3","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer's disease patients.","authors":"Amber Penning, Sarah Snoeck, Olmo Ruiz Ormaechea, Dilara Ayyildiz, Oliver Polzer, Martin Buitrago-Arango, Raffaella Capobianco, Fred de Winter, Sriram Balusu, Joost Verhaagen, Carlos P Fitzsimons, Constantin d'Ydewalle, Paul J Lucassen, Dieder Moechars, Lujia Zhou, Evgenia Salta","doi":"10.1186/s40478-026-02228-8","DOIUrl":"10.1186/s40478-026-02228-8","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation of expanded CGG repeats in LRP12 associated oculopharyngodistal myopathy.","authors":"Chengcheng Li, Jil A Daw, Sara K Pittman, Connor J Maltby, Hidetoshi Sakurai, Peter K Todd, Conrad C Weihl","doi":"10.1186/s40478-026-02272-4","DOIUrl":"10.1186/s40478-026-02272-4","url":null,"abstract":"<p><p>Oculopharyngodistal myopathy (OPDM) is characterized by ptosis, ophthalmoparesis, dysphagia, and distal weakness. Myopathological features include rimmed vacuoles and intranuclear inclusions. OPDM is associated with a pathogenic CGG repeat expansions in the 5'UTR of LRP12, NOTCH2NLC, GIPC1, RILPL1 and ABCD3. Translation of the repeat in the glycine reading frame has been demonstrated for expansions in FMR1, NOTCH2NLC and GIPC1. To assess for a similar phenomenon with LRP12, we expressed normal or expanded CGG repeats in the context of the 5'UTR of LRP12, upstream of a green fluorescent protein (GFP) in the three repeat reading frames. Repeat dependent translation occurs exclusively in the glycine reading frame. However, unlike other CGG repeat disorders, there is no proximal AUG, or near-AUG cognate initiated polyglycine (polyG) open reading frame in LRP12. Instead, our results support a model in which repeat-associated non-AUG (RAN) mediated polyG translation may initiate within the arginine reading frame and then undergo a + 1 translational frameshift into the glycine reading frame. LRP12-associated polyG products form intranuclear SQSTM1/ubiquitin positive inclusions that are cytotoxic and alter the nuclear lamina architecture in transfected cells. While FMR1-associated polyG inclusions are cytosolic, LRP12-associated polyG inclusions are nuclear in transfected skeletal muscle. LRP12 expansion carrier iPSC derived myotubes exhibit SQSTM1 positive intra- and peri- nuclear inclusions when compared with control patient myotubes, suggesting that polyG expression can occur in patients. Together, these findings provide evidence of RAN translation and polyG-toxicity in LRP12-associated OPDM pathology.</p>","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147368901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}