{"title":"Evaluation of the in vitro cytotoxicity and drug delivery of ytterbium (III)-doped versatile bioactive glasses for cancer treatment","authors":"Aylin M. Deliormanlı, Harika Atmaca","doi":"10.1007/s41779-024-01089-5","DOIUrl":"10.1007/s41779-024-01089-5","url":null,"abstract":"<div><p>In this study, the in vitro mineralization, as well as an antitumor drug (fluorouracil) delivery of sol-gel-derived bioactive glasses doped with a lanthanide (III) element (Yb<sup>3+</sup>), have been investigated. Additionally, the cytotoxicity of the related bioactive glasses was examined against osteosarcoma SaOS-2 and osteoblastic MC3T3-E1 cell lines under in vitro conditions. The results demonstrated that the bioactive glass samples containing rare earth element did not induce cytotoxic effects on the mentioned cell lines for up to 7 days. An increase in alkaline phosphatase enzyme activity was observed for all samples during the incubation period. Drug loading experiments showed that the anticancer drug amount adsorbed onto the bioactive glass powders at pH 7.4 ranged between 25% and 35%. Based on the drug delivery studies conducted in phosphate-buffered saline solution at pH 7.4 and 5.5, cumulative drug release from the bioactive glass powders after 500 h was between 60% and 70% at neutral pH. A higher drug delivery was observed at lower pH value. The drug release kinetics were found to be consistent with the Higuchi model. The findings of this study indicate that bioactive glasses containing trivalent ytterbium possess suitable biological properties for use in biomedical applications and they offer improved biocompatibility providing an ideal environment for bone regeneration.</p></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"61 2","pages":"501 - 515"},"PeriodicalIF":1.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41779-024-01089-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuta Otsuka, Tomohiro Masuzaki, Masahiro Nishimura, Hiroshi Kono, Masafumi Kikuchi
{"title":"Modeling of calcium phosphate based on an LCD 3D printer using brushite and calcium hydroxide","authors":"Yuta Otsuka, Tomohiro Masuzaki, Masahiro Nishimura, Hiroshi Kono, Masafumi Kikuchi","doi":"10.1007/s41779-024-01076-w","DOIUrl":"10.1007/s41779-024-01076-w","url":null,"abstract":"<div><p>There is demand for the development of highly functional and flexible bone fillers to treat bone defects. This research aimed to fabricate calcium phosphate implants with a flexible porous design and sufficient compressive stress using a three-dimensional 3D printer. A mixed slurry of dicalcium phosphate, calcium hydroxide, photopolymerized resin, and polyethylene glycol (PEG) was prepared using a planetary ball mill. The slurry was formed into a porous model using a stereolithography-type 3D printer. Upon sintering, the resin and PEG evaporated and/or combusted, yielding a β- tricalcium phosphate (TCP) molding with porosity. This study proposes a novel method for freely molding calcium phosphate implants.</p></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"60 5","pages":"1689 - 1696"},"PeriodicalIF":1.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41779-024-01076-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ranbir Kumar, Deep Shikha, Sanjay Kumar Sinha, José R. Guerra-López, Neda Aboudzadeh
{"title":"Assessment of antioxidant activity, thrombogenicity and MTT assay of bioceramic phosphate as a biomaterial","authors":"Ranbir Kumar, Deep Shikha, Sanjay Kumar Sinha, José R. Guerra-López, Neda Aboudzadeh","doi":"10.1007/s41779-024-01083-x","DOIUrl":"10.1007/s41779-024-01083-x","url":null,"abstract":"<div><p>Hydroxyapatite (HAP), a cornerstone of bone and teeth, has ignited interest due to its potential bioactivity and therapeutic implications. This study comprehensively assesses the multifaceted nature of HAP, delving into its antioxidant, thrombogenic, and cytocompatibility properties. HAP was synthesized via the sol-gel method, achieving a Ca/P ratio 1.66, confirmed by energy-dispersive X-ray spectroscopy (EDS). X-ray diffraction (XRD) verified compound formation, while Fourier transform infrared spectroscopy (FTIR) identified functional groups. Field emission electron microscopy revealed the surface morphology of HAP. Its structural characterization delves into HAP’s functional potential. Utilizing the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, pure HAP’s ability to neutralize free radicals, a symbol of antioxidant activity, was evaluated. Additionally, thrombogenic studies using the whole blood clotting assay explored HAP’s influence on blood clotting, a crucial factor for biocompatibility. The MTT (3-(4, 5-dimethythiazol-2-yl)-2, 5-diphenyl tetrazolium bromide) assay was employed in the L929 cell line to assess its interaction with living cells further, shedding light on HAP’s cytotoxicity or potential cell viability enhancement.</p></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"61 section","pages":"333 - 343"},"PeriodicalIF":2.1,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xin Zhao, Jiegang You, Jingjing Yue, Xudong Luo, Beiyue Ma
{"title":"Microstructure and Mechanistic analysis of high-calcium fused magnesia molten heap","authors":"Xin Zhao, Jiegang You, Jingjing Yue, Xudong Luo, Beiyue Ma","doi":"10.1007/s41779-024-01061-3","DOIUrl":"10.1007/s41779-024-01061-3","url":null,"abstract":"<div><p>To study the significant influence of the microstructure of high-calcium fused magnesia on MgO-based refractories products. The chemical composition, microstructure, phase composition, and densification of the high-calcium fused magnesia with the selected locations were studied. The results revealed that the high-calcium fused magnesia at the core of the furnace bottom and middle of the electrode had the highest MgO content and the content of various impurities is the least. The bond phase is dicalcium silicate (C<sub>2</sub>S) and a low melting point silicate phase, and a certain amount of srebrodolskite appears in the upper layer of the molten heap. The longitudinal position from the top to the bottom of the grain size first becomes small and then large. In the horizontal position from the inside to the outside of the grain size firstly becomes large and then small, whose the largest grain size being 938μm. At the bottom of the furnace core of the bulk density is the largest, reaching 3.57g/cm<sup>3</sup>, the lowest porosity of 1.05%.</p></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"60 5","pages":"1529 - 1539"},"PeriodicalIF":1.8,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahmoud S. Alkathy, Yalambaku Rajesh, H. A. Kassim, Mansour K. Gatasheh, Fabio L. Zabotto, K. C. James Raju, Jose A. Eiras
{"title":"Enhancing energy storage performance in barium titanate ceramics through mg-doping via creation of defect dipoles engineering","authors":"Mahmoud S. Alkathy, Yalambaku Rajesh, H. A. Kassim, Mansour K. Gatasheh, Fabio L. Zabotto, K. C. James Raju, Jose A. Eiras","doi":"10.1007/s41779-024-01087-7","DOIUrl":"10.1007/s41779-024-01087-7","url":null,"abstract":"<p>Enhancing the efficacy of energy storage materials is crucial for advancing contemporary electronic devices and energy storage technologies. This research focuses on boosting the energy storage capabilities of BaTiO<sub>3</sub> ceramics through Mg<sup>2+</sup> doping. Introducing Mg<sup>2+</sup> ions into the BaTiO<sub>3</sub> lattice induces defects and grain boundary effects, significantly influencing ferroelectric properties. Rietveld refinements of X-ray diffraction confirmed that both pure and Mg-doped samples show the same tetragonal phase. SEM analysis revealed a refined grain microstructure in the Mg<sup>2+</sup> doped BT sample, which resulted in improved thermal stability and pinched ferroelectric hysteresis loops. Incorporating Mg<sup>2+</sup> ions into the BT host lattice significantly enhanced energy storage density from 0.204 J/cm<sup>3</sup> to 1.42 J/cm<sup>3</sup> and efficiency rising from 21 to 89%. This enhancement is attributed to defect dipole engineering and the attainment of fine grain size. Furthermore, an examination of the electronic structure, overall density of states (DOS), and electronic density of both samples is undertaken. The defect dipole mechanism proposed in this study introduces a novel and promising strategy for developing high-performance energy storage in ferroelectric ceramics, holding great promise for next-generation applications.</p>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"60 5","pages":"1709 - 1721"},"PeriodicalIF":1.8,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of BaAl2O4: Eu2+/Li+ co-doped spinel: study of crystal structure, microstructure, and photoluminescence characteristics","authors":"Seyed Mahdi Rafiaei, Mehrdad Ahmadi, Davoud Nikooghadam","doi":"10.1007/s41779-024-01085-9","DOIUrl":"10.1007/s41779-024-01085-9","url":null,"abstract":"<div><p>In this research BaAl<sub>2</sub>O<sub>4</sub>: Eu<sup>2+</sup>/Li<sup>+</sup> luminescent materials were synthesized through a facile solid-state approach at 1100 °C. To study the effect of Li<sup>+</sup> ions, different amounts of LiCl were used within the synthesis of BaAl<sub>2</sub>O<sub>4</sub>-based compounds. The crystal structural, microstructure, surface characteristics, and photoluminescence properties were scrutinized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL), Fourier transform infrared (FTIR) analyses. It was shown that the addition of LiCl flux material results in very slight changes in the crystallographic properties of BaAl<sub>2</sub>O<sub>4</sub> crystal structure while the use of LiCl has severely reduced the average particle size from about 225 nm to 120 nm. Upon the excitation procedure at the wavelength of 343 nm, BaAl<sub>2</sub>O<sub>4</sub>: Eu<sup>2+</sup> shows a strong and wide emission in the range of 435–610 nm that is attributed to the 4f<sup>6</sup>5d<sup>1</sup>-4f<sup>7</sup> transition of Eu<sup>2+</sup>. The highest emission occurs when 2.5 wt% LiCl was utilized as flux material. Moreover, through the employment of XPS characterization, it was proved that the addition of Li<sup>+</sup> ions causes higher binding energies of elements and improvement of crystallization.</p></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"61 3","pages":"815 - 824"},"PeriodicalIF":2.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asma A. Alothman, Shafqat Manzoor, Jafar Hussain Shah, Saikh Mohammad, Abdul Ghafoor Abid, Shahroz Saleem
{"title":"Development of CoFe2O4 decorated on polyaniline for optimizing oxygen evolution process in alkaline medium","authors":"Asma A. Alothman, Shafqat Manzoor, Jafar Hussain Shah, Saikh Mohammad, Abdul Ghafoor Abid, Shahroz Saleem","doi":"10.1007/s41779-024-01082-y","DOIUrl":"10.1007/s41779-024-01082-y","url":null,"abstract":"<div><p>The development of inexpensive catalysts that perform extraordinarily well in the electrochemical oxygen evolution process (OER) is necessary for the quick development of renewable energy sources. To obtain a great effect of intrinsic activity and the exposure of interfacial active sites at a greater density is often recommended when designing active and effective catalysts for OER via water splitting to attain clean energy in the form of hydrogen. In present work, cobalt ferrite (CoFe<sub>2</sub>O<sub>4</sub>) and polyaniline (PANI) are combined to design cluster-based catalysts with robust efficiency. The CoFe<sub>2</sub>O<sub>4</sub> nanoflakes in this instance are uniformly adorned with PANI to provide an electronic effect on the CoFe<sub>2</sub>O<sub>4</sub> nanoflakes. Thus, the designed interface needs an overpotential of 151 mV for OER, which is steady for up to 80 h of testing. The exceptional activity and longstanding durability are a result of the higher revelation of active sites, and faster kinetic reactions. Furthermore, the resultant material shows a small 105 mV/dec Tafel slope, offering the outstanding performance. Hence, this work proposes a novel method for designing nanostructures and for quickly producing oxide heterostructures based on transition metals, which are useful for future electrochemical applications.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"61 section","pages":"165 - 177"},"PeriodicalIF":2.1,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synergizing additive manufacturing and machine learning for advanced hydroxyapatite scaffold design in bone regeneration","authors":"Atefeh Zarei, Ashkan Farazin","doi":"10.1007/s41779-024-01084-w","DOIUrl":"10.1007/s41779-024-01084-w","url":null,"abstract":"<div><p>Additive manufacturing (AM) methods have sparked interest within the tissue engineering domain due to their adaptability and capacity to fabricate constructs featuring intricate macroscopic shapes and specific patterns. Recently, composite materials, characterized by distinct phases a continuous phase (matrix) and a reinforcing phase (filler)—have emerged as viable inks for AM processes, enabling the creation of scaffolds with enhanced biomimetic and bioactive properties. Notably, significant attention has been directed towards hydroxyapatite (HA)-reinforced composites, particularly for bone tissue engineering applications, leveraging HA’s chemical resemblance to native mineralized tissue components. This review delves into the utilization of AM techniques for processing HA-reinforced composites and biocomposites to fabricate scaffolds embedded with biological matrices, including cellular tissues. It examines recent research findings concerning the morphological, structural, and in vitro/in vivo biological characteristics of these materials. The review also categorizes the approaches based on the matrix nature used to incorporate HA reinforcements and fabricate tissue substitutes, offering a critical analysis of the current state of research and future prospects. This comprehensive overview aims to elucidate the strategies explored and challenges faced in this evolving field of materiomics.</p></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"61 3","pages":"797 - 813"},"PeriodicalIF":2.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thermodynamic research of the reaction mechanism for TiB2 synthesized by carbothermal reduction","authors":"Xingguo Wang, Xin Li, Bin Chen, Jian Tang, Shilun Chang, Chen Xu","doi":"10.1007/s41779-024-01074-y","DOIUrl":"10.1007/s41779-024-01074-y","url":null,"abstract":"<div><p>The reaction mechanism of TiB<sub>2</sub> synthesized by carbothermal reduction is unclear due to a lack of thermodynamic research. In this work, the phase diagrams of TiO<sub>2</sub>-B<sub>2</sub>O<sub>3</sub>-C system were analyzed at a large temperature range (900–1800 °C), illustrating that Ti<sub>4</sub>O<sub>7</sub>, Ti<sub>3</sub>O<sub>5</sub>, and TiC were the main intermediate products. According to the Gibbs free energy minimum principle, the synthesis pathways of the main intermediate products and the target product TiB<sub>2</sub> were discussed, respectively. Based on the thermodynamic research, the reaction mechanism of TiO<sub>2</sub>-B<sub>2</sub>O<sub>3</sub>-C system was proposed and verified by experimental research at 900–1500 °C. X-ray-pure TiB<sub>2</sub> powder was synthesized at 1500 °C for 30 min and the possible reaction mechanism could be divided into three stages: TiO<sub>2</sub>(anatase)→TiO<sub>2</sub>(rutile)→Ti<sub>3</sub>O<sub>5</sub>, TiC →TiB<sub>2</sub>.</p></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"60 5","pages":"1669 - 1678"},"PeriodicalIF":1.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nur Nasyita Binti Kamaruddin, Syed Bahari Ramadzan Syed Adnan, Zainal Abidin Ali, Gopinath Venkatraman, Maryam Mohammed Mashghan
{"title":"Structural, mechanical and antibacterial properties of Mg2Sio4-clay based nanoparticles for biomedical application","authors":"Nur Nasyita Binti Kamaruddin, Syed Bahari Ramadzan Syed Adnan, Zainal Abidin Ali, Gopinath Venkatraman, Maryam Mohammed Mashghan","doi":"10.1007/s41779-024-01080-0","DOIUrl":"10.1007/s41779-024-01080-0","url":null,"abstract":"<div><p>Clay based Forsterite (Mg<sub>2</sub>SiO<sub>4</sub>-clay based) was synthesized using Halloysite nanotube clay via sol-gel method. The resultant materials were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), particle size analysis (PSA), and hardness analysis. The formation of Mg<sub>2</sub>SiO<sub>4</sub>-clay based nanoparticles was confirmed using X-ray diffraction and Fourier-transform infrared analysis. Mg<sub>2</sub>SiO<sub>4</sub>-clay based nanoparticles were treated at different high temperatures which are from 850 °C to 1050 °C. It was revealed that crystalline Mg<sub>2</sub>SiO<sub>4</sub>-clay based was formed at the lowest temperature (850 °C) and the different temperatures do not significantly affect the FTIR peaks. Moreover, the hardness and fracture toughness of Mg<sub>2</sub>SiO<sub>4</sub>-clay based was found to be higher than synth-Mg<sub>2</sub>SiO<sub>4,</sub> which are 1.03 ± 0.07 GPa and 5.7 ± 0.21 MPa m<sup>1/2,</sup> respectively. It was also found that the fracture toughness of Mg<sub>2</sub>SiO<sub>4</sub>-clay based was higher than a few types of cortical bones and synthetic Hydroxyapatite. Other than that, Mg<sub>2</sub>SiO<sub>4</sub>-clay based displayed remarkable antibacterial properties which is critical criteria for implant materials. These findings suggest that the Mg<sub>2</sub>SiO<sub>4</sub>-clay based possesses good structural, mechanical, and antibacterial properties and might be suitable for potential bioimplant materials.</p></div>","PeriodicalId":673,"journal":{"name":"Journal of the Australian Ceramic Society","volume":"61 3","pages":"785 - 796"},"PeriodicalIF":2.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}