血液科学(英文)最新文献

{"title":"Application of fresh frozen plasma transfusion in the management of excessive warfarin-associated anticoagulation.","authors":"Yuanyuan Luo,&nbsp;Chunya Ma,&nbsp;Yang Yu","doi":"10.1097/BS9.0000000000000108","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000108","url":null,"abstract":"<p><p>Warfarin is a commonly used oral anticoagulant. Patients with artificial valve replacement, atrial fibrillation, pulmonary embolism, deep vein thrombosis, and other diseases require long-term anticoagulant oral treatment with warfarin. As warfarin exhibits prompt action with long maintenance time, it has become a key drug for the treatment of patients at risk of developing thrombosis or thromboembolism. Warfarin is a bican coumarin anticoagulant, that exhibits competitive action against vitamin K as its mechanism of action, thereby inhibiting the synthesis of coagulation factors-predominantly the vitamin K-dependent coagulation factors II, VII, IX, and X-in hepatocytes. Long-term warfarin is known to significantly increase the risk of organ bleeding in some patients, while some patients may need to reverse the anticoagulation effect. For instance, patients scheduled for emergency or invasive surgery may require rapid anticoagulation reversal. During such medical circumstances, fresh frozen plasma (FFP) is clinically used for the reversal of excess warfarin-associated anticoagulation, as it contains all the coagulation factors that can alleviate the abnormal blood anticoagulation status in such patients. Accordingly, this article aims to perform an in-depth review of relevant literature on the reversal of warfarin with FFP, and insightful deliberation of the application and efficacy of this clinical intervention.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/24/bls-4-57.PMC9362864.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40715318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.","authors":"Biao Shen,&nbsp;Yueshen Ma,&nbsp;Haixiao Zhang,&nbsp;Mingyang Wang,&nbsp;Jia Liu,&nbsp;Jiaxin Cao,&nbsp;Wenwen Guo,&nbsp;Dan Feng,&nbsp;Donglin Yang,&nbsp;Rongli Zhang,&nbsp;Xin Chen,&nbsp;Qiaoling Ma,&nbsp;Weihua Zhai,&nbsp;Sizhou Feng,&nbsp;Mingzhe Han,&nbsp;Aiming Pang,&nbsp;Erlie Jiang","doi":"10.1097/BS9.0000000000000110","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000110","url":null,"abstract":"<p><p>Hemorrhagic cystitis (HC) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT). The incidence is about 7% to 68%, and some patients have to suffer a long period of frequent, urgent, and painful urination, which brings great pain. This study aimed to analyze risk factors of HC and its effect on patient survival. We collected the medical records of 859 patients who underwent HSCT at our hospital between August 2016 and August 2020. Patients with and without HC were matched using propensity score matching at a 1:1 ratio based on sex, age, and diagnosis, and logistic regression analyses were used to identify factors associated with HC. We used Kaplan-Meier curves to analyze the survival rates of patients in the HC and non-HC groups. We also analyzed the relationship between BK viral load and the occurrence of HC using receiver operating characteristic curve (ROC) analysis. After propensity score matching, there were 131 patients each in the HC and non-HC groups. In the HC group, 89 patients (67.9%) had mild HC (stage II°) and 43 (32.1%) had severe HC (stage III-IV). The median interval between stem cell transplantation and HC development was 31 (3-244) days. Univariate analysis indicated that donor age, hematopoietic stem cell source, HLA, acute graft-versus-host disease, busulfan, anti-thymocyte globulin (ATG), total body irradiation, cytomegalovirus (CMV) (urine), and BK polyomavirus (BKV) (urine) were significantly associated with HC. ATG, CMV (urine), and BKV (urine) were independent risk factors for HC based on the multivariate analysis. The Kaplan-Meier survival analysis showed no significant difference between the HC and non-HC groups (<i>P</i> = .14). The 1- and 2-year survival rates in the HC group were 78.4% and 69.6%, respectively, and the corresponding rates in the non-HC group were 84.4% and 80.7%, respectively. ROC analysis indicated that a urine BKV load of 1 × 10⁷ copies/mL was able to stratify the risk of HC. In conclusion, when the BKV load is >1 × 10⁷, we need to be aware of the potential for the development of HC.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/7e/bls-4-83.PMC9362868.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40715321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell analysis of transcription factor regulatory networks reveals molecular basis for subtype-specific dysregulation in acute myeloid leukemia.","authors":"Ruixia Sun,&nbsp;Lina Sun,&nbsp;Xiaowei Xie,&nbsp;Xuan Li,&nbsp;Peng Wu,&nbsp;Lu Wang,&nbsp;Ping Zhu","doi":"10.1097/BS9.0000000000000113","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000113","url":null,"abstract":"<p><p>Highly heterogeneous acute myeloid leukemia (AML) exhibits dysregulated transcriptional programs. Transcription factor (TF) regulatory networks underlying AML subtypes have not been elucidated at single-cell resolution. Here, we comprehensively mapped malignancy-related TFs activated in different AML subtypes by analyzing single-cell RNA sequencing data from AMLs and healthy donors. We first identified six modules of regulatory networks which were prevalently dysregulated in all AML patients. AML subtypes featured with different malignant cellular composition possessed subtype-specific regulatory TFs associated with differentiation suppression or immune modulation. At last, we validated that ERF was crucial for the development of hematopoietic stem/progenitor cells by performing loss- and gain-of-function experiments in zebrafish embryos. Collectively, our work thoroughly documents an abnormal spectrum of transcriptional regulatory networks in AML and reveals subtype-specific dysregulation basis, which provides a prospective view to AML pathogenesis and potential targets for both diagnosis and therapy.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/c4/bls-4-65.PMC9362874.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40715322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of STAT5b-RARA positive acute promyelocytic leukemia by Venetoclax combining with homoharringtonine, cytarabine: A case report and literature review.","authors":"Guangji Zhang,&nbsp;Yang Song,&nbsp;Li Wan,&nbsp;Kaiqi Liu,&nbsp;Shaowei Qiu,&nbsp;Jianxiang Wang,&nbsp;Yingchang Mi","doi":"10.1097/BS9.0000000000000111","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000111","url":null,"abstract":"<p><strong>Introduction: </strong>Acute promyelocytic leukemia (APL) is mostly due to the chromosome translocation t (15; 17) (q22; q12), leading to the formation of <i>PML-RARA</i> fusion protein. Some patients carried rare translocation involving RARA gene, who were called variant APL caused by RAR family (RARA, RARB, and RARG) and partner genes. <i>STAT5b-RARA</i> was a rare type of molecular genetic abnormality with unfavorable prognosis which have been reported in only 18 cases in variant APL. Knowledge of <i>STAT5b-RARA</i> (+) APL treatment is still limited.</p><p><strong>Case report: </strong>We presented a 38-year-old female variant APL case, who was <i>STAT5b-RARA</i> positive detected by reverse transcription polymerase chain reaction. The patient failed to respond after four-drug combined induction chemotherapy: idarubicin, cytarabine, all trans retinoic acid, and arsenic trioxide (As₂O₃). Then, the patient was re-induced with azacytidine, but still failed to achieve complete remission (CR). Next, she was treated with Venetoclax combining with homoharringtonine and cytarabine as the salvage therapy and achieved CR. Later, the patient received hematopoietic stem cell transplantation after 4 cycles of consolidation therapy.</p><p><strong>Conclusion: </strong>Venetoclax combining with homoharringtonine and cytarabine has been used as the salvage therapy in the <i>STAT5b-RARA</i> positive APL successfully.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/b3/bls-4-93.PMC9362865.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40715319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An old player, the right niche.","authors":"Cheng Cheng Zhang","doi":"10.1097/BS9.0000000000000105","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000105","url":null,"abstract":"The cellular and molecular components of the niche for hematopoietic stem cells (HSCs) are still not well de fi ned. Angiopoietin-like proteins (Angptls) are a group of secreted glycoproteins that have been reported to play various roles, including the regulation of HSC activity. 1 Speci fi cally, Angptl2, a member of the Angptl family, was demonstrated to support HSC stemness through binding to inhibitory receptors. 2 Angptl2 has also been shown to support HSC activity in exosomes. 3 However, whether and how Angptl2 regulates HSC activities in the HSC niche were still unknown. Yu et al used an elegant approach to study these questions. 1 Based on the expression pattern of Angptl2 in bone marrow, several conditional knockout (KO) mice were generated to deplete Angptl2 from endothelial, mesenchymal stromal cells, megakaryocytes, and HSCs. Using a number of functional assays, including reconstitution analysis, fl ow cytometry, and immuno fl uorescence microscopy, the authors discovered that only endothelial cell-derived Angptl2 but not Angptl2 from other niche cell types supported the repopulation capacity, quiescent status, and niche localization of HSCs. They further demonstrated that Angptl2 enhances peroxisome-proliferator-activated receptor D expression to transactivate G0s2 and sustain the perinuclear localization of nucleolin that prevents HSCs from entering the cell cycle. study HSCs","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/fd/bls-4-99.PMC9354721.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10798013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Tcf12 balances the reconstitution and differentiation capacity of hematopoietic stem cell.","authors":"","doi":"10.1097/BS9.0000000000000087","DOIUrl":"10.1097/BS9.0000000000000087","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000059.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42369757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Loss of Tet2 affects platelet function but not coagulation in mice.","authors":"","doi":"10.1097/BS9.0000000000000085","DOIUrl":"10.1097/BS9.0000000000000085","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000055.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42748213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis.","authors":"","doi":"10.1097/BS9.0000000000000088","DOIUrl":"10.1097/BS9.0000000000000088","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000064.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49480712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis.","authors":"","doi":"10.1097/BS9.0000000000000084","DOIUrl":"10.1097/BS9.0000000000000084","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000051.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43805095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells.","authors":"","doi":"10.1097/BS9.0000000000000086","DOIUrl":"10.1097/BS9.0000000000000086","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000057.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48851399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}