血液科学(英文)最新文献_第9页

Erratum: IL-12 supports in vitro self-renewal of LT HSC. IL-12支持LT-HSC的体外自我更新

IF 1.5

血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000080

引用次数: 0

Erratum: A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow. 解释骨髓中WHIM中性粒细胞积聚的趋化模型

IF 1.5

血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000081

引用次数: 0

Erratum: Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells. 小鼠多能干细胞再生免疫活性T细胞的两步方案

IF 1.5

血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000083

引用次数: 0

Erratum: RNA editing enzyme ADAR1 is required for early T cell development. RNA编辑酶ADAR1是早期T细胞发育所必需的

IF 1.5

血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000082

引用次数: 0

Erratum: Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases. 勘误：血小板减少症中巨核细胞的超微结构改变：43 例病例回顾。

IF 1.5

血液科学(英文) Pub Date : 2022-02-15 eCollection Date: 2022-01-01 DOI: 10.1097/BS9.0000000000000096

引用次数: 0

Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia. 综合基因组分析确定T细胞急性淋巴细胞白血病的高危因素和可操作的靶点

IF 1.5

血液科学(英文) Pub Date : 2022-02-04 eCollection Date: 2022-01-01 DOI: 10.1097/BS9.0000000000000102

Haichuan Zhu, Bingjie Dong, Yingchi Zhang, Mei Wang, Jianan Rao, Bowen Cui, Yu Liu, Qian Jiang, Weitao Wang, Lu Yang, Anqi Yu, Zongru Li, Chao Liu, Leping Zhang, Xiaojun Huang, Xiaofan Zhu, Hong Wu

{"title":"Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia.","authors":"Haichuan Zhu, Bingjie Dong, Yingchi Zhang, Mei Wang, Jianan Rao, Bowen Cui, Yu Liu, Qian Jiang, Weitao Wang, Lu Yang, Anqi Yu, Zongru Li, Chao Liu, Leping Zhang, Xiaojun Huang, Xiaofan Zhu, Hong Wu","doi":"10.1097/BS9.0000000000000102","DOIUrl":"10.1097/BS9.0000000000000102","url":null,"abstract":"T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy often associated with poor outcomes. To identify high-risk factors and potential actionable targets for T-ALL, we perform integrated genomic and transcriptomic analyses on samples from 165 Chinese pediatric and adult T-ALL patients, of whom 85% have outcome information. The genomic mutation landscape of this Chinese cohort is very similar to the Western cohort published previously, except that the rate of NOTCH1 mutations is significant lower in the Chinese T-ALL patients. Among 47 recurrently mutated genes in 7 functional categories, we identify RAS pathway and PTEN mutations as poor survival factors for non-TAL and TAL subtypes, respectively. Mutations in the PI3K pathway are mutually exclusive with mutations in the RAS and NOTCH1 pathways as well as transcription factors. Further analysis demonstrates that approximately 43% of the high-risk patients harbor at least one potential actionable alteration identified in this study, and T-ALLs with RAS pathway mutations are hypersensitive to MEKi in vitro and in vivo. Thus, our integrated genomic analyses not only systematically identify high-risk factors but suggest that these high-risk factors are promising targets for T-ALL therapies.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 1","pages":"16-28"},"PeriodicalIF":1.5,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48694676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In memory of Hal E. Broxmeyer, a pluripotent scientist, pioneer, and mentor. 纪念全能科学家、先驱和导师Hal E.Broxmeyer

IF 1.5

血液科学(英文) Pub Date : 2022-01-25 eCollection Date: 2022-01-01 DOI: 10.1097/BS9.0000000000000100

Linzhao Cheng, Bin Guo, Xinxin Huang, Tao Cheng

引用次数: 0

China's top 10 hematological advances in 2021 lists the key developments in hematology in China for that year. 2021年中国血液学十大进展列出了当年中国血液学的关键进展

IF 1.5

血液科学(英文) Pub Date : 2022-01-25 eCollection Date: 2022-01-01 DOI: 10.1097/BS9.0000000000000103

Xiaochen Wang

引用次数: 0

DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination. DNAH2通过调控FANCD2泛素化促进Fanconi贫血通路的同源重组修复

IF 1.5

血液科学(英文) Pub Date : 2021-06-07 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000076

Lixian Chang, Xingjie Gao, Yuxia Wang, Chunmin Huang, Min Gao, Xiaomin Wang, Chao Liu, Wenqi Wu, Wenbin An, Yang Wan, Aoli Zhang, Yingchi Zhang, Weiping Yuan, Xiaofan Zhu

{"title":"DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination.","authors":"Lixian Chang, Xingjie Gao, Yuxia Wang, Chunmin Huang, Min Gao, Xiaomin Wang, Chao Liu, Wenqi Wu, Wenbin An, Yang Wan, Aoli Zhang, Yingchi Zhang, Weiping Yuan, Xiaofan Zhu","doi":"10.1097/BS9.0000000000000076","DOIUrl":"10.1097/BS9.0000000000000076","url":null,"abstract":"Fanconi anemia (FA), an X-linked genetic or autosomal recessive disease, exhibits complicated pathogenesis. Previously, we detected the mutated Dynein Axonemal Heavy Chain 2 (DNAH2) gene in 2 FA cases. Herein, we further investigated the potential association between DNAH2 and the homologous recombination repair pathway of FA. The assays of homologous recombination repair, mitomycin C (MMC) sensitivity, immunofluorescence, and ubiquitination modification were performed in U2OS and DR-U2OS cell lines. In MMC-treated U2OS cells, the downregulation of the DNAH2 gene increased the sensitivity of cells to DNA inter-strand crosslinks. We also observed the reduced enrichment of FANCD2 protein to DNA damage sites. Furthermore, the ubiquitination modification level of FANCD2 was influenced by the deficiency of DNAH2. Thus, our results suggest that DNAH2 may modulate the cell homologous recombination repair partially by increasing the ubiquitination and the enrichment to DNA damage sites of FANCD2. DNAH2 may act as a novel co-pathogenic gene of FA patients.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"3 1","pages":"71-77"},"PeriodicalIF":1.5,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42344691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DDIT4 mediates the proliferation-promotive effect of IL-34 in human monocytic leukemia cells. DDIT4介导IL-34对人单核细胞白血病细胞增殖的促进作用

IF 1.5

血液科学(英文) Pub Date : 2021-04-27 eCollection Date: 2021-04-01 DOI: 10.1097/BS9.0000000000000069

Xiaoqian Lv, Yuting Hu, Lina Wang, Dongyue Zhang, Hao Wang, Yibo Dai, Xiaoxi Cui, Guoguang Zheng

引用次数: 0