Feline F W Benavides, Annabel L V Kempff, Hilde Smeenk, Bas Lendemeijer, Marla Lavrijsen, Johan A Slotman, Steven A Kushner, Femke M S de Vrij, Lisa Bauer, Debby van Riel
{"title":"Influenza A virus infection impairs neuronal activity in human iPSC-derived NGN2 neural co-cultures.","authors":"Feline F W Benavides, Annabel L V Kempff, Hilde Smeenk, Bas Lendemeijer, Marla Lavrijsen, Johan A Slotman, Steven A Kushner, Femke M S de Vrij, Lisa Bauer, Debby van Riel","doi":"10.1186/s40478-026-02292-0","DOIUrl":"https://doi.org/10.1186/s40478-026-02292-0","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jolanta Jagodzinska, Marie Péquignot, Emmanuelle Sarzi, Mélanie Quiles, Chantal Cazevieille, Agnès Müller, Sulev Koks, Cécile Delettre
{"title":"WFS1 gene delivery rescues visual function in a mouse model of Wolfram syndrome.","authors":"Jolanta Jagodzinska, Marie Péquignot, Emmanuelle Sarzi, Mélanie Quiles, Chantal Cazevieille, Agnès Müller, Sulev Koks, Cécile Delettre","doi":"10.1186/s40478-026-02295-x","DOIUrl":"https://doi.org/10.1186/s40478-026-02295-x","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Al Rawi, Pamela Tyers, Roger A Barker, Heike Laman
{"title":"rAAV Fbxo7 gene therapy rescues the progressive nigrostriatal pathology in a mouse model of juvenile parkinsonism.","authors":"Sara Al Rawi, Pamela Tyers, Roger A Barker, Heike Laman","doi":"10.1186/s40478-026-02294-y","DOIUrl":"https://doi.org/10.1186/s40478-026-02294-y","url":null,"abstract":"<p><p>Mutations in the PARK15/FBXO7 gene cause an early-onset parkinsonian syndrome. A mouse with conditional knockout of Fbxo7 in dopaminergic neurons models key features of this pathology, exhibiting a progressive loss of striatal tyrosine hydroxylase (TH)-positive terminals that precedes cell death. This gradual decline in a mammalian model provided an opportunity to test the capacity of Fbxo7 to act as a therapeutic agent and define a treatment window for gene replacement. Using a recombinant adeno-associated virus (rAAV), we delivered Fbxo7 to test its capacity to prevent (delivery prior to deficit onset) and rescue (delivery after nigrostriatal phenotypes were evident) dopaminergic markers. Remarkably, Fbxo7 re-expression rescued DAT and TH-immunoreactivity in the striatum and nucleus accumbens before and after the onset of the loss of TH + staining. These data establish that Fbxo7-dependent neurodegeneration is not an irreversible process, highlighting its regulated pathways as promising potential targets for developing therapies that will not only slow disease progression, but also ameliorate dopaminergic terminal deficits and potentially restore function.</p>","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yiwen Yuan, Suzhen Liang, Ao Guan, Jian Sun, Weiwei Shen, Qiang Dong, Min Guo, Mei Cui
{"title":"Angiotensin II impairs the remyelination mediated by brain endothelial cell-derived exosomes.","authors":"Yiwen Yuan, Suzhen Liang, Ao Guan, Jian Sun, Weiwei Shen, Qiang Dong, Min Guo, Mei Cui","doi":"10.1186/s40478-026-02288-w","DOIUrl":"https://doi.org/10.1186/s40478-026-02288-w","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paula Trigo-Alonso, Enrique Luengo, Cristina Fernández-Mendivíl, Lucía Viqueira, Nuria García-Magro, Eric Del Sastre, Juan Antonio Bernal, Pilar Negredo, Manuela G López
{"title":"Timing of microglial ablation determines protection from tau-mediated neurodegeneration and cognitive decline.","authors":"Paula Trigo-Alonso, Enrique Luengo, Cristina Fernández-Mendivíl, Lucía Viqueira, Nuria García-Magro, Eric Del Sastre, Juan Antonio Bernal, Pilar Negredo, Manuela G López","doi":"10.1186/s40478-026-02291-1","DOIUrl":"https://doi.org/10.1186/s40478-026-02291-1","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Avilés-Granados, Adriana Gea-González, Jorge Sáez-Leyva, Sylvia E Perez, Elliott J Mufson, Ann-Charlotte Granholm, María Carmona-Iragui, Henrik Zetterberg, Kaj Blennow, Juan Fortea, María-Salud García-Ayllón, Javier Sáez-Valero
{"title":"Cerebrospinal fluid and frontal cortex TMPRSS2 and ACE2 protein levels differ in Down syndrome and Alzheimer's disease.","authors":"Carlos Avilés-Granados, Adriana Gea-González, Jorge Sáez-Leyva, Sylvia E Perez, Elliott J Mufson, Ann-Charlotte Granholm, María Carmona-Iragui, Henrik Zetterberg, Kaj Blennow, Juan Fortea, María-Salud García-Ayllón, Javier Sáez-Valero","doi":"10.1186/s40478-026-02289-9","DOIUrl":"https://doi.org/10.1186/s40478-026-02289-9","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samantha M Calderazzo, Morgane L M D Butler, Kerry Breen, Hersh Kanner, Yorghos Tripodis, Thor D Stein, David M Holtzman, Jonathan D Cherry, Bertrand R Huber, Ann C McKee
{"title":"Meningeal and infiltrating T-cells are associated with repetitive head trauma and tau-mediated neurodegeneration in chronic traumatic encephalopathy.","authors":"Samantha M Calderazzo, Morgane L M D Butler, Kerry Breen, Hersh Kanner, Yorghos Tripodis, Thor D Stein, David M Holtzman, Jonathan D Cherry, Bertrand R Huber, Ann C McKee","doi":"10.1186/s40478-026-02285-z","DOIUrl":"10.1186/s40478-026-02285-z","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristian A Lasagna-Reeves, Urmi Sengupta, Diana Castillo-Carranza, Julia E Gerson, Marcos Guerrero-Munoz, Juan C Troncoso, George R Jackson, Rakez Kayed
{"title":"Correction: The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes.","authors":"Cristian A Lasagna-Reeves, Urmi Sengupta, Diana Castillo-Carranza, Julia E Gerson, Marcos Guerrero-Munoz, Juan C Troncoso, George R Jackson, Rakez Kayed","doi":"10.1186/s40478-026-02230-0","DOIUrl":"10.1186/s40478-026-02230-0","url":null,"abstract":"","PeriodicalId":6914,"journal":{"name":"Acta Neuropathologica Communications","volume":"14 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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