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Treatment of STAT5b-RARA positive acute promyelocytic leukemia by Venetoclax combining with homoharringtonine, cytarabine: A case report and literature review. Venetoclax联合高杉碱、阿糖胞苷治疗STAT5b-RARA阳性急性早幼粒细胞白血病1例并文献复习。
血液科学(英文) Pub Date : 2022-05-17 eCollection Date: 2022-04-01 DOI: 10.1097/BS9.0000000000000111
Guangji Zhang, Yang Song, Li Wan, Kaiqi Liu, Shaowei Qiu, Jianxiang Wang, Yingchang Mi
{"title":"Treatment of STAT5b-RARA positive acute promyelocytic leukemia by Venetoclax combining with homoharringtonine, cytarabine: A case report and literature review.","authors":"Guangji Zhang,&nbsp;Yang Song,&nbsp;Li Wan,&nbsp;Kaiqi Liu,&nbsp;Shaowei Qiu,&nbsp;Jianxiang Wang,&nbsp;Yingchang Mi","doi":"10.1097/BS9.0000000000000111","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000111","url":null,"abstract":"<p><strong>Introduction: </strong>Acute promyelocytic leukemia (APL) is mostly due to the chromosome translocation t (15; 17) (q22; q12), leading to the formation of <i>PML-RARA</i> fusion protein. Some patients carried rare translocation involving RARA gene, who were called variant APL caused by RAR family (RARA, RARB, and RARG) and partner genes. <i>STAT5b-RARA</i> was a rare type of molecular genetic abnormality with unfavorable prognosis which have been reported in only 18 cases in variant APL. Knowledge of <i>STAT5b-RARA</i> (+) APL treatment is still limited.</p><p><strong>Case report: </strong>We presented a 38-year-old female variant APL case, who was <i>STAT5b-RARA</i> positive detected by reverse transcription polymerase chain reaction. The patient failed to respond after four-drug combined induction chemotherapy: idarubicin, cytarabine, all trans retinoic acid, and arsenic trioxide (As<sub>2</sub>O<sub>3</sub>). Then, the patient was re-induced with azacytidine, but still failed to achieve complete remission (CR). Next, she was treated with Venetoclax combining with homoharringtonine and cytarabine as the salvage therapy and achieved CR. Later, the patient received hematopoietic stem cell transplantation after 4 cycles of consolidation therapy.</p><p><strong>Conclusion: </strong>Venetoclax combining with homoharringtonine and cytarabine has been used as the salvage therapy in the <i>STAT5b-RARA</i> positive APL successfully.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/b3/bls-4-93.PMC9362865.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40715319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An old player, the right niche. 老玩家，合适的利基市场。
血液科学(英文) Pub Date : 2022-04-01 DOI: 10.1097/BS9.0000000000000105
Cheng Cheng Zhang
{"title":"An old player, the right niche.","authors":"Cheng Cheng Zhang","doi":"10.1097/BS9.0000000000000105","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000105","url":null,"abstract":"The cellular and molecular components of the niche for hematopoietic stem cells (HSCs) are still not well de fi ned. Angiopoietin-like proteins (Angptls) are a group of secreted glycoproteins that have been reported to play various roles, including the regulation of HSC activity. 1 Speci fi cally, Angptl2, a member of the Angptl family, was demonstrated to support HSC stemness through binding to inhibitory receptors. 2 Angptl2 has also been shown to support HSC activity in exosomes. 3 However, whether and how Angptl2 regulates HSC activities in the HSC niche were still unknown. Yu et al used an elegant approach to study these questions. 1 Based on the expression pattern of Angptl2 in bone marrow, several conditional knockout (KO) mice were generated to deplete Angptl2 from endothelial, mesenchymal stromal cells, megakaryocytes, and HSCs. Using a number of functional assays, including reconstitution analysis, fl ow cytometry, and immuno fl uorescence microscopy, the authors discovered that only endothelial cell-derived Angptl2 but not Angptl2 from other niche cell types supported the repopulation capacity, quiescent status, and niche localization of HSCs. They further demonstrated that Angptl2 enhances peroxisome-proliferator-activated receptor D expression to transactivate G0s2 and sustain the perinuclear localization of nucleolin that prevents HSCs from entering the cell cycle. study HSCs","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/fd/bls-4-99.PMC9354721.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10798013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Tcf12 balances the reconstitution and differentiation capacity of hematopoietic stem cell. Tcf12平衡造血干细胞的重构和分化能力
IF 1.5
血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000087
{"title":"Erratum: Tcf12 balances the reconstitution and differentiation capacity of hematopoietic stem cell.","authors":"","doi":"10.1097/BS9.0000000000000087","DOIUrl":"10.1097/BS9.0000000000000087","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000059.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42369757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Loss of Tet2 affects platelet function but not coagulation in mice. Tet2缺失影响小鼠血小板功能，但不影响凝血
IF 1.5
血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000085
{"title":"Erratum: Loss of Tet2 affects platelet function but not coagulation in mice.","authors":"","doi":"10.1097/BS9.0000000000000085","DOIUrl":"10.1097/BS9.0000000000000085","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000055.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42748213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis. GSDME通过平衡pyroptosis和细胞凋亡维持造血干细胞
IF 1.5
血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000088
{"title":"Erratum: GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis.","authors":"","doi":"10.1097/BS9.0000000000000088","DOIUrl":"10.1097/BS9.0000000000000088","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000064.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49480712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis. BECN1通过靶向caspase -3- gsdme介导的焦亡来调节造血干细胞
IF 1.5
血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000084
{"title":"Erratum: BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis.","authors":"","doi":"10.1097/BS9.0000000000000084","DOIUrl":"10.1097/BS9.0000000000000084","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000051.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43805095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells. ALKBH3在维持造血干细胞方面是可有可无的，但强制ALKBH3纠正了衰老造血干细胞的分化偏斜
IF 1.5
血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000086
{"title":"Erratum: ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells.","authors":"","doi":"10.1097/BS9.0000000000000086","DOIUrl":"10.1097/BS9.0000000000000086","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000057.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48851399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: IL-12 supports in vitro self-renewal of LT HSC. IL-12支持LT-HSC的体外自我更新
IF 1.5
血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000080
{"title":"Erratum: IL-12 supports in vitro self-renewal of LT HSC.","authors":"","doi":"10.1097/BS9.0000000000000080","DOIUrl":"10.1097/BS9.0000000000000080","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000002.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46408228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow. 解释骨髓中WHIM中性粒细胞积聚的趋化模型
IF 1.5
血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000081
{"title":"Erratum: A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow.","authors":"","doi":"10.1097/BS9.0000000000000081","DOIUrl":"10.1097/BS9.0000000000000081","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000019.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48218383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells. 小鼠多能干细胞再生免疫活性T细胞的两步方案
IF 1.5
血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000083
{"title":"Erratum: Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells.","authors":"","doi":"10.1097/BS9.0000000000000083","DOIUrl":"10.1097/BS9.0000000000000083","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000049.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42615180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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