血液科学(英文)最新文献_第8页

RNA m⁶A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia. RNA m6A修饰:在急性髓性白血病中的定位方法、作用和机制。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000131

Rong Yin, Yashu Li, Wen Tian, Fuling Zhou, Haojian Zhang

{"title":"RNA m6A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia.","authors":"Rong Yin, Yashu Li, Wen Tian, Fuling Zhou, Haojian Zhang","doi":"10.1097/BS9.0000000000000131","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000131","url":null,"abstract":"N6-Methyladenosine (m6A) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that m6A modification plays a key role in hematologic malignancies, including acute myeloid leukemia. The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA m6A modification in a transcriptome-wide manner. In this review, we first briefly summarize the latest advances in RNA m6A biology by focusing on writers, readers, and erasers of m6A modification, and describe the development of high-throughput methods for RNA m6A mapping. We further discuss the important roles of m6A modifiers in acute myeloid leukemia, and highlight the identification of potential inhibitors for AML treatment by targeting of m6A modifiers. Overall, this review provides a comprehensive summary of RNA m6A biology in acute myeloid leukemia.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis. diulfiram是一种醛脱氢酶抑制剂，作为一种有效的药物，通过NETosis, pyroptosis, apoptosis, ferroptosis和cuprotosis治疗败血症和癌症。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000117

Dingrui Nie, Cunte Chen, Yangqiu Li, Chengwu Zeng

引用次数: 9

Beyond the horizon: the newly found sinner disturbing mesenchymal stromal niche. 地平线之外:新发现的罪人干扰间充质间质壁龛。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000119

Xi Zhang

{"title":"Beyond the horizon: the newly found sinner disturbing mesenchymal stromal niche.","authors":"Xi Zhang","doi":"10.1097/BS9.0000000000000119","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000119","url":null,"abstract":"Hematopoietic stem-cell transplantation (HSCT) is an important, potentially curative therapeutic option for hema-tological malignancies. However, poor and slow hematopoi- etic reconstitution remains a significant complication, which is correlated with abnormal hematopoietic stem-cell (HSC) func- tion. The maintenance and the preservation of HSC functional properties are supported by a highly specialized microenviron- ment within the bone marrow (BM), in which BM-derived mesenchymal stem cells (BMSCs) serve as the essential structural and functional basis for constituting the BM microenviron-ment. Damage, such as that due to chemotherapy, radiother- apy or inflammation, delays hematopoietic recovery or causes hematopoiesis dysfunction or failure, seriously affecting HSCT efficacy. 1 The key to remodeling and repairing the BM micro-environment lies in the repair of the niche structure by cellular therapies which include BMSCs. Research has increasingly confirmed that the most crucial functions of BMSCs are to main- tain the turnover of the BM stroma and skeletal tissues and to provide critical hematopoietic support. 2 However, the underly-ing mechanisms that regulate these different functions are not well known. In the recent BLOOD publication, the Dr. Zhao and Dr. Jiang group revealed that the retinoic acid-inducible gene I (RIG-I) plays a substantial role in regulating the stromal niche for hematopoietic reconstitution. 3 All-trans retinoic acid (ATRA) and inflammation stress upregulated RIG-I expres- sion, thus damaging the clonogenicity, the bone-forming ability of BMSCs and the supporting function in the stromal niche; mechanistically, this is achieved by suppressing the antioxidant impact of nuclear","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/9b/bs9-4-179.PMC9742105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10731050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological targeting EZH2 to modulate chronic graft-versus-host disease. 药物靶向EZH2调节慢性移植物抗宿主病。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000125

Ying Wang

引用次数: 0

Passion for moments and compassion for patients: in memory of Dr. Jianfeng Zhou (1966–2022) 对时刻的激情和对病人的同情:纪念周剑锋医生(1966-2022)

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000116

L. Qiu, Weiping Yuan, Gang Huang, Liang Huang

引用次数: 0

Comprehensive view on genetic features, therapeutic modalities and prognostic models in adult T-cell lymphoblastic lymphoma. 成人t细胞淋巴母细胞淋巴瘤的遗传特征、治疗方式和预后模式的综合观点。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000114

Qihua Zou, Shuyun Ma, Xiaopeng Tian, Qingqing Cai

{"title":"Comprehensive view on genetic features, therapeutic modalities and prognostic models in adult T-cell lymphoblastic lymphoma.","authors":"Qihua Zou, Shuyun Ma, Xiaopeng Tian, Qingqing Cai","doi":"10.1097/BS9.0000000000000114","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000114","url":null,"abstract":"Adult T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that differs from pediatric T-LBL and has a worse prognosis. Due to its rarity, little is known about the genetic and molecular characteristics, optimal treatment modalities, and prognostic factors of adult T-LBL. Therefore, we summarized the existing studies to comprehensively discuss the above issues in this review. Genetic mutations of NOTCH1/FBXW7, PTEN, RAS, and KMT2D, together with abnormal activation of signaling pathways, such as the JAK-STAT signaling pathway were described. We also discussed the therapeutic modalities. Once diagnosed, adult T-LBL patients should receive intensive or pediatric acute lymphoblastic leukemia regimen and central nervous system prophylaxis as soon as possible, and cranial radiation-free protocols are appropriate. Mediastinal radiotherapy improves clinical outcomes, but adverse events are of concern. Hematopoietic stem cell transplantation may be considered for adult T-LBL patients with high-risk factors or those with relapsed/refractory disease. Besides, several novel prognostic models have been constructed, such as the 5-miRNAs-based classifier, 11-gene-based classifier, and 4-CpG-based classifier, which have presented significant prognostic value in adult T-LBL.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Small noncoding RNAs play superior roles in maintaining hematopoietic stem cell homeostasis. 小的非编码rna在维持造血干细胞稳态中发挥着优越的作用。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000123

Hui Wang, Wenchang Qian, Yingli Han, Pengxu Qian

{"title":"Small noncoding RNAs play superior roles in maintaining hematopoietic stem cell homeostasis.","authors":"Hui Wang, Wenchang Qian, Yingli Han, Pengxu Qian","doi":"10.1097/BS9.0000000000000123","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000123","url":null,"abstract":"The maintenance of the mammalian blood system depends on hematopoietic stem cells (HSCs), which are a rare class of adult stem cells with self-renewal and multilineage differentiation capacities. The homeostasis of hematopoietic stem cells is finely tuned by a variety of endogenous and exogenous regulatory factors, and disrupted balance will lead to hematological diseases including leukemia and anemia. Recently, emerging studies have illustrated the cellular and molecular mechanisms underlying the regulation of HSC homeostasis. Particularly, the rapid development of second-generation sequencing technologies has uncovered that many small noncoding RNAs (ncRNAs) are highly expressed in HSCs, including snoRNAs, miRNAs, tsRNAs, circular RNAs, etc. In this study, we will summarize the essential roles and regulatory mechanisms of these small ncRNAs in maintaining HSC homeostasis. Overall, this review provides up-to-date information in the regulation of HSC homeostasis by small ncRNAs, which sheds light into the development of therapeutic strategies against hematopoietic malignancies.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NEK2, a promising target in TP53 mutant cancer. NEK2, TP53突变癌症的一个有希望的靶点。

血液科学(英文) Pub Date : 2022-05-17 eCollection Date: 2022-04-01 DOI: 10.1097/BS9.0000000000000106

Martina Cusan, Lili Wang

引用次数: 1

Complicated multiple organ infection of Purpureocillium lilacinum and varicella-zoster virus infection in a patient with Evans' syndrome. Evans综合征并发紫丁香紫球菌多脏器感染及水痘带状疱疹病毒感染1例。

血液科学(英文) Pub Date : 2022-05-17 eCollection Date: 2022-04-01 DOI: 10.1097/BS9.0000000000000107

Xiangrong Hu, Li Zhang, Qingsong Lin, Fengkui Zhang, Xin Zhao

引用次数: 1

LILRB4, an immune checkpoint on myeloid cells. LILRB4，骨髓细胞的免疫检查点。

血液科学(英文) Pub Date : 2022-05-17 eCollection Date: 2022-04-01 DOI: 10.1097/BS9.0000000000000109

Ting Yang, Yixin Qian, Xiaoting Liang, Jianbo Wu, Ming Zou, Mi Deng

引用次数: 2