{"title":"Preparation of nickel–cobalt metal organic framework bearing palladium and manganese nanoparticles and investigation of their anticancer activity","authors":"Kaveh Parvanak Boroujeni, Somayeh Reiisi, Soudabeh Abdollahi","doi":"10.1007/s13738-025-03258-0","DOIUrl":null,"url":null,"abstract":"<div><p>In this research, NiCo-MOF was first functionalized with ethylenediamine and then the obtained en/NiCo-MOF nanosheets were loaded with PdCl<sub>2</sub> and MnCl<sub>2</sub>. The structures of the resulting nanostructures (Pd@en/NiCo-MOF and Mn@en/NiCo-MOF) were characterized. The size of nanostructures was in the range 3–15 nm and exhibited powerful fluorescence emission bands. The optical band gaps of samples were determined by means of optical absorption spectra and were found to be in the range of 3.8–4.1 eV. The cytotoxic effect of nanostructures was tested against MCF-7 human breast cancer cells by MTT assay and based on the results their effectiveness follows the order of Pd@en/NiCo-MOF > Mn@en/NiCo-MOF > en/NiCo-MOF. The measured IC50 values ranged from 123.766 to 292.737. The expression of caspase 3, 8 and 9 genes in the treated cells of en/NiCo-MOF, Pd@ en/NiCo-MOF and Mn@en/NiCo-MOF was also investigated, and multifold increases compared to the control were observed in all cases.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 8","pages":"1749 - 1757"},"PeriodicalIF":2.3000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Iranian Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13738-025-03258-0","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In this research, NiCo-MOF was first functionalized with ethylenediamine and then the obtained en/NiCo-MOF nanosheets were loaded with PdCl2 and MnCl2. The structures of the resulting nanostructures (Pd@en/NiCo-MOF and Mn@en/NiCo-MOF) were characterized. The size of nanostructures was in the range 3–15 nm and exhibited powerful fluorescence emission bands. The optical band gaps of samples were determined by means of optical absorption spectra and were found to be in the range of 3.8–4.1 eV. The cytotoxic effect of nanostructures was tested against MCF-7 human breast cancer cells by MTT assay and based on the results their effectiveness follows the order of Pd@en/NiCo-MOF > Mn@en/NiCo-MOF > en/NiCo-MOF. The measured IC50 values ranged from 123.766 to 292.737. The expression of caspase 3, 8 and 9 genes in the treated cells of en/NiCo-MOF, Pd@ en/NiCo-MOF and Mn@en/NiCo-MOF was also investigated, and multifold increases compared to the control were observed in all cases.
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JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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