中国疾病预防控制中心周报最新文献

{"title":"Surveillance and Analysis of Animal Rabies - China, 2004-2024.","authors":"Sheng Sun, Jihong Ma, Yu Xu, Zheng Zeng, Jian Liu, Hada, Zhongzhong Tu, Weidi Xu, Huachao Feng, Zihan Zhao, Changchun Tu, Ye Feng","doi":"10.46234/ccdcw2025.208","DOIUrl":"https://doi.org/10.46234/ccdcw2025.208","url":null,"abstract":"<p><strong>Introduction: </strong>Rabies is a zoonotic disease caused by rabies viruses(RABV). China is a high-risk country for rabies. To address China's rabies situation, the Chinese Ministry of Agriculture and Rural Affairs issued the National Animal Disease Surveillance and Epidemiological Investigation Plan. This study systematically summarized animal rabies surveillance data from the past two decades based on the Program.</p><p><strong>Methods: </strong>Suspected rabies cases collected through the Program between 2004 and 2024 underwent confirmatory diagnosis at the National Reference Laboratory (NRL) for animal rabies using national standard protocols: direct fluorescent antibody testing (FAT) and real-time RT-PCR. Epidemiological data from confirmed cases were analyzed using Geographic Information System (GIS) mapping and statistical evaluation methods.</p><p><strong>Results: </strong>Laboratory diagnosis confirmed 331 of 433 suspected cases (76.44%) as rabies-positive. These confirmed cases originated from 15 provincial-level administrative divisions (PLADs) and revealed two distinct transmission patterns: a) dog-mediated rabies, accounting for 47.13% of cases and predominantly endemic in southern PLADs, where it poses ongoing human exposure risks; and b) wildlife-mediated rabies in livestock, comprising 52.87% of cases and primarily transmitted by foxes in northern PLADs, with the Inner Mongolia Autonomous Region (IMAR) experiencing the highest burden.</p><p><strong>Conclusions: </strong>This nationwide surveillance has elucidated current rabies transmission dynamics across China, revealing persistent threats from dog rabies to human health in southern PLADs and emerging threats from wildlife-mediated rabies to livestock in northern border regions. These findings underscore the critical need for enhanced surveillance systems and targeted vaccination strategies addressing both domestic dog populations and wildlife reservoirs to achieve effective rabies control.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 39","pages":"1235-1240"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let's Act Now to Make Rabies History.","authors":"Wenwu Yin","doi":"10.46234/ccdcw2025.207","DOIUrl":"https://doi.org/10.46234/ccdcw2025.207","url":null,"abstract":"","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 39","pages":"1233-1234"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic Next-Generation Sequencing Unmasks Atypical Rabies - Guangxi Zhuang Autonomous Region, China, 2024.","authors":"He Li, Jing Wei, Shuwu Zhou, Zhiqun Zhan, Jinfang Tang, Wei Wang, Huamin Tang","doi":"10.46234/ccdcw2025.211","DOIUrl":"https://doi.org/10.46234/ccdcw2025.211","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Human rabies remains nearly universally fatal despite medical advances. Diagnosis is frequently delayed when patients present with atypical symptoms, and the failure to receive postexposure prophylaxis (PEP) continues to be a major contributor to mortality worldwide.</p><p><strong>What is added by this report?: </strong>This represents the first confirmed human rabies case in Guangxi caused by the JSTZ190314 strain, successfully identified through metagenomic next-generation sequencing (mNGS). The patient initially presented with urinary symptoms that led to a misdiagnosis before characteristic neurological manifestations developed, ultimately progressing to brain death 28 days after neurological onset (34 days from initial urinary symptoms).</p><p><strong>What are the implications for public health practice?: </strong>This case demonstrates the critical importance of mNGS in diagnosing atypical rabies presentations and emphasizes the urgent need for enhanced early clinical recognition, standardized PEP administration protocols, and strengthened regional viral surveillance systems.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 39","pages":"1251-1257"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active Surveillance on Safety and Compliance of Freeze-dried Human Rabies Vaccine (Vero Cell) - Jiangsu Province, China, 2023-2024.","authors":"Yanjun Chen, Mingwei Wei, Xiaoteng Xu, Yunfeng Shi, Shixuan Zhang, Chenhao Wang, Qi Liang, Xue Guo, Hongxing Pan","doi":"10.46234/ccdcw2025.210","DOIUrl":"https://doi.org/10.46234/ccdcw2025.210","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Both the 4-dose (Zagreb) and 5-dose (Essen) rabies vaccination regimens demonstrate comparable immunogenicity and safety profiles in clinical trials and are approved for use in China.</p><p><strong>What is added by this report?: </strong>This study pioneers active safety surveillance via a mobile application, identifying an adverse reaction rate of 2.10% for the Zagreb regimen and 2.70% for the Essen regimen. The Zagreb regimen had a lower out-of-window administration rate of 8.41% compared to 16.38%. Compliance was influenced by age, marital status, and exposure level, while the Essen regimen involved additional factors, including education level and perceived convenience.</p><p><strong>What are the implications for public health practice?: </strong>This study supports broader adoption of the 4-dose regimen to reduce logistical challenges and enhance compliance. Mobile application-based active surveillance presents a novel approach to enhancing real-world monitoring quality.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 39","pages":"1246-1250"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy Evaluation of Virus Clearance of SYN023 in A Murine Rabies Model - China, 2025.","authors":"Yixiang Ma, Zixin Fang, Xiaoyan Tao, Shuqing Liu, Qian Liu, Minghui Zhang, Pengcheng Yu, Si Liu, Wuyang Zhu","doi":"10.46234/ccdcw2025.209","DOIUrl":"https://doi.org/10.46234/ccdcw2025.209","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Rabies is a fatal, but preventable, viral disease. Post-exposure prophylaxis (PEP), which includes the administration of passive immune preparations, is critical after exposure to the rabies virus, particularly in high-risk cases. The delayed or missed application of passive immunizing agents may increase the risk of infection.</p><p><strong>What is added by this report?: </strong>SYN023, a novel anti-rabies monoclonal antibody cocktail, can effectively reverse the course of rabies infection, even at a late stage of the disease. In a mouse model infected with the rabies virus strain SC16, multiple high-dose injections of SYN023 administered 5 days post-inoculation rescued 69% of the animals.</p><p><strong>What are the implications for public health practice?: </strong>These findings suggest that SYN023 could serve as a promising therapeutic agent for rabies PEP, particularly in cases in which treatment initiation is delayed. This study provides a scientific basis for future clinical trials aimed at improving rabies treatment protocols.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 39","pages":"1241-1245"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Dementia Care Continuity: The 3A (Awareness, Attitude, Action) Framework.","authors":"Huali Wang","doi":"10.46234/ccdcw2025.202","DOIUrl":"https://doi.org/10.46234/ccdcw2025.202","url":null,"abstract":"<p><p>In the context of World Alzheimer's Month 2025, this perspective article examines the current state of care continuity for people living with dementia in China and identifies critical gaps in this domain. The article further reviews existing global dementia action plans, highlighting the strategic approaches outlined in China's National Action Plan on Response to Dementia (2024-2030). To transform knowledge into meaningful change, this perspective proposes the 3A approach - Awareness, Attitude, and Action - as a comprehensive guiding framework to strengthen and advance the continuum of care.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 38","pages":"1209-1213"},"PeriodicalIF":2.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curriculum Factors in Real-World Training Scenarios for Improving Intention of Laypersons to Perform Cardiopulmonary Resuscitation - Beijing Municipality, China, 2025.","authors":"Guixiu Chen, Lei Hou, Keyi Quan, Bo Chen, Xuefei Feng, Yibing Ji, Ning Wang, Baohua Wang","doi":"10.46234/ccdcw2025.205","DOIUrl":"https://doi.org/10.46234/ccdcw2025.205","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Training laypersons can increase cardiopulmonary resuscitation (CPR) attempts by bystanders by improving their intention to perform CPR. However, the association between curriculum content and post-training intention to perform CPR remains unclear.</p><p><strong>What is added by this report?: </strong>Key curriculum factors in CPR training can effectively improve laypersons' intention to perform CPR following training, and 74.7% of the laypersons enrolled in the training programs reported high CPR intention following training. In the low-intention laypersons, relative to the presence of zero to four factors, the coexistence of five to seven factors and eight or nine factors were associated with 174.7% [rate ratio (<i>RR</i>)=2.747; 95% confidence interval (<i>CI</i>): 0.964-7.826] and 283.6% (<i>RR</i>=3.836; 95% <i>CI</i>: 1.493-9.857) increase in high-intention incidence, respectively. A dose-response relationship was found in an indirect pathway in high-intention laypersons before training. However, the overall proportion of participants exposed to all nine curriculum factors was only 57.7%.</p><p><strong>What are the implications for public health practice?: </strong>The translation of training into high post-course intention remains suboptimal in China. Identifying and improving curriculum factors linked to CPR intention would increase the prevalence of layperson interventions in China, especially factors that can increase trainees' self-efficacy in recognizing cardiac arrest and performing CPR correctly.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 38","pages":"1220-1226"},"PeriodicalIF":2.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Survey on Nutrition Knowledge Assessment Among Junior High School Students - 31 PLADs, China, 2023-2024.","authors":"Yujie Qiu, Caicui Ding, Fan Yuan, Tanchun Yu, Ailing Liu","doi":"10.46234/ccdcw2025.204","DOIUrl":"https://doi.org/10.46234/ccdcw2025.204","url":null,"abstract":"<p><strong>Introduction: </strong>Nutrition knowledge (NK) is a key modifiable factor influencing the dietary behavior and nutritional status of children. Currently, nationally representative data assessing NK among Chinese junior high school students are unavailable. This study aimed to assess NK levels using recent, nationally representative data from China.</p><p><strong>Methods: </strong>A multistage stratified random cluster sampling method was used to select 28,629 junior high school students from 195 survey sites across 31 provincial-level administrative divisions in China. Data were collected using a standardized questionnaire developed using rigorous scientific procedures. NK awareness rates were described as weighted prevalence rates with 95% confidence intervals (<i>CI</i>s). Subgroup comparisons were performed using the Rao-Scott chi-square test.</p><p><strong>Results: </strong>The overall NK awareness rate among Chinese junior high school students was 40.0% (95% <i>CI</i>: 36.5%-43.5%). The rates for the five dimensions, dietary recommendations, nutrient content of foods, food and health, food choices, and food safety, were 20.1%, 46.2%, 65.3%, 65.2%, and 65.2%, respectively. The analysis revealed significant variations in overall and dimension-specific awareness rates across groups. Boys, students from rural and western regions, and students from families with lower socioeconomic status had poorer NK levels than their counterparts. Among the 10 knowledge points with the lowest correct rates, seven belonged to dietary recommendations, two to food safety, and one to food and health.</p><p><strong>Conclusion: </strong>NK awareness rates among junior high school students require improvement, especially regarding dietary recommendations, which remain a key component of students' nutrition education. Boys, students from rural and western regions, and students from families with lower socioeconomic status should be the key populations for NK dissemination in the future.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 38","pages":"1214-1219"},"PeriodicalIF":2.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Dengue Infection After Allogeneic Hematopoietic Stem Cell Transplantation in Patient with Acute B-Lymphoblastic Leukemia - China, 2025.","authors":"Ying Zhou, Chaofeng Sun, Qinglian Liu, Yuanli Ling, Bo Yang","doi":"10.46234/ccdcw2025.206","DOIUrl":"https://doi.org/10.46234/ccdcw2025.206","url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>Dengue fever represents one of the most prevalent viral infections annually affecting the general population in endemic regions. It is widely recognized as an acute self-limiting disease, with the virus typically being completely cleared within 2-3 weeks post-infection, without establishing long-term latency. The current consensus is that primary infection with a specific serotype confers lifelong type-specific immunity, thereby preventing reinfection with an identical dengue virus serotype.</p><p><strong>What is added by this report?: </strong>We report the case of a patient with leukemia who developed a confirmed dengue virus serotype 1 (DENV-1) infection during chemotherapy and targeted therapy. Notably, 6 months after the resolution of the initial infection, the same patient tested positive again for DENV-1 nucleic acid while undergoing intensive immunosuppression following allogeneic hematopoietic stem cell transplantation.</p><p><strong>What are the implications for public health practice?: </strong>For patients undergoing hematopoietic stem cell transplantation and receiving immunosuppressive therapy, clinicians should be vigilant about the potential for persistent dengue infection, particularly in dengue-endemic regions. Furthermore, implementing prolonged serological monitoring post-infection is also crucial for the clinical management of this patient population.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 38","pages":"1227-1230"},"PeriodicalIF":2.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reported Cases and Deaths of National Notifiable Infectious Diseases - China, July 2025.","authors":"","doi":"10.46234/ccdcw2025.203","DOIUrl":"https://doi.org/10.46234/ccdcw2025.203","url":null,"abstract":"","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"7 38","pages":"1231-1232"},"PeriodicalIF":2.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}