血液科学(英文)最新文献_第10页

Erratum: IL-12 supports in vitro self-renewal of LT HSC. IL-12支持LT-HSC的体外自我更新

IF 1.5

血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000080

引用次数: 0

Erratum: A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow. 解释骨髓中WHIM中性粒细胞积聚的趋化模型

IF 1.5

血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000081

引用次数: 0

Erratum: Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells. 小鼠多能干细胞再生免疫活性T细胞的两步方案

IF 1.5

血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000083

引用次数: 0

Erratum: RNA editing enzyme ADAR1 is required for early T cell development. RNA编辑酶ADAR1是早期T细胞发育所必需的

IF 1.5

血液科学(英文) Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000082

引用次数: 0

Higher efficacy of oral etoposide for mobilization of peripheral blood stem cells in patients with multiple myeloma 口服依托泊苷对多发性骨髓瘤患者外周血干细胞动员的更高疗效

血液科学(英文) Pub Date : 2022-02-23 DOI: 10.1097/BS9.0000000000000104

W. Qiang, Hua Jiang, Pei Guo, Jing Lu, Jin Liu, Lu Li, Haiyan He, Xiao Hu, W. Fu, J. Du

{"title":"Higher efficacy of oral etoposide for mobilization of peripheral blood stem cells in patients with multiple myeloma","authors":"W. Qiang, Hua Jiang, Pei Guo, Jing Lu, Jin Liu, Lu Li, Haiyan He, Xiao Hu, W. Fu, J. Du","doi":"10.1097/BS9.0000000000000104","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000104","url":null,"abstract":"Abstract This study compares the efficacy, toxicity, hematopoietic recovery, and cost of stem-cell mobilization using intermediate-dose cyclophosphamide (IDCy) plus granulocyte colony-stimulating factor (G-CSF) compared with etoposide (VP-16) plus pegylated granulocyte colony-stimulating factor (PEG-rhG-CSF) in multiple myeloma (MM) patients. Two hundred forty-four consecutive patients undergoing mobilization with IDCy (3-3.5 g/m2) plus G-CSF (n = 155) were compared with patients receiving VP-16 plus PEG-rhG-CSF (n = 89), including oral etoposide (n = 65) and intravenous etoposide (n = 24). Compared with IDCy, VP-16 use was associated with significantly higher median peak peripheral blood CD34 + cell count (8.20 [range: 1.84-84] × 106/kg vs 4.58 [range: 0.1-27.9] × 106/kg, P = .000), and ideal CD34 + cell yield of more than 6 × 106/kg (56.8% vs 35.1%, P = .001), notably with a higher efficacy in oral VP-16 use compared with IDCy use (CD 34 + cell counts: median peak peripheral blood 5.87 vs 4.58 × 106/kg and ≥6 × 106/kg [48.4% vs 35.1%]). The median number of apheresis courses was reduced from two in the IDCy group to one in the VP-16 group (P = .000). IDCy use was associated with significantly more frequent episodes of neutropenia (70.2% vs 35.2%; P = .000), intravenous antibiotic use (13.2% vs 11.4%; P = .672), and hospitalization (P = .000). The recoveries of neutrophils and platelets after autologous stem-cell transplantation were significantly faster in the VP-16 group compared with the IDCy group (P = .000). Our data indicate robust stem-cell mobilization in MM patients with VP-16 delivered either orally or intravenously. When compared with intravenous VP-16, oral VP-16 mobilization was associated with significantly more convenient, lower average total costs, and especially decreased the risk of hospital visits and exposure.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46586625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases. 勘误：血小板减少症中巨核细胞的超微结构改变：43 例病例回顾。

IF 1.5

血液科学(英文) Pub Date : 2022-02-15 eCollection Date: 2022-01-01 DOI: 10.1097/BS9.0000000000000096

引用次数: 0

Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia. 综合基因组分析确定T细胞急性淋巴细胞白血病的高危因素和可操作的靶点

IF 1.5

血液科学(英文) Pub Date : 2022-02-04 eCollection Date: 2022-01-01 DOI: 10.1097/BS9.0000000000000102

Haichuan Zhu, Bingjie Dong, Yingchi Zhang, Mei Wang, Jianan Rao, Bowen Cui, Yu Liu, Qian Jiang, Weitao Wang, Lu Yang, Anqi Yu, Zongru Li, Chao Liu, Leping Zhang, Xiaojun Huang, Xiaofan Zhu, Hong Wu

{"title":"Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia.","authors":"Haichuan Zhu, Bingjie Dong, Yingchi Zhang, Mei Wang, Jianan Rao, Bowen Cui, Yu Liu, Qian Jiang, Weitao Wang, Lu Yang, Anqi Yu, Zongru Li, Chao Liu, Leping Zhang, Xiaojun Huang, Xiaofan Zhu, Hong Wu","doi":"10.1097/BS9.0000000000000102","DOIUrl":"10.1097/BS9.0000000000000102","url":null,"abstract":"T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy often associated with poor outcomes. To identify high-risk factors and potential actionable targets for T-ALL, we perform integrated genomic and transcriptomic analyses on samples from 165 Chinese pediatric and adult T-ALL patients, of whom 85% have outcome information. The genomic mutation landscape of this Chinese cohort is very similar to the Western cohort published previously, except that the rate of NOTCH1 mutations is significant lower in the Chinese T-ALL patients. Among 47 recurrently mutated genes in 7 functional categories, we identify RAS pathway and PTEN mutations as poor survival factors for non-TAL and TAL subtypes, respectively. Mutations in the PI3K pathway are mutually exclusive with mutations in the RAS and NOTCH1 pathways as well as transcription factors. Further analysis demonstrates that approximately 43% of the high-risk patients harbor at least one potential actionable alteration identified in this study, and T-ALLs with RAS pathway mutations are hypersensitive to MEKi in vitro and in vivo. Thus, our integrated genomic analyses not only systematically identify high-risk factors but suggest that these high-risk factors are promising targets for T-ALL therapies.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48694676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In memory of Hal E. Broxmeyer, a pluripotent scientist, pioneer, and mentor. 纪念全能科学家、先驱和导师Hal E.Broxmeyer

IF 1.5

血液科学(英文) Pub Date : 2022-01-25 eCollection Date: 2022-01-01 DOI: 10.1097/BS9.0000000000000100

Linzhao Cheng, Bin Guo, Xinxin Huang, Tao Cheng

引用次数: 0

China's top 10 hematological advances in 2021 lists the key developments in hematology in China for that year. 2021年中国血液学十大进展列出了当年中国血液学的关键进展

IF 1.5

血液科学(英文) Pub Date : 2022-01-25 eCollection Date: 2022-01-01 DOI: 10.1097/BS9.0000000000000103

Xiaochen Wang

引用次数: 0

Mature plasmacytoid dendritic cells associated with acute myeloid leukemia show similar genetic mutations and expression profiles to leukemia cells 与急性髓系白血病相关的成熟浆细胞样树突状细胞表现出与白血病细胞相似的基因突变和表达谱

血液科学(英文) Pub Date : 2022-01-01 DOI: 10.1097/BS9.0000000000000097

X. Gong, Chunhong Li, Ying Wang, Q. Rao, Y. Mi, Min Wang, H. Wei, Jianxiang Wang

{"title":"Mature plasmacytoid dendritic cells associated with acute myeloid leukemia show similar genetic mutations and expression profiles to leukemia cells","authors":"X. Gong, Chunhong Li, Ying Wang, Q. Rao, Y. Mi, Min Wang, H. Wei, Jianxiang Wang","doi":"10.1097/BS9.0000000000000097","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000097","url":null,"abstract":"Introduction: Mature plasmacytoid dendritic cells (pDCs) proliferation associated with myeloid neoplasms (MPDMN) are recognized as a neoplasm related to fully differentiated pDCs. Although it has been reported for many years, the genomic landscape of MPDMN is poorly understood. Methods: We reported two patients who developed acute myeloid leukemia (French-American-British M5 subtype) coexisted with immunophenotypically mature pDCs proliferation, which fit the diagnosis of MPDMN. We sorted pDCs from myeloid blasts by flow cytometry and performed whole-exome sequencing and RNA sequencing of the two cell populations, respectively. Results: The immunophenotypes of pDCs in both patients were positive for CD123bri, HLA-DR, CD4, CD303, CD304, and negative for CD56, CD34, CD117, and TdT. The variant allele frequency of gene mutations in myeloid blasts and pDCs were similar. The expression data showed myeloid blasts clustered tightly with hematopoietic stem cells, and pDCs from patients clustered tightly with granulocyte-monocyte progenitors/common myeloid progenitor, rather than with pDCs from the GEO platform. Conclusion: Our study suggested that pDCs derived from the leukemic clone, evidenced by a shared mutation profile and similar transcriptional signatures between pDCs and concurrent myeloid blasts.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46428166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4