中国疾病预防控制中心周报Pub Date : 2025-05-09DOI: 10.46234/ccdcw2025.110
Yili Zhang, Yao Fu, Haiyuan Zhu, Zhaohuan Luo, Lichang Zhong, Jingru Lin, Xia Wu, Xiangyang Cao, Wangqiu Deng, Weiwei Liu, Zhiqian Yang
{"title":"A Retrospective Analysis of 112 Mushroom Poisoning Patients - Guangzhou City, Guangdong Province, China, 2016-2023.","authors":"Yili Zhang, Yao Fu, Haiyuan Zhu, Zhaohuan Luo, Lichang Zhong, Jingru Lin, Xia Wu, Xiangyang Cao, Wangqiu Deng, Weiwei Liu, Zhiqian Yang","doi":"10.46234/ccdcw2025.110","DOIUrl":"https://doi.org/10.46234/ccdcw2025.110","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Mushroom poisoning is a significant food safety issue with an increasing incidence, with Southwest China being the most severely affected region.</p><p><strong>What is added by this report?: </strong>This study analyzed 112 cases of mushroom poisoning admitted to a specialized toxicology hospital in Guangzhou City, Guangdong Province, China. A total of 9 mushroom species were identified across 4 poisoning types. Among 51 poisoning incidents, gastroenteritis was the most common presentation. However, acute liver failure caused by lethal <i>Amanita</i> spp. accounted for all mortality in this cohort. Shorter latency periods were associated with less severe poisoning outcomes. Our study applied the HOPE6 and TALK Chinese clinical assessment protocols to evaluate poisoning severity and prioritize multidisciplinary diagnostic processes. Initial treatment decisions based on poisoning type classification, consumption history, and latency period were key factors in preventing further morbidity in clinical management of mushroom poisoning.</p><p><strong>What are the implications for public health practice?: </strong>Clinical management of mushroom poisoning requires improved diagnostic processes, particularly in mushroom species identification for informed clinical decision-making. Excessive medical interventions and their associated risks should be avoided during clinical management.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 19","pages":"665-671"},"PeriodicalIF":4.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国疾病预防控制中心周报Pub Date : 2025-05-09DOI: 10.46234/ccdcw2025.111
Xinyue Han, Xiaotao Zhou, Huifang Yang, Qiao Deng, Wanting Feng, Yilin Teng, Yanan Wang, Jialu Yang, Yan Liu, Min Xia, Ben Zhang, Shouling Wu, Tao Zhang, Jiayuan Li
{"title":"The iCARE-DM Model for Five-Year T2DM Risk Prediction in the Elderly Population from Chinese Routine Public Health Services - China, 2017-2024.","authors":"Xinyue Han, Xiaotao Zhou, Huifang Yang, Qiao Deng, Wanting Feng, Yilin Teng, Yanan Wang, Jialu Yang, Yan Liu, Min Xia, Ben Zhang, Shouling Wu, Tao Zhang, Jiayuan Li","doi":"10.46234/ccdcw2025.111","DOIUrl":"https://doi.org/10.46234/ccdcw2025.111","url":null,"abstract":"<p><strong>Introduction: </strong>Risk assessment for high-risk populations is critical for preventing Type 2 Diabetes Mellitus (T2DM). Although China's public health services have continuously contributed to early grass-roots diagnosis of diabetes for years, universally applicable tools for identifying latent high-risk elderly populations urgently need to account for heterogeneity, robustness, and generalizability. Therefore, this study developed and validated the integrated Chinese Adapted Risk Evaluation for Diabetes Mellitus (iCARE-DM) model for elderly Chinese individuals.</p><p><strong>Methods: </strong>The iCARE-DM model was developed based on pooled effect estimates from a meta-analysis of cohort studies that identified T2DM risk factors in East Asian populations and validated in three multicenter Chinese populations. Predictive performance was evaluated using area under the curve (AUC), sensitivity, specificity, accuracy, log-rank tests, and compared with the guideline-recommended model (i.e., New Chinese Diabetes Risk Score, NCDRS) as well as four machine learning (ML) models.</p><p><strong>Results: </strong>The iCARE-DM model achieved AUC values of 0.741, 0.783, and 0.766, outperforming the NCDRS model by at least 12%. Although the best-performing ML model achieved AUC values comparable to the iCARE-DM model, its performance varied significantly across populations (with a range as high as 9%). Subgroup analyses of the iCARE-DM model confirmed consistent performance across age, gender and rural-urban groups.</p><p><strong>Conclusion: </strong>The iCARE-DM model demonstrated higher accuracy than the NCDRS model and exhibited superior robustness and generalizability compared to the ML models. The iCARE-DM model provides a robust, culturally adapted tool for T2DM risk assessment in elderly Chinese individuals.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 19","pages":"675-682"},"PeriodicalIF":4.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国疾病预防控制中心周报Pub Date : 2025-05-09DOI: 10.46234/ccdcw2025.107
Chenglong Wang, Mei Wang, Qiang Feng, Chaoqun Fan, Huiqi Song, Mingzhe Li, Chenhui Xiao, Jingjing Wang
{"title":"National Survey on the Prevalence and Geospatial Variation of Body Fat Percentage Among Preschoolers - 31 PLADs, China, 2020.","authors":"Chenglong Wang, Mei Wang, Qiang Feng, Chaoqun Fan, Huiqi Song, Mingzhe Li, Chenhui Xiao, Jingjing Wang","doi":"10.46234/ccdcw2025.107","DOIUrl":"https://doi.org/10.46234/ccdcw2025.107","url":null,"abstract":"<p><strong>What is already known on this topic?: </strong>Body fat percentage (BF%) is a fundamental indicator of body composition that provides critical insights into fat distribution patterns. However, comprehensive national data on BF% and its geographical distribution patterns among the Chinese preschoolers aged 3 to 6 years remain limited.</p><p><strong>What is added by this report?: </strong>This study presents novel national data analyzing the prevalence and geographical patterns of BF% among Chinese preschool children, along with key determinants. The findings reveal a mean BF% of 20.7% among the Chinese preschoolers, with distinct geographical clustering patterns. The analysis identifies significant hotspots and cold spots aligned with major geographical boundaries, while demonstrating that sex, parental characteristics, education level, and environmental factors significantly influence preschool children's BF%.</p><p><strong>What are the implications for public health practice?: </strong>These findings provide critical baseline data on preschool children's BF% levels and reveal substantial geographical disparities. The observed regional variations suggest the need for targeted public health interventions and region-specific strategies for childhood obesity prevention, emphasizing the importance of implementing evidence-based health education and intervention programs tailored to local contexts.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 19","pages":"650-657"},"PeriodicalIF":4.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国疾病预防控制中心周报Pub Date : 2025-05-09DOI: 10.46234/ccdcw2025.112
{"title":"Reported Cases and Deaths of National Notifiable Infectious Diseases - China, March 2025.","authors":"","doi":"10.46234/ccdcw2025.112","DOIUrl":"https://doi.org/10.46234/ccdcw2025.112","url":null,"abstract":"","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 19","pages":"683-684"},"PeriodicalIF":4.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Food Education for Infants and Young Children Aged 0-3 Years in China.","authors":"Qiong Wu, Shimiao Gong, Xuening Li, Chen Zhao, Lin Li, Yiwen Huang, Yanfeng Zhang","doi":"10.46234/ccdcw2025.109","DOIUrl":"https://doi.org/10.46234/ccdcw2025.109","url":null,"abstract":"<p><p>The concept of Food Education (, Shiokuiku), first proposed by Japanese researcher Sagen Ishizuka in 1861, has evolved globally over the years, encompassing food knowledge, healthy dietary behaviors, food preparation, and food safety. Professor Li Lite introduced this concept to China in 2006. This article specifically addresses food education for infants and young children. In 2022, the National Health Commission of China issued Guidelines on Feeding and Nutrition of Infants and Young Children in Nursery Institutions. These guidelines delineate the scope of Food Education for infants and young children as encompassing food cognition, eating behaviors, and dietary culture. Early childhood represents a critical period for establishing food preferences and dietary habits. Food education plays a pivotal role in familiarizing infants and young children with new foods and promoting healthy eating patterns. Without structured food education, young children are more susceptible to developing food neophobia and other unhealthy eating habits. We propose strategies to enhance Food Education for infants and young children in China by establishing a comprehensive food education system that leverages multiple channels including families, nursery institutions, early childhood education institutions, and healthcare facilities. Additionally, we emphasize the need for targeted research on food education specifically designed for this age group.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 19","pages":"672-674"},"PeriodicalIF":4.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国疾病预防控制中心周报Pub Date : 2025-05-09DOI: 10.46234/ccdcw2025.108
Lin Tang, Lun Li, Lifang Huang, Jing An, Yang Zhou, Yi Liu, Xiaoxue Liu, Qianqian Liu, Xiaoqi Wang, Siyu Liu, Hong Yang, Ning Wen, Zundong Yin, Fuzhen Wang
{"title":"A Multi-Regional Epidemiological Evaluation on Post-vaccination Serological Testing in Prevention of Vertical Transmission of Hepatitis B Virus - 10 Counties, 5 Provinces, China, 2019-2024.","authors":"Lin Tang, Lun Li, Lifang Huang, Jing An, Yang Zhou, Yi Liu, Xiaoxue Liu, Qianqian Liu, Xiaoqi Wang, Siyu Liu, Hong Yang, Ning Wen, Zundong Yin, Fuzhen Wang","doi":"10.46234/ccdcw2025.108","DOIUrl":"https://doi.org/10.46234/ccdcw2025.108","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Post-vaccination serologic testing (PVST) of infants born to hepatitis B virus (HBV) infected mothers is important for evaluating effectiveness of strategies for preventing mother-to-child transmission (MTCT) of HBV.</p><p><strong>What is added by this report?: </strong>PVST was conducted in 43.7% of 7,425 infants born to HBV-infected mothers and showed that 0.8% of infants had breakthrough infections, indicating a very low level of prevention failure; anti-HBs positivity was 97.0% showing vaccine-induced protection; and 2.2% of HBV-exposed infants needed revaccination. Prevention failure was 12.7-fold higher among infants born to HBeAg-positive mothers.</p><p><strong>What are the implications for public health practice?: </strong>MTCT prevention strategy is highly effective. PVST evaluates MTCT prevention strategy and identifies infants needing revaccination; its use should be increased. Findings support WHO's HBV elimination strategy.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 19","pages":"658-664"},"PeriodicalIF":4.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mushroom Poisoning Outbreaks - China, 2024.","authors":"Haijiao Li, Yizhe Zhang, Hongshun Zhang, Jing Zhou, Zhongfeng Li, Yu Yin, Qian He, Shaofeng Jiang, Yutao Zhang, Yuan Yuan, Nan Lang, Bowen Cheng, Jiaju Zhong, Mingxuan Yuan, Zhiyuan Liu, Chengye Sun","doi":"10.46234/ccdcw2025.106","DOIUrl":"https://doi.org/10.46234/ccdcw2025.106","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Mushroom poisoning is a serious food safety problem in China. Since 2019, China CDC has conducted a series of investigations into mushroom poisoning outbreaks. These investigations have revealed the spatial and temporal distribution patterns of mushroom poisoning and the diversity of poisonous mushroom species in China.</p><p><strong>What is added by this report?: </strong>In 2024, China CDC investigated 599 mushroom poisoning incidents across 28 provincial-level administrative divisions (PLADs). These incidents affected 1,486 patients and resulted in 13 deaths, with a case fatality rate of 0.87%. Investigators identified 110 poisonous mushroom species causing 7 distinct clinical disease types, including 8 species newly documented as poisonous mushrooms in China.</p><p><strong>What are the implications for public health practice?: </strong>Timely species identification, toxin detection, and clinical type confirmation are crucial for effective mushroom poisoning control and proper patient treatment.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 19","pages":"645-649"},"PeriodicalIF":4.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国疾病预防控制中心周报Pub Date : 2025-05-02DOI: 10.46234/ccdcw2025.101
Jingjing Jiang, Zijian Liu, Hongzheng Lu, Tao Zhang, Xiaofeng Lyu, Xian Xu, Shuqi Wang, Qinshu Chu, Weidong Li, Duoquan Wang
{"title":"Application of Remote Sensing Methods in Predicting the Dynamics of <i>Anopheles sinensis</i> - Anhui Province, China, 2019-2023.","authors":"Jingjing Jiang, Zijian Liu, Hongzheng Lu, Tao Zhang, Xiaofeng Lyu, Xian Xu, Shuqi Wang, Qinshu Chu, Weidong Li, Duoquan Wang","doi":"10.46234/ccdcw2025.101","DOIUrl":"https://doi.org/10.46234/ccdcw2025.101","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Remote sensing information provides indirect insights into infectious disease dynamics. Public health practice has significantly benefited from the increasing availability and accessibility of remote sensing data.</p><p><strong>What is added by this report?: </strong>This study explores the relationship between meteorological and environmental factors and malaria vector abundance using remote sensing technology, establishing predictive models for <i>Anopheles sinensis</i> population dynamics.</p><p><strong>What are the implications for public health practice?: </strong>Identifying reliable predictors of malaria vector abundance enables policymakers to allocate resources more efficiently to regions at high risk of malaria transmission. In areas where an abnormal increase in malaria vector populations is predicted, proactive measures can be implemented, including environmental management, enhancement of local malaria diagnostic capabilities, and strengthening of targeted public health education campaigns.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 18","pages":"609-613"},"PeriodicalIF":4.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国疾病预防控制中心周报Pub Date : 2025-05-02DOI: 10.46234/ccdcw2025.105
Shuxun Wang, Wei Ding, Shenning Lu, Linjia Li, Furong Qian, Canhui Chen, Longsheng Liu, Yongtong Cai, Xian Liu, Sandra Perez, Roger Frutos, Hangping Yao, Yuhang Zhou, Chunsheng Ye, Danna Wu, Shizhu Li, Xiaoxiao Jiang Kwete, Yuan Sui, Duoquan Wang
{"title":"China's Malaria R&D Innovations: A Scoping Review from 2013-2023.","authors":"Shuxun Wang, Wei Ding, Shenning Lu, Linjia Li, Furong Qian, Canhui Chen, Longsheng Liu, Yongtong Cai, Xian Liu, Sandra Perez, Roger Frutos, Hangping Yao, Yuhang Zhou, Chunsheng Ye, Danna Wu, Shizhu Li, Xiaoxiao Jiang Kwete, Yuan Sui, Duoquan Wang","doi":"10.46234/ccdcw2025.105","DOIUrl":"https://doi.org/10.46234/ccdcw2025.105","url":null,"abstract":"<p><p>Malaria remains a major global health challenge. Understanding the research progress of the potential innovative tools is important for malaria elimination. This scoping review aims to explore China's research and development (R&D) advances from 2013-2023 in addressing the current challenges and contributing to global malaria elimination. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), this review searched the English and Simplified Chinese data sources from five databases. A total of 11,112 English articles and 2,944 Chinese articles were retrieved. After screening, 44 English and 13 Chinese articles were included. Key advancements were identified in three domains: vector control, pathogen screening and diagnosis, and prevention and treatment. Innovations in vector control include studies such as the use of <i>Serratia</i> strains and symbiont-mediated RNAi approaches to block malaria transmission. Advances in pathogen screening and diagnosis feature biosensor development, AI monitoring technologies, and novel amplification gene and nucleic acid detection technologies. In prevention and treatment, artemisinin-based combination therapies (ACTs) remain a cornerstone, with additional progress in industrial pharmaceuticals and technologies already in field and semi-field-testing stages. This review underscores the importance of leveraging China's R&D capacity to meet global challenges. To maximize impact, we call for global attention to strengthening international collaboration with China in malaria R&D to accelerate the commercialization, regulatory approval, and large-scale deployment of innovations.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 18","pages":"635-643"},"PeriodicalIF":4.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国疾病预防控制中心周报Pub Date : 2025-05-02DOI: 10.46234/ccdcw2025.103
Junyi Shi, Minmin Wang, Adelard Kakunze, Hawa Catherine Margai, Huang Hu, Yikai Feng, Daniel Okaka, Muhammad Abdullahi Idris, Yinzi Jin, Minghui Ren
{"title":"Global Assistance and the Cascade of Malaria Prevention and Control - Sub-Saharan Africa, 2011-2022.","authors":"Junyi Shi, Minmin Wang, Adelard Kakunze, Hawa Catherine Margai, Huang Hu, Yikai Feng, Daniel Okaka, Muhammad Abdullahi Idris, Yinzi Jin, Minghui Ren","doi":"10.46234/ccdcw2025.103","DOIUrl":"https://doi.org/10.46234/ccdcw2025.103","url":null,"abstract":"<p><strong>Introduction: </strong>Approximately 70% of funding for malaria prevention and control (P&C) in Sub-Saharan Africa comes from global assistance, yet progress has stagnated over the past decade.</p><p><strong>Methods: </strong>We constructed a cascade of malaria P&C services and analyzed its coverage and quality across 26 African countries from 2011-2022. Panel analysis was conducted to examine the effectiveness of four major donors [the United States of America (USA), the United Kingdom (UK), the Global Fund to Fight AIDS, Tuberculosis and Malaria (GF), and United Nations International Children's Emergency Fund (UNICEF)], which account for 90% of global funding, in implementing the cascade.</p><p><strong>Results: </strong>Recommended practice coverage doubled during 2011-2016 but decreased by 10% by 2022. Unrecommended practices followed the same pattern. Total funding from 2011-2020 reached 7.15 billion USA Dollar (USD), with the USA and GF steadily contributing 94.65%, while the UK and UNICEF demonstrated notable funding reductions. Overall, the funding showed limited correlation with the cascade coverage and quality, promoting directly only the upstream measures.</p><p><strong>Conclusion: </strong>Our findings highlight four key challenges: retrogression of cascade coverage since the late 2010s, persistent gaps between recommended and unrecommended practices, funding constraints, and limited direct effects of donor funding. Strengthening health system capacity at the farthest end of the cascade may provide a solution to this dilemma.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 18","pages":"620-627"},"PeriodicalIF":4.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}