Active Surveillance on Safety and Compliance of Freeze-dried Human Rabies Vaccine (Vero Cell) - Jiangsu Province, China, 2023-2024.

IF 2.9 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

中国疾病预防控制中心周报 Pub Date : 2025-09-26 DOI:10.46234/ccdcw2025.210

Yanjun Chen, Mingwei Wei, Xiaoteng Xu, Yunfeng Shi, Shixuan Zhang, Chenhao Wang, Qi Liang, Xue Guo, Hongxing Pan

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引用次数: 0

Abstract

What is already known about this topic?: Both the 4-dose (Zagreb) and 5-dose (Essen) rabies vaccination regimens demonstrate comparable immunogenicity and safety profiles in clinical trials and are approved for use in China.

What is added by this report?: This study pioneers active safety surveillance via a mobile application, identifying an adverse reaction rate of 2.10% for the Zagreb regimen and 2.70% for the Essen regimen. The Zagreb regimen had a lower out-of-window administration rate of 8.41% compared to 16.38%. Compliance was influenced by age, marital status, and exposure level, while the Essen regimen involved additional factors, including education level and perceived convenience.

What are the implications for public health practice?: This study supports broader adoption of the 4-dose regimen to reduce logistical challenges and enhance compliance. Mobile application-based active surveillance presents a novel approach to enhancing real-world monitoring quality.

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冻干人狂犬病疫苗（Vero Cell）安全性和合规性的主动监测-江苏省，中国，2023-2024。

关于这个话题我们已经知道了什么？4剂（萨格勒布）和5剂（埃森）狂犬病疫苗接种方案在临床试验中显示出相当的免疫原性和安全性，并已被批准在中国使用。这份报告增加了什么内容？本研究率先通过移动应用程序进行主动安全监测，发现萨格勒布方案的不良反应率为2.10%，埃森方案为2.70%。萨格勒布方案的窗外给药率较低，分别为8.41%和16.38%。依从性受年龄、婚姻状况和暴露水平的影响，而埃森方案还涉及其他因素，包括教育水平和感知的便利性。这对公共卫生实践有什么影响？本研究支持更广泛地采用四剂量方案，以减少后勤挑战并提高依从性。基于移动应用的主动监控提供了一种提高现实世界监控质量的新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国疾病预防控制中心周报

CiteScore

5.90

自引率

0.00%

发文量