血液科学(英文)Pub Date : 2022-07-01DOI: 10.1097/BS9.0000000000000119
Xi Zhang
{"title":"Beyond the horizon: the newly found sinner disturbing mesenchymal stromal niche.","authors":"Xi Zhang","doi":"10.1097/BS9.0000000000000119","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000119","url":null,"abstract":"Hematopoietic stem-cell transplantation (HSCT) is an important, potentially curative therapeutic option for hema-tological malignancies. However, poor and slow hematopoi- etic reconstitution remains a significant complication, which is correlated with abnormal hematopoietic stem-cell (HSC) func- tion. The maintenance and the preservation of HSC functional properties are supported by a highly specialized microenviron- ment within the bone marrow (BM), in which BM-derived mesenchymal stem cells (BMSCs) serve as the essential structural and functional basis for constituting the BM microenviron-ment. Damage, such as that due to chemotherapy, radiother- apy or inflammation, delays hematopoietic recovery or causes hematopoiesis dysfunction or failure, seriously affecting HSCT efficacy. 1 The key to remodeling and repairing the BM micro-environment lies in the repair of the niche structure by cellular therapies which include BMSCs. Research has increasingly confirmed that the most crucial functions of BMSCs are to main- tain the turnover of the BM stroma and skeletal tissues and to provide critical hematopoietic support. 2 However, the underly-ing mechanisms that regulate these different functions are not well known. In the recent BLOOD publication, the Dr. Zhao and Dr. Jiang group revealed that the retinoic acid-inducible gene I (RIG-I) plays a substantial role in regulating the stromal niche for hematopoietic reconstitution. 3 All-trans retinoic acid (ATRA) and inflammation stress upregulated RIG-I expres- sion, thus damaging the clonogenicity, the bone-forming ability of BMSCs and the supporting function in the stromal niche; mechanistically, this is achieved by suppressing the antioxidant impact of nuclear","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"179-180"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/9b/bs9-4-179.PMC9742105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10731050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
血液科学(英文)Pub Date : 2022-07-01DOI: 10.1097/BS9.0000000000000114
Qihua Zou, Shuyun Ma, Xiaopeng Tian, Qingqing Cai
{"title":"Comprehensive view on genetic features, therapeutic modalities and prognostic models in adult T-cell lymphoblastic lymphoma.","authors":"Qihua Zou, Shuyun Ma, Xiaopeng Tian, Qingqing Cai","doi":"10.1097/BS9.0000000000000114","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000114","url":null,"abstract":"<p><p>Adult T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that differs from pediatric T-LBL and has a worse prognosis. Due to its rarity, little is known about the genetic and molecular characteristics, optimal treatment modalities, and prognostic factors of adult T-LBL. Therefore, we summarized the existing studies to comprehensively discuss the above issues in this review. Genetic mutations of <i>NOTCH1/FBXW7</i>, <i>PTEN</i>, <i>RAS</i>, and <i>KMT2D</i>, together with abnormal activation of signaling pathways, such as the JAK-STAT signaling pathway were described. We also discussed the therapeutic modalities. Once diagnosed, adult T-LBL patients should receive intensive or pediatric acute lymphoblastic leukemia regimen and central nervous system prophylaxis as soon as possible, and cranial radiation-free protocols are appropriate. Mediastinal radiotherapy improves clinical outcomes, but adverse events are of concern. Hematopoietic stem cell transplantation may be considered for adult T-LBL patients with high-risk factors or those with relapsed/refractory disease. Besides, several novel prognostic models have been constructed, such as the 5-miRNAs-based classifier, 11-gene-based classifier, and 4-CpG-based classifier, which have presented significant prognostic value in adult T-LBL.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"155-160"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
血液科学(英文)Pub Date : 2022-07-01DOI: 10.1097/BS9.0000000000000123
Hui Wang, Wenchang Qian, Yingli Han, Pengxu Qian
{"title":"Small noncoding RNAs play superior roles in maintaining hematopoietic stem cell homeostasis.","authors":"Hui Wang, Wenchang Qian, Yingli Han, Pengxu Qian","doi":"10.1097/BS9.0000000000000123","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000123","url":null,"abstract":"<p><p>The maintenance of the mammalian blood system depends on hematopoietic stem cells (HSCs), which are a rare class of adult stem cells with self-renewal and multilineage differentiation capacities. The homeostasis of hematopoietic stem cells is finely tuned by a variety of endogenous and exogenous regulatory factors, and disrupted balance will lead to hematological diseases including leukemia and anemia. Recently, emerging studies have illustrated the cellular and molecular mechanisms underlying the regulation of HSC homeostasis. Particularly, the rapid development of second-generation sequencing technologies has uncovered that many small noncoding RNAs (ncRNAs) are highly expressed in HSCs, including snoRNAs, miRNAs, tsRNAs, circular RNAs, etc. In this study, we will summarize the essential roles and regulatory mechanisms of these small ncRNAs in maintaining HSC homeostasis. Overall, this review provides up-to-date information in the regulation of HSC homeostasis by small ncRNAs, which sheds light into the development of therapeutic strategies against hematopoietic malignancies.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"125-132"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
血液科学(英文)Pub Date : 2022-04-01DOI: 10.1097/BS9.0000000000000105
Cheng Cheng Zhang
{"title":"An old player, the right niche.","authors":"Cheng Cheng Zhang","doi":"10.1097/BS9.0000000000000105","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000105","url":null,"abstract":"The cellular and molecular components of the niche for hematopoietic stem cells (HSCs) are still not well de fi ned. Angiopoietin-like proteins (Angptls) are a group of secreted glycoproteins that have been reported to play various roles, including the regulation of HSC activity. 1 Speci fi cally, Angptl2, a member of the Angptl family, was demonstrated to support HSC stemness through binding to inhibitory receptors. 2 Angptl2 has also been shown to support HSC activity in exosomes. 3 However, whether and how Angptl2 regulates HSC activities in the HSC niche were still unknown. Yu et al used an elegant approach to study these questions. 1 Based on the expression pattern of Angptl2 in bone marrow, several conditional knockout (KO) mice were generated to deplete Angptl2 from endothelial, mesenchymal stromal cells, megakaryocytes, and HSCs. Using a number of functional assays, including reconstitution analysis, fl ow cytometry, and immuno fl uorescence microscopy, the authors discovered that only endothelial cell-derived Angptl2 but not Angptl2 from other niche cell types supported the repopulation capacity, quiescent status, and niche localization of HSCs. They further demonstrated that Angptl2 enhances peroxisome-proliferator-activated receptor D expression to transactivate G0s2 and sustain the perinuclear localization of nucleolin that prevents HSCs from entering the cell cycle. study HSCs","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 2","pages":"99"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/fd/bls-4-99.PMC9354721.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10798013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
血液科学(英文)Pub Date : 2022-03-08eCollection Date: 2021-07-01DOI: 10.1097/BS9.0000000000000087
{"title":"Erratum: Tcf12 balances the reconstitution and differentiation capacity of hematopoietic stem cell.","authors":"","doi":"10.1097/BS9.0000000000000087","DOIUrl":"10.1097/BS9.0000000000000087","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000059.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"3 1","pages":"105"},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42369757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
血液科学(英文)Pub Date : 2022-03-08eCollection Date: 2021-07-01DOI: 10.1097/BS9.0000000000000085
{"title":"Erratum: Loss of Tet2 affects platelet function but not coagulation in mice.","authors":"","doi":"10.1097/BS9.0000000000000085","DOIUrl":"10.1097/BS9.0000000000000085","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000055.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"3 1","pages":"103"},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42748213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
血液科学(英文)Pub Date : 2022-03-08eCollection Date: 2021-07-01DOI: 10.1097/BS9.0000000000000086
{"title":"Erratum: ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells.","authors":"","doi":"10.1097/BS9.0000000000000086","DOIUrl":"10.1097/BS9.0000000000000086","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000057.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"3 1","pages":"104"},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48851399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}