中国疾病预防控制中心周报最新文献

{"title":"Preparing for the Next Influenza Pandemic: Vaccine Progress, Challenges, and Prospects.","authors":"Na Zhang, Dayan Wang","doi":"10.46234/ccdcw2025.231","DOIUrl":"10.46234/ccdcw2025.231","url":null,"abstract":"<p><p>Influenza pandemics arise when novel influenza virus subtypes emerge in populations with little or no pre-existing immunity. The recent expansion of H5N1 virus circulation in mammals - including documented spread in cattle and sporadic human infections - coupled with the emergence of mutations associated with enhanced pandemic potential, underscores the persistent threat of novel influenza strains. Pandemic preparedness critically depends on developing effective vaccines capable of providing broad protection across diverse viral strains. While vaccination remains the most effective strategy for preventing influenza and its complications, pandemic vaccine development faces substantial challenges. These include the rapid mutation rates characteristic of influenza viruses, driven by error-prone RNA replication, broad host range, environmental selection pressures, and frequent genetic recombination. Such factors complicate predictions of which strain will trigger the next pandemic and hinder efforts to create universal vaccines. Recent advances in vaccine production platforms, bioinformatics, and artificial intelligence have accelerated pandemic vaccine development capabilities. Continued research is essential to enhance vaccine technology, expedite production timelines, and broaden vaccine efficacy against the full spectrum of influenza virus strains.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 44","pages":"1377-1382"},"PeriodicalIF":2.9,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12620569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145552093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Salmonella</i> <i>enterica</i> ST8333 Was Isolated as Early as July 2015.","authors":"Yanan Wang, Yue Liu, Baoli Zhu, George F Gao, Xuebin Xu","doi":"10.46234/ccdcw2025.226","DOIUrl":"10.46234/ccdcw2025.226","url":null,"abstract":"","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 43","pages":"1347-1349"},"PeriodicalIF":2.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Characteristics and Spatiotemporal Clustering Analysis of Human Rabies - China, 2005-2024.","authors":"Xi Chen, Jinhui Zhang, Shouming Lyu, Canjun Zheng, Wenwu Yin, Di Mu, Yanping Zhang","doi":"10.46234/ccdcw2025.227","DOIUrl":"10.46234/ccdcw2025.227","url":null,"abstract":"<p><strong>Introduction: </strong>Rabies remains a significant zoonotic disease in China. Following comprehensive control measures implemented since 2006, annual human cases declined steadily from 2008 through 2023. However, 2024 witnessed a 36.9% increase in cases compared with 2023, indicating possible changes in transmission dynamics or control effectiveness. This study analyzes the epidemiological characteristics and spatiotemporal patterns of rabies from 2005 to 2024 to inform targeted prevention strategies.</p><p><strong>Methods: </strong>We employed descriptive epidemiological methods to analyze the spatiotemporal distribution and demographic characteristics of rabies cases in China. Spatial clustering was assessed using global and local Moran's I statistics (<i>P</i><0.05). Retrospective space-time scan analysis (2005-2024) was performed using SaTScan software to identify significant disease clusters. We conducted spatial frequency analysis by calculating the number of years each county reported at least one case during the study period; counties reporting cases in ≥10 years were classified as high-frequency areas.</p><p><strong>Results: </strong>Following a peak of 3,300 cases in 2007, rabies incidence declined continuously for 16 years before resurging in 2024 (167 cases, representing a 36.9% increase compared with 2023). Cases remained geographically concentrated, with 76.0% occurring in six central and southern provincial-level administrative divisions. The majority of affected counties (74%) reported only a single case. Males (70.0%), farmers (68.6%), and individuals aged 41-70 years (53.8%) comprised the highest-risk populations. Spatial analysis revealed that High-High clusters decreased in number over time. These clusters also shifted geographically: from widespread distribution across southwestern provincial-level administrative divisions (PLADs) during 2005-2014 to concentration in central agricultural zones during 2020-2024, particularly along the border regions of Henan, Hunan, Hubei, and Anhui PLADs. We identified 352 high-frequency counties. Spatiotemporal scan statistics detected seven significant clusters during 2005-2024, all located in central and southwestern regions. Outbreaks within these clusters peaked during summer and autumn months (July-November) from 2006 to 2013, with no new clusters emerging after 2014.</p><p><strong>Conclusions: </strong>Our findings demonstrate that China's rabies control efforts have successfully transitioned the epidemic from widespread endemic transmission to sporadic occurrence with localized clustering. The 2024 resurgence occurred predominantly in historically endemic hotspots identified through spatial analysis. Sustaining these control achievements will require implementing precision prevention strategies specifically targeted at these persistent high-risk counties.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 43","pages":"1350-1356"},"PeriodicalIF":2.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Dengue Virus RNA in Breast Milk Following Peripartum Infection - Guangzhou City, Guangdong Province, China, 2024.","authors":"Fang Peng, Yuanjing Xu, Minghao Li, Zhixi Tan, Yuyan Lin, Jianting Chen, Yongliang Ou, Shuxian Pan","doi":"10.46234/ccdcw2025.229","DOIUrl":"10.46234/ccdcw2025.229","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Dengue fever is primarily transmitted by Aedes mosquitoes. While most cases are asymptomatic or mild, some may progress to severe complications. Laboratory diagnosis relies on detection of nucleic acid, antigen, or antibodies in blood specimens.</p><p><strong>What is added by this report?: </strong>A patient who developed dengue fever 1 day before delivery had dengue virus RNA, NS1 antigen, and IgM detected in breast milk within 10 days of symptom onset. Nucleic acid and NS1 turned negative by day 15, while IgM antibodies remained positive and turned negative by day 22, suggesting potential transmission risk via early breastfeeding.</p><p><strong>What are the implications for public health practice?: </strong>Breastfeeding should be avoided until 22 days post-onset, after confirming clearance of viral RNA and IgM from breast milk and excluding infection in the infant. Household members of pregnant women exhibiting suspected dengue symptoms should seek immediate medical attention for dengue NS1 antigen testing during dengue season.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 43","pages":"1364-1367"},"PeriodicalIF":2.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Study on Clinical Performance of Host DNA Methylation Assay for Triage in Women Who Are HPV-Positive - 4 Provinces, China, 2018-2021.","authors":"Jing Zhang, Jinxueyue Chen, Hui Feng, Ying Hong, Jing Zhao, Xiaohua Pan, Yan Chen, Jian Zhao, Yan Zhang","doi":"10.46234/ccdcw2025.230","DOIUrl":"10.46234/ccdcw2025.230","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Persistent infection with high-risk human papillomavirus (hrHPV) is recognized as the primary cause of cervical cancer and its precancerous lesions. However, most HPV infections are transient and naturally clear. Currently effective triage tools for distinguishing between transient HPV infections and clinically relevant hrHPV-induced diseases are lacking, leading to excessive referrals and overtreatment.</p><p><strong>What is added by this report?: </strong>This is the first large-scale, prospective, multicenter study to evaluate the triage performance of host DNA six-methylation marker assay (<i>ASTN1</i>, <i>DLX1</i>, <i>ITGA4</i>, <i>RXFP3</i>, <i>SOX17</i>, and <i>ZNF671</i>) in women who are hrHPV-positive in China. Compared with HPV genotyping and cytology [≥ atypical squamous cells of undetermined significance (ASCUS)] screening, the six-methylation marker assay demonstrated superior triage performance, with sensitivities of 82.2% and 90.3% and specificities of 92.4% and 84.1% for cervical intraepithelial grade II/III and worse (CIN2+ and CIN3+), respectively. Further subgroup analysis of women <30 years of age revealed its efficacy. The methylation positivity rate increased with the severity of cervical lesions, and the most significant marker was <i>ZNF671</i>. Moreover, the six-methylation marker assay required the fewest colposcopy referrals, with only 1.32 and 2.39 per CIN2+ and CIN3+ cases, respectively, highlighting its strong health and economic advantages.</p><p><strong>What are the implications for public health practice?: </strong>The large number of women with HPV infections in China each year has led to excessive cytological screenings and colposcopy referrals. A feasible triage tool for women who are hrHPV-positive significantly reduces unnecessary medical resource utilization and offers substantial health and economic benefits.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 43","pages":"1368-1376"},"PeriodicalIF":2.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic Characterization of Human Adenovirus Type 21 Strains - 7 PLADs, China, 2023-2024.","authors":"Yali Jin, Naiying Mao, Xueping Ma, Linqing Zhao, Liwei Sun, Jikui Deng, Shu Liang, Hongmei Xu, Xin Li, Chunyu Zhu, Baicheng Xia, Aili Cui, Yan Zhang, Zhen Zhu","doi":"10.46234/ccdcw2025.228","DOIUrl":"10.46234/ccdcw2025.228","url":null,"abstract":"<p><strong>Introduction: </strong>Recent sentinel surveillance has revealed a rising prevalence of human adenovirus type 21 (HAdV-21) among HAdV infections in China. This study aimed to elucidate the molecular features of currently circulating HAdV-21 strains in China.</p><p><strong>Methods: </strong>Whole-genome sequencing (WGS) was performed on 23 HAdV-21 strains isolated from acute respiratory infection cases, 56.5% involving lower respiratory tract infections, across 7 Chinese sentinel surveillance provincial-level administrative divisions (PLADs) (2023-2024). These sequences, along with 50 previously reported HAdV-21 genomes from 6 countries (1956-2019), were integrated into a WGS dataset for comprehensive phylogenetic, genetic variation, and recombination analyses.</p><p><strong>Results: </strong>WGS categorized the HAdV-21 strains into 3 subtypes: HAdV-21a, HAdV-21b, and historical HAdV-21p (isolated in the 1950s). HAdV-21a (1956-2024, involving 5 of the 6 countries) and HAdV-21b (2005-2024, involving 3 of the 6 countries) exhibited extensive spatiotemporal distributions. Recent Chinese strains (2023-2024) belonged to HAdV-21a and HAdV-21b (HAdV-21a/b), showing extremely high genetic homology with Chinese 2019 strains (genetic distance: 0.00007) and global strains (distance: <0.00040). Phylogenetic analysis confirmed that HAdV-21a/b shared a common ancestor and maintained a highly conserved genome despite decades of circulation. Sequence variation analysis identified shared and subtype-specific mutations in these two subtypes. Recombination pattern analysis further revealed that HAdV-21a/b acquired an HAdV-3-derived fragment in the E4 region (breakpoint: nt32,843).</p><p><strong>Conclusions: </strong>Recombinant HAdV-21a/b subtypes have co-circulated in China in recent years with remarkable genetic conservation. Enhanced surveillance is essential to quantify associated disease burden and guide targeted prevention and control strategies.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 43","pages":"1357-1363"},"PeriodicalIF":2.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody Levels Against Mumps Virus in Children After Implementation of the Two-Dose MMR Vaccine Policy - Fujian Province, China, 2023.","authors":"Zhifei Chen, Rui Chen, Ruihong Wu, Suhan Zhang, Xiuhui Yang, Weiyi Pan, Hairong Zhang, Mengping Zhang, Yong Zhou, Dong Li","doi":"10.46234/ccdcw2025.223","DOIUrl":"10.46234/ccdcw2025.223","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>The Measles-Mumps-Rubella (MMR) vaccine plays a crucial role in preventing mumps. Before the implementation of the two-dose MMR vaccine policy, baseline data on mumps virus antibody seroprevalence and geometric mean concentrations (GMCs) among children and adolescents in Fujian Province were available.</p><p><strong>What is added by this report?: </strong>This report provides a post-policy evaluation following the introduction of Fujian's two-dose MMR policy in June 2020. The 2023 survey shows an overall seroprevalence of 79.53% and a GMC of 265.61 U/mL. Compared with 2018, significant improvements were observed in children under 2 years; however, a concerning decline was noted among adolescents aged 15-17 years. Antibody levels peaked shortly after vaccination, and two doses were found to confer significantly higher immunity than one dose within a 270-day period.</p><p><strong>What are the implications for public health practices?: </strong>The two-dose MMR policy has been effective in improving early childhood immunity. However, the observed waning immunity in adolescents underscores the urgent need for ongoing serological surveillance, particularly in individuals aged 6-19 years, to inform potential recommendations for booster vaccinations.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 42","pages":"1315-1320"},"PeriodicalIF":2.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect and Immune Mechanism of EPCP009 Booster Immunization after BCG Prime Immunization Against Tuberculosis in Mice - China, 2024.","authors":"Ruihuan Wang, Xueting Fan, Machao Li, Xiuqin Zhao, Xinyue He, Kanglin Wan, Haican Liu","doi":"10.46234/ccdcw2025.225","DOIUrl":"10.46234/ccdcw2025.225","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>At present, relatively few theoretical studies exist on the immunization strategies of tuberculosis vaccines, especially regarding the types of subunit protein vaccines suitable for combined application with Bacillus Calmette-Guérin (BCG).</p><p><strong>What is added by this report?: </strong>The study demonstrated that EPCP009, a novel subunit vaccine candidate, maintains BCG colonization in murine spleens while enhancing protection. Notably, a single dose of EPCP009 combined with BCG was superior to multiple doses in terms of both short-term (6-week) and long-term (12-week) protection.</p><p><strong>What are the implications for public health practice?: </strong>These studies provide a theoretical basis for enhancing the immune strategy of tuberculosis vaccines and contribute to the development of combined BCG and subunit protein vaccines.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 42","pages":"1329-1336"},"PeriodicalIF":2.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Measles Vaccine Immunogenicity and Durability Using A Pseudotyped Virus Neutralization Assay.","authors":"Qi Jiang, Xi Wu, Jie Zhang, Huiling Wang, Fangyu Dong, Xuelian Wu, Pengju Yu, Jianhui Nie, Youchun Wang, Weijin Huang, Jiuyue Zhou, Yaru Quan, Yan Zhang, Suting Wang, Juan Li","doi":"10.46234/ccdcw2025.224","DOIUrl":"10.46234/ccdcw2025.224","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to establish a robust method for monitoring measles vaccine-induced immunity and assessing population-level serostatus.</p><p><strong>Methods: </strong>This study constructed a vesicular stomatitis virus (VSV)-based pseudotyped virus system expressing envelope proteins from seven major circulating measles genotypes (H1, B3, D4, D8, D9, D11, G3) and the Schwarz vaccine strain (genotype A), thereby enabling a high-throughput neutralization assay for antibody detection.</p><p><strong>Results: </strong>Vaccination induced a substantial increase in neutralizing antibody geometric mean titers (GMT) post-immunization (4,808 after the first dose; 5,326 after the second dose), with antibody levels remaining elevated in 4-year-old children (GMT: 3,834). Cross-neutralization activity against different genotypes varied by less than 6.4-fold, demonstrating broad protective immunity. However, 12% of adult sera tested were seronegative, revealing the presence of susceptible populations.</p><p><strong>Conclusions: </strong>This study confirms the robust immunogenicity of the current measles vaccine and establishes a valuable tool for serosurveillance and long-term immunity assessment.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 42","pages":"1337-1346"},"PeriodicalIF":2.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of PCV13 Vaccination on Pharyngeal Detection of <i>Streptococcus pneumoniae</i> Among Children - Suqian City, Jiangsu Province, China, February 2023-February 2025.","authors":"Lisha Ma, Mingwei Wei, Tao Wu, Ran Tao, Jinbo Gou, Yue Liu, Manrong Zhang, Mengjuan Yuan, Lunbiao Cui, Jingxin Li","doi":"10.46234/ccdcw2025.222","DOIUrl":"10.46234/ccdcw2025.222","url":null,"abstract":"<p><strong>What is already known on this topic?: </strong>Pneumococcal conjugate vaccines (PCVs), including the 13-valent PCV (PCV13), effectively reduce the nasopharyngeal carriage of vaccine-type <i>Streptococcus pneumoniae</i> (<i>S. pneumoniae</i>) and prevent invasive pneumococcal disease in children. However, an increasing prevalence of non-vaccine serotypes and serotype replacement has been documented globally, with notable variations in the predominant replacement serotypes across different geographic settings.</p><p><strong>What is added by this report?: </strong>This study demonstrated that PCV13 vaccination significantly reduced the pharyngeal detection of <i>S. pneumoniae</i> among children with acute respiratory infections, with three to four doses decreasing the detection rate by 30.2%. This reduction encompassed both vaccine and non-vaccine serotypes. Additionally, non-PCV13 serotypes, particularly 10A and 15A/15F, were predominant in positive samples, underscoring the current dominance of non-vaccine serotypes in the study population.</p><p><strong>What are the implications for public health practice?: </strong>The PCV13 program successfully reduced pneumococcal detection rates, particularly among children who complete the 3-4 dose series. Continued surveillance of circulating <i>S. pneumoniae</i> serotypes is essential to monitor serotype replacement patterns and develop future vaccination strategies.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 42","pages":"1321-1328"},"PeriodicalIF":2.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12569534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}