血液科学(英文)最新文献_第7页

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000128

Jia Yu

引用次数: 0

Chimeric antigen receptor-T-cell therapy: China leading the way. 嵌合抗原受体- t细胞疗法:中国领先。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000118

Robert Peter Gale

引用次数: 0

A typical bedside-to-bench investigation of leukemogenic driver MEF2D fusion reveals new targeted therapy in B-cell acute lymphoblastic leukemia. 一项典型的白血病驱动因子MEF2D融合的临床研究揭示了b细胞急性淋巴细胞白血病的新靶向治疗方法。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000126

Hao Zhang, Guoyu Meng

引用次数: 1

Epitranscriptomics in myeloid malignancies. 髓系恶性肿瘤的表转录组学研究。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000124

Li Han, Jianjun Chen, Rui Su

{"title":"Epitranscriptomics in myeloid malignancies.","authors":"Li Han, Jianjun Chen, Rui Su","doi":"10.1097/BS9.0000000000000124","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000124","url":null,"abstract":"In eukaryotes, gene expression is highly orchestrated not only by genomic promoters and enhancers but also by covalent modifications added to either chromatin or RNAs. Traditionally, “epigenetics” refers to the chemical modifications that govern heritable changes in gene expression independent of the DNA sequence; “epitranscriptomics” indicates the covalent decorations in RNA, which plays a central role in posttranscriptional gene regulation. To date, >170 RNA chemical modifications have been characterized. Most of these modifications were originally identified in highly abundant noncoding RNA species, such as ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), and small nuclear RNA (snRNAs). Recently, the substantial advances in high-throughput sequencing and analytical chemistry have enabled the precise detection and characterization of chemical modifications in messenger RNA (mRNA). Indeed, a consid- erable number of mRNA decorations have been documented, including N 6 -methyladenosine (m 6 A); N 1 -methyladenosine (m 1 A); N 6 ,2 ʹ -O-dimethyladenosine (m 6 A m ); 3-methylcytidine (m 3 C); 5-methylcytidine (m 5 C); 5-hydroxymethylcytidine (hm 5 C); N 4 -acetylcytidine (ac 4 C); Adenosine-to-inosine (A-to-I) editing; pseudouridine ( Ψ ); N 7 -methylguanosine (m 7 G) and 2 ʹ -O-methylated nucleotides (","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"133-135"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10731043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination. 预防13肺炎球菌疫苗接种前后稳态镰状细胞病尼日利亚儿童体液免疫和营养必需微量元素的评估

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000115

Ganiyu Olatunbosun Arinola, Elizabeth Disu, Adedokun Babatunde, Christopher Olopade, Olufunmilayo Olopade

{"title":"Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and after Prevenar 13 pneumococcal vaccination.","authors":"Ganiyu Olatunbosun Arinola, Elizabeth Disu, Adedokun Babatunde, Christopher Olopade, Olufunmilayo Olopade","doi":"10.1097/BS9.0000000000000115","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000115","url":null,"abstract":"Children with sickle cell disease (SCD) are particularly prone to pneumococcal infection and administration of Prevenar 13 pneumococcal vaccine in Nigerian children with SCD is yet to be wide spread. This call for the need to study humoral immune responses stimulated by Prevenar 13 pneumococcal vaccine in SCD children to confirm the benefit or otherwise for the use of Prevenar 13 pneumococcal vaccine.Method: The levels of humoral (innate and adaptive) immune factors and associated nutritionally essential trace elements were determined following Prevenar 13 pneumococcal vaccination of 23 Nigerian children with SCD. Serum innate humoral immune factors [Complement factors (C1q and C4), transferrin, ferritin, and C-reactive protein (CRP)] and adaptive humoral immune factors [IgG, IgA, IgM, and IgE] were determined using ELISA. Nutritionally essential trace elements such as iron (Fe), copper (Cu), and zinc (Zn) were measured also using an atomic absorption spectrophotometer.Results: The serum levels of certain innate humoral immune factors (ferritin, CRP, and C4), only one adaptive humoral immune factors (IgE), and essential trace elements (Fe, Zn, and Cu) were significantly elevated in children with SCD post Prevenar 13 pneumococcal vaccination when compared to prevaccination levels.Conclusion: Vaccination of children with SCD with Prevenar 13 pneumococcal vaccine was associated with increased levels of more innate humoral immune factors than adaptive factors. This study thus supports the administration of Prevenar 13 pneumococcal vaccination to children with SCD.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"170-173"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10706565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Centrosome Defects in Hematological Malignancies: Molecular Mechanisms and Therapeutic Insights. 血液恶性肿瘤的中心体缺陷:分子机制和治疗见解。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000127

Mingzheng Hu, Yijie Wang, Jun Zhou

引用次数: 4

Risk factors for CMV infection within 100 days posttransplantation in patients with acute leukemia. 急性白血病患者移植后100天内巨细胞病毒感染的危险因素

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000121

Juan Chen, Aiming Pang, Yuanqi Zhao, Li Liu, Runzhi Ma, Jialin Wei, Xin Chen, Yi He, Donglin Yang, Rongli Zhang, Weihua Zhai, Qiaoling Ma, Erlie Jiang, Mingzhe Han, Jiaxi Zhou, Sizhou Feng

{"title":"Risk factors for CMV infection within 100 days posttransplantation in patients with acute leukemia.","authors":"Juan Chen, Aiming Pang, Yuanqi Zhao, Li Liu, Runzhi Ma, Jialin Wei, Xin Chen, Yi He, Donglin Yang, Rongli Zhang, Weihua Zhai, Qiaoling Ma, Erlie Jiang, Mingzhe Han, Jiaxi Zhou, Sizhou Feng","doi":"10.1097/BS9.0000000000000121","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000121","url":null,"abstract":"To investigate the risk factors for cytomegalovirus (CMV) infection within 100 days and the relationship between early CMV infection and 1-year relapse for patients with acute leukemia following allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods: Three hundred fifty-nine patients with acute leukemia who received allo-HSCT at our center between January 2015 and January 2020 were retrospectively reviewed.Results: Of 359 patients, 48.19% (173) patients experienced CMV infection within 100 days posttransplantation. In univariate and multivariate logistic analysis, haploidentical-related donor (HRD) (P < 0.001; odds ratio [OR], 5.542; 95% confidence interval [CI], 3.186-9.639), and ratio of CD3+CD8+ cells in lymphocytes <14.825% (P < 0.001; OR, 3.005; 95% CI, 1.712-5.275) were identified as 2 independent risk factors. One-year relapse rate (RR) between the CMV infection group and the non-CMV infection group was not statistically significant (18.5% vs 19.9%, P = 0.688). When we divided the total cohort into AML, ALL, and MAL subgroups, there were no significant differences as well (P = 0.138; P = 0.588; P = 0.117; respectively).Conclusion: In conclusion, donor type (HRD) and the insufficient recovery of CD3+CD8+ cells were independent risk factors for CMV infection within 100 days posttransplantation in patients with acute leukemia. CMV infection within 100 days did not influence the incidence of relapse in 1 year for patients with acute leukemia.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"164-169"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/84/bs9-4-164.PMC9742110.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation. KHSRP结合转录和转录后机制调节单核细胞分化。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000122

Jiayue Xu, Dongsheng Wang, Hongliu Ma, Xueying Zhai, Yue Huo, Yue Ren, Weiqian Li, Le Chang, Dongxu Lu, Yuehong Guo, Yanmin Si, Yufeng Gao, Xiaoshuang Wang, Yanni Ma, Fang Wang, Jia Yu

{"title":"KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation.","authors":"Jiayue Xu, Dongsheng Wang, Hongliu Ma, Xueying Zhai, Yue Huo, Yue Ren, Weiqian Li, Le Chang, Dongxu Lu, Yuehong Guo, Yanmin Si, Yufeng Gao, Xiaoshuang Wang, Yanni Ma, Fang Wang, Jia Yu","doi":"10.1097/BS9.0000000000000122","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000122","url":null,"abstract":"RNA-binding proteins (RBPs) are widely involved in the transcriptional and posttranscriptional regulation of multiple biological processes. The transcriptional regulatory ability of RBPs was indicated by the identification of chromatin-enriched RBPs (Che-RBPs). One of these proteins, KH-type splicing regulatory protein (KHSRP), is a multifunctional RBP that has been implicated in mRNA decay, alternative splicing, and miRNA biogenesis and plays an essential role in myeloid differentiation by facilitating the maturation of miR-129. In this study, we revealed that KHSRP regulates monocytic differentiation by regulating gene transcription and RNA splicing. KHSRP-occupied specific genomic sites in promoter and enhancer regions to regulate the expression of several hematopoietic genes through transcriptional activation and bound to pre-mRNA intronic regions to modulate alternative splicing during monocytic differentiation. Of note, KHSRP had co-regulatory effects at both the transcriptional and posttranscriptional levels on MOGOH and ADARB1. Taken together, our analyses revealed the dual DNA- and RNA-binding activities of KHSRP and have provided a paradigm to guide the analysis of other functional Che-RBPs in different biological systems.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"103-115"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10731051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA m⁶A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia. RNA m6A修饰:在急性髓性白血病中的定位方法、作用和机制。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000131

Rong Yin, Yashu Li, Wen Tian, Fuling Zhou, Haojian Zhang

{"title":"RNA m6A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia.","authors":"Rong Yin, Yashu Li, Wen Tian, Fuling Zhou, Haojian Zhang","doi":"10.1097/BS9.0000000000000131","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000131","url":null,"abstract":"N6-Methyladenosine (m6A) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that m6A modification plays a key role in hematologic malignancies, including acute myeloid leukemia. The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA m6A modification in a transcriptome-wide manner. In this review, we first briefly summarize the latest advances in RNA m6A biology by focusing on writers, readers, and erasers of m6A modification, and describe the development of high-throughput methods for RNA m6A mapping. We further discuss the important roles of m6A modifiers in acute myeloid leukemia, and highlight the identification of potential inhibitors for AML treatment by targeting of m6A modifiers. Overall, this review provides a comprehensive summary of RNA m6A biology in acute myeloid leukemia.","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"116-124"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis. diulfiram是一种醛脱氢酶抑制剂，作为一种有效的药物，通过NETosis, pyroptosis, apoptosis, ferroptosis和cuprotosis治疗败血症和癌症。

血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000117

Dingrui Nie, Cunte Chen, Yangqiu Li, Chengwu Zeng

引用次数: 9