Acta Neuropathologica Communications最新文献

{"title":"Tumor-suppressive role of miR-216b impacts cell cycle regulation in high-grade glioma.","authors":"Alexandra Lang, Sabine Buerger, Leah Mager, Lea Erjavc, Barbara Kiesel, Sibylle Madlener, Carola Nadine Jaunecker, Linda Pacher, Finn Christopher Robert, Leonie Krausgruber, Andrezza Nascimento, Sarah Machreich, Gerda Ricken, Lisa Gabler-Pamer, Anna Laemmerer, Sabine Spiegl-Kreinecker, Matthias Hackl, Marianne Pultar, Johannes Reisecker, Katharina Bruckner, Barbara Neudert, Leonhard Muellauer, Dominik Kirchhofer, Mario Mischkulnig, Anna Sophie Berghoff, Adelheid Woehrer, Daniel Senfter, Karl Roessler, Thomas Roetzer-Pejrimovsky, Walter Berger, Johannes Andreas Hainfellner, Romana Hoeftberger, Georg Widhalm, Friedrich Erhart, Daniela Lötsch-Gojo","doi":"10.1186/s40478-025-02215-5","DOIUrl":"10.1186/s40478-025-02215-5","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":"14 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI guided discovery of a murine model of asymptomatic Alzheimer's disease.","authors":"Suborno Jati, Sahar Taheri, Satadeepa Kal, Subhash C Sinha, Brian P Head, Sushil K Mahata, Debashis Sahoo","doi":"10.1186/s40478-026-02286-y","DOIUrl":"10.1186/s40478-026-02286-y","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular signatures of melanocortin pathway genes across the locus coeruleus.","authors":"Alisha Basak, Fahrünisa Meryem Betül Erol, Maria Caterina De Rosa, Zhangji Dong, Victor Ogbolu, Hannah J Glover, Rick Rausch, Gunnar Hargus, Jordi Creus-Muncunill, Heather Buchanan, Yu Bai, Qi Su, Betty Chang, Christina Adler, Delaney Flaherty, Benjamin Ciener, Harrison Xiao, Hasini Reddy, Pascaline Aime-Wilson, Christiane Reitz, Mark W Sleeman, Judith Y Altarejos, Rudolph L Leibel, Liang Oscar Qiang, Andrew F Teich, Claudia A Doege","doi":"10.1186/s40478-026-02287-x","DOIUrl":"10.1186/s40478-026-02287-x","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MALDI mass spectrometry imaging (MSI) reveals molecular and structural heterogeneity of amyloid-β in sporadic Alzheimer's disease and Down syndrome.","authors":"Karolina Minta, Linda Söderberg, Eleni Gkanatsiou, Malin Johannesson, Christer Möller, My Björklund, Gunilla Osswald, Lars Lannfelt, Susanne Fabre, Wojciech Michno","doi":"10.1186/s40478-026-02280-4","DOIUrl":"10.1186/s40478-026-02280-4","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meningeal-tumor interactions define distinct modes of leptomeningeal colonization in Group 3 medulloblastoma.","authors":"Leyre Jimenez Garcia, Lindsay N Ryan, Amy C Gross, Annika M Albrecht, Jefferson H Walters, Jeffrey R Leonard, Ryan D Roberts, James B Reinecke","doi":"10.1186/s40478-026-02253-7","DOIUrl":"https://doi.org/10.1186/s40478-026-02253-7","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy.","authors":"Elvira Valera, Brian Spencer, Jerel A Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats, Eliezer Masliah","doi":"10.1186/s40478-026-02278-y","DOIUrl":"10.1186/s40478-026-02278-y","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":"14 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13023175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ActIIR inhibition improves motor outcome and preserves muscle fibers after experimental autoimmune neuritis.","authors":"Ivo Gerlach, Manuel Koch, Graziana Gatto, Jan-Wilm Lackmann, Helmar C Lehmann, Michael Schroeter, Felix Kohle","doi":"10.1186/s40478-026-02277-z","DOIUrl":"10.1186/s40478-026-02277-z","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy.","authors":"Brian Spencer, Elvira Valera, Edward Rockenstein, Cassia Overk, Michael Mante, Anthony Adame, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Dora Games, Robert A Rissman, Eliezer Masliah","doi":"10.1186/s40478-026-02279-x","DOIUrl":"10.1186/s40478-026-02279-x","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":"14 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13020304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presenilin-dependent regulation of neuronal tau pathology via the autophagy and proteasome pathways.","authors":"Anna Del Ser-Badia, Carlos M Soto-Faguás, Rebeca Vecino, Carles Vendrell, Laura Molina-Porcel, Raquel Sánchez-Valle, José Rodríguez-Alvarez, Carlos Vicario, Carlos A Saura","doi":"10.1186/s40478-026-02270-6","DOIUrl":"10.1186/s40478-026-02270-6","url":null,"abstract":"<p><p>Mutations in the presenilin (PS/PSEN) genes cause early-onset familial Alzheimer's disease (AD) by enhancing cerebral accumulation of amyloid-β (Aβ) peptides and microtubule-associated protein tau (MAPT). How PS mutations affect Aβ generation is well characterized, but the precise cellular mechanisms by which PS dysfunction drives neuronal tau pathology are not fully understood. Here, we investigated the mechanisms linking PS/γ-secretase-dependent tau pathology and autophagy/proteasome by employing pathological, imaging and molecular approaches in human brains, fibroblasts and induced pluripotent stem cells (iPSC)-derived neurons from PSEN1-linked familial AD carriers, and in a novel neuronal PS-deficient tauopathy transgenic mouse. We found enhanced levels and colocalization of pathological phosphorylated tau (pTau) and ubiquitin factor p62 in the hippocampus of dementia patients with familial AD-linked PSEN1 mutations, corticobasal degeneration and Pick's disease, suggesting disrupted proteasomal degradation in tauopathies. Human primary fibroblasts from PSEN1 G206D and/or L286P carriers showed elevated LC3-I and autolysosomes indicating autophagy flux alterations. Human iPSC-derived neurons harboring the familial-AD linked PSEN1 G206D mutation showed increased aggregated tau and reduced secreted tau, whereas pharmacological proteasome inhibition reduced significantly total and pTau (Ser396/404) while increasing its release. Consistently, proteasomal inhibition decreased intracellular tau and pTau and promoted tau release in human tau-expressing neurons through a mechanism that partially depends on PS. In the hippocampus of neuronal PS-deficient mice, Akt activation and GSK3β inhibition were associated with elevated levels of phosphorylated and aggregated tau and the ubiquitin-binding protein p62. In conclusion, PS function is required for autophagy/proteasome-mediated tau elimination in neurons, whereas that FAD-linked PSEN1 mutations cause progressive tau pathology by disrupting the proteasome and autophagy/lysosomal pathways.</p>","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CX3CL1/CX3CR1 axis dysregulation contributes to epileptogenic mechanisms in focal cortical dysplasia.","authors":"Lei Lei, Shengyu Yang, Yinchao Li, Jiahao Tian, Yubao Fang, Tiancai Huang, Shuda Chen, Liemin Zhou","doi":"10.1186/s40478-026-02274-2","DOIUrl":"10.1186/s40478-026-02274-2","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}