Journal of the Iranian Chemical Society最新文献

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Surfactant-modified carbon nano-onion-β-cyclodextrin nanocomposite as an efficient sorbent in dispersive solid phase extraction of metoprolol and atenolol from plasma samples prior to HPLC–PDA analysis 表面活性剂修饰的纳米碳离子-β-环糊精纳米复合材料作为一种高效吸附剂,用于在 HPLC-PDA 分析前从血浆样品中分散固相萃取美托洛尔和阿替洛尔
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-29 DOI: 10.1007/s13738-024-03107-6
Zahra Aslanabadi, Mohammad Reza Afshar Mogaddam, Faranak Ghaderi, Elnaz Marzi Khosrowshahi, Aysa Abasalizadeh, Mir Ali Farajzadeh, Mahboob Nemati
{"title":"Surfactant-modified carbon nano-onion-β-cyclodextrin nanocomposite as an efficient sorbent in dispersive solid phase extraction of metoprolol and atenolol from plasma samples prior to HPLC–PDA analysis","authors":"Zahra Aslanabadi,&nbsp;Mohammad Reza Afshar Mogaddam,&nbsp;Faranak Ghaderi,&nbsp;Elnaz Marzi Khosrowshahi,&nbsp;Aysa Abasalizadeh,&nbsp;Mir Ali Farajzadeh,&nbsp;Mahboob Nemati","doi":"10.1007/s13738-024-03107-6","DOIUrl":"10.1007/s13738-024-03107-6","url":null,"abstract":"<div><p>In the present study, a modified carbon nano-onion and β–cyclodextrin composite was utilized in micro-solid phase extraction of atenolol and metoprolol from human plasma samples. The synthesized sorbent structure and morphology were evaluated. In this method, a proper amount of the sorbent was contacted with the diluted plasma sample under vortexing (to promote the sorbent contact area with the solution). The separated particles by centrifugation were contacted with a proper eluent to desorb the target analytes. After that, the eluent was separated by centrifugation and used during analysis of the analytes by high-performance liquid chromatograph. Several effective extraction parameters such as the sorbent amount, type and elution solvent volume, and extraction time were evaluated and optimized. The validated factors showed that detection and quantification were 0.09 and 0.01 and 0.29 and 0.03 ng mL<sup>–1</sup>, for metoprolol and atenolol, respectively. The method precision, considered as relative standard deviation, was ≤ 2.5 and ≤ 3.6% for intra- (<i>n</i> = 5) and inter-day (<i>n</i> = 4) precisions, respectively. The extraction recovery values were obtained 84 and 63% for metoprolol and atenolol, respectively. Lastly, the developed method was utilized successfully on the plasma samples of patients treated with metoprolol and atenolol.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 11","pages":"2767 - 2774"},"PeriodicalIF":2.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Eu(III) and Tb(III) complexes bearing carboxamide ligand: antiproliferative activity, photoluminescence properties, and thermogravimetric studies 含羧酰胺配体的新型 Eu(III)和 Tb(III)配合物:抗增殖活性、光致发光特性和热重研究
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-28 DOI: 10.1007/s13738-024-03112-9
Ahmet Oral Sarıoğlu, Hatice Gamze Sogukomerogullari, Ayşegül Köse, Senem Akkoc, Mehmet Sönmez, Mehmet Hakan Morcalı
{"title":"Novel Eu(III) and Tb(III) complexes bearing carboxamide ligand: antiproliferative activity, photoluminescence properties, and thermogravimetric studies","authors":"Ahmet Oral Sarıoğlu,&nbsp;Hatice Gamze Sogukomerogullari,&nbsp;Ayşegül Köse,&nbsp;Senem Akkoc,&nbsp;Mehmet Sönmez,&nbsp;Mehmet Hakan Morcalı","doi":"10.1007/s13738-024-03112-9","DOIUrl":"10.1007/s13738-024-03112-9","url":null,"abstract":"<div><p>In this study, β-diketone derivative new carboxamide Eu(III) and Tb(III) lanthanide complexes were synthesized and characterized by FT-IR, elemental analysis, UV–Vis, and molar conductivity techniques. There is no electrolytic conductivity in the compounds. Moreover, the photoluminescence properties and thermal behavior of the synthesized lanthanide complexes were investigated. Photoluminescence data revealed that the Tb(III) complex showed metal-based f-f transitions. The β-diketone derivative carboxamide ligand exhibited as antenna that transmitted the excited energy to the emission energy levels of the Tb(III) ion. These metal complexes were screened in two different common cancer cell lines and a human normal embryonic kidney cell line for 48 h. The results showed that these complexes have more antiproliferative activities in the colon cancer cell line compared to the lung cancer cell line.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 12","pages":"2923 - 2931"},"PeriodicalIF":2.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrocatalytic reduction of nitrate using Mg(OH)2 copper modified electrode 使用改性铜镁(OH)2 电极电催化还原硝酸盐
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-28 DOI: 10.1007/s13738-024-03115-6
Nadia Ait Ahmed, Katia Hebbache, Samia Kerakra, Nabila Aliouane, Marielle Eyraud
{"title":"Electrocatalytic reduction of nitrate using Mg(OH)2 copper modified electrode","authors":"Nadia Ait Ahmed,&nbsp;Katia Hebbache,&nbsp;Samia Kerakra,&nbsp;Nabila Aliouane,&nbsp;Marielle Eyraud","doi":"10.1007/s13738-024-03115-6","DOIUrl":"10.1007/s13738-024-03115-6","url":null,"abstract":"<div><p>In order to improve the activity of copper (Cu) towards electrolytic reduction of nitrate, thin films of magnesium hydroxide (Mg(OH)<sub>2</sub>) were deposited on Cu substrate. For the first time, these films were synthesized by electrochemical deposition in a potassium sulfate bath containing Mg<sup>2+</sup> at 70 °C. The effect of various experimental parameters, such as deposition time and potential, on the electrocatalytic activity for the nitrate reduction was investigated. Surface analysis techniques (SEM, EDX and XRD) were used to get information on the morphology, the composition and the structure of the deposits. The activity of the modified electrode was studied by cyclic voltammetry, and amperometric method. The modified Mg(OH)<sub>2</sub>/Cu sensor exhibited a good electrocatalytic behavior towards the reduction of nitrates with high reproducible reduction peak currents. In addition, the sensor exhibits a linear answer for concentration in nitrate between 0.125 to 7 mM, combined with high sensitivity (24.6 µA mM<sup>−1</sup> cm<sup>−2</sup>) and limit of detection (225.35 µM) values. When common interfering molecules were added to the solution, Mg(OH)<sub>2</sub>/Cu electrodes have kept their good selectivity. They demonstrated acceptable detection levels for nitrates in tap water.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 11","pages":"2829 - 2840"},"PeriodicalIF":2.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catalyst-free one-pot three-component synthesis and in silico bioactivity of new 4-pyrazolyl pyrano[3,4-c] pyrrole derivatives 新型 4-吡唑基吡喃并[3,4-c] 吡咯衍生物的无催化剂一锅三组份合成及其硅学生物活性
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-25 DOI: 10.1007/s13738-024-03125-4
Brahim Cherfaoui, Houria Lakhdari, Norah Bennamane, Hocine Merazig, Ahmed Djafri, Abdelghani Bouchama, Bellara Nedjar-Kolli
{"title":"Catalyst-free one-pot three-component synthesis and in silico bioactivity of new 4-pyrazolyl pyrano[3,4-c] pyrrole derivatives","authors":"Brahim Cherfaoui,&nbsp;Houria Lakhdari,&nbsp;Norah Bennamane,&nbsp;Hocine Merazig,&nbsp;Ahmed Djafri,&nbsp;Abdelghani Bouchama,&nbsp;Bellara Nedjar-Kolli","doi":"10.1007/s13738-024-03125-4","DOIUrl":"10.1007/s13738-024-03125-4","url":null,"abstract":"<div><p>An unexpected route for the synthesis of pyrano [3,4-<i>c</i>] pyrrole derivatives has been reported via catalyst-free, three-component reaction of 1,3-dicarbonyl pyrazole, aromatic primary amines and fumaryl chloride. This novel cascade reaction sequence led to create two new rings and four new <i>σ</i> bonds containing two C–N, one C–C, and one C–O bond. The newly synthesized compounds were elucidated on the basis of their spectroscopic data (<sup>1</sup>H, <sup>13</sup>C, 2D NMR, HRMS, IR) and additionally confirmed by single-crystal X-ray diffraction analysis. The molecular docking simulation was performed utilizing the AutoDock 4.2 program to predict the binding affinity of one derivative of the synthesized compounds to the target mitogen-activated protein kinase P38 (MAPK P38) and mitogen-activated protein kinase 14 (MAPK 14).</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 12","pages":"2975 - 2982"},"PeriodicalIF":2.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct oxidative esterification of benzaldehydes and benzylalcohols using task-specific imidazolium based perchlorate ionic liquid 使用任务特异性咪唑基高氯酸盐离子液体直接氧化酯化苯甲醛和苯甲醇
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-25 DOI: 10.1007/s13738-024-03121-8
Hassan Valizadeh, Mina Ahmadi
{"title":"Direct oxidative esterification of benzaldehydes and benzylalcohols using task-specific imidazolium based perchlorate ionic liquid","authors":"Hassan Valizadeh,&nbsp;Mina Ahmadi","doi":"10.1007/s13738-024-03121-8","DOIUrl":"10.1007/s13738-024-03121-8","url":null,"abstract":"<div><p>Imidazolium perchlorate task-specific ionic liquids (TSILs) were used for in-situ oxidation esterification of benzaldehydes and benzylalcohols in reaction with alcohols. CO<sub>2</sub>H functional group containing TSIL show dual role as catalyst and reaction media toward oxidative esterifications. Excellent yields of esters could be obtained for a series of benzaldehydes and benzylalcohols via the reaction with alcohols. This reaction can be regarded as a new method for the efficient oxidation esterification of benzaldehydes and benzylalcohols under mild catalyst and solvent-free conditions.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 12","pages":"2955 - 2959"},"PeriodicalIF":2.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An electrochemical sensor based on NH2-MWCNTS-CMC and ZIF-67 peroxidase-like nanocomposite for sensitive luteolin detection 一种基于 NH2-MWCNTS-CMC 和 ZIF-67 过氧化物酶样纳米复合材料的电化学传感器,用于灵敏检测木犀草素
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-23 DOI: 10.1007/s13738-024-03122-7
Lin-Lin Ma, Ke-Xin Xu, Bao-Lin Xiao, Sanad Abdalbage Mohammed Abdalsadeg, Yu-Jie Chen, Yu-Ying Li, Jun Hong, Ali Akbar Moosavi-Movahedi
{"title":"An electrochemical sensor based on NH2-MWCNTS-CMC and ZIF-67 peroxidase-like nanocomposite for sensitive luteolin detection","authors":"Lin-Lin Ma,&nbsp;Ke-Xin Xu,&nbsp;Bao-Lin Xiao,&nbsp;Sanad Abdalbage Mohammed Abdalsadeg,&nbsp;Yu-Jie Chen,&nbsp;Yu-Ying Li,&nbsp;Jun Hong,&nbsp;Ali Akbar Moosavi-Movahedi","doi":"10.1007/s13738-024-03122-7","DOIUrl":"10.1007/s13738-024-03122-7","url":null,"abstract":"<div><p>Luteolin (Lut) is a flavonoid compound with antioxidant, anti-inflammatory and other biological properties. Lut has been used in many fields such as biomedicine and food safety. Therefore, the quantitative measurement of Lut is of great significance. In this study, an electrochemical sensor based on aminated multi-walled carbon (NH<sub>2</sub>-MWCNTs), sodium carboxymethylcellulose (CMC), ZIF-67 and chitosan (Chi) is developed for the measurement of Lut. NH<sub>2</sub>-MWCNTs are better dispersed by CMC, and NH<sub>2</sub>-MWCNTs are cross-linked with ZIF-67, which further improves the response and sensitivity of the electrode to the Lut due to the peroxide-like properties of ZIF-67. The detection limit and linear range of the electrochemical sensor for Lut are 2.1 nM and 0.1–7 μM, respectively. Dandelion is a traditional Chinese medicine plant containing Lut component. The prepared electrochemical sensor is also used to analysis Lut content in various parts of dandelion. The results show that the flowers part of dandelion exhibits the highest concentration of Lut; while, the leaves contain a moderate amount, and the roots are nearly devoid of Lut. These results are consistent with those obtained by ultra-high performance liquid chromatography. The electrochemical sensor has good stability and anti-interference ability, and has good potential application value in drug concentration detection and screening.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 11","pages":"2873 - 2886"},"PeriodicalIF":2.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Core shell ZnO-MnO2 nanocomposites for dye degradation and DFT simulation 用于染料降解的核壳 ZnO-MnO2 纳米复合材料及 DFT 模拟
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-23 DOI: 10.1007/s13738-024-03118-3
F. Joudi, W. Selmi, J. Ben Naceur, R. Chtourou
{"title":"Core shell ZnO-MnO2 nanocomposites for dye degradation and DFT simulation","authors":"F. Joudi,&nbsp;W. Selmi,&nbsp;J. Ben Naceur,&nbsp;R. Chtourou","doi":"10.1007/s13738-024-03118-3","DOIUrl":"10.1007/s13738-024-03118-3","url":null,"abstract":"<div><p>To enhance the photogeneration and separation of charge carriers, ZnO/MnO<sub>2</sub> nanocomposites were efficiently synthesized using a simple hydrothermal process and tested as photocatalyst for dye degradation. The samples of ZnO, MnO<sub>2</sub>, and ZnO/MnO<sub>2</sub> nanocomposites were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), UV–vis diffuse reflection spectroscopy, and photoluminescence spectra (PL). The photocatalytic activity of the ZnO/MnO<sub>2</sub> prepared using 10 mg was significantly higher than that of ZnO or MnO<sub>2</sub>, as demonstrated by optical and photoluminescence measurements. In fact, the degradation efficiency of methyl orange (MO) with ZnO/MnO<sub>2</sub> (10 mg) reaching to 98% after 2 h of sunlight irradiation. The enhanced degradation of MO compared with pure ZnO and MnO<sub>2</sub> can be attributed to the high surface area, efficient sunlight absorption, and excellent charge carrier separation of the ZnO/MnO<sub>2</sub> photocatalyst. Density functional theory (DFT) simulations of ZnO and MnO<sub>2</sub> further revealed the electronic origins of the structural properties, showing that the photocatalytic activity is due to the electron transitions between the valence and conduction bands of materials.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 11","pages":"2851 - 2861"},"PeriodicalIF":2.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental and computational insights into polymorphism in an antimicrobial sulfadrug: discovery of a novel monoclinic form of sulfamerazine 通过实验和计算深入了解抗菌磺胺药的多态性:发现磺胺嘧啶的新型单斜形态
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-22 DOI: 10.1007/s13738-024-03110-x
Amani Direm, Cemal Parlak, Brahim El Bali, Mohammed S. M. Abdelbaky, Santiago García-Granda
{"title":"Experimental and computational insights into polymorphism in an antimicrobial sulfadrug: discovery of a novel monoclinic form of sulfamerazine","authors":"Amani Direm,&nbsp;Cemal Parlak,&nbsp;Brahim El Bali,&nbsp;Mohammed S. M. Abdelbaky,&nbsp;Santiago García-Granda","doi":"10.1007/s13738-024-03110-x","DOIUrl":"10.1007/s13738-024-03110-x","url":null,"abstract":"<div><p>Sulfamerazine (4-Amino-N-(4-methylpyrimidin-2-yl) benzenesulfonamide) is a polymorphic molecule crystallizing in three forms: Form I: <i>Pn</i>2<sub>1</sub><i>a</i> polymorph (with three entries in the Cambridge Structural Database CSD), Form II: <i>Pbca</i> polymorph (with two entries in the CSD) and Form III: <i>P</i>2<sub>1</sub>/<i>c</i> polymorph with only one entry in the CSD). We have experimentally prepared a novel monoclinic <i>P</i>2<sub>1</sub>/<i>c</i> polymorph (Form IV) of the sulfadrug and also obtained crystals of Form II (<i>Pbca</i> polymorph) by following a different synthesis procedure. Both crystals were structurally characterized by single-crystal X-ray diffraction XRD and geometrically optimized by density functional theory DFT. The five crystal structures (<b>1</b>), (<b>3</b>)–(<b>6</b>) of the four mentioned polymorphs were analyzed and discussed in terms of crystal packing, <i>Hirshfeld</i> surface analysis HSA of the intermolecular interactions, voids’ distribution in the crystal packing, their related energies and the resulting underlying topologies. The energy and activity relations of the compounds were also investigated by DFT.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 11","pages":"2799 - 2815"},"PeriodicalIF":2.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of novel propargylated derivatives of noscapine using A3-coupling reaction and their anticancer properties 利用 A3 偶联反应合成莨菪碱的新型丙炔基衍生物及其抗癌特性
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-21 DOI: 10.1007/s13738-024-03116-5
Fatemeh Famarini, Peyman Salehi, Bahareh Heidari, Morteza Bararjanian, Atefeh Hajiagha Bozorgi, Afsaneh Tavasoli, Zahra Davarzani
{"title":"Synthesis of novel propargylated derivatives of noscapine using A3-coupling reaction and their anticancer properties","authors":"Fatemeh Famarini,&nbsp;Peyman Salehi,&nbsp;Bahareh Heidari,&nbsp;Morteza Bararjanian,&nbsp;Atefeh Hajiagha Bozorgi,&nbsp;Afsaneh Tavasoli,&nbsp;Zahra Davarzani","doi":"10.1007/s13738-024-03116-5","DOIUrl":"10.1007/s13738-024-03116-5","url":null,"abstract":"<div><p>A series of 21 novel compounds based on noscapine were synthesized and investigated as potential anticancer therapeutics. These new compounds were prepared from the <i>N</i>-demethylation of noscapine followed by the three-component A<sup>3</sup>-coupling of <i>N</i>-nornoscapine as a secondary amine, an aldehyde and a terminal alkyne catalyzed by copper iodide (CuI). Two classes of derivatives were synthesized by applying phenylacetylene and propargyl alcohol as the alkyne moiety. Chemical structures of the products were confirmed by <sup>1</sup>HNMR, <sup>13</sup>CNMR, and HR-MS. In vitro cytotoxicity of the synthesized derivatives was studied on MCF-7 breast cancer cell line treated with different doses of compounds for 48 h. Compounds <b>6l</b>, <b>6n</b> and <b>6h (</b>IC<sub>50</sub> = 18.94, 19.29 and 32.11 µM, respectively) displayed the highest potency compared to that of noscapine (IC<sub>50</sub> = 36.38 µM).</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 11","pages":"2841 - 2849"},"PeriodicalIF":2.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Covalent attachment of Mn-porphyrin onto functionalized activated carbon for green oxidation of olefins 将锰卟啉共价附着到功能化活性炭上,实现烯烃的绿色氧化
IF 2.2 4区 化学
Journal of the Iranian Chemical Society Pub Date : 2024-10-21 DOI: 10.1007/s13738-024-03114-7
Saeed Rayati, Makan Etefagh
{"title":"Covalent attachment of Mn-porphyrin onto functionalized activated carbon for green oxidation of olefins","authors":"Saeed Rayati,&nbsp;Makan Etefagh","doi":"10.1007/s13738-024-03114-7","DOIUrl":"10.1007/s13738-024-03114-7","url":null,"abstract":"<div><p>Complexes of first row transition metals are a promising class of inexpensive catalysts for oxidation reactions. In this work, we studied the influence of covalent immobilization of Mn-porphyrin onto the surface of activated carbon in the green oxidation of various olefins. <i>meso</i>-tetrakis(4-carboxyphenyl)porphyrinatomanganese(III) acetate (MnTCPP) immobilized onto hydroxylated activated carbon (AC-OH). The anchored catalyst was characterized using FTIR, UV–VIS, atomic absorption and EDX spectroscopies. TGA analysis and BET-BJH method were employed to determine thermal behavior and surface properties of complex respectively. Then, catalytic performance of MnTCPP@AC-OH was investigated in the green oxidation of olefins with molecular oxygen and hydrogen peroxide. A comparison between two green oxidants (molecular oxygen and hydrogen peroxide) shows that although more product is obtained with hydrogen peroxide, more recyclability is obtained with molecular oxygen. The separation and recovery of the nanocatalyst was simple, effective and economical in this green oxidation method and the supported catalyst can be reused at least five times without significant loss of activity.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 11","pages":"2817 - 2827"},"PeriodicalIF":2.2,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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