发布求助
文献互助 智能选刊 最新文献

血液科学(英文)最新文献

筛选
英文 中文
Acquired hemophilia associated with vedolizumab in a patient with hemorrhagic rectocolitis. 出血性直肠结肠炎患者与vedolizumab相关的获得性血友病。
血液科学(英文) Pub Date : 2023-01-01 DOI: 10.1097/BS9.0000000000000138
Thomas Schiestel
{"title":"Acquired hemophilia associated with vedolizumab in a patient with hemorrhagic rectocolitis.","authors":"Thomas Schiestel","doi":"10.1097/BS9.0000000000000138","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000138","url":null,"abstract":"To The Editor","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"5 1","pages":"60-61"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10717135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of genetic polymorphisms on methotrexate levels and toxicity in Chinese patients with acute lymphoblastic leukemia. 基因多态性对中国急性淋巴细胞白血病患者甲氨蝶呤水平和毒性的影响。
血液科学(英文) Pub Date : 2023-01-01 DOI: 10.1097/BS9.0000000000000142
Qishan Hao, Yang Song, Qiuyun Fang, Yani Lin, Long Chen, Xiaodan Wang, Ping Zhang, Zhe Wang, Xiaoyuan Gong, Kaiqi Liu, Qinghua Li, Zheng Tian, Min Wang, Jianxiang Wang, Yingchang Mi
{"title":"Effects of genetic polymorphisms on methotrexate levels and toxicity in Chinese patients with acute lymphoblastic leukemia.","authors":"Qishan Hao,&nbsp;Yang Song,&nbsp;Qiuyun Fang,&nbsp;Yani Lin,&nbsp;Long Chen,&nbsp;Xiaodan Wang,&nbsp;Ping Zhang,&nbsp;Zhe Wang,&nbsp;Xiaoyuan Gong,&nbsp;Kaiqi Liu,&nbsp;Qinghua Li,&nbsp;Zheng Tian,&nbsp;Min Wang,&nbsp;Jianxiang Wang,&nbsp;Yingchang Mi","doi":"10.1097/BS9.0000000000000142","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000142","url":null,"abstract":"<p><p>Methotrexate (MTX) has an antitumor effect when used for the treatment of acute lymphoblastic leukemia (ALL). This study aims at evaluating the associations between 14 polymorphisms of six genes involved in MTX metabolism with serum MTX concentration and toxicity accompanying high-dose MTX. Polymorphisms in 183 Chinese patients with ALL were analyzed using TaqMan single nucleotide polymorphism genotyping assay. The serum MTX concentration was determined using homogeneous enzyme immunoassay. MTX-related toxicities were also evaluated. Renal toxicity was significantly associated with higher serum MTX concentrations at 24, 48, and 72 hours, and MTX elimination delay (<i>P</i> = 0.001, <i>P</i> < 0.001, <i>P</i> < 0.001, and <i>P</i> < 0.001, respectively), whereas <i>SLCO1B1</i> rs4149056 was associated with serum MTX concentrations at 48 and 72 hours, and MTX elimination delay in candidate polymorphisms (<i>P</i> = 0.014, <i>P</i> = 0.019, and <i>P</i> = 0.007, respectively). <i>SLC19A1</i> rs2838958 and rs3788200 were associated with serum MTX concentrations at 24 hours (<i>P</i> = 0.016, <i>P</i> = 0.043, respectively). <i>MTRR</i> rs1801394 was associated with serum MTX concentrations at 72 hours (<i>P</i> = 0.045). Neutropenia was related to <i>SLC19A1</i> rs4149056 (odds ratio [OR]: 3.172, 95% confidence interval [CI]: 1.310-7.681, <i>P</i> = 0.011). Hepatotoxicity was associated with <i>ABCC2</i> rs2273697 (OR: 3.494, 95% CI: 1.236-9.873, <i>P</i> = 0.018) and <i>MTRR</i> rs1801394 (OR: 0.231, 95% CI: 0.084-0.632, <i>P</i> = 0.004). Polymorphisms of <i>SLCO1B1, SLC19A1, ABCC2</i>, and <i>MTRR</i> genes help predict higher risk of increased MTX levels or MTX-related toxicities in adult ALL patients.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"5 1","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10661697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The eighth International Forum on Stem Cells: virtual meeting, October 20-21, 2022. 第八届干细胞国际论坛：虚拟会议，2022年10月20日至21日
血液科学(英文) Pub Date : 2022-12-27 eCollection Date: 2023-01-01 DOI: 10.1097/BS9.0000000000000147
Brian Eyden, Xiaochen Wang
{"title":"The eighth International Forum on Stem Cells: virtual meeting, October 20-21, 2022.","authors":"Brian Eyden, Xiaochen Wang","doi":"10.1097/BS9.0000000000000147","DOIUrl":"10.1097/BS9.0000000000000147","url":null,"abstract":",","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"1 1","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46010084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatially resolved transcriptomics: advances and applications. 空间解析转录组学:进展与应用。
血液科学(英文) Pub Date : 2022-11-04 eCollection Date: 2023-01-01 DOI: 10.1097/BS9.0000000000000141
Honglin Duan, Tao Cheng, Hui Cheng
{"title":"Spatially resolved transcriptomics: advances and applications.","authors":"Honglin Duan, Tao Cheng, Hui Cheng","doi":"10.1097/BS9.0000000000000141","DOIUrl":"10.1097/BS9.0000000000000141","url":null,"abstract":"<p><p>Spatial transcriptomics, which is capable of both measuring all gene activity in a tissue sample and mapping where this activity occurs, is vastly improving our understanding of biological processes and disease. The field has expanded rapidly in recent years, and the development of several new technologies has resulted in spatially resolved transcriptomics (SRT) becoming highly multiplexed, high-resolution, and high-throughput. Here, we summarize and compare the major methods of SRT, including imaging-based methods, sequencing-based methods, and in situ sequencing methods. We also highlight some typical applications of SRT in neuroscience, cancer biology, developmental biology, and hematology. Finally, we discuss future possibilities for improving spatially resolved transcriptomic methods and the expected applications of such methods, especially in the adult bone marrow, anticipating that new developments will unlock the full potential of spatially resolved multi-omics in both biological research and the clinic.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"5 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10717130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
BCR-ABL1 is a secondary event after JAK2V617F in a patient with essential thrombocythemia who develop chronic myeloid leukemia. BCR-ABL1是JAK2V617F后原发性血小板增多症并发慢性髓性白血病患者的次要事件。
血液科学(英文) Pub Date : 2022-10-01 DOI: 10.1097/BS9.0000000000000129
Yanqing Zhang, Hailiang Bi, Ying Wang, Long Chen, Jiaqi Pan, Ping Xu, Wei Wang, Shaobin Yang
{"title":"<i>BCR-ABL1</i> is a secondary event after JAK2V617F in a patient with essential thrombocythemia who develop chronic myeloid leukemia.","authors":"Yanqing Zhang,&nbsp;Hailiang Bi,&nbsp;Ying Wang,&nbsp;Long Chen,&nbsp;Jiaqi Pan,&nbsp;Ping Xu,&nbsp;Wei Wang,&nbsp;Shaobin Yang","doi":"10.1097/BS9.0000000000000129","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000129","url":null,"abstract":"<p><p>Several cases such as myeloproliferative neoplasms (MPN) with the coexistence of JAK2 and BCR-ABL have been reported. However, cases of transformation of essential thrombocythemia (ET) into chronic myeloid leukemia (CML) during the disease progression were rarely reported. Here, we report the case of a patient with <i>JAK2 V617F</i>- positive ET who subsequently acquired BCR-ABL1, which transformed the disease into CML after 10 years from the initial diagnosis. In this study, we dynamically monitored JAK2 V617F and BCR-ABL and observed multiple gene mutations, including IDH2, IDH1, ASXL1, KRAS, and RUNX1. It is important to be aware of this potentially clone evolution in disease progression.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 4","pages":"199-204"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10423608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary tuberculosis infection and CMV reactivation following daratumumab treatment in a patient with relapsed plasmablastic lymphoma. 复发性浆母细胞淋巴瘤患者达拉单抗治疗后的肺结核感染和巨细胞病毒再激活
血液科学(英文) Pub Date : 2022-10-01 DOI: 10.1097/BS9.0000000000000134
Wenyue Cao, Yuling Wan, Xingcheng Yang, Wei Huang, Jia Wei
{"title":"Pulmonary tuberculosis infection and CMV reactivation following daratumumab treatment in a patient with relapsed plasmablastic lymphoma.","authors":"Wenyue Cao,&nbsp;Yuling Wan,&nbsp;Xingcheng Yang,&nbsp;Wei Huang,&nbsp;Jia Wei","doi":"10.1097/BS9.0000000000000134","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000134","url":null,"abstract":"<p><p>Plasmablastic lymphoma (PBL) is an aggressive lymphoma with limited treatment strategies. Tuberculosis (TB) infection poses a high risk for patients with hematologic malignancies, especially those treated with immune agents but were never reported post-daratumumab treatment. Herein, we reported a TB infection in a 57-year-old male diagnosed with HIV-negative PBL receiving daratumumab-based treatment, who showed atypical lung infection and yielded <i>Mycobacterium tuberculosis</i> and cytomegalovirus (CMV) in the bronchoalveolar lavage fluid. Anti-TB therapy was administered, and the following daratumumab treatment was complete with good tolerance. In this case, we demonstrated that TB infection might occur after daratumumab therapy, and adequate attention should be paid to atypical symptoms.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 4","pages":"205-208"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10362509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel non-viral PDCD1 site-integrated CAR design: killing 2 birds with 1 stone. 一种新的非病毒PDCD1位点集成CAR设计:一石二鸟。
血液科学(英文) Pub Date : 2022-10-01 DOI: 10.1097/BS9.0000000000000135
Yuanbin Cui, Yunlin Huang, Le Qin, Peng Li
{"title":"A novel non-viral <i>PDCD1</i> site-integrated CAR design: killing 2 birds with 1 stone.","authors":"Yuanbin Cui,&nbsp;Yunlin Huang,&nbsp;Le Qin,&nbsp;Peng Li","doi":"10.1097/BS9.0000000000000135","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000135","url":null,"abstract":"Although chimeric antigen receptor T-cell (CAR-T-cell) ther- apy has shown excellent efficacy against refractory/relapsed B-cell lymphoma","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 4","pages":"211-213"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10362503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence and its applications in digital hematopathology. 人工智能及其在数字血液病理学中的应用。
IF 1.5
血液科学(英文) Pub Date : 2022-07-14 eCollection Date: 2022-07-01 DOI: 10.1097/BS9.0000000000000130
Yongfei Hu, Yinglun Luo, Guangjue Tang, Yan Huang, Juanjuan Kang, Dong Wang
{"title":"Artificial intelligence and its applications in digital hematopathology.","authors":"Yongfei Hu, Yinglun Luo, Guangjue Tang, Yan Huang, Juanjuan Kang, Dong Wang","doi":"10.1097/BS9.0000000000000130","DOIUrl":"10.1097/BS9.0000000000000130","url":null,"abstract":"<p><p>The advent of whole-slide imaging, faster image data generation, and cheaper forms of data storage have made it easier for pathologists to manipulate digital slide images and interpret more detailed biological processes in conjunction with clinical samples. In parallel, with continuous breakthroughs in object detection, image feature extraction, image classification and image segmentation, artificial intelligence (AI) is becoming the most beneficial technology for high-throughput analysis of image data in various biomedical imaging disciplines. Integrating digital images into biological workflows, advanced algorithms, and computer vision techniques expands the biologist's horizons beyond the microscope slide. Here, we introduce recent developments in AI applied to microscopy in hematopathology. We give an overview of its concepts and present its applications in normal or abnormal hematopoietic cells identification. We discuss how AI shows great potential to push the limits of microscopy and enhance the resolution, signal and information content of acquired data. Its shortcomings are discussed, as well as future directions for the field.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"136-142"},"PeriodicalIF":1.5,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/33/7f/bs9-4-136.PMC9742095.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carbon dots for the treatment of cancer-related anemia. 用于治疗癌症相关贫血症的碳点。
血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000120
Xu Han, Peng Ji
{"title":"Carbon dots for the treatment of cancer-related anemia.","authors":"Xu Han, Peng Ji","doi":"10.1097/BS9.0000000000000120","DOIUrl":"10.1097/BS9.0000000000000120","url":null,"abstract":"","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"174-175"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA and hematopoiesis. RNA和造血。
血液科学(英文) Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000128
Jia Yu
{"title":"RNA and hematopoiesis.","authors":"Jia Yu","doi":"10.1097/BS9.0000000000000128","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000128","url":null,"abstract":"Hematopoietic stem cells (HSCs) can differentiate into all mature functional blood cells via hematopoiesis","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":"4 3","pages":"101-102"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信